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Acquired von Willebrand syndrome in patients on long-term left ventricular assist device support: Results of a Belgian center.

Deconinck SJ, Tersteeg C, Bailleul E, Delrue L, Vandeputte N, Pareyn I, Deckmyn H, De Meyer SF, Vanhoorelbeke K, Vanderheyden M.

Thromb Res. 2019 Dec;184:77-80. doi: 10.1016/j.thromres.2019.10.012. Epub 2019 Oct 21. No abstract available.


Crucial Role for Endothelial Cell α2β1 Integrin Receptor Clustering in Collagen-Induced Angiogenesis.

Turner KR, Adams C, Staelens S, Deckmyn H, San Antonio J.

Anat Rec (Hoboken). 2019 Oct 3. doi: 10.1002/ar.24277. [Epub ahead of print]


Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation.

Chimen M, Evryviadou A, Box CL, Harrison MJ, Hazeldine J, Dib LH, Kuravi SJ, Payne H, Price JMJ, Kavanagh D, Iqbal AJ, Lax S, Kalia N, Brill A, Thomas SG, Belli A, Crombie N, Adams RA, Evans SA, Deckmyn H, Lord JM, Harrison P, Watson SP, Nash GB, Rainger GE.

Haematologica. 2019 Aug 29. pii: haematol.2018.215145. doi: 10.3324/haematol.2018.215145. [Epub ahead of print]


Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation.

Vermeersch E, Nuyttens BP, Tersteeg C, Broos K, De Meyer SF, Vanhoorelbeke K, Deckmyn H.

TH Open. 2018 Sep 10;2(3):e272-e279. doi: 10.1055/s-0038-1670630. eCollection 2018 Jul. Review.


von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome.

Kraisin S, Verhenne S, Pham TT, Martinod K, Tersteeg C, Vandeputte N, Deckmyn H, Vanhoorelbeke K, Van den Steen PE, De Meyer SF.

J Thromb Haemost. 2019 Aug;17(8):1372-1383. doi: 10.1111/jth.14485. Epub 2019 Jun 12.


Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance.

Staessens S, Denorme F, François O, Desender L, Dewaele T, Vanacker P, Deckmyn H, Vanhoorelbeke K, Andersson T, De Meyer SF.

Haematologica. 2019 May 2. pii: haematol.2019.219881. doi: 10.3324/haematol.2019.219881. [Epub ahead of print]


Exposure of von Willebrand Factor on Isolated Hepatocytes Promotes Tethering of Platelets to the Cell Surface.

Gustafson E, Hamad OA, Deckmyn H, Barbu A, Ekdahl KN, Nilsson B.

Transplantation. 2019 Aug;103(8):1630-1638. doi: 10.1097/TP.0000000000002707.


Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients.

Schelpe AS, Roose E, Joly BS, Pareyn I, Mancini I, Biganzoli M, Deckmyn H, Voorberg J, Fijnheer R, Peyvandi F, De Meyer SF, Coppo P, Veyradier A, Vanhoorelbeke K.

Haematologica. 2019 Jun;104(6):1268-1276. doi: 10.3324/haematol.2018.205666. Epub 2018 Dec 6.


von Willebrand factor deficiency does not influence angiotensin II-induced abdominal aortic aneurysm formation in mice.

Portier I, Martinod K, Desender L, Vandeputte N, Deckmyn H, Vanhoorelbeke K, De Meyer SF.

Sci Rep. 2018 Nov 9;8(1):16645. doi: 10.1038/s41598-018-35029-8.


Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device-induced acquired von Willebrand syndrome.

Deconinck S, Tersteeg C, Bailleul E, Delrue L, Vandeputte N, Pareyn I, Itzhar-Baikian N, Deckmyn H, De Meyer SF, Vanderheyden M, Vanhoorelbeke K.

Res Pract Thromb Haemost. 2018 Oct 8;2(4):762-766. doi: 10.1002/rth2.12150. eCollection 2018 Oct.


Preparation and characterization of large-format macroporous cryogel disks for use in affinity chromatography and biotechnological applications.

Noppe W, Cordier R, Baatsen P, Deckmyn H.

Anal Bioanal Chem. 2018 Nov;410(29):7765-7771. doi: 10.1007/s00216-018-1393-z. Epub 2018 Oct 3.


Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura.

