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Items: 1 to 50 of 197

1.

Anti-Infectives Restore ORKAMBI® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa.

Laselva O, Stone TA, Bear CE, Deber CM.

Biomolecules. 2020 Feb 19;10(2). pii: E334. doi: 10.3390/biom10020334.

2.

CFTR transmembrane segments are impaired in their conformational adaptability by a pathogenic loop mutation and dynamically stabilized by Lumacaftor.

Krainer G, Schenkel M, Hartmann A, Ravamehr-Lake D, Deber CM, Schlierf M.

J Biol Chem. 2020 Feb 14;295(7):1985-1991. doi: 10.1074/jbc.AC119.011360. Epub 2019 Dec 27.

PMID:
31882543
3.

Peptide-Based Efflux Pump Inhibitors of the Small Multidrug Resistance Protein from Pseudomonas aeruginosa.

Mitchell CJ, Stone TA, Deber CM.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00730-19. doi: 10.1128/AAC.00730-19. Print 2019 Sep.

4.

Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability.

Stone TA, Cole GB, Ravamehr-Lake D, Nguyen HQ, Khan F, Sharpe S, Deber CM.

J Med Chem. 2019 Jul 11;62(13):6276-6286. doi: 10.1021/acs.jmedchem.9b00657. Epub 2019 Jul 1.

PMID:
31194548
5.

A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR.

Krainer G, Treff A, Hartmann A, Stone TA, Schenkel M, Keller S, Deber CM, Schlierf M.

Commun Biol. 2018 Sep 28;1:154. doi: 10.1038/s42003-018-0153-0. eCollection 2018.

6.

Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms.

Beaudoin T, Stone TA, Glibowicka M, Adams C, Yau Y, Ahmadi S, Bear CE, Grasemann H, Waters V, Deber CM.

Sci Rep. 2018 Oct 3;8(1):14728. doi: 10.1038/s41598-018-33016-7.

7.

Structure of the EmrE multidrug transporter and its use for inhibitor peptide design.

Ovchinnikov V, Stone TA, Deber CM, Karplus M.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7932-E7941. doi: 10.1073/pnas.1802177115. Epub 2018 Aug 6.

8.

Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB.

Garton M, Nim S, Stone TA, Wang KE, Deber CM, Kim PM.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1505-1510. doi: 10.1073/pnas.1711837115. Epub 2018 Jan 29.

9.

Structural effects of extracellular loop mutations in CFTR helical hairpins.

Chang YH, Stone TA, Chin S, Glibowicka M, Bear CE, Deber CM.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1092-1098. doi: 10.1016/j.bbamem.2018.01.003. Epub 2018 Jan 5.

10.

Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides.

Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM.

Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020. Epub 2017 Oct 21.

PMID:
29275987
11.

Hydrophobic Clusters Raise the Threshold Hydrophilicity for Insertion of Transmembrane Sequences in Vivo.

Stone TA, Schiller N, Workewych N, von Heijne G, Deber CM.

Biochemistry. 2016 Oct 11;55(40):5772-5779. Epub 2016 Sep 29.

PMID:
27620701
12.

Therapeutic design of peptide modulators of protein-protein interactions in membranes.

Stone TA, Deber CM.

Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):577-585. doi: 10.1016/j.bbamem.2016.08.013. Epub 2016 Aug 28. Review.

13.

Modulating Transmembrane α-Helix Interactions through pH-Sensitive Boundary Residues.

Ng DP, Deber CM.

Biochemistry. 2016 Aug 9;55(31):4306-15. doi: 10.1021/acs.biochem.6b00380. Epub 2016 Aug 1.

PMID:
27434090
14.

Structural impact of proline mutations in the loop region of an ancestral membrane protein.

Nadeau VG, Deber CM.

Biopolymers. 2016 Jan;106(1):37-42. doi: 10.1002/bip.22765.

PMID:
26566586
15.

Design and characterization of a membrane protein unfolding platform in lipid bilayers.

Nadeau VG, Gao A, Deber CM.

PLoS One. 2015 Mar 23;10(3):e0120253. doi: 10.1371/journal.pone.0120253. eCollection 2015.

16.

Helix-helix interactions: is the medium the message?

Deber CM, Ng DP.

Structure. 2015 Mar 3;23(3):437-438. doi: 10.1016/j.str.2015.02.004.

17.

Hydrophobic blocks facilitate lipid compatibility and translocon recognition of transmembrane protein sequences.

Stone TA, Schiller N, von Heijne G, Deber CM.

Biochemistry. 2015 Feb 24;54(7):1465-73. doi: 10.1021/bi5014886. Epub 2015 Feb 12.

18.

Efflux by small multidrug resistance proteins is inhibited by membrane-interactive helix-stapled peptides.

Bellmann-Sickert K, Stone TA, Poulsen BE, Deber CM.

