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Items: 1 to 50 of 122

1.

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells.

Van Hoecke L, Raes L, Stremersch S, Brans T, Fraire JC, Roelandt R, Declercq W, Vandenabeele P, Raemdonck K, Braeckmans K, Saelens X.

Int J Mol Sci. 2019 Aug 30;20(17). pii: E4254. doi: 10.3390/ijms20174254.

2.

Filaggrin expression and processing deficiencies impair corneocyte surface texture and stiffness in mice.

Thyssen JP, Jakasa I, Riethmüller C, Schön MP, Braun A, Haftek M, Fallon PG, Wróblewski J, Jakubowski H, Eckhart L, Declercq W, Koppes S, Engebretsen KA, Bonefeld C, Irvine AD, Keita-Alassane S, Simon M, Kawasaki H, Kubo A, Amagai M, Matsui T, Kezic S.

J Invest Dermatol. 2019 Aug 31. pii: S0022-202X(19)33201-4. doi: 10.1016/j.jid.2019.07.716. [Epub ahead of print]

PMID:
31479664
3.

Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers.

Tanc M, Cleenewerck M, Kurdi A, Roelandt R, Declercq W, De Meyer G, Augustyns K, Martinet W, Van der Veken P.

Bioorg Chem. 2019 Jun;87:163-168. doi: 10.1016/j.bioorg.2019.03.021. Epub 2019 Mar 13.

PMID:
30884310
4.

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration.

Vandenabeele P, Declercq W, Roelandt R, Vanden Berghe T.

Mol Cell. 2018 Nov 1;72(3):397-399. doi: 10.1016/j.molcel.2018.10.025.

PMID:
30388406
5.

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

Devos M, Mogilenko DA, Fleury S, Gilbert B, Becquart C, Quemener S, Dehondt H, Tougaard P, Staels B, Bachert C, Vandenabeele P, Van Loo G, Staumont-Salle D, Declercq W, Dombrowicz D.

J Invest Dermatol. 2019 Jan;139(1):135-145. doi: 10.1016/j.jid.2018.06.191. Epub 2018 Aug 14.

PMID:
30118730
6.

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.

Tanghe G, Urwyler-Rösselet C, De Groote P, Dejardin E, De Bock PJ, Gevaert K, Vandenabeele P, Declercq W.

Cell Mol Life Sci. 2018 Aug;75(15):2827-2841. doi: 10.1007/s00018-018-2763-6. Epub 2018 Feb 12.

PMID:
29435596
7.

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation.

Urwyler-Rösselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W.

J Invest Dermatol. 2018 Jun;138(6):1268-1278. doi: 10.1016/j.jid.2017.12.031. Epub 2018 Jan 6.

8.

Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris.

Hariton WVJ, Galichet A, Vanden Berghe T, Overmiller AM, Mahoney MG, Declercq W, Müller EJ.

Exp Dermatol. 2017 Dec;26(12):1274-1277. doi: 10.1111/exd.13458.

PMID:
29105150
9.

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice.

Kurdi A, Cleenewerck M, Vangestel C, Lyssens S, Declercq W, Timmermans JP, Stroobants S, Augustyns K, De Meyer GRY, Van Der Veken P, Martinet W.

Biochem Pharmacol. 2017 Aug 15;138:150-162. doi: 10.1016/j.bcp.2017.06.119. Epub 2017 Jun 19.

PMID:
28642033
10.

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.

Teufelberger AR, Nordengrün M, Braun H, Maes T, De Grove K, Holtappels G, O'Brien C, Provoost S, Hammad H, Gonçalves A, Beyaert R, Declercq W, Vandenabeele P, Krysko DV, Bröker BM, Bachert C, Krysko O.

J Allergy Clin Immunol. 2018 Feb;141(2):549-559.e7. doi: 10.1016/j.jaci.2017.05.004. Epub 2017 May 19.

PMID:
28532656
11.

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition.

Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, Dubois C, Nkusi E, Lenglez S, Checinska A, Vercauteren Drubbel A, Devos M, Declercq W, Yi R, Blanpain C.

Cell Stem Cell. 2017 Feb 2;20(2):191-204.e5. doi: 10.1016/j.stem.2016.10.018. Epub 2016 Nov 23.