Roose E, Vidarsson G, Kangro K, Verhagen OJHM, Mancini I, Desender L, Pareyn I, Vandeputte N, Vandenbulcke A, Vendramin C, Schelpe AS, Voorberg J, Azerad MA, Gilardin L, Scully M, Dierickx D, Deckmyn H, De Meyer SF, Peyvandi F, Vanhoorelbeke K.

Thromb Haemost. 2018 Oct;118(10):1729-1742. doi: 10.1055/s-0038-1669459. Epub 2018 Sep 20.


Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.

Vermeersch E, Liénart S, Collignon A, Lucas S, Gallimore A, Gysemans C, Unutmaz D, Vanhoorelbeke K, De Meyer SF, Maes W, Deckmyn H.

Cell Immunol. 2018 Oct;332:129-133. doi: 10.1016/j.cellimm.2018.07.011. Epub 2018 Jul 30.


Major Changes of von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Stable Disease or Acute Decompensation.

Palyu E, Harsfalvi J, Tornai T, Papp M, Udvardy M, Szekeres-Csiki K, Pataki L, Vanhoorelbeke K, Feys HB, Deckmyn H, Tornai I.

Thromb Haemost. 2018 Aug;118(8):1397-1408. doi: 10.1055/s-0038-1661393. Epub 2018 Jul 4.


Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13.

Schelpe AS, Orlando C, Ercig B, Geeroms C, Pareyn I, Vandeputte N, Velásquez Pereira LC, Roose E, Fostier K, Nicolaes GAF, Deckmyn H, De Meyer SF, Vanhoorelbeke K, Jochmans K.

Eur J Haematol. 2018 May 15. doi: 10.1111/ejh.13094. [Epub ahead of print]


Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque-triggered thrombus formation in humans.

Busygina K, Jamasbi J, Seiler T, Deckmyn H, Weber C, Brandl R, Lorenz R, Siess W.

Blood. 2018 Jun 14;131(24):2605-2616. doi: 10.1182/blood-2017-09-808808. Epub 2018 Mar 20.


Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura.

Roose E, Tersteeg C, Demeersseman R, Schelpe AS, Deforche L, Pareyn I, Vandenbulcke A, Vandeputte N, Dierickx D, Voorberg J, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

TH Open. 2018 Jan 8;2(1):e8-e15. doi: 10.1055/s-0037-1615252. eCollection 2018 Jan.


High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.

Portier I, Vanhoorelbeke K, Verhenne S, Pareyn I, Vandeputte N, Deckmyn H, Goldenberg DS, Samal HB, Singh M, Ivics Z, Izsvák Z, De Meyer SF.

J Thromb Haemost. 2018 Mar;16(3):592-604. doi: 10.1111/jth.13938. Epub 2018 Jan 31.


An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura.

Roose E, Schelpe AS, Joly BS, Peetermans M, Verhamme P, Voorberg J, Greinacher A, Deckmyn H, De Meyer SF, Coppo P, Veyradier A, Vanhoorelbeke K.

J Thromb Haemost. 2018 Feb;16(2):378-388. doi: 10.1111/jth.13922. Epub 2018 Jan 23.


Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.

Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R.

Blood. 2018 Feb 15;131(7):787-796. doi: 10.1182/blood-2017-05-784975. Epub 2017 Dec 4.


Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice.

Tersteeg C, Joly BS, Gils A, Lijnen R, Deckmyn H, Declerck PJ, Plaimauer B, Coppo P, Veyradier A, Maas C, De Meyer SF, Vanhoorelbeke K.

J Thromb Haemost. 2017 Dec;15(12):2432-2442. doi: 10.1111/jth.13859. Epub 2017 Oct 27.


Neutrophil extracellular traps in ischemic stroke thrombi.

Laridan E, Denorme F, Desender L, François O, Andersson T, Deckmyn H, Vanhoorelbeke K, De Meyer SF.

Ann Neurol. 2017 Aug;82(2):223-232. doi: 10.1002/ana.24993. Epub 2017 Aug 11.


Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease.

Denorme F, Kraft P, Pareyn I, Drechsler C, Deckmyn H, Vanhoorelbeke K, Kleinschnitz C, De Meyer SF.

PLoS One. 2017 Jun 7;12(6):e0179258. doi: 10.1371/journal.pone.0179258. eCollection 2017.


Development and screening of epoxy-spacer-phage cryogels for affinity chromatography: Enhancing the binding capacity.

