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Items: 1 to 50 of 376

1.

Statistical modelling of HER2-positivity in breast cancer: Final analyses from two large, multicentre, non-interventional studies in Germany.

Rüschoff J, Lebeau A, Sinn P, Schildhaus HU, Decker T, Ammann J, Künzel C, Koch W, Untch M.

Breast. 2019 Dec 18;49:246-253. doi: 10.1016/j.breast.2019.12.005. [Epub ahead of print]

2.

Relation of cetuximab-induced skin toxicity and early tumor shrinkage in metastatic colorectal cancer patients: results of the randomized phase 3 trial FIRE-3 (AIO KRK0306).

Holch JW, Held S, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Kaiser F, Heintges T, Kahl C, Kullmann F, Scheithauer W, Moehler M, von Einem JC, Michl M, Heinemann V.

Ann Oncol. 2020 Jan;31(1):72-78. doi: 10.1016/j.annonc.2019.10.001.

PMID:
31912799
3.

Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial.

Stintzing S, Wirapati P, Lenz HJ, Neureiter D, Fischer von Weikersthal L, Decker T, Kiani A, Kaiser F, Al-Batran S, Heintges T, Lerchenmüller C, Kahl C, Seipelt G, Kullmann F, Moehler M, Scheithauer W, Held S, Modest DP, Jung A, Kirchner T, Aderka D, Tejpar S, Heinemann V.

Ann Oncol. 2019 Nov 1;30(11):1796-1803. doi: 10.1093/annonc/mdz387.

4.

Analog-sensitive cell line identifies cellular substrates of CDK9.

Decker TM, Forné I, Straub T, Elsaman H, Ma G, Shah N, Imhof A, Eick D.

Oncotarget. 2019 Dec 10;10(65):6934-6943. doi: 10.18632/oncotarget.27334. eCollection 2019 Dec 10.

5.

Luminal A versus B breast cancer: MammaTyper® mRNA versus immunohistochemical subtyping with emphasis on standardised Ki67-Labelling or Mitotic Activity Index based proliferation assessment.

Finsterbusch K, Decker T, van Diest PJ, Focke CM.

Histopathology. 2019 Dec 17. doi: 10.1111/his.14048. [Epub ahead of print]

PMID:
31846096
6.

A Phase 4 Study of Everolimus to Evaluate Efficacy and Safety in Patients with Metastatic Renal-Cell Carcinoma after Failure of First-Line Sunitinib or Pazopanib (SUNPAZ).

Schostak M, de Geeter P, Decker T, Resch A, Quiering C, Schmitz S.

Urol Int. 2019 Nov 14:1-6. doi: 10.1159/000503870. [Epub ahead of print]

PMID:
31726458
7.

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.

Zamudio AV, Dall'Agnese A, Henninger JE, Manteiga JC, Afeyan LK, Hannett NM, Coffey EL, Li CH, Oksuz O, Sabari BR, Boija A, Klein IA, Hawken SW, Spille JH, Decker TM, Cisse II, Abraham BJ, Lee TI, Taatjes DJ, Schuijers J, Young RA.

Mol Cell. 2019 Dec 5;76(5):753-766.e6. doi: 10.1016/j.molcel.2019.08.016. Epub 2019 Sep 25.

PMID:
31563432
8.

Rare Coexistence of a Cerebellar Hemangioblastoma and Angiomatosis of the Breast without Underlying Phakomatosis.

Wegner U, Balschat S, Decker T, Ryan AG.

J Clin Imaging Sci. 2019 Mar 28;9:8. doi: 10.25259/JCIS-9-8. eCollection 2019.

9.

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.

Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, Lee TI, Cisse II, Sharp PA, Taatjes DJ, Young RA.

Nature. 2019 Aug;572(7770):543-548. doi: 10.1038/s41586-019-1464-0. Epub 2019 Aug 7.

PMID:
31391587
10.

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.

Platanitis E, Demiroz D, Schneller A, Fischer K, Capelle C, Hartl M, Gossenreiter T, Müller M, Novatchkova M, Decker T.

Nat Commun. 2019 Jul 2;10(1):2921. doi: 10.1038/s41467-019-10970-y.

11.

Correction to: Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Rageth CJ, O'Flynn EAM, Pinker K, Kubik-Huch RA, Mundinger A, Decker T, Tausch C, Dammann F, Baltzer PA, Fallenberg EM, Foschini MP, Dellas S, Knauer M, Malhaire C, Sonnenschein M, Boos A, Morris E, Varga Z.

