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Items: 1 to 50 of 53

1.

PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.

de Semir D, Bezrookove V, Nosrati M, Dar AA, Wu C, Shen J, Rieken C, Venkatasubramanian M, Miller JR 3rd, Desprez PY, McAllister S, Soroceanu L, Debs RJ, Salomonis N, Schadendorf D, Cleaver JE, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5766-E5775. doi: 10.1073/pnas.1804779115. Epub 2018 Jun 4.

2.

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.

McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, Almanza C, Pakdel A, Lee J, Limbad C, Liu Y, Debs RJ, Moore DH, Desprez PY.

Breast Cancer Res Treat. 2011 Aug;129(1):37-47. doi: 10.1007/s10549-010-1177-4. Epub 2010 Sep 22. Erratum in: Breast Cancer Res Treat. 2012 May;133(1):401-4.

3.

Ribozyme-mediated targeting of IkappaBgamma inhibits melanoma invasion and metastasis.

Torabian SZ, de Semir D, Nosrati M, Bagheri S, Dar AA, Fong S, Liu Y, Federman S, Simko J, Haqq C, Debs RJ, Kashani-Sabet M.

Am J Pathol. 2009 Mar;174(3):1009-16. doi: 10.2353/ajpath.2009.080207. Epub 2009 Jan 29.

4.

Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types.

Liu Y, Liggitt D, Fong S, Debs RJ.

Gene Ther. 2006 Dec;13(24):1724-30. Epub 2006 Aug 3.

PMID:
16886001
5.

Genes and pathways downstream of telomerase in melanoma metastasis.

Bagheri S, Nosrati M, Li S, Fong S, Torabian S, Rangel J, Moore DH, Federman S, Laposa RR, Baehner FL, Sagebiel RW, Cleaver JE, Haqq C, Debs RJ, Blackburn EH, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11306-11. Epub 2006 Jul 17.

6.
7.

Id genes and proteins as promising targets in cancer therapy.

Fong S, Debs RJ, Desprez PY.

Trends Mol Med. 2004 Aug;10(8):387-92. Review.

PMID:
15310459
8.

Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA.

Nosrati M, Li S, Bagheri S, Ginzinger D, Blackburn EH, Debs RJ, Kashani-Sabet M.

Clin Cancer Res. 2004 Aug 1;10(15):4983-90.

9.

The effect of liposome size on the final lipid/DNA ratio of cationic lipoplexes.

Gonçalves E, Debs RJ, Heath TD.

Biophys J. 2004 Mar;86(3):1554-63.

10.

NF-kappa B in the vascular progression of melanoma.

Kashani-Sabet M, Shaikh L, Miller JR 3rd, Nosrati M, Ferreira CM, Debs RJ, Sagebiel RW.

J Clin Oncol. 2004 Feb 15;22(4):617-23.

PMID:
14966085
11.

Cationic liposome-mediated gene delivery in vivo.

Liu Y, Fong S, Debs RJ.

Methods Enzymol. 2003;373:536-50. No abstract available.

PMID:
14714426
12.

Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family.

Fong S, Mounkes L, Liu Y, Maibaum M, Alonzo E, Desprez PY, Thor AD, Kashani-Sabet M, Debs RJ.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14253-8. Epub 2003 Nov 11.

13.

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.

Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM, Debs RJ, Desprez PY.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13543-8. Epub 2003 Oct 24.

14.

Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice.

Kashani-Sabet M, Liu Y, Fong S, Desprez PY, Liu S, Tu G, Nosrati M, Handumrongkul C, Liggitt D, Thor AD, Debs RJ.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3878-83. Epub 2002 Mar 12.

15.
16.

Strain-based genetic differences regulate the efficiency of systemic gene delivery as well as expression.

Liu Y, Liggitt HD, Dow S, Handumrongkul C, Heath TD, Debs RJ.

J Biol Chem. 2002 Feb 15;277(7):4966-72. Epub 2001 Dec 3.

17.

Evaluation of the role of lipoprotein metabolism genes in systemic cationic liposome-mediated gene transfer in vivo.

Mounkes LC, Zhong W, de Silva HV, Handumrongkul C, Desai B, Tse E, Taylor JM, Debs RJ.

