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Items: 48

1.

In vitro skin penetration enhancement techniques: A combined approach of ethosomes and microneedles.

Bellefroid C, Lechanteur A, Evrard B, Mottet D, Debacq-Chainiaux F, Piel G.

Int J Pharm. 2019 Dec 15;572:118793. doi: 10.1016/j.ijpharm.2019.118793. Epub 2019 Nov 9.

PMID:
31715350
2.

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study.

Pinchuk I, Weber D, Kochlik B, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen EHJM, Gonos ES, Sikora E, Breusing N, Gradinaru D, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T, Lichtenberg D.

Redox Biol. 2019 Jun;24:101204. doi: 10.1016/j.redox.2019.101204. Epub 2019 Apr 15.

3.

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins.

Mitchell R, Mellows B, Sheard J, Antonioli M, Kretz O, Chambers D, Zeuner MT, Tomkins JE, Denecke B, Musante L, Joch B, Debacq-Chainiaux F, Holthofer H, Ray S, Huber TB, Dengjel J, De Coppi P, Widera D, Patel K.

Stem Cell Res Ther. 2019 Apr 5;10(1):116. doi: 10.1186/s13287-019-1213-1.

4.

Health and frailty among older spousal caregivers: an observational cohort study in Belgium.

Potier F, Degryse JM, Bihin B, Debacq-Chainiaux F, Charlet-Renard C, Martens H, de Saint-Hubert M.

BMC Geriatr. 2018 Nov 26;18(1):291. doi: 10.1186/s12877-018-0980-3.

5.

Spousal Caregiving Is Associated with an Increased Risk of Frailty: A Case-Control Study.

Potier F, Degryse JM, Aubouy G, Henrard S, Bihin B, Debacq-Chainiaux F, Martens H, de Saint-Hubert M.

J Frailty Aging. 2018;7(3):170-175. doi: 10.14283/jfa.2018.11.

PMID:
30095147
6.

Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta.

Luyten LJ, Saenen ND, Janssen BG, Vrijens K, Plusquin M, Roels HA, Debacq-Chainiaux F, Nawrot TS.

Environ Res. 2018 Oct;166:310-323. doi: 10.1016/j.envres.2018.03.025. Epub 2018 Jun 13.

PMID:
29908461
7.

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study.

Rietman ML, Spijkerman AMW, Wong A, van Steeg H, Bürkle A, Moreno-Villanueva M, Sindlinger T, Franceschi C, Grubeck-Loebenstein B, Bernhardt J, Slagboom PE, Toussaint O, Debacq-Chainiaux F, Sikora E, Gonos ES, Breusing N, Stuetz W, Weber D, Grune T, Basso A, Piacenza F, Malavolta M, Collino S, Jansen EHJM, Verschuren WMM, Dollé MET.

Mech Ageing Dev. 2019 Jan;177:135-143. doi: 10.1016/j.mad.2018.04.007. Epub 2018 Apr 30.

PMID:
29719199
8.

Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis.

Toutfaire M, Dumortier E, Fattaccioli A, Van Steenbrugge M, Proby CM, Debacq-Chainiaux F.

Int J Biochem Cell Biol. 2018 May;98:113-126. doi: 10.1016/j.biocel.2018.03.005. Epub 2018 Mar 14.

PMID:
29550586
9.

Stress and Senescence: A Special Issue dedicated to Olivier Toussaint.

Debacq-Chainiaux F, Gonos ES.

Mech Ageing Dev. 2018 Mar;170:1. doi: 10.1016/j.mad.2018.02.003. No abstract available.

PMID:
29499849
10.

Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project.

Giacconi R, Costarelli L, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Hervonen A, Slagboom E, Ciccarone F, Zampieri M, Caiafa P, Jansen E, Dollé MET, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753. doi: 10.1093/gerona/glx192.

PMID:
29045571
11.

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study.

Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B.

Exp Gerontol. 2018 May;105:109-112. doi: 10.1016/j.exger.2017.08.037. Epub 2017 Oct 7.

