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Items: 1 to 50 of 289

1.

Capsid labelled HIV to investigate the role of capsid during nuclear import and integration.

Zurnic Bönisch I, Dirix L, Lemmens V, Borrenberghs D, De Wit F, Vernaillen F, Rocha S, Christ F, Hendrix J, Hofkens J, Debyser Z.

J Virol. 2020 Jan 15. pii: JVI.01024-19. doi: 10.1128/JVI.01024-19. [Epub ahead of print]

PMID:
31941774
2.

Block-And-Lock Strategies to Cure HIV Infection.

Vansant G, Bruggemans A, Janssens J, Debyser Z.

Viruses. 2020 Jan 10;12(1). pii: E84. doi: 10.3390/v12010084. Review.

3.

The free energy landscape of retroviral integration.

Vanderlinden W, Brouns T, Walker PU, Kolbeck PJ, Milles LF, Ott W, Nickels PC, Debyser Z, Lipfert J.

Nat Commun. 2019 Oct 18;10(1):4738. doi: 10.1038/s41467-019-12649-w.

4.

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection.

Rodríguez-Mora S, De Wit F, García-Perez J, Bermejo M, López-Huertas MR, Mateos E, Martí P, Rocha S, Vigón L, Christ F, Debyser Z, Vílchez JJ, Coiras M, Alcamí J.

PLoS Pathog. 2019 Aug 29;15(8):e1007958. doi: 10.1371/journal.ppat.1007958. eCollection 2019 Aug.

5.

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach.

Sirous H, Chemi G, Gemma S, Butini S, Debyser Z, Christ F, Saghaie L, Brogi S, Fassihi A, Campiani G, Brindisi M.

Front Chem. 2019 Aug 13;7:574. doi: 10.3389/fchem.2019.00574. eCollection 2019.

6.

Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing.

Maule G, Casini A, Montagna C, Ramalho AS, De Boeck K, Debyser Z, Carlon MS, Petris G, Cereseto A.

Nat Commun. 2019 Aug 7;10(1):3556. doi: 10.1038/s41467-019-11454-9.

7.

Design of reverse transcriptase-specific nucleosides to visualize early steps of HIV-1 replication by click labeling.

De Wit F, Pillalamarri SR, Sebastián-Martín A, Venkatesham A, Van Aerschot A, Debyser Z.

J Biol Chem. 2019 Aug 2;294(31):11863-11875. doi: 10.1074/jbc.RA118.007185. Epub 2019 Jun 14.

PMID:
31201270
8.

Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry.

Scala A, Piperno A, Micale N, Christ F, Debyser Z.

ACS Med Chem Lett. 2018 Dec 15;10(4):398-401. doi: 10.1021/acsmedchemlett.8b00511. eCollection 2019 Apr 11.

9.

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription.

Vansant G, Vranckx LS, Zurnic I, Van Looveren D, Van de Velde P, Nobles C, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2019 Apr 2;16(1):8. doi: 10.1186/s12977-019-0472-3.

10.

Establishment of latent HIV-1 reservoirs: what do we really know?

Vanhamel J, Bruggemans A, Debyser Z.

J Virus Erad. 2019 Jan 1;5(1):3-9.

11.

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection.

Lampi Y, Van Looveren D, Vranckx LS, Thiry I, Bornschein S, Debyser Z, Gijsbers R.

Sci Rep. 2019 Feb 20;9(1):2389. doi: 10.1038/s41598-019-38718-0.

12.

Propargylated Purine Deoxynucleosides: New Tools for Fluorescence Imaging Strategies.

Venkatesham A, Pillalamarri SR, De Wit F, Lescrinier E, Debyser Z, Van Aerschot A.

Molecules. 2019 Jan 28;24(3). pii: E468. doi: 10.3390/molecules24030468.

13.

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection.

Debyser Z, Vansant G, Bruggemans A, Janssens J, Christ F.