J Biol Chem. 2015 Jan 16;290(3):1752-9. doi: 10.1074/jbc.M114.616185. Epub 2014 Nov 25.

19.

Functional response of the small multidrug resistance protein EmrE to mutations in transmembrane helix 2.

Wang J, Rath A, Deber CM.

FEBS Lett. 2014 Oct 16;588(20):3720-5. doi: 10.1016/j.febslet.2014.08.018. Epub 2014 Aug 23.

20.

Terminal residue hydrophobicity modulates transmembrane helix-helix interactions.

Ng DP, Deber CM.

Biochemistry. 2014 Jun 17;53(23):3747-57. doi: 10.1021/bi500317h. Epub 2014 Jun 9.

PMID:
24857611
21.

Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.

Strandberg LS, Cui X, Rath A, Liu J, Silverman ED, Liu X, Siragam V, Ackerley C, Su BB, Yan JY, Capecchi M, Biavati L, Accorroni A, Yuen W, Quattrone F, Lung K, Jaeggi ET, Backx PH, Deber CM, Hamilton RM.

PLoS One. 2013 Sep 9;8(9):e72668. doi: 10.1371/journal.pone.0072668. eCollection 2013.

22.

Acrylamide concentration determines the direction and magnitude of helical membrane protein gel shifts.

Rath A, Cunningham F, Deber CM.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15668-73. doi: 10.1073/pnas.1311305110. Epub 2013 Sep 9.

23.

Inside-out signaling promotes dynamic changes in the carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) oligomeric state to control its cell adhesion properties.

Patel PC, Lee HS, Ming AY, Rath A, Deber CM, Yip CM, Rocheleau JV, Gray-Owen SD.

J Biol Chem. 2013 Oct 11;288(41):29654-69. doi: 10.1074/jbc.M113.504639. Epub 2013 Sep 4.

24.

Design of transmembrane peptides: coping with sticky situations.

Rath A, Deber CM.

Methods Mol Biol. 2013;1063:197-210. doi: 10.1007/978-1-62703-583-5_11.

PMID:
23975779
25.

Loop sequence dictates the secondary structure of a human membrane protein hairpin.

Nadeau VG, Deber CM.

Biochemistry. 2013 Apr 9;52(14):2419-26. doi: 10.1021/bi400187w. Epub 2013 Mar 29.

PMID:
23488803
26.

Differential binding of L- vs. D-isomers of cationic antimicrobial peptides to the biofilm exopolysaccharide alginate.

Yin LM, Lee S, Mak JS, Helmy AS, Deber CM.

Protein Pept Lett. 2013 Aug;20(8):843-7.

PMID:
23458077
27.

Design, expression, and purification of de novo transmembrane "hairpin" peptides.

Tulumello DV, Johnson RM, Isupov I, Deber CM.

Biopolymers. 2012;98(6):546-56. doi: 10.1002/bip.22149.

PMID:
23203760
28.

Correction factors for membrane protein molecular weight readouts on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

Rath A, Deber CM.

Anal Biochem. 2013 Mar 1;434(1):67-72. doi: 10.1016/j.ab.2012.11.007. Epub 2012 Nov 29.

PMID:
23201391
29.

Effects of a polar amino acid substitution on helix formation and aggregate size along the detergent-induced peptide folding pathway.

Alvares RD, Tulumello DV, Macdonald PM, Deber CM, Prosser RS.

Biochim Biophys Acta. 2013 Feb;1828(2):373-81. doi: 10.1016/j.bbamem.2012.09.024. Epub 2012 Sep 29.

30.

Sequence hydropathy dominates membrane protein response to detergent solubilization.

Nadeau VG, Rath A, Deber CM.

Biochemistry. 2012 Aug 7;51(31):6228-37. Epub 2012 Jul 25.

PMID:
22779403
31.

Protein structure in membrane domains.

Rath A, Deber CM.

Annu Rev Biophys. 2012;41:135-55. doi: 10.1146/annurev-biophys-050511-102310. Review.

PMID:
22577820
32.

Drug efflux by a small multidrug resistance protein is inhibited by a transmembrane peptide.

Poulsen BE, Deber CM.

Antimicrob Agents Chemother. 2012 Jul;56(7):3911-6. doi: 10.1128/AAC.00158-12. Epub 2012 Apr 23.

33.

Thioester-isocyanides: versatile reagents for the synthesis of cycle-tail peptides.

Rotstein BH, Winternheimer DJ, Yin LM, Deber CM, Yudin AK.

Chem Commun (Camb). 2012 Apr 18;48(31):3775-7. doi: 10.1039/c2cc16027g. Epub 2012 Mar 9.

PMID:
22430393
34.

Efficiency of detergents at maintaining membrane protein structures in their biologically relevant forms.

Tulumello DV, Deber CM.