PMID:
29017961
12.

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project.

Weber D, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen E, Gonos ES, Franceschi C, Sikora E, Hervonen A, Breusing N, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T.

Oxid Med Cell Longev. 2017;2017:1401452. doi: 10.1155/2017/1401452. Epub 2017 Jul 19.

13.

Role of Prion protein in premature senescence of human fibroblasts.

Boilan E, Winant V, Dumortier E, ElMoualij B, Quatresooz P, Osiewacz HD, Debacq-Chainiaux F, Toussaint O.

Mech Ageing Dev. 2018 Mar;170:106-113. doi: 10.1016/j.mad.2017.08.002. Epub 2017 Aug 8.

PMID:
28800967
14.

Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis.

Mellows B, Mitchell R, Antonioli M, Kretz O, Chambers D, Zeuner MT, Denecke B, Musante L, Ramachandra DL, Debacq-Chainiaux F, Holthofer H, Joch B, Ray S, Widera D, David AL, Huber TB, Dengjel J, De Coppi P, Patel K.

Stem Cells Dev. 2017 Sep 15;26(18):1316-1333. doi: 10.1089/scd.2017.0089. Epub 2017 Aug 22.

PMID:
28679310
15.

Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization.

Mound A, Lozanova V, Warnon C, Hermant M, Robic J, Guere C, Vie K, Lambert de Rouvroit C, Tyteca D, Debacq-Chainiaux F, Poumay Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):958-971. doi: 10.1016/j.bbalip.2017.06.001. Epub 2017 Jun 6.

16.

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies.

Toutfaire M, Bauwens E, Debacq-Chainiaux F.

Biochem Pharmacol. 2017 Oct 15;142:1-12. doi: 10.1016/j.bcp.2017.04.011. Epub 2017 Apr 10. Review.

PMID:
28408343
17.

In memory of Dr. Olivier Toussaint.

Debacq-Chainiaux F, de Magalhães JP.

Biogerontology. 2017 Feb;18(1):1. doi: 10.1007/s10522-017-9679-7. Epub 2017 Jan 23. No abstract available.

PMID:
28116571
18.

Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty.

Bodart G, Goffinet L, Morrhaye G, Farhat K, de Saint-Hubert M, Debacq-Chainiaux F, Swine C, Geenen V, Martens HJ.

Ann N Y Acad Sci. 2015 Sep;1351:61-7. doi: 10.1111/nyas.12857. Epub 2015 Aug 18. Review.

19.

Novel ageing-biomarker discovery using data-intensive technologies.

Griffiths HR, Augustyniak EM, Bennett SJ, Debacq-Chainiaux F, Dunston CR, Kristensen P, Melchjorsen CJ, Navarrete SA, Simm A, Toussaint O.

Mech Ageing Dev. 2015 Nov;151:114-21. doi: 10.1016/j.mad.2015.05.010. Epub 2015 Jun 6. Review.

20.

MARK-AGE population: From the human model to new insights.

Capri M, Moreno-Villanueva M, Cevenini E, Pini E, Scurti M, Borelli V, Palmas MG, Zoli M, Schön C, Siepelmeyer A, Bernhardt J, Fiegl S, Zondag G, de Craen AJ, Hervonen A, Hurme M, Sikora E, Gonos ES, Voutetakis K, Toussaint O, Debacq-Chainiaux F, Grubeck-Loebenstein B, Bürkle A, Franceschi C.

Mech Ageing Dev. 2015 Nov;151:13-7. doi: 10.1016/j.mad.2015.03.010. Epub 2015 Apr 2. Review. No abstract available.

21.

Role of p38MAPK and oxidative stress in copper-induced senescence.

Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O.

Age (Dordr). 2013 Dec;35(6):2255-71. doi: 10.1007/s11357-013-9521-3. Epub 2013 Apr 12.

22.

UV, stress and aging.

Debacq-Chainiaux F, Leduc C, Verbeke A, Toussaint O.

Dermatoendocrinol. 2012 Jul 1;4(3):236-40. doi: 10.4161/derm.23652.