Viruses. 2018 Dec 26;11(1). pii: E12. doi: 10.3390/v11010012. Review.

14.

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.

Sirous H, Fassihi A, Brogi S, Campiani G, Christ F, Debyser Z, Gemma S, Butini S, Chemi G, Grillo A, Zabihollahi R, Aghasadeghi MR, Saghaie L, Memarian HR.

Med Chem. 2019;15(7):755-770. doi: 10.2174/1573406415666181219113225.

PMID:
30569867
15.

Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration.

Borrenberghs D, Zurnic I, De Wit F, Acke A, Dirix L, Cereseto A, Debyser Z, Hendrix J.

Nucleic Acids Res. 2019 Feb 20;47(3):1195-1210. doi: 10.1093/nar/gky1157.

16.

Analysis of ex vivo HIV-1 infection in a controller-discordant couple.

Madlala P, Van de Velde P, Van Remoortel B, Vets S, Van Wijngaerden E, Van Laethem K, Gijsbers R, Schrijvers R, Debyser Z.

J Virus Erad. 2018 Jul 1;4(3):170-173.

17.

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

Sharma S, Čermáková K, De Rijck J, Demeulemeester J, Fábry M, El Ashkar S, Van Belle S, Lepšík M, Tesina P, Duchoslav V, Novák P, Hubálek M, Srb P, Christ F, Řezáčová P, Hodges HC, Debyser Z, Veverka V.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7053-E7062. doi: 10.1073/pnas.1803909115. Epub 2018 Jul 11.

18.

Y-box-binding protein 1 supports the early and late steps of HIV replication.

Weydert C, van Heertum B, Dirix L, De Houwer S, De Wit F, Mast J, Husson SJ, Busschots K, König R, Gijsbers R, De Rijck J, Debyser Z.

PLoS One. 2018 Jul 11;13(7):e0200080. doi: 10.1371/journal.pone.0200080. eCollection 2018.

19.

Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.

Demeulemeester J, Blokken J, De Houwer S, Dirix L, Klaassen H, Marchand A, Chaltin P, Christ F, Debyser Z.

Retrovirology. 2018 Jan 12;15(1):5. doi: 10.1186/s12977-018-0389-2.

20.

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.

J Biol Chem. 2018 Jan 5;293(1):114. doi: 10.1074/jbc.W117.001458. No abstract available.

21.

Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets.

Blokken J, De Rijck J, Christ F, Debyser Z.

Drug Discov Today Technol. 2017 Jun;24:25-31. doi: 10.1016/j.ddtec.2017.11.002. Epub 2017 Nov 23. Review.

PMID:
29233296
22.

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J.

Blood. 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30.

23.

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication.

Hofmann S, Dehn S, Businger R, Bolduan S, Schneider M, Debyser Z, Brack-Werner R, Schindler M.

Open Biol. 2017 Oct;7(10). pii: 170115. doi: 10.1098/rsob.170115.

24.

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.

El Ashkar S, Van Looveren D, Schenk F, Vranckx LS, Demeulemeester J, De Rijck J, Debyser Z, Modlich U, Gijsbers R.

Mol Ther Nucleic Acids. 2017 Jun 16;7:231-245. doi: 10.1016/j.omtn.2017.04.002. Epub 2017 Apr 12.

25.

N-terminal half of transportin SR2 interacts with HIV integrase.

Tsirkone VG, Blokken J, De Wit F, Breemans J, De Houwer S, Debyser Z, Christ F, Strelkov SV.

J Biol Chem. 2017 Jun 9;292(23):9699-9710. doi: 10.1074/jbc.M117.777029. Epub 2017 Mar 29.

26.

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection.

Saleh S, Vranckx L, Gijsbers R, Christ F, Debyser Z.

J Virus Erad. 2017 Jan 1;3(1):7-14.

27.

Tenofovir prodrugs: similar but not the same.

Bruggemans A, Debyser Z.