Hum Gene Ther. 2001 Nov 1;12(16):1939-54.

PMID:
11686936
18.

Efficient gene expression in skin wound sites following local plasmid injection.

Meuli M, Liu Y, Liggitt D, Kashani-Sabet M, Knauer S, Meuli-Simmen C, Harrison MR, Adzick NS, Heath TD, Debs RJ.

J Invest Dermatol. 2001 Jan;116(1):131-5.

19.

Non-replicating Epstein-Barr virus-based plasmids extend gene expression and can improve gene therapy in vivo.

Tu G, Kirchmaier AL, Liggitt D, Liu Y, Liu S, Yu WH, Heath TD, Thor A, Debs RJ.

J Biol Chem. 2000 Sep 29;275(39):30408-16.

20.

Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes.

Gaensler KM, Tu G, Bruch S, Liggitt D, Lipshutz GS, Metkus A, Harrison M, Heath TD, Debs RJ.

Nat Biotechnol. 1999 Dec;17(12):1188-92.

PMID:
10585716
21.

Gene expression along the cerebral-spinal axis after regional gene delivery.

Meuli-Simmen C, Liu Y, Yeo TT, Liggitt D, Tu G, Yang T, Meuli M, Knauer S, Heath TD, Longo FM, Debs RJ.

Hum Gene Ther. 1999 Nov 1;10(16):2689-700.

PMID:
10566897
22.

Systemic gene delivery expands the repertoire of effective antiangiogenic agents.

Liu Y, Thor A, Shtivelman E, Cao Y, Tu G, Heath TD, Debs RJ.

J Biol Chem. 1999 May 7;274(19):13338-44.

23.

Topical gene delivery to murine skin.

Yu WH, Kashani-Sabet M, Liggitt D, Moore D, Heath TD, Debs RJ.

J Invest Dermatol. 1999 Mar;112(3):370-5.

24.

Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo.

Mounkes LC, Zhong W, Cipres-Palacin G, Heath TD, Debs RJ.

J Biol Chem. 1998 Oct 2;273(40):26164-70.

25.

Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery.

Liu Y, Mounkes LC, Liggitt HD, Brown CS, Solodin I, Heath TD, Debs RJ.

Nat Biotechnol. 1997 Feb;15(2):167-73.

PMID:
9035144
26.

Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes.

Friend DS, Papahadjopoulos D, Debs RJ.

Biochim Biophys Acta. 1996 Jan 12;1278(1):41-50.

27.

A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery.

Solodin I, Brown CS, Bruno MS, Chow CY, Jang EH, Debs RJ, Heath TD.

Biochemistry. 1995 Oct 17;34(41):13537-44.

PMID:
7577942
28.

The role of tumor necrosis factor-alpha in acute murine cytomegalovirus infection in BALB/c mice.

Shanley JD, Goff E, Debs RJ, Forman SJ.

J Infect Dis. 1994 May;169(5):1088-91.

PMID:
8169397
29.

Cationic lipid-mediated transfection of liver cells in primary culture.

Jarnagin WR, Debs RJ, Wang SS, Bissell DM.

Nucleic Acids Res. 1992 Aug 25;20(16):4205-11.

30.

Reduction in intensity of Pneumocystis carinii pneumonia in mice by aerosol administration of gamma interferon.

Beck JM, Liggitt HD, Brunette EN, Fuchs HJ, Shellito JE, Debs RJ.

Infect Immun. 1991 Nov;59(11):3859-62.

31.

Chemotherapeutic potential of free and liposome encapsulated streptomycin against experimental Mycobacterium avium complex infections in beige mice.

Gangadharam PR, Ashtekar DA, Ghori N, Goldstein JA, Debs RJ, Düzgünes N.

J Antimicrob Chemother. 1991 Sep;28(3):425-35.

PMID:
1960123
32.

Treatment of Mycobacterium avium-intracellulare complex infection in beige mice with free and liposome-encapsulated streptomycin: role of liposome type and duration of treatment.

Düzgüneş N, Ashtekar DR, Flasher DL, Ghori N, Debs RJ, Friend DS, Gangadharam PR.

J Infect Dis. 1991 Jul;164(1):143-51.

PMID:
2056201
33.

