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Items: 1 to 50 of 66

1.

In Vitro Analyses of Novel HCN4 Gene Mutations.

Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S, Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E, Seebohm G.

Cell Physiol Biochem. 2018;49(3):1197-1207. doi: 10.1159/000493301. Epub 2018 Sep 7.

2.

The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N.

FASEB J. 2018 Jun 7:fj201800246R. doi: 10.1096/fj.201800246R. [Epub ahead of print]

PMID:
29879376
3.

Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish.

Pott A, Bock S, Berger IM, Frese K, Dahme T, Keßler M, Rinné S, Decher N, Just S, Rottbauer W.

J Mol Cell Cardiol. 2018 Jul;120:42-52. doi: 10.1016/j.yjmcc.2018.05.005. Epub 2018 May 8.

PMID:
29750993
4.

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.

Henrich MT, Geibl FF, Lee B, Chiu WH, Koprich JB, Brotchie JM, Timmermann L, Decher N, Matschke LA, Oertel WH.

Acta Neuropathol Commun. 2018 May 10;6(1):39. doi: 10.1186/s40478-018-0541-1.

5.

Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons.

Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM, Decher N.

Mol Cell Neurosci. 2018 Apr;88:330-341. doi: 10.1016/j.mcn.2018.03.002. Epub 2018 Mar 8.

PMID:
29524627
6.

Stress-Kinase Regulation of TASK-1 and TASK-3.

Rinné S, Kiper AK, Schmidt C, Ortiz-Bonnin B, Zwiener S, Seebohm G, Decher N.

Cell Physiol Biochem. 2017;44(3):1024-1037. doi: 10.1159/000485402. Epub 2017 Nov 27.

7.

Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.

Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape HC, Decher N, Meuth SG, Budde T.

J Physiol. 2017 Sep 1;595(17):5875-5893. doi: 10.1113/JP274527. Epub 2017 Aug 3.

8.

Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias.

Decher N, Kiper AK, Rinné S.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):223-232. doi: 10.1016/j.pbiomolbio.2017.05.005. Epub 2017 May 16. Review.

PMID:
28526352
9.

Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels.

Ramírez D, Arévalo B, Martínez G, Rinné S, Sepúlveda FV, Decher N, González W.

Mol Pharm. 2017 Jul 3;14(7):2197-2208. doi: 10.1021/acs.molpharmaceut.7b00005. Epub 2017 May 30.

PMID:
28494157
10.

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.

Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM.

Cell Death Differ. 2017 May;24(5):761-773. doi: 10.1038/cdd.2017.2. Epub 2017 Mar 10.

11.

Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.

Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B, Schulze-Bahr E.

EMBO Mol Med. 2017 Apr;9(4):403-414. doi: 10.15252/emmm.201606690.

12.

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E.

Circ Res. 2017 May 12;120(10):e33-e44. doi: 10.1161/CIRCRESAHA.116.310112. Epub 2017 Feb 20.

PMID:
28219978
13.

Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: identification of novel LQTS3 and BrS mutations.

Ortiz-Bonnin B, Rinné S, Moss R, Streit AK, Scharf M, Richter K, Stöber A, Pfeufer A, Seemann G, Kääb S, Beckmann BM, Decher N.

Pflugers Arch. 2016 Aug;468(8):1375-87. doi: 10.1007/s00424-016-1844-3. Epub 2016 Jun 11.

PMID:
27287068
14.

Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.

Goldstein M, Rinné S, Kiper AK, Ramírez D, Netter MF, Bustos D, Ortiz-Bonnin B, González W, Decher N.

Sci Rep. 2016 Jan 22;6:19492. doi: 10.1038/srep19492.

15.

POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking.

Schindler RF, Scotton C, Zhang J, Passarelli C, Ortiz-Bonnin B, Simrick S, Schwerte T, Poon KL, Fang M, Rinné S, Froese A, Nikolaev VO, Grunert C, Müller T, Tasca G, Sarathchandra P, Drago F, Dallapiccola B, Rapezzi C, Arbustini E, Di Raimo FR, Neri M, Selvatici R, Gualandi F, Fattori F, Pietrangelo A, Li W, Jiang H, Xu X, Bertini E, Decher N, Wang J, Brand T, Ferlini A.

J Clin Invest. 2016 Jan;126(1):239-53. doi: 10.1172/JCI79562. Epub 2015 Dec 7.

16.

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.

Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T, Decher N.

Front Mol Neurosci. 2015 Nov 3;8:63. doi: 10.3389/fnmol.2015.00063. eCollection 2015.

17.

A concerted action of L- and T-type Ca(2+) channels regulates locus coeruleus pacemaking.

Matschke LA, Bertoune M, Roeper J, Snutch TP, Oertel WH, Rinné S, Decher N.