Biochim Biophys Acta. 2012 May;1818(5):1351-8. doi: 10.1016/j.bbamem.2012.01.013. Epub 2012 Jan 21.

35.

Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions.

Yin LM, Edwards MA, Li J, Yip CM, Deber CM.

J Biol Chem. 2012 Mar 2;287(10):7738-45. doi: 10.1074/jbc.M111.303602. Epub 2012 Jan 17.

36.

Structural basis for misfolding at a disease phenotypic position in CFTR: comparison of TM3/4 helix-loop-helix constructs with TM4 peptides.

Mulvihill CM, Deber CM.

Biochim Biophys Acta. 2012 Jan;1818(1):49-54. doi: 10.1016/j.bbamem.2011.09.027. Epub 2011 Oct 3.

37.

Modulation of substrate efflux in bacterial small multidrug resistance proteins by mutations at the dimer interface.

Poulsen BE, Cunningham F, Lee KK, Deber CM.

J Bacteriol. 2011 Nov;193(21):5929-35. doi: 10.1128/JB.05846-11. Epub 2011 Sep 2.

38.

Membrane protein misassembly in disease.

Ng DP, Poulsen BE, Deber CM.

Biochim Biophys Acta. 2012 Apr;1818(4):1115-22. doi: 10.1016/j.bbamem.2011.07.046. Epub 2011 Aug 5. Review.

39.

Positions of polar amino acids alter interactions between transmembrane segments and detergents.

Tulumello DV, Deber CM.

Biochemistry. 2011 May 17;50(19):3928-35. doi: 10.1021/bi200238g. Epub 2011 Apr 20.

PMID:
21473646
40.

Converting a marginally hydrophobic soluble protein into a membrane protein.

Nørholm MH, Cunningham F, Deber CM, von Heijne G.

J Mol Biol. 2011 Mar 18;407(1):171-9. doi: 10.1016/j.jmb.2011.01.035. Epub 2011 Jan 22.

PMID:
21262233
41.

Novel hydrophobic standards for membrane protein molecular weight determinations via sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

Rath A, Nadeau VG, Poulsen BE, Ng DP, Deber CM.

Biochemistry. 2010 Dec 21;49(50):10589-91. doi: 10.1021/bi101840j. Epub 2010 Nov 30.

PMID:
21105732
42.

Beta-branched residues adjacent to GG4 motifs promote the efficient association of glycophorin A transmembrane helices.

Cunningham F, Poulsen BE, Ip W, Deber CM.

Biopolymers. 2011;96(3):340-7. doi: 10.1002/bip.21565.

PMID:
21072853
43.

Modulation of the oligomerization of myelin proteolipid protein by transmembrane helix interaction motifs.

Ng DP, Deber CM.

Biochemistry. 2010 Aug 17;49(32):6896-902. doi: 10.1021/bi100739r.

PMID:
20695528
44.

Evidence that the translocon may function as a hydropathy partitioning filter.

Mulvihill CM, Deber CM.

Biochim Biophys Acta. 2010 Oct;1798(10):1995-8. doi: 10.1016/j.bbamem.2010.07.007. Epub 2010 Jul 18.

45.

Deletion of a terminal residue disrupts oligomerization of a transmembrane alpha-helix.

Ng DP, Deber CM.

Biochem Cell Biol. 2010 Apr;88(2):339-45. doi: 10.1139/o09-162.

PMID:
20453934
46.

SDS micelles as a membrane-mimetic environment for transmembrane segments.

Tulumello DV, Deber CM.

Biochemistry. 2009 Dec 29;48(51):12096-103. doi: 10.1021/bi9013819.

PMID:
19921933
47.

A Modified Alderman-Grant Coil makes possible an efficient cross-coil probe for high field solid-state NMR of lossy biological samples.

Grant CV, Yang Y, Glibowicka M, Wu CH, Park SH, Deber CM, Opella SJ.

J Magn Reson. 2009 Nov;201(1):87-92. doi: 10.1016/j.jmr.2009.08.009. Epub 2009 Aug 15.

48.

Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs.

Kim Chiaw P, Huan LJ, Gagnon S, Ly D, Sweezey N, Rotin D, Deber CM, Bear CE.

Chem Biol. 2009 May 29;16(5):520-30. doi: 10.1016/j.chembiol.2009.04.005.

49.

Hydrophobic peptide segments in soluble proteins competent for membrane insertion: role in amyloidogenesis.

Cunningham F, Rath A, Deber CM.

Adv Exp Med Biol. 2009;611:299-300. No abstract available.

PMID:
19400201
50.

A novel method for monitoring the cytosolic delivery of peptide cargo.

Cheung JC, Kim Chiaw P, Deber CM, Bear CE.

J Control Release. 2009 Jul 1;137(1):2-7. doi: 10.1016/j.jconrel.2009.02.022. Epub 2009 Mar 12.

PMID:
19285529

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