Noppe W, Deckmyn H.

J Sep Sci. 2017 Jun;40(12):2575-2583. doi: 10.1002/jssc.201700247. Epub 2017 May 26.


The role of platelet and endothelial GARP in thrombosis and hemostasis.

Vermeersch E, Denorme F, Maes W, De Meyer SF, Vanhoorelbeke K, Edwards J, Shevach EM, Unutmaz D, Fujii H, Deckmyn H, Tersteeg C.

PLoS One. 2017 Mar 9;12(3):e0173329. doi: 10.1371/journal.pone.0173329. eCollection 2017.


Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy.

Verhenne S, Vandeputte N, Pareyn I, Izsvák Z, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):836-844. doi: 10.1161/ATVBAHA.116.308680. Epub 2017 Mar 2. Erratum in: Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):e245.


N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura.

Tersteeg C, Roodt J, Van Rensburg WJ, Dekimpe C, Vandeputte N, Pareyn I, Vandenbulcke A, Plaimauer B, Lamprecht S, Deckmyn H, Lopez JA, De Meyer SF, Vanhoorelbeke K.

Blood. 2017 Feb 23;129(8):1030-1038. doi: 10.1182/blood-2016-09-738856. Epub 2016 Dec 23.


Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.

Deforche L, Tersteeg C, Roose E, Vandenbulcke A, Vandeputte N, Pareyn I, De Cock E, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

PLoS One. 2016 Aug 1;11(8):e0160388. doi: 10.1371/journal.pone.0160388. eCollection 2016.


Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

Denorme F, Wyseure T, Peeters M, Vandeputte N, Gils A, Deckmyn H, Vanhoorelbeke K, Declerck PJ, De Meyer SF.

Stroke. 2016 Sep;47(9):2419-22. doi: 10.1161/STROKEAHA.116.014091. Epub 2016 Jul 28.


Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.

Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K.

Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Erratum in: Xenotransplantation. 2016 Sep;23(5):423.


ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.

Denorme F, Langhauser F, Desender L, Vandenbulcke A, Rottensteiner H, Plaimauer B, François O, Andersson T, Deckmyn H, Scheiflinger F, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF.

Blood. 2016 May 12;127(19):2337-45. doi: 10.1182/blood-2015-08-662650. Epub 2016 Feb 29.


ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies.

Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

Expert Rev Hematol. 2016;9(2):209-21. doi: 10.1586/17474086.2016.1122515. Epub 2015 Dec 8. Review.


Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.

Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

J Thromb Haemost. 2015 Nov;13(11):2063-75. doi: 10.1111/jth.13149. Epub 2015 Oct 20.


Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice.

Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, Lambrecht A, Nieswandt B, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF.

Blood. 2015 Oct 1;126(14):1715-22. doi: 10.1182/blood-2015-03-632901. Epub 2015 Jul 24.


Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing.

Thijs T, Broos K, Soenen SJ, Vandenbulcke A, Vanhoorelbeke K, Deckmyn H, Salles-Crawley II.

PLoS One. 2015 Jul 15;10(7):e0132899. doi: 10.1371/journal.pone.0132899. eCollection 2015.


Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding.

Swieringa F, Lancé MD, Fuchs B, Feijge MA, Solecka BA, Verheijen LP, Hughes KR, van Oerle R, Deckmyn H, Kannicht C, Heemskerk JW, van der Meijden PE.

J Thromb Haemost. 2015 Aug;13(8):1503-13. doi: 10.1111/jth.13007. Epub 2015 Jun 11.


Choline Transporter-Like Protein-2: New von Willebrand Factor-Binding Partner Involved in Antibody-Mediated Neutrophil Activation and Transfusion-Related Acute Lung Injury.

Bayat B, Tjahjono Y, Berghöfer H, Werth S, Deckmyn H, De Meyer SF, Sachs UJ, Santoso S.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1616-22. doi: 10.1161/ATVBAHA.115.305259. Epub 2015 Apr 30.


Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall.

Meyer Dos Santos S, Blankenbach K, Scholich K, Dörr A, Monsefi N, Keese M, Linke B, Deckmyn H, Nelson K, Harder S.

Thromb Haemost. 2015 Aug;114(2):297-312. doi: 10.1160/TH14-11-0911. Epub 2015 Apr 23.


The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice.