Breast Cancer Res Treat. 2019 Jul;176(2):481-482. doi: 10.1007/s10549-019-05287-9.

12.

VicTORia: a randomised phase II study to compare vinorelbine in combination with the mTOR inhibitor everolimus versus vinorelbine monotherapy for second-line chemotherapy in advanced HER2-negative breast cancer.

Decker T, Marschner N, Muendlein A, Welt A, Hagen V, Rauh J, Schröder H, Jaehnig P, Potthoff K, Lerchenmüller C.

Breast Cancer Res Treat. 2019 Aug;176(3):637-647. doi: 10.1007/s10549-019-05280-2. Epub 2019 May 21.

PMID:
31115844
13.

Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells.

Shah N, Decker TM, Eick D.

Biol Lett. 2019 May 31;15(5):20190068. doi: 10.1098/rsbl.2019.0068.

14.

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.

Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR.

Nat Microbiol. 2019 Apr;4(4):701-713. doi: 10.1038/s41564-019-0367-z. Epub 2019 Feb 25.

15.

Understanding Costs and Supporting Transparency-Keys to Quality Care.

Decker TF.

Front Health Serv Manage. 2019 Spring;35(3):14-24. doi: 10.1097/HAP.0000000000000052.

PMID:
30789371
16.

Bent Knee Temporary Prosthesis to Support Early Ambulation after Transtibial Amputation: A Case Report.

Decker TD, Gradinar Y, Elert S, Alexander JQ.

PM R. 2019 Sep;11(9):1027-1030. doi: 10.1002/pmrj.12136. Epub 2019 Apr 24.

PMID:
30746858
17.

Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils.

Krishack PA, Louviere TJ, Decker TS, Kuzel TG, Greenberg JA, Camacho DF, Hrusch CL, Sperling AI, Verhoef PA.

JCI Insight. 2019 Mar 21;4(6). pii: 124168. doi: 10.1172/jci.insight.124168. eCollection 2019 Mar 21.

18.

Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.

Kollmann S, Grundschober E, Maurer B, Warsch W, Grausenburger R, Edlinger L, Huuhtanen J, Lagger S, Hennighausen L, Valent P, Decker T, Strobl B, Mueller M, Mustjoki S, Hoelbl-Kovacic A, Sexl V.

Leukemia. 2019 Jul;33(7):1583-1597. doi: 10.1038/s41375-018-0369-5. Epub 2019 Jan 24.

19.

The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.

Parrini M, Meissl K, Ola MJ, Lederer T, Puga A, Wienerroither S, Kovarik P, Decker T, Müller M, Strobl B.

Front Immunol. 2018 Dec 6;9:2879. doi: 10.3389/fimmu.2018.02879. eCollection 2018.

20.

A Microscale Planar Linear Ion Trap Mass Spectrometer.

Decker TK, Zheng Y, Ruben AJ, Wang X, Lammert SA, Austin DE, Hawkins AR.

J Am Soc Mass Spectrom. 2019 Mar;30(3):482-488. doi: 10.1007/s13361-018-2104-x. Epub 2018 Dec 12.

PMID:
30542974
21.

Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Rageth CJ, O'Flynn EAM, Pinker K, Kubik-Huch RA, Mundinger A, Decker T, Tausch C, Dammann F, Baltzer PA, Fallenberg EM, Foschini MP, Dellas S, Knauer M, Malhaire C, Sonnenschein M, Boos A, Morris E, Varga Z.

Breast Cancer Res Treat. 2019 Apr;174(2):279-296. doi: 10.1007/s10549-018-05071-1. Epub 2018 Nov 30. Review. Erratum in: Breast Cancer Res Treat. 2019 Jul;176(2):481-482.

22.

The impact of mammalian target of rapamycin inhibition on bone health in postmenopausal women with hormone receptor-positive advanced breast cancer receiving everolimus plus exemestane in the phase IIIb 4EVER trial.

Hadji P, Stoetzer O, Decker T, Kurbacher CM, Marmé F, Schneeweiss A, Mundhenke C, Distelrath A, Fasching PA, Lux MP, Lüftner D, Janni W, Muth M, Kreuzeder J, Quiering C, Grischke EM, Tesch H.

