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Items: 49

1.

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.

Acosta MI, Urbach S, Doye A, Ng YW, Boudeau J, Mettouchi A, Debant A, Manser E, Visvikis O, Lemichez E.

Sci Rep. 2018 Jan 23;8(1):1410. doi: 10.1038/s41598-018-19471-2.

2.

Recurrent TRIO Fusion in Nontranslocation-Related Sarcomas.

Delespaul L, Lesluyes T, Pérot G, Brulard C, Lartigue L, Baud J, Lagarde P, Le Guellec S, Neuville A, Terrier P, Vince-Ranchère D, Schmidt S, Debant A, Coindre JM, Chibon F.

Clin Cancer Res. 2017 Feb 1;23(3):857-867. doi: 10.1158/1078-0432.CCR-16-0290. Epub 2016 Aug 15.

3.

Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly.

Pengelly RJ, Greville-Heygate S, Schmidt S, Seaby EG, Jabalameli MR, Mehta SG, Parker MJ, Goudie D, Fagotto-Kaufmann C, Mercer C; DDD Study, Debant A, Ennis S, Baralle D.

J Med Genet. 2016 Nov;53(11):735-742. doi: 10.1136/jmedgenet-2016-103942. Epub 2016 Jul 14.

4.

Comprehensive prognostic analysis in breast cancer integrating clinical, tumoral, micro-environmental and immunohistochemical criteria.

de Mascarel I, Debled M, Brouste V, Mauriac L, Sierankowski G, Velasco V, Croce S, Chibon F, Boudeau J, Debant A, MacGrogan G.

Springerplus. 2015 Sep 21;4:528. doi: 10.1186/s40064-015-1297-8. eCollection 2015.

5.

Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.

DeGeer J, Kaplan A, Mattar P, Morabito M, Stochaj U, Kennedy TE, Debant A, Cayouette M, Fournier AE, Lamarche-Vane N.

J Cell Biol. 2015 Aug 31;210(5):817-32. doi: 10.1083/jcb.201505084.

6.

The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.

Jaudon F, Raynaud F, Wehrlé R, Bellanger JM, Doulazmi M, Vodjdani G, Gasman S, Fagni L, Dusart I, Debant A, Schmidt S.

Mol Biol Cell. 2015 Jun 1;26(11):2112-27. doi: 10.1091/mbc.E14-08-1310. Epub 2015 Apr 7.

7.

Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis.

Cannet A, Schmidt S, Delaval B, Debant A.

Mol Biol Cell. 2014 Dec 15;25(25):4063-71. doi: 10.1091/mbc.E14-06-1153. Epub 2014 Oct 29.

8.

Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.

van Haren J, Boudeau J, Schmidt S, Basu S, Liu Z, Lammers D, Demmers J, Benhari J, Grosveld F, Debant A, Galjart N.

Curr Biol. 2014 Aug 4;24(15):1778-85. doi: 10.1016/j.cub.2014.06.037. Epub 2014 Jul 24.

9.

Function and regulation of the Rho guanine nucleotide exchange factor Trio.

Schmidt S, Debant A.

Small GTPases. 2014;5:e29769. doi: 10.4161/sgtp.29769. Epub 2014 Jul 2. Review.

10.

Aptamer-derived peptide inhibitors of Rho guanine nucleotide exchange factors.

Schmidt S, Debant A.

Enzymes. 2013;33 Pt A:147-68. doi: 10.1016/B978-0-12-416749-0.00007-5. Epub 2013 Aug 8. Review.

PMID:
25033804
11.

Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth.

DeGeer J, Boudeau J, Schmidt S, Bedford F, Lamarche-Vane N, Debant A.

Mol Cell Biol. 2013 Feb;33(4):739-51. doi: 10.1128/MCB.01264-12. Epub 2012 Dec 10.

12.

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS.

Mol Cell. 2013 Jan 10;49(1):94-108. doi: 10.1016/j.molcel.2012.10.018. Epub 2012 Nov 21.

13.

The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons.

Bellanger JM, Cueva JG, Baran R, Tang G, Goodman MB, Debant A.

J Cell Sci. 2012 Nov 15;125(Pt 22):5417-27. doi: 10.1242/jcs.108381. Epub 2012 Sep 6.

