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Items: 28

1.

Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition.

Dey J, Deckwerth TL, Kerwin WS, Casalini JR, Merrell AJ, Grenley MO, Burns C, Ditzler SH, Dixon CP, Beirne E, Gillespie KC, Kleinman EF, Klinghoffer RA.

Sci Rep. 2017 Dec 21;7(1):18007. doi: 10.1038/s41598-017-18368-w.

2.

A technology platform to assess multiple cancer agents simultaneously within a patient's tumor.

Klinghoffer RA, Bahrami SB, Hatton BA, Frazier JP, Moreno-Gonzalez A, Strand AD, Kerwin WS, Casalini JR, Thirstrup DJ, You S, Morris SM, Watts KL, Veiseh M, Grenley MO, Tretyak I, Dey J, Carleton M, Beirne E, Pedro KD, Ditzler SH, Girard EJ, Deckwerth TL, Bertout JA, Meleo KA, Filvaroff EH, Chopra R, Press OW, Olson JM.

Sci Transl Med. 2015 Apr 22;7(284):284ra58. doi: 10.1126/scitranslmed.aaa7489.

3.

A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood.

Wintner EA, Deckwerth TL, Langston W, Bengtsson A, Leviten D, Hill P, Insko MA, Dumpit R, VandenEkart E, Toombs CF, Szabo C.

Br J Pharmacol. 2010 Jun;160(4):941-57. doi: 10.1111/j.1476-5381.2010.00704.x.

4.

Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide.

Toombs CF, Insko MA, Wintner EA, Deckwerth TL, Usansky H, Jamil K, Goldstein B, Cooreman M, Szabo C.

Br J Clin Pharmacol. 2010 Jun;69(6):626-36. doi: 10.1111/j.1365-2125.2010.03636.x. Erratum in: Br J Clin Pharmacol. 2010 Oct;70(4):628.

5.

Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide.

Insko MA, Deckwerth TL, Hill P, Toombs CF, Szabo C.

Br J Pharmacol. 2009 Jul;157(6):944-51. doi: 10.1111/j.1476-5381.2009.00248.x. Epub 2009 May 7.

6.

An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH.

Nature. 2005 Jun 2;435(7042):677-81. Epub 2005 May 15.

7.

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW.

J Med Chem. 2004 Aug 26;47(18):4417-26.

PMID:
15317454
8.

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.

Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC.

Bioorg Med Chem Lett. 2004 May 17;14(10):2685-91.

PMID:
15109679
9.

Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.

Ullman BR, Aja T, Deckwerth TL, Diaz JL, Herrmann J, Kalish VJ, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC.

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3623-6.

PMID:
14505683
10.

Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons.

Besirli CG, Deckwerth TL, Crowder RJ, Freeman RS, Johnson EM Jr.

Cell Death Differ. 2003 Sep;10(9):1045-58.

11.

Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis.

Bien CG, Bauer J, Deckwerth TL, Wiendl H, Deckert M, Wiestler OD, Schramm J, Elger CE, Lassmann H.

Ann Neurol. 2002 Mar;51(3):311-8.

PMID:
11891826
12.

Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes.

Bauer J, Bradl M, Klein M, Leisser M, Deckwerth TL, Wekerle H, Lassmann H.

J Neuropathol Exp Neurol. 2002 Jan;61(1):12-22.

PMID:
11829340
13.

Expression of cell death-associated proteins in neuronal apoptosis associated with pontosubicular neuron necrosis.

Stadelman C, Mews I, Srinivasan A, Deckwerth TL, Lassmann H, Brück W.

Brain Pathol. 2001 Jul;11(3):273-81.

PMID:
11414470
14.

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Brück W, Jellinger K, Lassmann H.

Am J Pathol. 1999 Nov;155(5):1459-66.

15.

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice.

Mosinger Ogilvie J, Deckwerth TL, Knudson CM, Korsmeyer SJ.

Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1713-20. Erratum in: Invest Ophthalmol Vis Sci 1998 Nov;39(12):2244.

PMID:
9699561
16.

Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation.

Deckwerth TL, Easton RM, Knudson CM, Korsmeyer SJ, Johnson EM Jr.

Exp Neurol. 1998 Jul;152(1):150-62.

PMID:
9682022
17.
18.

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases.

Deshmukh M, Vasilakos J, Deckwerth TL, Lampe PA, Shivers BD, Johnson EM Jr.

J Cell Biol. 1996 Dec;135(5):1341-54.

19.

Neuronal death in developmental models: possible implications in neuropathology.

Johnson EM Jr, Deckwerth TL, Deshmukh M.

Brain Pathol. 1996 Oct;6(4):397-409. Review.

PMID:
8944313
20.

BAX is required for neuronal death after trophic factor deprivation and during development.

Deckwerth TL, Elliott JL, Knudson CM, Johnson EM Jr, Snider WD, Korsmeyer SJ.

Neuron. 1996 Sep;17(3):401-11.

21.
22.

Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: modeling the cholinergic degeneration of Alzheimer's disease.

Wiley RG, Berbos TG, Deckwerth TL, Johnson EM Jr, Lappi DA.

J Neurol Sci. 1995 Feb;128(2):157-66.

PMID:
7738592
23.
24.
26.

Neurotrophic factor deprivation-induced death.

Deckwerth TL, Johnson EM Jr.

Ann N Y Acad Sci. 1993 May 28;679:121-31. Review.

PMID:
8512180
27.

Molecular mechanisms of developmental neuronal death.

Johnson EM Jr, Deckwerth TL.

Annu Rev Neurosci. 1993;16:31-46. Review.

PMID:
8460896
28.

Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region.

Hennessy SW, Frazier BA, Kim DD, Deckwerth TL, Baumgartel DM, Rotwein P, Frazier WA.

J Cell Biol. 1989 Feb;108(2):729-36.

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