Mol Cell Neurosci. 2015 Sep;68:293-302. doi: 10.1016/j.mcn.2015.08.012. Epub 2015 Aug 25.

PMID:
26319746
18.

TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes.

Rinné S, Kiper AK, Schlichthörl G, Dittmann S, Netter MF, Limberg SH, Silbernagel N, Zuzarte M, Moosdorf R, Wulf H, Schulze-Bahr E, Rolfes C, Decher N.

J Mol Cell Cardiol. 2015 Apr;81:71-80. doi: 10.1016/j.yjmcc.2015.01.017. Epub 2015 Feb 2.

PMID:
25655935
19.

Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.

Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N.

J Mol Cell Cardiol. 2015 Mar;80:186-95. doi: 10.1016/j.yjmcc.2015.01.002. Epub 2015 Jan 26.

PMID:
25633834
20.

Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons.

Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HC, Oliver D, Meuth SG, Budde T.

J Physiol. 2015 Jan 1;593(1):127-44. doi: 10.1113/jphysiol.2014.276527. Epub 2014 Nov 3.

21.

Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?

Kiper AK, Rinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W, Decher N.

Pflugers Arch. 2015 May;467(5):1081-90. doi: 10.1007/s00424-014-1665-1. Epub 2014 Dec 17.

PMID:
25511502
22.

The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias.

Decher N, Kiper AK, Rolfes C, Schulze-Bahr E, Rinné S.

Pflugers Arch. 2015 May;467(5):1055-67. doi: 10.1007/s00424-014-1637-5. Epub 2014 Nov 19. Review.

PMID:
25404566
23.

RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1.

Streit AK, Matschke LA, Dolga AM, Rinné S, Decher N.

J Biol Chem. 2014 Sep 26;289(39):26762-71. doi: 10.1074/jbc.M113.545731. Epub 2014 Aug 6.

24.

Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.

Friedrich C, Rinné S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E, Decher N.

EMBO Mol Med. 2014 Jul;6(7):937-51. doi: 10.15252/emmm.201303783.

25.

Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1.

Renigunta V, Fischer T, Zuzarte M, Kling S, Zou X, Siebert K, Limberg MM, Rinné S, Decher N, Schlichthörl G, Daut J.

Mol Biol Cell. 2014 Jun 15;25(12):1877-91. doi: 10.1091/mbc.E13-10-0592. Epub 2014 Apr 17.

26.

Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3.

Munoz C, Pakladok T, Almilaji A, Elvira B, Decher N, Shumilina E, Lang F.

Cell Physiol Biochem. 2014;33(2):491-500. doi: 10.1159/000358629. Epub 2014 Feb 14.

27.

A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.

Rinné S, Renigunta V, Schlichthörl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Müller R.

Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013 Nov 7.

PMID:
24196565
28.

Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N.

Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2.

29.

Non dominant-negative KCNJ2 gene mutations leading to Andersen-Tawil syndrome with an isolated cardiac phenotype.

Limberg MM, Zumhagen S, Netter MF, Coffey AJ, Grace A, Rogers J, Böckelmann D, Rinné S, Stallmeyer B, Decher N, Schulze-Bahr E.

Basic Res Cardiol. 2013 May;108(3):353. doi: 10.1007/s00395-013-0353-1. Epub 2013 May 5.

PMID:
23644778
30.

Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.

Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C.

J Biol Chem. 2013 Apr 12;288(15):10792-804. doi: 10.1074/jbc.M113.453522. Epub 2013 Feb 19.

31.

Putative impact of RNA editing on drug discovery.

Decher N, Netter MF, Streit AK.

Chem Biol Drug Des. 2013 Jan;81(1):13-21. doi: 10.1111/cbdd.12045. Review.

PMID:
23253127
32.

The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.

Netter MF, Zuzarte M, Schlichthörl G, Klöcker N, Decher N.

Cell Physiol Biochem. 2012;30(5):1227-40. doi: 10.1159/000343314. Epub 2012 Oct 15.

33.

A leucine zipper motif essential for gating of hyperpolarization-activated channels.

Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ, Decher N.

J Biol Chem. 2012 Nov 23;287(48):40150-60. doi: 10.1074/jbc.M112.378513. Epub 2012 Oct 9.

34.

The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C.

Schiekel J, Lindner M, Hetzel A, Wemhöner K, Renigunta V, Schlichthörl G, Decher N, Oliver D, Daut J.

Cardiovasc Res. 2013 Jan 1;97(1):97-105. doi: 10.1093/cvr/cvs285. Epub 2012 Sep 12.

PMID:
22977011
35.

Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.

Froese A, Breher SS, Waldeyer C, Schindler RF, Nikolaev VO, Rinné S, Wischmeyer E, Schlueter J, Becher J, Simrick S, Vauti F, Kuhtz J, Meister P, Kreissl S, Torlopp A, Liebig SK, Laakmann S, Müller TD, Neumann J, Stieber J, Ludwig A, Maier SK, Decher N, Arnold HH, Kirchhof P, Fabritz L, Brand T.

