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Items: 48

1.

Inbred Mouse Populations Exhibit Intergenerational Changes in Intestinal Microbiota Composition and Function Following Introduction to a Facility.

Choo JM, Trim PJ, Leong LEX, Abell GCJ, Brune C, Jeffries N, Wesselingh S, Dear TN, Snel MF, Rogers GB.

Front Microbiol. 2017 Apr 11;8:608. doi: 10.3389/fmicb.2017.00608. eCollection 2017.

2.

A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development.

Diggle CP, Martinez-Garay I, Molnar Z, Brinkworth MH, White E, Fowler E, Hughes R, Hayward BE, Carr IM, Watson CM, Crinnion L, Asipu A, Woodman B, Coletta PL, Markham AF, Dear TN, Bonthron DT, Peckham M, Morrison EE, Sheridan E.

PLoS One. 2017 Apr 7;12(4):e0174264. doi: 10.1371/journal.pone.0174264. eCollection 2017.

3.

Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure.

Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H.

J Biol Chem. 2016 Dec 2;291(49):25762. No abstract available.

4.

Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism.

Pilorge M, Fassier C, Le Corronc H, Potey A, Bai J, De Gois S, Delaby E, Assouline B, Guinchat V, Devillard F, Delorme R, Nygren G, Råstam M, Meier JC, Otani S, Cheval H, James VM, Topf M, Dear TN, Gillberg C, Leboyer M, Giros B, Gautron S, Hazan J, Harvey RJ, Legendre P, Betancur C.

Mol Psychiatry. 2016 Jul;21(7):936-45. doi: 10.1038/mp.2015.139. Epub 2015 Sep 15.

5.

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.

Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H.

J Biol Chem. 2015 Oct 23;290(43):25907-19. doi: 10.1074/jbc.M115.665695. Epub 2015 Sep 14. Erratum in: J Biol Chem. 2016 Dec 2;291(49):25762.

6.

Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo.

Haider MT, Hunter KD, Robinson SP, Graham TJ, Corey E, Dear TN, Hughes R, Brown NJ, Holen I.

Bone. 2015 Dec;81:581-592. doi: 10.1016/j.bone.2015.08.003. Epub 2015 Aug 14.

7.

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.

Abraham S, Scarcia M, Bagshaw RD, McMahon K, Grant G, Harvey T, Yeo M, Esteves FOG, Thygesen HH, Jones PF, Speirs V, Hanby AM, Selby PJ, Lorger M, Dear TN, Pawson T, Marshall CJ, Mavria G.

Nat Commun. 2015 Jul 1;6:7286. doi: 10.1038/ncomms8286.

8.

Piezo1 integration of vascular architecture with physiological force.

Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ.

Nature. 2014 Nov 13;515(7526):279-282. doi: 10.1038/nature13701. Epub 2014 Aug 10.

9.

Modifying the osteoblastic niche with zoledronic acid in vivo-potential implications for breast cancer bone metastasis.

Haider MT, Holen I, Dear TN, Hunter K, Brown HK.

Bone. 2014 Sep;66:240-50. doi: 10.1016/j.bone.2014.06.023. Epub 2014 Jun 24.

10.

Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models.

Wang N, Docherty FE, Brown HK, Reeves KJ, Fowles AC, Ottewell PD, Dear TN, Holen I, Croucher PI, Eaton CL.

J Bone Miner Res. 2014 Dec;29(12):2688-96. doi: 10.1002/jbmr.2300.

11.

Sequential gene targeting to make chimeric tumor models with de novo chromosomal abnormalities.

Chambers JS, Tanaka T, Brend T, Ali H, Geisler NJ, Khazin L, Cigudosa JC, Dear TN, MacLennan K, Rabbitts TH.

Cancer Res. 2014 Mar 1;74(5):1588-97. doi: 10.1158/0008-5472.CAN-13-1783. Epub 2014 Jan 13.

12.

Glycine receptor α2 subunit activation promotes cortical interneuron migration.

Avila A, Vidal PM, Dear TN, Harvey RJ, Rigo JM, Nguyen L.

Cell Rep. 2013 Aug 29;4(4):738-50. doi: 10.1016/j.celrep.2013.07.016. Epub 2013 Aug 15.

13.

Generation of a novel mouse model for the inducible depletion of macrophages in vivo.

Gheryani N, Coffelt SB, Gartland A, Rumney RM, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN, Miller G.

Genesis. 2013 Jan;51(1):41-9. doi: 10.1002/dvg.22343. Epub 2012 Sep 20.

PMID:
22927121
14.

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse.

Miller G, Moore CJ, Terry R, La Riviere T, Mitchell A, Piggott R, Dear TN, Wells DJ, Winder SJ.

Hum Mol Genet. 2012 Oct 15;21(20):4508-20. Epub 2012 Jul 18.

15.

Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.

Williamson CM, Ball ST, Dawson C, Mehta S, Beechey CV, Fray M, Teboul L, Dear TN, Kelsey G, Peters J.

PLoS Genet. 2011 Mar;7(3):e1001347. doi: 10.1371/journal.pgen.1001347. Epub 2011 Mar 24.

16.