J Bone Oncol. 2018 Oct 2;14:010-10. doi: 10.1016/j.jbo.2018.09.010. eCollection 2019 Feb.

23.

Relevance of baseline carcinoembryonic antigen for first-line treatment against metastatic colorectal cancer with FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial).

Holch JW, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling-Kaiser U, Heintges T, Kahl C, Kullmann F, Scheithauer W, Moehler M, Jelas I, Modest DP, Westphalen CB, von Einem JC, Michl M, Heinemann V.

Eur J Cancer. 2019 Jan;106:115-125. doi: 10.1016/j.ejca.2018.10.001. Epub 2018 Nov 27.

PMID:
30496943
24.

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation.

Platanitis E, Decker T.

Front Immunol. 2018 Nov 13;9:2542. doi: 10.3389/fimmu.2018.02542. eCollection 2018. Review.

25.

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

Szappanos D, Tschismarov R, Perlot T, Westermayer S, Fischer K, Platanitis E, Kallinger F, Novatchkova M, Lassnig C, Müller M, Sexl V, Bennett KL, Foong-Sobis M, Penninger JM, Decker T.

PLoS Pathog. 2018 Nov 26;14(11):e1007397. doi: 10.1371/journal.ppat.1007397. eCollection 2018 Nov.

26.

Sequential Versus Combination Therapy of Metastatic Colorectal Cancer Using Fluoropyrimidines, Irinotecan, and Bevacizumab: A Randomized, Controlled Study-XELAVIRI (AIO KRK0110).

Modest DP, Fischer von Weikersthal L, Decker T, Vehling-Kaiser U, Uhlig J, Schenk M, Freiberg-Richter J, Peuser B, Denzlinger C, Peveling Genannt Reddemann C, Graeven U, Schuch G, Schwaner I, Stahler A, Jung A, Kirchner T, Held S, Stintzing S, Giessen-Jung C, Heinemann V; XELAVIRI/AIO KRK0110 Investigators.

J Clin Oncol. 2019 Jan 1;37(1):22-32. doi: 10.1200/JCO.18.00052. Epub 2018 Nov 2.

PMID:
30388045
27.

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth.

Wagh K, Kreider EF, Li Y, Barbian HJ, Learn GH, Giorgi E, Hraber PT, Decker TG, Smith AG, Gondim MV, Gillis L, Wandzilak J, Chuang GY, Rawi R, Cai F, Pellegrino P, Williams I, Overbaugh J, Gao F, Kwong PD, Haynes BF, Shaw GM, Borrow P, Seaman MS, Hahn BH, Korber B.

Cell Rep. 2018 Oct 23;25(4):893-908.e7. doi: 10.1016/j.celrep.2018.09.087.

28.

Double resonance ejection using novel radiofrequency phase tracking circuitry in a miniaturized planar linear ion trap mass spectrometer.

Decker TK, Zheng Y, McClellan JS, Ruben AJ, Lammert SA, Austin DE, Hawkins AR.

Rapid Commun Mass Spectrom. 2018 Dec 15;32(23):2024-2030. doi: 10.1002/rcm.8267.

PMID:
30133876
29.

Delayed Onset of Nonthermal Melting in Single-Crystal Silicon Pumped with Hard X Rays.

Pardini T, Alameda J, Aquila A, Boutet S, Decker T, Gleason AE, Guillet S, Hamilton P, Hayes M, Hill R, Koglin J, Kozioziemski B, Robinson J, Sokolowski-Tinten K, Soufli R, Hau-Riege SP.

Phys Rev Lett. 2018 Jun 29;120(26):265701. doi: 10.1103/PhysRevLett.120.265701.

PMID:
30004754
30.

Efficacy and safety of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer: Results of the single-arm, phase IIIB 4EVER trial.

Tesch H, Stoetzer O, Decker T, Kurbacher CM, Marmé F, Schneeweiss A, Mundhenke C, Distelrath A, Fasching PA, Lux MP, Lüftner D, Hadji P, Janni W, Muth M, Kreuzeder J, Quiering C, Taran FA.

Int J Cancer. 2019 Feb 15;144(4):877-885. doi: 10.1002/ijc.31738. Epub 2018 Oct 30.

31.

Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.