12.

Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation.

Devos M, Gilbert B, Denecker G, Leurs K, Mc Guire C, Lemeire K, Hochepied T, Vuylsteke M, Lambert J, Van Den Broecke C, Libbrecht L, Haigh J, Berx G, Lippens S, Vandenabeele P, Declercq W.

J Invest Dermatol. 2017 Feb;137(2):494-505. doi: 10.1016/j.jid.2016.09.026. Epub 2016 Oct 7.

13.

Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay.

Cleenewerck M, Grootaert MOJ, Gladysz R, Adriaenssens Y, Roelandt R, Joossens J, Lambeir AM, De Meyer GRY, Declercq W, Augustyns K, Martinet W, Van der Veken P.

Eur J Med Chem. 2016 Nov 10;123:631-638. doi: 10.1016/j.ejmech.2016.07.073. Epub 2016 Jul 31.

PMID:
27517808
14.

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells.

De Groote P, Grootjans S, Lippens S, Eichperger C, Leurs K, Kahr I, Tanghe G, Bruggeman I, De Schamphelaire W, Urwyler C, Vandenabeele P, Haustraete J, Declercq W.

Biotechniques. 2016 May 1;60(5):252-9. doi: 10.2144/000114417. eCollection 2016.

15.

Martin Leverkus, MD (1965-2016).

Panayotova-Dimitrova D, Declercq W.

J Invest Dermatol. 2016 May;136(5):891-2. doi: 10.1016/j.jid.2016.03.012. Epub 2016 Apr 20. No abstract available.

16.

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.

Aaes TL, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, Delrue I, Taminau J, Wiernicki B, De Groote P, Garg AD, Leybaert L, Grooten J, Bertrand MJ, Agostinis P, Berx G, Declercq W, Vandenabeele P, Krysko DV.

Cell Rep. 2016 Apr 12;15(2):274-87. doi: 10.1016/j.celrep.2016.03.037. Epub 2016 Mar 31.

17.

Interaction of Mycobacterium leprae with the HaCaT human keratinocyte cell line: new frontiers in the cellular immunology of leprosy.

Lyrio EC, Campos-Souza IC, Corrêa LC, Lechuga GC, Verícimo M, Castro HC, Bourguignon SC, Côrte-Real S, Ratcliffe N, Declercq W, Santos DO.

Exp Dermatol. 2015 Jul;24(7):536-42. doi: 10.1111/exd.12714. Epub 2015 May 4.

PMID:
25828729
18.

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes.

De Groote P, Tran HT, Fransen M, Tanghe G, Urwyler C, De Craene B, Leurs K, Gilbert B, Van Imschoot G, De Rycke R, Guérin CJ, Holland P, Berx G, Vandenabeele P, Lippens S, Vleminckx K, Declercq W.

Cell Death Differ. 2015 Jun;22(6):1012-24. doi: 10.1038/cdd.2014.191. Epub 2014 Nov 28.

19.

Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability.

Quimbaya M, Raspé E, Denecker G, De Craene B, Roelandt R, Declercq W, Sagaert X, De Veylder L, Berx G.

Neoplasia. 2014 Sep;16(9):694-709. doi: 10.1016/j.neo.2014.07.011.

20.

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P.

Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706.

PMID:
25186904
21.

The skin microbiome of caspase-14-deficient mice shows mild dysbiosis.

Kubica M, Hildebrand F, Brinkman BM, Goossens D, Del Favero J, Vercammen K, Cornelis P, Schröder JM, Vandenabeele P, Raes J, Declercq W.

Exp Dermatol. 2014 Aug;23(8):561-7. doi: 10.1111/exd.12458. Epub 2014 Jul 16.

PMID:
24863253
22.

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

Dondelinger Y, Declercq W, Montessuit S, Roelandt R, Goncalves A, Bruggeman I, Hulpiau P, Weber K, Sehon CA, Marquis RW, Bertin J, Gough PJ, Savvides S, Martinou JC, Bertrand MJ, Vandenabeele P.

Cell Rep. 2014 May 22;7(4):971-81. doi: 10.1016/j.celrep.2014.04.026. Epub 2014 May 9.

23.

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock.