14.

Random mutagenesis of peptide aptamers as an optimization strategy for inhibitor screening.

Bouquier N, Fromont S, Debant A, Schmidt S.

Methods Mol Biol. 2012;928:97-118. doi: 10.1007/978-1-62703-008-3_8.

15.

A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.

Plageman TF Jr, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA.

Development. 2011 Dec;138(23):5177-88. doi: 10.1242/dev.067868. Epub 2011 Oct 26.

16.

Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio.

Neubrand VE, Thomas C, Schmidt S, Debant A, Schiavo G.

J Cell Sci. 2010 Jun 15;123(Pt 12):2111-23. doi: 10.1242/jcs.064055.

17.

Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat.

Bouquier N, Fromont S, Zeeh JC, Auziol C, Larrousse P, Robert B, Zeghouf M, Cherfils J, Debant A, Schmidt S.

Chem Biol. 2009 Apr 24;16(4):391-400. doi: 10.1016/j.chembiol.2009.02.006.

18.

Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.

Briançon-Marjollet A, Ghogha A, Nawabi H, Triki I, Auziol C, Fromont S, Piché C, Enslen H, Chebli K, Cloutier JF, Castellani V, Debant A, Lamarche-Vane N.

Mol Cell Biol. 2008 Apr;28(7):2314-23. doi: 10.1128/MCB.00998-07. Epub 2008 Jan 22.

19.

Trio controls the mature organization of neuronal clusters in the hindbrain.

Backer S, Hidalgo-Sánchez M, Offner N, Portales-Casamar E, Debant A, Fort P, Gauthier-Rouvière C, Bloch-Gallego E.

J Neurosci. 2007 Sep 26;27(39):10323-32. Erratum in: J Neurosci. 2007 Oct 24;27(43):11776.

20.

M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.

Charrasse S, Comunale F, Fortier M, Portales-Casamar E, Debant A, Gauthier-Rouvière C.

Mol Biol Cell. 2007 May;18(5):1734-43. Epub 2007 Mar 1.

21.

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay.

Blangy A, Bouquier N, Gauthier-Rouvière C, Schmidt S, Debant A, Leonetti JP, Fort P.

Biol Cell. 2006 Sep;98(9):511-22.

22.

Identification of novel neuronal isoforms of the Rho-GEF Trio.

Portales-Casamar E, Briançon-Marjollet A, Fromont S, Triboulet R, Debant A.

Biol Cell. 2006 Mar;98(3):183-93.

PMID:
16033331
23.

Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse.

Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME.

Neuron. 2005 Apr 21;46(2):191-204.

24.

SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.

Salinas S, Briançon-Marjollet A, Bossis G, Lopez MA, Piechaczyk M, Jariel-Encontre I, Debant A, Hipskind RA.

J Cell Biol. 2004 Jun 21;165(6):767-73.

25.

Different regulation of the Trio Dbl-Homology domains by their associated PH domains.

Bellanger JM, Estrach S, Schmidt S, Briançon-Marjollet A, Zugasti O, Fromont S, Debant A.

Biol Cell. 2003 Dec;95(9):625-34.

PMID:
14720465
26.

Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio.

Schmidt S, Diriong S, Méry J, Fabbrizio E, Debant A.

FEBS Lett. 2002 Jul 17;523(1-3):35-42.

27.

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth.

Estrach S, Schmidt S, Diriong S, Penna A, Blangy A, Fort P, Debant A.

Curr Biol. 2002 Feb 19;12(4):307-12.

28.

Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.

Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP.

J Cell Sci. 2002 Feb 1;115(Pt 3):629-40.

29.

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin.

Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME.

Cell. 2001 Apr 20;105(2):233-44.

30.

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin.

Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A.

Nat Cell Biol. 2000 Dec;2(12):888-92.

PMID:
11146652
31.

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila.

Newsome TP, Schmidt S, Dietzl G, Keleman K, Asling B, Debant A, Dickson BJ.

Cell. 2000 Apr 28;101(3):283-94.

32.

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG.

Blangy A, Vignal E, Schmidt S, Debant A, Gauthier-Rouvière C, Fort P.