Porpaczy E, Tripolt S, Hoelbl-Kovacic A, Gisslinger B, Bago-Horvath Z, Casanova-Hevia E, Clappier E, Decker T, Fajmann S, Fux DA, Greiner G, Gueltekin S, Heller G, Herkner H, Hoermann G, Kiladjian JJ, Kolbe T, Kornauth C, Krauth MT, Kralovics R, Muellauer L, Mueller M, Prchal-Murphy M, Putz EM, Raffoux E, Schiefer AI, Schmetterer K, Schneckenleithner C, Simonitsch-Klupp I, Skrabs C, Sperr WR, Staber PB, Strobl B, Valent P, Jaeger U, Gisslinger H, Sexl V.

Blood. 2018 Aug 16;132(7):694-706. doi: 10.1182/blood-2017-10-810739. Epub 2018 Jun 14. Erratum in: Blood. 2019 Feb 14;133(7):768.

PMID:
29907599
32.

Endocide-Induced Abnormal Growth Forms of Invasive Giant Salvinia (Salvinia molesta).

Li S, Wang P, Su Z, Lozano E, LaMaster O, Grogan JB, Weng Y, Decker T, Findeisen J, McGarrity M.

Sci Rep. 2018 May 22;8(1):8006. doi: 10.1038/s41598-018-25986-5.

33.

Experimental Observation of the Effects of Translational and Rotational Electrode Misalignment on a Planar Linear Ion Trap Mass Spectrometer.

Tian Y, Decker TK, McClellan JS, Wu Q, De la Cruz A, Hawkins AR, Austin DE.

J Am Soc Mass Spectrom. 2018 Jul;29(7):1376-1385. doi: 10.1007/s13361-018-1942-x. Epub 2018 Apr 5.

PMID:
29623663
34.

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.

Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forné I, Decker TM, Martin D, Schüller R, Krebs S, Blum H, Imhof A, Eick D, Andrau JC.

Mol Cell. 2018 Jan 4;69(1):48-61.e6. doi: 10.1016/j.molcel.2017.12.009.

35.

Exploring the effect of primary tumor sidedness on therapeutic efficacy across treatment lines in patients with metastatic colorectal cancer: analysis of FIRE-3 (AIOKRK0306).

Modest DP, Stintzing S, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Kahl C, Seipelt G, Kullmann F, Scheithauer W, Moehler M, Holch JW, von Einem JC, Held S, Heinemann V.

Oncotarget. 2017 Nov 11;8(62):105749-105760. doi: 10.18632/oncotarget.22396. eCollection 2017 Dec 1.

36.

Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial.

Di Leo A, Johnston S, Lee KS, Ciruelos E, Lønning PE, Janni W, O'Regan R, Mouret-Reynier MA, Kalev D, Egle D, Csőszi T, Bordonaro R, Decker T, Tjan-Heijnen VCG, Blau S, Schirone A, Weber D, El-Hashimy M, Dharan B, Sellami D, Bachelot T.

Lancet Oncol. 2018 Jan;19(1):87-100. doi: 10.1016/S1470-2045(17)30688-5. Epub 2017 Dec 7. Erratum in: Lancet Oncol. 2018 Mar;19(3):e137.

PMID:
29223745
37.

Invasion in breast lesions: the role of the epithelial-stroma barrier.

Rakha EA, Miligy IM, Gorringe KL, Toss MS, Green AR, Fox SB, Schmitt FC, Tan PH, Tse GM, Badve S, Decker T, Vincent-Salomon A, Dabbs DJ, Foschini MP, Moreno F, Wentao Y, Geyer FC, Reis-Filho JS, Pinder SE, Lakhani SR, Ellis IO.

Histopathology. 2018 Jun;72(7):1075-1083. doi: 10.1111/his.13446. Epub 2018 Feb 13. Review.

PMID:
29197112
38.

Optimal fabrication methods for miniature coplanar ion traps.

Decker TK, Tian Y, McClellan JS, Bennett L, Lammert SA, Austin DE, Hawkins AR.

Rapid Commun Mass Spectrom. 2018 Feb 28;32(4):289-294. doi: 10.1002/rcm.8028.

PMID:
29131427
39.

Detection Rates of Ductal Carcinoma in Situ with Biennial Digital Mammography Screening: Radiologic Findings Support Pathologic Model of Tumor Progression.

Weigel S, Khil L, Hense HW, Decker T, Wellmann J, Heidrich J, Sommer A, Heidinger O, Heindel W.

Radiology. 2018 Feb;286(2):424-432. doi: 10.1148/radiol.2017170673. Epub 2017 Nov 6.