23.

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture.

Vo TK, de Saint-Hubert M, Morrhaye G, Godard P, Geenen V, Martens HJ, Debacq-Chainiaux F, Swine C, Toussaint O.

Mech Ageing Dev. 2011 Mar;132(3):131-9. doi: 10.1016/j.mad.2011.02.002. Epub 2011 Feb 16.

PMID:
21335025
24.

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Debacq-Chainiaux F, Swine C, Geenen V, Martens HJ, Toussaint O.

Exp Gerontol. 2011 Apr;46(4):257-64. doi: 10.1016/j.exger.2010.10.012. Epub 2010 Nov 11.

PMID:
21074600
25.

p38(MAPK) in the senescence of human and murine fibroblasts.

Debacq-Chainiaux F, Boilan E, Dedessus Le Moutier J, Weemaels G, Toussaint O.

Adv Exp Med Biol. 2010;694:126-37. Review.

PMID:
20886761
26.

Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology.

Toussaint O, Weemaels G, Debacq-Chainiaux F, Scharffetter-Kochanek K, Wlaschek M.

J Cell Physiol. 2011 Feb;226(2):315-21. doi: 10.1002/jcp.22416. Review.

PMID:
20857403
27.

Serum N-glycan profile shift during human ageing.

Vanhooren V, Dewaele S, Libert C, Engelborghs S, De Deyn PP, Toussaint O, Debacq-Chainiaux F, Poulain M, Glupczynski Y, Franceschi C, Jaspers K, van der Pluijm I, Hoeijmakers J, Chen CC.

Exp Gerontol. 2010 Oct;45(10):738-43. doi: 10.1016/j.exger.2010.08.009. Epub 2010 Aug 27.

PMID:
20801208
28.

Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases.

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Swine C, Geenen V, Martens HJ, Debacq-Chainiaux F, Toussaint O.

Immun Ageing. 2010 Aug 17;7:9. doi: 10.1186/1742-4933-7-9.

29.

Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor.

Bertrand-Vallery V, Belot N, Dieu M, Delaive E, Ninane N, Demazy C, Raes M, Salmon M, Poumay Y, Debacq-Chainiaux F, Toussaint O.

PLoS One. 2010 May 3;5(5):e10462. doi: 10.1371/journal.pone.0010462.

30.

Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O.

Nat Protoc. 2009;4(12):1798-806. doi: 10.1038/nprot.2009.191.

PMID:
20010931
31.

Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA.

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Bauwens E, Debacq-Chainiaux F, Glupczynski Y, Swine C, Geenen V, Martens HJ, Toussaint O.

Exp Gerontol. 2010 Mar;45(3):188-94. doi: 10.1016/j.exger.2009.12.001. Epub 2009 Dec 6.

32.

Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16(INK-4A).

Bertrand-Vallery V, Boilan E, Ninane N, Demazy C, Friguet B, Toussaint O, Poumay Y, Debacq-Chainiaux F.

Biogerontology. 2010 Apr;11(2):167-81. doi: 10.1007/s10522-009-9238-y. Epub 2009 Jun 24.

PMID:
19554468
33.

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts.

Scheckhuber CQ, Grief J, Boilan E, Luce K, Debacq-Chainiaux F, Rittmeyer C, Gredilla R, Kolbesen BO, Toussaint O, Osiewacz HD.

PLoS One. 2009;4(3):e4919. doi: 10.1371/journal.pone.0004919. Epub 2009 Mar 23.

34.

p53 and ATF-2 partly mediate the overexpression of COX-2 in H(2)O (2)-induced premature senescence of human fibroblasts.

Zdanov S, Toussaint O, Debacq-Chainiaux F.

Biogerontology. 2009 Jun;10(3):291-8. doi: 10.1007/s10522-008-9204-0. Epub 2008 Dec 11.

PMID:
19082758
35.

Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts.

Debacq-Chainiaux F, Pascal T, Boilan E, Bastin C, Bauwens E, Toussaint O.