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

Ashrafian H, Docherty L, Leo V, Towlson C, Neilan M, Steeples V, Lygate CA, Hough T, Townsend S, Williams D, Wells S, Norris D, Glyn-Jones S, Land J, Barbaric I, Lalanne Z, Denny P, Szumska D, Bhattacharya S, Griffin JL, Hargreaves I, Fernandez-Fuentes N, Cheeseman M, Watkins H, Dear TN.

PLoS Genet. 2010 Jun 24;6(6):e1001000. doi: 10.1371/journal.pgen.1001000.

17.

ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

Miller G, Neilan M, Chia R, Gheryani N, Holt N, Charbit A, Wells S, Tucci V, Lalanne Z, Denny P, Fisher EM, Cheeseman M, Askew GN, Dear TN.

PLoS One. 2010 Feb 9;5(2):e9137. doi: 10.1371/journal.pone.0009137.

18.

Culture of murine embryonic stem cells.

Barbaric I, Dear TN.

Methods Mol Biol. 2009;561:161-84. doi: 10.1007/978-1-60327-019-9_11.

PMID:
19504071
19.
20.

An ENU-induced mutation in the Ankrd11 gene results in an osteopenia-like phenotype in the mouse mutant Yoda.

Barbaric I, Perry MJ, Dear TN, Rodrigues Da Costa A, Salopek D, Marusic A, Hough T, Wells S, Hunter AJ, Cheeseman M, Brown SD.

Physiol Genomics. 2008 Feb 19;32(3):311-21. Epub 2007 Nov 6.

PMID:
17986521
21.

Appearances can be deceiving: phenotypes of knockout mice.

Barbaric I, Miller G, Dear TN.

Brief Funct Genomic Proteomic. 2007 Jun;6(2):91-103. Epub 2007 Jun 20. Review.

PMID:
17584761
22.

A new coat color mouse line for testing germline transmission of embryonic stem cells while retaining an inbred genetic background.

Barbaric I, Stewart M, Wells S, Dear TN.

J Am Assoc Lab Anim Sci. 2007 May;46(3):37-40.

PMID:
17487951
23.

Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.

Barbaric I, Wells S, Russ A, Dear TN.

Environ Mol Mutagen. 2007 Mar;48(2):124-42.

PMID:
17295309
24.

Development and function of the mammalian spleen.

Brendolan A, Rosado MM, Carsetti R, Selleri L, Dear TN.

Bioessays. 2007 Feb;29(2):166-77. Review.

PMID:
17226804
25.
26.

Capn5 is expressed in a subset of T cells and is dispensable for development.

Franz T, Winckler L, Boehm T, Dear TN.

Mol Cell Biol. 2004 Feb;24(4):1649-54.

27.

Identification and characterization of two novel calpain large subunit genes.

Dear TN, Boehm T.

Gene. 2001 Aug 22;274(1-2):245-52.

PMID:
11675017
29.
30.
31.

Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen.

Koehler K, Franz T, Dear TN.

Dev Dyn. 2000 May;218(1):201-6.

32.
33.
34.

CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6.

Dear TN, Möller A, Boehm T.

Genomics. 1999 Jul 15;59(2):243-7.

PMID:
10409436
35.

A novel serine protease overexpressed in the hair follicles of nude mice.

Meier N, Dear TN, Boehm T.

Biochem Biophys Res Commun. 1999 May 10;258(2):374-8.

PMID:
10329394
36.

Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain.

Franz T, Vingron M, Boehm T, Dear TN.

Mamm Genome. 1999 Mar;10(3):318-21. No abstract available.

PMID:
10051333
37.

Identification of interaction partners for the basic-helix-loop-helix protein E47.

Dear TN, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, Boehm T.

Oncogene. 1997 Feb 27;14(8):891-8.

38.

Characterization of mouse and human nude genes.

Schorpp M, Hofmann M, Dear TN, Boehm T.

Immunogenetics. 1997;46(6):509-15.

PMID:
9321431
39.

The Hox11 gene is essential for cell survival during spleen development.

Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH.

Development. 1995 Sep;121(9):2909-15.

40.
41.

The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.

Dear TN, Sanchez-Garcia I, Rabbitts TH.

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4431-5.

42.

Molecular cloning of putative odorant-binding and odorant-metabolizing proteins.

Dear TN, Campbell K, Rabbitts TH.

Biochemistry. 1991 Oct 29;30(43):10376-82.

PMID:
1931961
43.

Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa.

Dear TN, Boehm T, Keverne EB, Rabbitts TH.

EMBO J. 1991 Oct;10(10):2813-9.

44.

The WDNM1 gene product is a novel member of the 'four-disulphide core' family of proteins.

Dear TN, Kefford RF.

Biochem Biophys Res Commun. 1991 Apr 15;176(1):247-54.

PMID:
2018519
46.

Molecular oncogenetics of metastasis.

Dear TN, Kefford RF.

Mol Aspects Med. 1990;11(4):243-324. Review.

PMID:
2137550
47.

Transcriptional down-regulation of a rat gene, WDNM2, in metastatic DMBA-8 cells.

Dear TN, McDonald DA, Kefford RF.

Cancer Res. 1989 Oct 1;49(19):5323-8.

48.

Differential expression of a novel gene, WDNM1, in nonmetastatic rat mammary adenocarcinoma cells.

Dear TN, Ramshaw IA, Kefford RF.

Cancer Res. 1988 Sep 15;48(18):5203-9.

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