PMID:
29106821
40.

Relevance of liver-limited disease in metastatic colorectal cancer: Subgroup findings of the FIRE-3/AIO KRK0306 trial.

Holch JW, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Lerchenmüller C, Kahl C, Kullmann F, Scheithauer W, Scholz M, Müller S, Link H, Rost A, Höffkes HG, Moehler M, Lindig RU, Miller-Phillips L, Kirchner T, Jung A, von Einem JC, Modest DP, Heinemann V.

Int J Cancer. 2018 Mar 1;142(5):1047-1055. doi: 10.1002/ijc.31114. Epub 2017 Nov 7.

41.

CDK9-dependent RNA polymerase II pausing controls transcription initiation.

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P.

Elife. 2017 Oct 10;6. pii: e29736. doi: 10.7554/eLife.29736.

42.

Correction: The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes.

Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Högler S, Kovarik P, Decker T, Jamieson AM.

PLoS Pathog. 2017 Aug 30;13(8):e1006591. doi: 10.1371/journal.ppat.1006591. eCollection 2017 Aug.

43.

Evaluation of survival across several treatment lines in metastatic colorectal cancer: Analysis of the FIRE-3 trial (AIO KRK0306).

Modest DP, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Kahl C, Seipelt G, Kullmann F, Scheithauer W, Moehler M, Westphalen CB, Holch JW, von Einem JC, Held S, Heinemann V; for FIRE-3/AIOKRK0306-investigators.

Eur J Cancer. 2017 Oct;84:262-269. doi: 10.1016/j.ejca.2017.07.030. Epub 2017 Aug 23.

PMID:
28843184
44.

Improved Miniaturized Linear Ion Trap Mass Spectrometer Using Lithographically Patterned Plates and Tapered Ejection Slit.

Tian Y, Decker TK, McClellan JS, Bennett L, Li A, De la Cruz A, Andrews D, Lammert SA, Hawkins AR, Austin DE.

J Am Soc Mass Spectrom. 2018 Feb;29(2):213-222. doi: 10.1007/s13361-017-1759-z. Epub 2017 Aug 23.

PMID:
28836122
45.

Interlaboratory variability of Ki67 staining in breast cancer.

Focke CM, Bürger H, van Diest PJ, Finsterbusch K, Gläser D, Korsching E, Decker T; German Breast Screening Pathology Initiative.

Eur J Cancer. 2017 Oct;84:219-227. doi: 10.1016/j.ejca.2017.07.041. Epub 2017 Aug 19.

PMID:
28829990
46.

A randomized phase II study of paclitaxel alone versus paclitaxel plus sorafenib in second- and third-line treatment of patients with HER2-negative metastatic breast cancer (PASO).

Decker T, Overkamp F, Rösel S, Nusch A, Göhler T, Indorf M, Sahlmann J, Trarbach T.

BMC Cancer. 2017 Jul 25;17(1):499. doi: 10.1186/s12885-017-3492-1.

47.

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis.

Kovarik JJ, Kernbauer E, Hölzl MA, Hofer J, Gualdoni GA, Schmetterer KG, Miftari F, Sobanov Y, Meshcheryakova A, Mechtcheriakova D, Witzeneder N, Greiner G, Ohradanova-Repic A, Waidhofer-Söllner P, Säemann MD, Decker T, Zlabinger GJ.

PLoS One. 2017 Jul 24;12(7):e0180900. doi: 10.1371/journal.pone.0180900. eCollection 2017.

48.

Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee.

Barbian HJ, Jackson-Jewett R, Brown CS, Bibollet-Ruche F, Learn GH, Decker T, Kreider EF, Li Y, Denny TN, Sharp PM, Shaw GM, Lifson J, Acosta EP, Saag MS, Bar KJ, Hahn BH.

Retrovirology. 2017 Jun 2;14(1):35. doi: 10.1186/s12977-017-0359-0.

49.

Research: Continuous Surveillance of Sleep Apnea Patients in a Medical-Surgical Unit.

Supe D, Baron L, Decker T, Parker K, Venella J, Williams S, Beaton K, Zaleski J.

Biomed Instrum Technol. 2017 May/Jun;51(3):236-251. doi: 10.2345/0899-8205-51.3.236.

PMID:
28530876
50.

Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1.

Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D.

Sci Rep. 2017 May 10;7(1):1684. doi: 10.1038/s41598-017-01943-6.

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