J Cell Sci. 2000 Feb;113 ( Pt 4):729-39.

33.

[Role of the multifunctional Trio protein in the control of the Rac1 and RhoA gtpase signaling pathways].

Bellanger JM, Zugasti O, Lazaro JB, Diriong S, Lamb N, Sardet C, Debant A.

C R Seances Soc Biol Fil. 1998;192(2):367-74. French.

PMID:
9759378
34.

Arg777 plays a major role in the conformation of the colony-stimulating factor-1 receptor intracellular kinase domain.

Schmid-Antomarchi H, Husson H, Debant A, Breittmayer V, Ramos-Morales F, Fischer S, Rossi B.

Eur Cytokine Netw. 1998 Mar;9(1):99-108.

35.

The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo.

Bellanger JM, Lazaro JB, Diriong S, Fernandez A, Lamb N, Debant A.

Oncogene. 1998 Jan 15;16(2):147-52.

36.

Cleavage site mutants of the subtype B insulin receptor are uncleaved and fully functional.

Auzan C, Debant A, Rossi B, Clauser E.

Mol Cell Endocrinol. 1997 Apr 4;128(1-2):129-37.

PMID:
9140084
37.

Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1-->p 14 by in situ hybridization.

Taviaux S, Diriong S, Bellanger JM, Streuli M, Debant A.

Cytogenet Cell Genet. 1997;76(1-2):107-8. No abstract available.

PMID:
9154137
38.
39.

The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.

Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M.

EMBO J. 1995 Jun 15;14(12):2827-38.

40.

N-linked oligosaccharide chains of the insulin receptor beta subunit are essential for transmembrane signaling.

Leconte I, Auzan C, Debant A, Rossi B, Clauser E.

J Biol Chem. 1992 Aug 25;267(24):17415-23.

41.

Inhibitors of chymotrypsin-like activities selectively block the mitotic pathway in rat hepatoma cells.

Ponzio G, Contreres JO, Debant A, Auberger P, Farahifar D, Rossi B.

Growth Factors. 1990;4(1):37-44.

PMID:
1982214
42.

Cell-cycle regulation of insulin-stimulated tyrosine aminotransferase activity in rat hepatoma cells.

Contreres JO, Debant A, Ponzio G, Rossi B.

Cell Signal. 1990;2(5):439-50.

PMID:
1980597
43.

Wheat-germ agglutinin mimics metabolic effects of insulin without increasing receptor autophosphorylation.

Ponzio G, Debant A, Contreres JO, Rossi B.

Cell Signal. 1990;2(4):377-86.

PMID:
1979229
44.

Receptor cross-linking restores an insulin metabolic effect altered by mutation on tyrosine 1162 and tyrosine 1163.

Debant A, Ponzio G, Clauser E, Contreres JO, Rossi B.

Biochemistry. 1989 Jan 10;28(1):14-7.

PMID:
2650737
45.

Use of an anti-insulin receptor antibody to discriminate between metabolic and mitogenic effects of insulin: correlation with receptor autophosphorylation.

Ponzio G, Contreres JO, Debant A, Baron V, Gautier N, Dolais-Kitabgi J, Rossi B.

EMBO J. 1988 Dec 20;7(13):4111-7.

46.

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.

Debant A, Clauser E, Ponzio G, Filloux C, Auzan C, Contreres JO, Rossi B.

Proc Natl Acad Sci U S A. 1988 Nov;85(21):8032-6.

47.

Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats.

Debant A, Guerre-Millo M, Le Marchand-Brustel Y, Freychet P, Lavau M, Van Obberghen E.

Am J Physiol. 1987 Feb;252(2 Pt 1):E273-8.

PMID:
3548422
48.

The insulin receptor kinase.

Van Obberghen E, Ballotti R, Gazzano H, Fehlmann M, Rossi B, Gammeltoft S, Debant A, Le Marchand-Brustel Y, Kowalski A.

Biochimie. 1985 Oct-Nov;67(10-11):1119-24.

PMID:
3000460
49.

Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase.

Sadoul JL, Peyron JF, Ballotti R, Debant A, Fehlmann M, Van Obberghen E.

Biochem J. 1985 May 1;227(3):887-92.

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