Liposomes modulate human immunodeficiency virus infectivity.

Konopka K, Davis BR, Larsen CE, Alford DR, Debs RJ, Düzgüneş N.

J Gen Virol. 1990 Dec;71 ( Pt 12):2899-907.

PMID:
2273389
34.

Differential effects of free and liposome encapsulated amikacin on the survival of Mycobacterium avium complex in mouse peritoneal macrophages.

Kesavalu L, Goldstein JA, Debs RJ, Düzgünes N, Gangadharam PR.

Tubercle. 1990 Sep;71(3):215-7.

PMID:
2238129
35.

Occupational exposure to aerosolized pentamidine.

Montgomery AB, Corkery KJ, Brunette ER, Leoung GS, Waskin H, Debs RJ.

Chest. 1990 Aug;98(2):386-8.

PMID:
2376170
36.

Monocyte-mediated lysis of HIV-infected tumor cells.

Debs RJ, Krowka J, Stites D, Brunette EN, Düzgünes N, Philip R.

AIDS Res Hum Retroviruses. 1990 Aug;6(8):1005-9.

PMID:
1699572
37.

Regulation of gene expression in vivo by liposome-mediated delivery of a purified transcription factor.

Debs RJ, Freedman LP, Edmunds S, Gaensler KL, Düzgünes N, Yamamoto KR.

J Biol Chem. 1990 Jun 25;265(18):10189-92.

38.

Interaction of antimycobacterial and anti-pneumocystis drugs with phospholipid membranes.

Pedroso de Lima MC, Chiche BH, Debs RJ, Düzgüneş N.

Chem Phys Lipids. 1990 Mar;53(4):361-71.

PMID:
2160335
39.

Immunomodulatory and toxic effects of free and liposome-encapsulated tumor necrosis factor alpha in rats.

Debs RJ, Fuchs HJ, Philip R, Brunette EN, Düzgüneş N, Shellito JE, Liggitt D, Patton JR.

Cancer Res. 1990 Jan 15;50(2):375-80.

PMID:
2295077
40.

Liposome-associated tumor necrosis factor retains bioactivity in the presence of neutralizing anti-tumor necrosis factor antibodies.

Debs RJ, Düzgüneş N, Brunette EN, Fendly B, Patton J, Philip R.

J Immunol. 1989 Aug 15;143(4):1192-7.

PMID:
2787358
41.

Aerosolized pentamidine as second line therapy in patients with AIDS and Pneumocystis carinii pneumonia.

Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Hopewell PC.

Chest. 1989 Apr;95(4):747-50.

PMID:
2784371
42.
44.

Liposome-based therapy of human ovarian cancer: parameters determining potency of negatively charged and antibody-targeted liposomes.

Straubinger RM, Lopez NG, Debs RJ, Hong K, Papahadjopoulos D.

Cancer Res. 1988 Sep 15;48(18):5237-45.

45.

Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice.

Düzgüneş N, Perumal VK, Kesavalu L, Goldstein JA, Debs RJ, Gangadharam PR.

Antimicrob Agents Chemother. 1988 Sep;32(9):1404-11.

46.

Enhanced human monocyte cytotoxicity by platelet-activating factor.

Valone FH, Philip R, Debs RJ.

Immunology. 1988 Aug;64(4):715-8.

47.

Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats.

Debs RJ, Fuchs HJ, Philip R, Montgomery AB, Brunette EN, Liggitt D, Patton JS, Shellito JE.

J Immunol. 1988 May 15;140(10):3482-8.

PMID:
3283235
48.

Selective delivery of pentamidine to the lung by aerosol.

Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Brunette EN, Lin ET, Hopewell PC.

Am Rev Respir Dis. 1988 Feb;137(2):477-8.

PMID:
3257663
49.

Aerosol administration of antiviral agents to treat lung infection due to murine cytomegalovirus.

Debs RJ, Montgomery AB, Brunette EN, DeBruin M, Shanley JD.

J Infect Dis. 1988 Feb;157(2):327-31.

PMID:
2826613
50.

Aerosolised pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome.

Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Brunette EN, Lin ET, Hopewell PC.

Lancet. 1987 Aug 29;2(8557):480-3.

PMID:
2887779

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