Vanden Berghe T, Demon D, Bogaert P, Vandendriessche B, Goethals A, Depuydt B, Vuylsteke M, Roelandt R, Van Wonterghem E, Vandenbroecke J, Choi SM, Meyer E, Krautwald S, Declercq W, Takahashi N, Cauwels A, Vandenabeele P.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):282-91. doi: 10.1164/rccm.201308-1535OC.

PMID:
24456467
24.

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation.

Beck IM, Drebert ZJ, Hoya-Arias R, Bahar AA, Devos M, Clarisse D, Desmet S, Bougarne N, Ruttens B, Gossye V, Denecker G, Lievens S, Bracke M, Tavernier J, Declercq W, Gevaert K, Vanden Berghe W, Haegeman G, De Bosscher K.

PLoS One. 2013 Jul 30;8(7):e69115. doi: 10.1371/journal.pone.0069115. Print 2013.

25.

Caspase-14 overexpression in hairless mice is not involved in utricle formation.

Devos M, De Groote P, Gilbert B, Bruggeman I, Leurs K, Lippens S, Vandenabeele P, Declercq W.

Exp Dermatol. 2013 Jul;22(7):484-6. doi: 10.1111/exd.12165.

PMID:
23800061
26.

Cell death by cornification.

Eckhart L, Lippens S, Tschachler E, Declercq W.

Biochim Biophys Acta. 2013 Dec;1833(12):3471-3480. doi: 10.1016/j.bbamcr.2013.06.010. Epub 2013 Jun 20. Review.

27.

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.

PLoS Genet. 2013 May;9(5):e1003546. doi: 10.1371/journal.pgen.1003546. Epub 2013 May 30.

28.

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.

Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, Vandenabeele P.

Cell Death Dis. 2012 Nov 29;3:e437. doi: 10.1038/cddis.2012.176.

29.

Caspase-14-deficient mice are more prone to the development of parakeratosis.

Hoste E, Denecker G, Gilbert B, Van Nieuwerburgh F, van der Fits L, Asselbergh B, De Rycke R, Hachem JP, Deforce D, Prens EP, Vandenabeele P, Declercq W.

J Invest Dermatol. 2013 Mar;133(3):742-750. doi: 10.1038/jid.2012.350. Epub 2012 Sep 27.

30.

Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis.

Devos M, Prawitt J, Staumont-Salle D, Hoste E, Fleury S, Bouchaert E, Gilbert B, Lippens S, Vandenabeele P, Dombrowicz D, Declercq W.

J Invest Dermatol. 2012 Dec;132(12):2857-60. doi: 10.1038/jid.2012.236. Epub 2012 Aug 30. No abstract available.

31.

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome.

Duprez L, Takahashi N, Van Hauwermeiren F, Vandendriessche B, Goossens V, Vanden Berghe T, Declercq W, Libert C, Cauwels A, Vandenabeele P.

Immunity. 2011 Dec 23;35(6):908-18. doi: 10.1016/j.immuni.2011.09.020.

32.

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis.

Declercq W, Takahashi N, Vandenabeele P.

Immunity. 2011 Oct 28;35(4):493-5. doi: 10.1016/j.immuni.2011.10.007.

33.

Caspase deficiency alters the murine gut microbiome.

Brinkman BM, Hildebrand F, Kubica M, Goosens D, Del Favero J, Declercq W, Raes J, Vandenabeele P.

Cell Death Dis. 2011 Oct 20;2:e220. doi: 10.1038/cddis.2011.101.

34.

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

Bertrand MJ, Lippens S, Staes A, Gilbert B, Roelandt R, De Medts J, Gevaert K, Declercq W, Vandenabeele P.

PLoS One. 2011;6(9):e22356. doi: 10.1371/journal.pone.0022356. Epub 2011 Sep 12.

35.

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.

Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, Gilbert B, Lippens S, De Groote P, Roelandt R, Van Damme P, Gevaert K, Presland RB, Takahara H, Puppels G, Caspers P, Vandenabeele P, Declercq W.

J Invest Dermatol. 2011 Nov;131(11):2233-41. doi: 10.1038/jid.2011.153. Epub 2011 Jun 9.

36.

18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010.

Declercq W, Agostinis P, Vandenabeele P.