De Cock E, Hermans C, De Raeymaecker J, De Ceunynck K, De Maeyer B, Vandeputte N, Vandenbulcke A, Deckmyn H, Rottensteiner H, De Maeyer M, De Meyer SF, Vanhoorelbeke K.

J Thromb Haemost. 2015 Feb;13(2):283-92. doi: 10.1111/jth.12804. Epub 2015 Jan 17.


Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade.

LaMattina JC, Burdorf L, Zhang T, Rybak E, Cheng X, Munivenkatappa R, Salles II, Broos K, Sievert E, McCormick B, Decarlo M, Ayares D, Deckmyn H, Azimzadeh AM, Pierson RN 3rd, Barth RN.

Xenotransplantation. 2014 May-Jun;21(3):274-86. doi: 10.1111/xen.12093. Epub 2014 Mar 17.


Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings.

De Ceunynck K, Rocha S, De Meyer SF, Sadler JE, Uji-i H, Deckmyn H, Hofkens J, Vanhoorelbeke K.

J Biol Chem. 2014 Mar 28;289(13):8903-15. doi: 10.1074/jbc.M113.535963. Epub 2014 Feb 18.


Affinity comparison of p3 and p8 peptide displaying bacteriophages using surface plasmon resonance.

Knez K, Noppe W, Geukens N, Janssen KP, Spasic D, Heyligen J, Vriens K, Thevissen K, Cammue BP, Petrenko V, Ulens C, Deckmyn H, Lammertyn J.

Anal Chem. 2013 Nov 5;85(21):10075-82. doi: 10.1021/ac402192k. Epub 2013 Oct 16.


Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα.

Gitz E, Koopman CD, Giannas A, Koekman CA, van den Heuvel DJ, Deckmyn H, Akkerman JW, Gerritsen HC, Urbanus RT.

Haematologica. 2013 Nov;98(11):1810-8. doi: 10.3324/haematol.2013.087221. Epub 2013 Jun 10.


Patient autoantibodies induce platelet destruction signals via raft-associated glycoprotein Ibα and Fc RIIa in immune thrombocytopenia.

Urbanus RT, van der Wal DE, Koekman CA, Huisman A, van den Heuvel DJ, Gerritsen HC, Deckmyn H, Akkerman JW, Schutgens RE, Gitz E.

Haematologica. 2013 Jul;98(7):e70-2. doi: 10.3324/haematol.2013.087874. Epub 2013 May 28. No abstract available.


An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα interaction.

Jose RA, Voet A, Broos K, Jakobi AJ, Bruylants G, Egle B, Zhang KY, De Maeyer M, Deckmyn H, De Borggraeve WM.

Chem Commun (Camb). 2012 Nov 28;48(92):11349-51. doi: 10.1039/c2cc35269a.


Inhibitors of the interactions between collagen and its receptors on platelets.

Deckmyn H, De Meyer SF, Broos K, Vanhoorelbeke K.

Handb Exp Pharmacol. 2012;(210):311-37. doi: 10.1007/978-3-642-29423-5_13. Review.


Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons.

Feys HB, Roodt J, Vandeputte N, Pareyn I, Mottl H, Hou S, Lamprecht S, Van Rensburg WJ, Deckmyn H, Vanhoorelbeke K.

Blood. 2012 Oct 25;120(17):3611-4. doi: 10.1182/blood-2012-04-421248. Epub 2012 Jul 31.


Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.

Gitz E, Koekman CA, van den Heuvel DJ, Deckmyn H, Akkerman JW, Gerritsen HC, Urbanus RT.

Haematologica. 2012 Dec;97(12):1873-81. doi: 10.3324/haematol.2012.066290. Epub 2012 Jun 24.


New insights into von Willebrand disease and platelet function.

Szántó T, Joutsi-Korhonen L, Deckmyn H, Lassila R.

Semin Thromb Hemost. 2012 Feb;38(1):55-63. doi: 10.1055/s-0031-1300952. Epub 2012 Feb 7. Review.


Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interaction.

Broos K, Trekels M, Jose RA, Demeulemeester J, Vandenbulcke A, Vandeputte N, Venken T, Egle B, De Borggraeve WM, Deckmyn H, De Maeyer M.

J Biol Chem. 2012 Mar 16;287(12):9461-72. doi: 10.1074/jbc.M111.311431. Epub 2012 Jan 9.

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