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Items: 24


East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide.

Li H, Marceau M, Yang T, Liao T, Tang X, Hu R, Xie Y, Tang H, Tay A, Shi Y, Shen Y, Yang T, Pi X, Lamichhane B, Luo Y, Debowski AW, Nilsson HO, Haslam SM, Mulloy B, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

PLoS Genet. 2019 Nov 20;15(11):e1008497. doi: 10.1371/journal.pgen.1008497. eCollection 2019 Nov.


Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori.

Chua EG, Debowski AW, Webberley KM, Peters F, Lamichhane B, Loke MF, Vadivelu J, Tay CY, Marshall BJ, Wise MJ.

Gastroenterol Rep (Oxf). 2019 Feb;7(1):42-49. doi: 10.1093/gastro/goy048. Epub 2019 Jan 2.


Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors.

Coyle T, Wu L, Debowski AW, Davies GJ, Stubbs KA.

Chembiochem. 2019 Jun 3;20(11):1365-1368. doi: 10.1002/cbic.201800710. Epub 2019 Mar 18.


A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch.

Fisher MF, Zhang J, Taylor NL, Howard MJ, Berkowitz O, Debowski AW, Behsaz B, Whelan J, Pevzner PA, Mylne JS.

Plant Direct. 2018 Feb;2(2). pii: e00042. doi: 10.1002/pld3.42. Epub 2018 Feb 28.


Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains.

Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M.

Toxins (Basel). 2018 Sep 8;10(9). pii: E364. doi: 10.3390/toxins10090364. Review.


A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.

Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA.

Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub 2018 Sep 4.


Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action.

Wallace MD, Waraich NF, Debowski AW, Corral MG, Maxwell A, Mylne JS, Stubbs KA.

Chem Commun (Camb). 2018 Feb 15;54(15):1869-1872. doi: 10.1039/c7cc09518j.


Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains.

Li H, Yang T, Liao T, Debowski AW, Nilsson HO, Haslam SM, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

Microb Cell. 2017 Apr 25;4(5):175-178. doi: 10.15698/mic2017.05.574.


Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection.

Debowski AW, Walton SM, Chua EG, Tay AC, Liao T, Lamichhane B, Himbeck R, Stubbs KA, Marshall BJ, Fulurija A, Benghezal M.

PLoS Pathog. 2017 Jun 23;13(6):e1006464. doi: 10.1371/journal.ppat.1006464. eCollection 2017 Jun.


The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains.

Li H, Yang T, Liao T, Debowski AW, Nilsson HO, Fulurija A, Haslam SM, Mulloy B, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

PLoS Pathog. 2017 Mar 17;13(3):e1006280. doi: 10.1371/journal.ppat.1006280. eCollection 2017 Mar.


Exploiting sp2 -Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors.

Coyle T, Debowski AW, Varrot A, Stubbs KA.

Chembiochem. 2017 Jun 1;18(11):974-978. doi: 10.1002/cbic.201700073. Epub 2017 Apr 20.


Understanding protein glycosylation pathways in bacteria.

Li H, Debowski AW, Liao T, Tang H, Nilsson HO, Marshall BJ, Stubbs KA, Benghezal M.

Future Microbiol. 2017 Jan;12:59-72. doi: 10.2217/fmb-2016-0166. Epub 2016 Sep 30. Review.


Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori.

Li H, Liao T, Debowski AW, Tang H, Nilsson HO, Stubbs KA, Marshall BJ, Benghezal M.

Helicobacter. 2016 Dec;21(6):445-461. doi: 10.1111/hel.12301. Epub 2016 Mar 2. Review.


Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases.

Hattie M, Cekic N, Debowski AW, Vocadlo DJ, Stubbs KA.

Org Biomol Chem. 2016 Mar 28;14(12):3193-7. doi: 10.1039/c6ob00297h.


Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori.

Debowski AW, Sehnal M, Liao T, Stubbs KA, Marshall BJ, Benghezal M.

Appl Environ Microbiol. 2015 Dec;81(23):7969-80. doi: 10.1128/AEM.02191-15. Epub 2015 Sep 11.


Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis.

Hattie M, Ito T, Debowski AW, Arakawa T, Katayama T, Yamamoto K, Fushinobu S, Stubbs KA.

Chem Commun (Camb). 2015 Oct 18;51(81):15008-11. doi: 10.1039/c5cc05494j.


Development of a tetracycline-inducible gene expression system for the study of Helicobacter pylori pathogenesis.

Debowski AW, Verbrugghe P, Sehnal M, Marshall BJ, Benghezal M.

Appl Environ Microbiol. 2013 Dec;79(23):7351-9. doi: 10.1128/AEM.02701-13. Epub 2013 Sep 20.


Xer-cise in Helicobacter pylori: one-step transformation for the construction of markerless gene deletions.

Debowski AW, Gauntlett JC, Li H, Liao T, Sehnal M, Nilsson HO, Marshall BJ, Benghezal M.

Helicobacter. 2012 Dec;17(6):435-43. doi: 10.1111/j.1523-5378.2012.00969.x. Epub 2012 Jun 24.


Development of tools to study lacto-N-biosidase: an important enzyme involved in the breakdown of human milk oligosaccharides.

Hattie M, Debowski AW, Stubbs KA.

Chembiochem. 2012 May 29;13(8):1128-31. doi: 10.1002/cbic.201200135. Epub 2012 Apr 19.


Xer recombinase and genome integrity in Helicobacter pylori, a pathogen without topoisomerase IV.

Debowski AW, Carnoy C, Verbrugghe P, Nilsson HO, Gauntlett JC, Fulurija A, Camilleri T, Berg DE, Marshall BJ, Benghezal M.

PLoS One. 2012;7(4):e33310. doi: 10.1371/journal.pone.0033310. Epub 2012 Apr 12. Erratum in: PLoS One. 2012;7(7): 10.1371/annotation/f5629404-e0e6-4cc1-9d76-ab16238a48c0.


A general method for affinity-based proteomic profiling of exo-α-glycosidases.

Gandy MN, Debowski AW, Stubbs KA.

Chem Commun (Camb). 2011 May 7;47(17):5037-9. doi: 10.1039/c1cc10308c. Epub 2011 Mar 22.


Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ.

Stubbs KA, Scaffidi A, Debowski AW, Mark BL, Stick RV, Vocadlo DJ.

J Am Chem Soc. 2008 Jan 9;130(1):327-35. Epub 2007 Dec 8.


Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor.

Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A.

Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29.


O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ.

J Biol Chem. 2005 Jul 8;280(27):25313-22. Epub 2005 Mar 28.

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