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Items: 27


Role of Coiled-coil Registry Shifts in Activation of Human Bicaudal D2 for Dynein Recruitment Upon Cargo-Binding.

Noell CR, Loh JY, Debler EW, Loftus KM, Cui H, Russ BB, Zhang K, Goyal P, Solmaz SR.

J Phys Chem Lett. 2019 Jul 15. doi: 10.1021/acs.jpclett.9b01865. [Epub ahead of print]


Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.

Kafková L, Tu C, Pazzo KL, Smith KP, Debler EW, Paul KS, Qu J, Read LK.

MBio. 2018 Dec 18;9(6). pii: e02430-18. doi: 10.1128/mBio.02430-18.


A Quantitative Model for BicD2/Cargo Interactions.

Noell CR, Loftus KM, Cui H, Grewer C, Kizer M, Debler EW, Solmaz SR.

Biochemistry. 2018 Nov 20;57(46):6538-6550. doi: 10.1021/acs.biochem.8b00987. Epub 2018 Nov 5.


The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.

Kafková L, Debler EW, Fisk JC, Jain K, Clarke SG, Read LK.

J Biol Chem. 2017 Feb 10;292(6):2089-2100. doi: 10.1074/jbc.M116.757112. Epub 2016 Dec 20.


Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures.

Jain K, Warmack RA, Debler EW, Hadjikyriacou A, Stavropoulos P, Clarke SG.

J Biol Chem. 2016 Aug 26;291(35):18299-308. doi: 10.1074/jbc.M116.740399. Epub 2016 Jul 7.


A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase.

Debler EW, Jain K, Warmack RA, Feng Y, Clarke SG, Blobel G, Stavropoulos P.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2068-73. doi: 10.1073/pnas.1525783113. Epub 2016 Feb 8.


Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

Schulz D, Mugnier MR, Paulsen EM, Kim HS, Chung CW, Tough DF, Rioja I, Prinjha RK, Papavasiliou FN, Debler EW.

PLoS Biol. 2015 Dec 8;13(12):e1002316. doi: 10.1371/journal.pbio.1002316. eCollection 2015 Dec.


Structural and functional analysis of an essential nucleoporin heterotrimer on the cytoplasmic face of the nuclear pore complex.

Yoshida K, Seo HS, Debler EW, Blobel G, Hoelz A.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16571-6. doi: 10.1073/pnas.1112846108. Epub 2011 Sep 19.


The structure of the nuclear pore complex.

Hoelz A, Debler EW, Blobel G.

Annu Rev Biochem. 2011;80:613-43. doi: 10.1146/annurev-biochem-060109-151030. Review.


Characterization of the membrane-coating Nup84 complex: paradigm for the nuclear pore complex structure.

Debler EW, Hsia KC, Nagy V, Seo HS, Hoelz A.

Nucleus. 2010 Mar-Apr;1(2):150-7. doi: 10.4161/nucl.1.2.11120. Epub 2010 Jan 3. Review.


An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket.

Debler EW, Müller R, Hilvert D, Wilson IA.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18539-44. doi: 10.1073/pnas.0902700106. Epub 2009 Oct 21.


Structure of a trimeric nucleoporin complex reveals alternate oligomerization states.

Nagy V, Hsia KC, Debler EW, Kampmann M, Davenport AM, Blobel G, Hoelz A.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17693-8. doi: 10.1073/pnas.0909373106. Epub 2009 Oct 1.


Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.

Seo HS, Ma Y, Debler EW, Wacker D, Kutik S, Blobel G, Hoelz A.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14281-6. doi: 10.1073/pnas.0907453106. Epub 2009 Aug 11.


Nuclear transport comes full circle.

Debler EW, Blobel G, Hoelz A.

Nat Struct Mol Biol. 2009 May;16(5):457-9. doi: 10.1038/nsmb0509-457. No abstract available.


Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.

Napetschnig J, Kassube SA, Debler EW, Wong RW, Blobel G, Hoelz A.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3089-94. doi: 10.1073/pnas.0813267106. Epub 2009 Feb 10.


A fence-like coat for the nuclear pore membrane.

Debler EW, Ma Y, Seo HS, Hsia KC, Noriega TR, Blobel G, Hoelz A.

Mol Cell. 2008 Dec 26;32(6):815-26. doi: 10.1016/j.molcel.2008.12.001.


Conformational isomerism can limit antibody catalysis.

Debler EW, Müller R, Hilvert D, Wilson IA.

J Biol Chem. 2008 Jun 13;283(24):16554-60. doi: 10.1074/jbc.M710256200. Epub 2008 Apr 16.


Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex.

Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA.

Science. 2008 Feb 29;319(5867):1232-5. doi: 10.1126/science.1153445.


Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA.

Stoll R, Lee BM, Debler EW, Laity JH, Wilson IA, Dyson HJ, Wright PE.

J Mol Biol. 2007 Oct 5;372(5):1227-45. Epub 2007 Jul 21.


Crystal structures of a quorum-quenching antibody.

Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA.

J Mol Biol. 2007 May 18;368(5):1392-402. Epub 2007 Mar 6.


Bifunctional catalysis of proton transfer at an antibody active site.

Müller R, Debler EW, Steinmann M, Seebeck FP, Wilson IA, Hilvert D.

J Am Chem Soc. 2007 Jan 24;129(3):460-1. No abstract available.


Characterization of two novel missense mutations in the AQP2 gene causing nephrogenic diabetes insipidus.

Iolascon A, Aglio V, Tamma G, D'Apolito M, Addabbo F, Procino G, Simonetti MC, Montini G, Gesualdo L, Debler EW, Svelto M, Valenti G.

Nephron Physiol. 2007;105(3):p33-41. Epub 2006 Dec 28.


The effects of antibodies on stilbene excited-state energetics.

Tian F, Debler EW, Millar DP, Deniz AA, Wilson IA, Schultz PG.

Angew Chem Int Ed Engl. 2006 Nov 27;45(46):7763-5. No abstract available.


Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.

Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2788-93. Epub 2006 Feb 13.


Dual modes of RNA-silencing suppression by Flock House virus protein B2.

Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR.

Nat Struct Mol Biol. 2005 Nov;12(11):952-7.


Structural origins of efficient proton abstraction from carbon by a catalytic antibody.

Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4984-9. Epub 2005 Mar 23.


Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A.

Kelker MS, Debler EW, Wilson IA.

J Mol Biol. 2004 Dec 10;344(5):1175-81.


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