Cell Death Differ. 2011 Sep;18(9):1540-2. doi: 10.1038/cdd.2011.76. Epub 2011 Jun 3. No abstract available.

37.

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.

Lippens S, Lefebvre S, Gilbert B, Sze M, Devos M, Verhelst K, Vereecke L, Mc Guire C, Guérin C, Vandenabeele P, Pasparakis M, Mikkola ML, Beyaert R, Declercq W, van Loo G.

Cell Death Differ. 2011 Dec;18(12):1845-53. doi: 10.1038/cdd.2011.55. Epub 2011 May 13.

38.

p63, a story of mice and men.

Vanbokhoven H, Melino G, Candi E, Declercq W.

J Invest Dermatol. 2011 Jun;131(6):1196-207. doi: 10.1038/jid.2011.84. Epub 2011 Apr 7. Review.

39.

Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6.

Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schröder JM, Meyer-Hoffert U.

Peptides. 2011 Jun;32(6):1187-92. doi: 10.1016/j.peptides.2011.03.009. Epub 2011 Mar 23.

PMID:
21439340
40.

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.

Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T.

Sci Signal. 2010 Mar 30;3(115):re4. doi: 10.1126/scisignal.3115re4. Review.

PMID:
20354226
41.

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question.

Van Herreweghe F, Festjens N, Declercq W, Vandenabeele P.

Cell Mol Life Sci. 2010 May;67(10):1567-79. doi: 10.1007/s00018-010-0283-0. Epub 2010 Mar 4. Review.

PMID:
20198502
42.

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, Roelandt R, De Rycke R, Verspurten J, Declercq W, Agostinis P, Vanden Berghe T, Lippens S, Vandenabeele P.

Cell Death Dis. 2010;1:e18. doi: 10.1038/cddis.2009.16.

43.

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

Vanden Berghe T, Vanlangenakker N, Parthoens E, Deckers W, Devos M, Festjens N, Guerin CJ, Brunk UT, Declercq W, Vandenabeele P.

Cell Death Differ. 2010 Jun;17(6):922-30. doi: 10.1038/cdd.2009.184. Epub 2009 Dec 11.

44.

Caspase substrates: easily caught in deep waters?

Demon D, Van Damme P, Vanden Berghe T, Vandekerckhove J, Declercq W, Gevaert K, Vandenabeele P.

Trends Biotechnol. 2009 Dec;27(12):680-8. doi: 10.1016/j.tibtech.2009.09.007. Epub 2009 Oct 29. Review.

PMID:
19879007
45.

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity.

Demon D, Van Damme P, Vanden Berghe T, Deceuninck A, Van Durme J, Verspurten J, Helsens K, Impens F, Wejda M, Schymkowitz J, Rousseau F, Madder A, Vandekerckhove J, Declercq W, Gevaert K, Vandenabeele P.

Mol Cell Proteomics. 2009 Dec;8(12):2700-14. doi: 10.1074/mcp.M900310-MCP200. Epub 2009 Sep 16.

46.

Function of caspase-14 in trophoblast differentiation.

White LJ, Declercq W, Arfuso F, Charles AK, Dharmarajan AM.

Reprod Biol Endocrinol. 2009 Sep 14;7:98. doi: 10.1186/1477-7827-7-98.

47.

The emerging roles of serine protease cascades in the epidermis.

Ovaere P, Lippens S, Vandenabeele P, Declercq W.

Trends Biochem Sci. 2009 Sep;34(9):453-63. doi: 10.1016/j.tibs.2009.08.001. Epub 2009 Aug 31. Review.

PMID:
19726197
48.

RIP kinases at the crossroads of cell death and survival.

Declercq W, Vanden Berghe T, Vandenabeele P.

Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006. Review.

49.

SitePredicting the cleavage of proteinase substrates.

Verspurten J, Gevaert K, Declercq W, Vandenabeele P.

Trends Biochem Sci. 2009 Jul;34(7):319-23. doi: 10.1016/j.tibs.2009.04.001. Epub 2009 Jun 21.

PMID:
19546006
50.

Cell death in the skin.

Lippens S, Hoste E, Vandenabeele P, Agostinis P, Declercq W.

Apoptosis. 2009 Apr;14(4):549-69. doi: 10.1007/s10495-009-0324-z. Review.

PMID:
19221876

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