J Clin Invest. 2012 Mar;122(3):1119-30. doi: 10.1172/JCI59410. Epub 2012 Feb 22.

36.

TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.

Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB, Decher N.

Cell Physiol Biochem. 2011;28(4):613-24. doi: 10.1159/000335757. Epub 2011 Dec 14.

37.

A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors.

Streit AK, Decher N.

Biochemistry (Mosc). 2011 Aug;76(8):890-9. doi: 10.1134/S0006297911080049. Review.

PMID:
22022962
38.

Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome.

Seebohm G, Strutz-Seebohm N, Ursu ON, Preisig-Müller R, Zuzarte M, Hill EV, Kienitz MC, Bendahhou S, Fauler M, Tapken D, Decher N, Collins A, Jurkat-Rott K, Steinmeyer K, Lehmann-Horn F, Daut J, Tavaré JM, Pott L, Bloch W, Lang F.

FASEB J. 2012 Feb;26(2):513-22. doi: 10.1096/fj.11-189126. Epub 2011 Oct 14.

PMID:
22002906
39.

Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.

Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J, Sachse FB, Maier SK.

Cell Physiol Biochem. 2011;28(1):77-86. doi: 10.1159/000331715. Epub 2011 Aug 16.

40.

The pore structure and gating mechanism of K2P channels.

Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T.

EMBO J. 2011 Aug 5;30(17):3607-19. doi: 10.1038/emboj.2011.268. Erratum in: EMBO J. 2011 Nov 2;30(21):4515. Erhlich, Gunter [corrected to Ehrlich, Gunter].

41.

RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats.

Streit AK, Derst C, Wegner S, Heinemann U, Zahn RK, Decher N.

Epilepsia. 2011 Mar;52(3):645-8. doi: 10.1111/j.1528-1167.2011.02986.x. Epub 2011 Mar 3.

42.

A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore.

Streit AK, Netter MF, Kempf F, Walecki M, Rinné S, Bollepalli MK, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom MS, Stansfeld PJ, Decher N.

J Biol Chem. 2011 Apr 22;286(16):13977-84. doi: 10.1074/jbc.M111.227884. Epub 2011 Mar 1.

43.

Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.

Renigunta A, Renigunta V, Saritas T, Decher N, Mutig K, Waldegger S.

J Biol Chem. 2011 Jan 21;286(3):2224-35. doi: 10.1074/jbc.M110.149880. Epub 2010 Nov 16.

44.

RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.

Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T, Daut J.

EMBO J. 2010 Jul 7;29(13):2101-13. doi: 10.1038/emboj.2010.88. Epub 2010 May 11.

45.

Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide.

Moreno-Galindo EG, Barrio-Echavarría GF, Vásquez JC, Decher N, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA, Navarro-Polanco RA.

Mol Pharmacol. 2010 May;77(5):751-8. doi: 10.1124/mol.109.063008. Epub 2010 Feb 4.

46.

Influence of hydration status on pacing during trail running in the heat.

Stearns RL, Casa DJ, Lopez RM, McDermott BP, Ganio MS, Decher NR, Scruggs IC, West AE, Armstrong LE, Maresh CM.

J Strength Cond Res. 2009 Dec;23(9):2533-41. doi: 10.1519/JSC.0b013e3181b73c3f.

PMID:
19675477
47.

Hydration status, knowledge, and behavior in youths at summer sports camps.

Decher NR, Casa DJ, Yeargin SW, Ganio MS, Levreault ML, Dann CL, James CT, McCaffrey MA, Oconnor CB, Brown SW.

Int J Sports Physiol Perform. 2008 Sep;3(3):262-78.

PMID:
19211940
48.

Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2.

Decher N, Gonzalez T, Streit AK, Sachse FB, Renigunta V, Soom M, Heinemann SH, Daut J, Sanguinetti MC.

EMBO J. 2008 Dec 3;27(23):3164-74. doi: 10.1038/emboj.2008.231. Epub 2008 Nov 6.

49.

Kv1.5 open channel block by the antiarrhythmic drug disopyramide: molecular determinants of block.

Aréchiga IA, Barrio-Echavarria GF, Rodríguez-Menchaca AA, Moreno-Galindo EG, Decher N, Tristani-Firouzi M, Sánchez-Chapula JA, Navarro-Polanco RA.

J Pharmacol Sci. 2008 Sep;108(1):49-55.

50.

Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and binding mode.

Strutz-Seebohm N, Gutcher I, Decher N, Steinmeyer K, Lang F, Seebohm G.

Cell Physiol Biochem. 2007;20(6):791-800.

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