Lancet HIV. 2017 May;4(5):e190-e191. doi: 10.1016/S2352-3018(17)30033-4. Epub 2017 Mar 2. No abstract available.

PMID:
28259775
28.

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry.

Borrenberghs D, Dirix L, De Wit F, Rocha S, Blokken J, De Houwer S, Gijsbers R, Christ F, Hofkens J, Hendrix J, Debyser Z.

Sci Rep. 2016 Nov 10;6:36485. doi: 10.1038/srep36485.

29.

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.

Vranckx LS, Demeulemeester J, Debyser Z, Gijsbers R.

PLoS One. 2016 Oct 27;11(10):e0164167. doi: 10.1371/journal.pone.0164167. eCollection 2016.

30.

A novel translational model for fetoscopic intratracheal delivery of nanoparticles in piglets.

Carlon MS, Engels AC, Bosch B, Joyeux L, Mori da Cunha MG, Vidović D, Debyser Z, De Boeck K, Neyrinck A, Deprest JA.

Prenat Diagn. 2016 Oct;36(10):926-934. doi: 10.1002/pd.4915. Epub 2016 Sep 18.

PMID:
27567969
31.

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors.

De Luca L, Agharbaoui FE, Gitto R, Buemi MR, Christ F, Debyser Z, Ferro S.

Mol Inform. 2016 Sep;35(8-9):460-73. doi: 10.1002/minf.201501034. Epub 2016 Jul 25.

PMID:
27546050
32.

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.

Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z.

EBioMedicine. 2016 Jun;8:248-264. doi: 10.1016/j.ebiom.2016.04.039. Epub 2016 May 13.

33.

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia.

Cermakova K, Weydert C, Christ F, De Rijck J, Debyser Z.

Trends Pharmacol Sci. 2016 Aug;37(8):660-671. doi: 10.1016/j.tips.2016.05.005. Epub 2016 Jun 9. Review.

PMID:
27290878
34.

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates.

Ory D, Celen S, Gijsbers R, Van Den Haute C, Postnov A, Koole M, Vandeputte C, Andrés JI, Alcazar J, De Angelis M, Langlois X, Bhattacharya A, Schmidt M, Letavic MA, Vanduffel W, Van Laere K, Verbruggen A, Debyser Z, Bormans G.

J Nucl Med. 2016 Sep;57(9):1436-41. doi: 10.2967/jnumed.115.169995. Epub 2016 May 19.

35.

2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.

Billamboz M, Suchaud V, Bailly F, Lion C, Andréola ML, Christ F, Debyser Z, Cotelle P.

Eur J Med Chem. 2016 Jul 19;117:256-68. doi: 10.1016/j.ejmech.2016.03.083. Epub 2016 Mar 28.

PMID:
27105029
36.

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions.

Quercioli V, Di Primio C, Casini A, Mulder LCF, Vranckx LS, Borrenberghs D, Gijsbers R, Debyser Z, Cereseto A.

J Virol. 2016 Apr 29;90(10):5205-5209. doi: 10.1128/JVI.03188-15. Print 2016 May 15.

37.

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex.

Gerits A, Vancraeyenest P, Vreysen S, Laramée ME, Michiels A, Gijsbers R, Van den Haute C, Moons L, Debyser Z, Baekelandt V, Arckens L, Vanduffel W.

Neurophotonics. 2015 Jul;2(3):031209. doi: 10.1117/1.NPh.2.3.031209. Epub 2015 Oct 1.

38.

An integrated multi-electrode-optrode array for in vitro optogenetics.

Welkenhuysen M, Hoffman L, Luo Z, De Proft A, Van den Haute C, Baekelandt V, Debyser Z, Gielen G, Puers R, Braeken D.

Sci Rep. 2016 Feb 2;6:20353. doi: 10.1038/srep20353.

39.

HIV-1 integrase inhibition: looking at cofactor interactions.

Christ F, Debyser Z.

