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Items: 7

1.

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.

Fujimoto J, Kurasawa O, Takagi T, Liu X, Banno H, Kojima T, Asano Y, Nakamura A, Nambu T, Hata A, Ishii T, Sameshima T, Debori Y, Miyamoto M, Klein MG, Tjhen R, Sang BC, Levin I, Lane SW, Snell GP, Li K, Kefala G, Hoffman ID, Ding SC, Cary DR, Mizojiri R.

ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503. doi: 10.1021/acsmedchemlett.9b00400. eCollection 2019 Oct 10.

PMID:
31620240
2.

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.

Shiokawa Z, Hashimoto K, Saito B, Oguro Y, Sumi H, Yabuki M, Yoshimatsu M, Kosugi Y, Debori Y, Morishita N, Dougan DR, Snell GP, Yoshida S, Ishikawa T.

Bioorg Med Chem. 2013 Dec 15;21(24):7938-54. doi: 10.1016/j.bmc.2013.09.067. Epub 2013 Oct 12.

PMID:
24169315
3.

Expression and transport function of drug uptake transporters in differentiated HepaRG cells.

Kotani N, Maeda K, Debori Y, Camus S, Li R, Chesne C, Sugiyama Y.

Mol Pharm. 2012 Dec 3;9(12):3434-41. doi: 10.1021/mp300171p. Epub 2012 Nov 6.

PMID:
22897388
4.

Hepatic uptake in the dog: comparison of uptake in hepatocytes and human embryonic kidney cells expressing dog organic anion-transporting polypeptide 1B4.

Wilby AJ, Maeda K, Courtney PF, Debori Y, Webborn PJ, Kitamura Y, Kusuhara H, Riley RJ, Sugiyama Y.

Drug Metab Dispos. 2011 Dec;39(12):2361-9. doi: 10.1124/dmd.111.041814. Epub 2011 Sep 22.

PMID:
21940906
5.

Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments.

Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y.

Drug Metab Dispos. 2011 Jun;39(6):1031-8. doi: 10.1124/dmd.110.036129. Epub 2011 Mar 7.

PMID:
21383204
6.

Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.

Matsushima S, Maeda K, Hayashi H, Debori Y, Schinkel AH, Schuetz JD, Kusuhara H, Sugiyama Y.

Mol Pharmacol. 2008 May;73(5):1474-83. doi: 10.1124/mol.107.041459. Epub 2008 Feb 1.

PMID:
18245269
7.

Synchronous evaluation of toxico- and pharmaco-dynamics of yttrium-90 by a novel autoradiographic procedure.

Shigematsu A, Kawai N, Kuroiwa H, Higashi N, Debori Y, Yui J, Hamai Y, Hatori A, Awazu S, Takeuchi N, Yamabayashi H, Sato Y, Yamamoto T.

Regul Toxicol Pharmacol. 2004 Dec;40(3):207-18.

PMID:
15546676

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