Free Radic Biol Med. 2008 May 15;44(10):1817-32. doi: 10.1016/j.freeradbiomed.2008.02.001. Epub 2008 Feb 20.

PMID:
18329388
36.

Expression profiling of senescent-associated genes in human dermis from young and old donors. Proof-of-concept study.

Borlon C, Weemaels G, Godard P, Debacq-Chainiaux F, Lemaire P, Deroanne C, Toussaint O.

Biogerontology. 2008 Jun;9(3):197-208. doi: 10.1007/s10522-008-9127-9. Epub 2008 Feb 13.

37.

Prematurely senescent ARPE-19 cells display features of age-related macular degeneration.

Glotin AL, Debacq-Chainiaux F, Brossas JY, Faussat AM, Tréton J, Zubielewicz A, Toussaint O, Mascarelli F.

Free Radic Biol Med. 2008 Apr 1;44(7):1348-61. doi: 10.1016/j.freeradbiomed.2007.12.023. Epub 2008 Jan 28.

PMID:
18226607
38.

Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology.

Borlon C, Vankoningsloo S, Godard P, Debacq-Chainiaux F, Toussaint O.

Mech Ageing Dev. 2008 Mar;129(3):109-19. Epub 2007 Nov 9.

PMID:
18068755
39.

Transient increased extracellular release of H2O2 during establishment of UVB-induced premature senescence.

Borlon C, Chretien A, Debacq-Chainiaux F, Toussaint O.

Ann N Y Acad Sci. 2007 Nov;1119:72-7.

PMID:
18056956
40.

Replicative aging down-regulates the myogenic regulatory factors in human myoblasts.

Bigot A, Jacquemin V, Debacq-Chainiaux F, Butler-Browne GS, Toussaint O, Furling D, Mouly V.

Biol Cell. 2008 Mar;100(3):189-99.

PMID:
17988214
41.

The gene expression profile of psoralen plus UVA-induced premature senescence in skin fibroblasts resembles a combined DNA-damage and stress-induced cellular senescence response phenotype.

Borlon C, Debacq-Chainiaux F, Hinrichs C, Scharffetter-Kochanek K, Toussaint O, Wlaschek M.

Exp Gerontol. 2007 Sep;42(9):911-23. Epub 2007 Apr 29.

PMID:
17574363
42.

Normal or stress-induced fibroblast senescence involves COX-2 activity.

Zdanov S, Bernard D, Debacq-Chainiaux F, Martien S, Gosselin K, Vercamer C, Chelli F, Toussaint O, Abbadie C.

Exp Cell Res. 2007 Aug 15;313(14):3046-56. Epub 2007 May 22.

PMID:
17560572
44.

Identification of potential anti-photoageing algal compounds using an in-vitro model of photoageing.

Debacq-Chainiaux F, Borlon C, De Hertogh B, Remacle J, Morvan PY, Vallée R, Toussaint O.

J Pharm Pharmacol. 2006 Dec;58(12):1577-83.

PMID:
17331320
45.

Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol.

Pascal T, Debacq-Chainiaux F, Boilan E, Ninane N, Raes M, Toussaint O.

Biogerontology. 2007 Aug;8(4):409-22. Epub 2007 Feb 13.

PMID:
17295091
46.

Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts.

Zdanov S, Debacq-Chainiaux F, Remacle J, Toussaint O.

FEBS Lett. 2006 Nov 27;580(27):6455-63. Epub 2006 Nov 7.

47.

Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays.

Pascal T, Debacq-Chainiaux F, Chrétien A, Bastin C, Dabée AF, Bertholet V, Remacle J, Toussaint O.

FEBS Lett. 2005 Jul 4;579(17):3651-9.

48.

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.

Debacq-Chainiaux F, Borlon C, Pascal T, Royer V, Eliaers F, Ninane N, Carrard G, Friguet B, de Longueville F, Boffe S, Remacle J, Toussaint O.

J Cell Sci. 2005 Feb 15;118(Pt 4):743-58. Epub 2005 Jan 25.

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