Future Med Chem. 2015;7(18):2407-10. doi: 10.4155/fmc.15.162. Epub 2015 Dec 15. No abstract available.

40.

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.

Macchi F, Deleersnijder A, Van den Haute C, Munck S, Pottel H, Michiels A, Debyser Z, Gerard M, Baekelandt V.

J Neurosci Methods. 2016 Mar 1;261:117-27. doi: 10.1016/j.jneumeth.2015.11.009. Epub 2015 Nov 24.

PMID:
26620202
41.

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector.

Vidović D, Gijsbers R, Quiles-Jimenez A, Dooley J, Van den Haute C, Van der Perren A, Liston A, Baekelandt V, Debyser Z, Carlon MS.

Hum Gene Ther. 2016 Jan;27(1):60-71. doi: 10.1089/hum.2015.109. Epub 2015 Dec 21. Erratum in: Hum Gene Ther. 2016 Nov;27(11):946.

PMID:
26567984
42.

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.

Vidović D, Carlon MS, da Cunha MF, Dekkers JF, Hollenhorst MI, Bijvelds MJ, Ramalho AS, Van den Haute C, Ferrante M, Baekelandt V, Janssens HM, De Boeck K, Sermet-Gaudelus I, de Jonge HR, Gijsbers R, Beekman JM, Edelman A, Debyser Z.

Am J Respir Crit Care Med. 2016 Feb 1;193(3):288-98. doi: 10.1164/rccm.201505-0914OC.

PMID:
26509335
43.

Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation.

Esposito F, Tintori C, Martini R, Christ F, Debyser Z, Ferrarese R, Cabiddu G, Corona A, Ceresola ER, Calcaterra A, Iovine V, Botta B, Clementi M, Canducci F, Botta M, Tramontano E.

Chembiochem. 2015 Nov;16(17):2507-12. doi: 10.1002/cbic.201500385. Epub 2015 Oct 26.

PMID:
26360521
44.

Targeting Virus-host Interactions of HIV Replication.

Weydert C, De Rijck J, Christ F, Debyser Z.

Curr Top Med Chem. 2016;16(10):1167-90. Review.

PMID:
26324041
45.

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.

Demeulemeester J, De Rijck J, Gijsbers R, Debyser Z.

Bioessays. 2015 Nov;37(11):1202-14. doi: 10.1002/bies.201500051. Epub 2015 Aug 21. Review.

46.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.

Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck J, Veverka V, Řezáčová P.

Nat Commun. 2015 Aug 6;6:7968. doi: 10.1038/ncomms8968.

PMID:
26245978
47.

PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide.

Ory D, Planas A, Dresselaers T, Gsell W, Postnov A, Celen S, Casteels C, Himmelreich U, Debyser Z, Van Laere K, Verbruggen A, Bormans G.

Nucl Med Biol. 2015 Oct;42(10):753-61. doi: 10.1016/j.nucmedbio.2015.06.010. Epub 2015 Jun 23.

PMID:
26220690
48.

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

Cuzzucoli Crucitti G, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Novellino E, Debyser Z, Christ F, Costi R, Di Santo R.

Eur J Med Chem. 2015 Aug 28;101:288-94. doi: 10.1016/j.ejmech.2015.06.036. Epub 2015 Jun 22.

PMID:
26150289
49.

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.

Scheyltjens I, Laramée ME, Van den Haute C, Gijsbers R, Debyser Z, Baekelandt V, Vreysen S, Arckens L.

J Comp Neurol. 2015 Oct 1;523(14):2019-42. doi: 10.1002/cne.23819. Epub 2015 Jun 19.

PMID:
26012540
50.

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.

Ferro S, De Luca L, Agharbaoui FE, Christ F, Debyser Z, Gitto R.

Bioorg Med Chem. 2015 Jul 1;23(13):3208-14. doi: 10.1016/j.bmc.2015.04.072. Epub 2015 May 2.

PMID:
25999203

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