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Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose.

Pettie JM, Caparrotta TM, Hunter RW, Morrison EE, Wood DM, Dargan PI, Thanacoody RH, Thomas SHL, Elamin MEMO, Francis B, Webb DJ, Sandilands EA, Eddleston M, Dear JW.

EClinicalMedicine. 2019 May 2;11:11-17. doi: 10.1016/j.eclinm.2019.04.005. eCollection 2019 May-Jun.


Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).

Morrison EE, Oatey K, Gallagher B, Grahamslaw J, O'Brien R, Black P, Oosthuyzen W, Lee RJ, Weir CJ, Henriksen D, Dear JW; POP Trial Investigators.

EBioMedicine. 2019 Jul 13. pii: S2352-3964(19)30448-7. doi: 10.1016/j.ebiom.2019.07.013. [Epub ahead of print]


Endothelin Receptor Antagonism Improves Lipid Profiles and Lowers PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) in Patients With Chronic Kidney Disease.

Farrah TE, Anand A, Gallacher PJ, Kimmitt R, Carter E, Dear JW, Mills NL, Webb DJ, Dhaun N.

Hypertension. 2019 Aug;74(2):323-330. doi: 10.1161/HYPERTENSIONAHA.119.12919. Epub 2019 Jun 10.


Comment on "What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?" by Hendrickson et al.

Bateman DN, Dear JW.

Clin Toxicol (Phila). 2019 May 9:1. doi: 10.1080/15563650.2019.1594873. [Epub ahead of print] No abstract available.


Urinary Extracellular Vesicle Protein Profiling and Endogenous Lithium Clearance Support Excessive Renal Sodium Wasting and Water Reabsorption in Thiazide-Induced Hyponatremia.

Channavajjhala SK, Bramley R, Peltz T, Oosthuyzen W, Jia W, Kinnear S, Sampson B, Martin N, Hall IP, Bailey MA, Dear JW, Glover M.

Kidney Int Rep. 2018 Sep 22;4(1):139-147. doi: 10.1016/j.ekir.2018.09.011. eCollection 2019 Jan.


Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.

Wong A, Homer N, Dear JW, Choy KW, Doery J, Graudins A.

Clin Toxicol (Phila). 2019 May;57(5):312-317. doi: 10.1080/15563650.2018.1517881. Epub 2018 Nov 19.


Sensitivity and specificity of microRNA-122 for liver disease in dogs.

Oosthuyzen W, Ten Berg PWL, Francis B, Campbell S, Macklin V, Milne E, Gow AG, Fisher C, Mellanby RJ, Dear JW.

J Vet Intern Med. 2018 Sep;32(5):1637-1644. doi: 10.1111/jvim.15250. Epub 2018 Aug 2.


Attending a social event and consuming alcohol is associated with changes in serum microRNA: a before and after study in healthy adults.

Ten Berg PW, Shaffer J, Vliegenthart ADB, McCrae J, Sharkey N, Webb DJ, Dear JW.

Biomarkers. 2018 Dec;23(8):781-786. doi: 10.1080/1354750X.2018.1499128. Epub 2018 Aug 23.


Long-term adverse effects of paracetamol - a review.

McCrae JC, Morrison EE, MacIntyre IM, Dear JW, Webb DJ.

Br J Clin Pharmacol. 2018 Oct;84(10):2218-2230. doi: 10.1111/bcp.13656. Epub 2018 Jul 20. Review.


Evaluation of plasma microRNA-122, high-mobility group box 1 and keratin-18 concentrations to stratify acute gallstone disease: a pilot observational cohort study in an emergency general surgery unit.

Th'ng F, Vliegenthart B, Lea JD, Antoine DJ, Dear JW, Mole DJ; Edinburgh Emergency Surgery Study Group, Royal Infirmary of Edinburgh, NHS Lothian.

BMJ Open. 2018 Apr 27;8(4):e020061. doi: 10.1136/bmjopen-2017-020061.


Acute carbon monoxide toxicity in a paediatric cohort: analysis of 10 boys poisoned during a scuba diving lesson.

McDermott JH, Reynard C, Perry J, Dear JW, Child F, Jenner R.

Clin Toxicol (Phila). 2018 Sep;56(9):856-859. doi: 10.1080/15563650.2018.1444175. Epub 2018 Mar 8.


New biomarkers for drug-induced liver injury.

Dear JW.

Hepatology. 2018 Jun;67(6):2480-2481. doi: 10.1002/hep.29865. Epub 2018 Apr 27. No abstract available.


Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

Dear JW, Clarke JI, Francis B, Allen L, Wraight J, Shen J, Dargan PI, Wood D, Cooper J, Thomas SHL, Jorgensen AL, Pirmohamed M, Park BK, Antoine DJ.

Lancet Gastroenterol Hepatol. 2018 Feb;3(2):104-113. doi: 10.1016/S2468-1253(17)30266-2. Epub 2017 Nov 14.


Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature.

Caparrotta TM, Antoine DJ, Dear JW.

Eur J Clin Pharmacol. 2018 Feb;74(2):147-160. doi: 10.1007/s00228-017-2356-6. Epub 2017 Oct 24. Review.


Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.

Vliegenthart ADB, Wei C, Buckley C, Berends C, de Potter CMJ, Schneemann S, Del Pozo J, Tucker C, Mullins JJ, Webb DJ, Dear JW.

Toxicol Sci. 2017 Oct 1;159(2):380-391. doi: 10.1093/toxsci/kfx144.


Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.

Rissin DM, López-Longarela B, Pernagallo S, Ilyine H, Vliegenthart ADB, Dear JW, Díaz-Mochón JJ, Duffy DC.

PLoS One. 2017 Jul 5;12(7):e0179669. doi: 10.1371/journal.pone.0179669. eCollection 2017.


First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis.

Hunter RW, Moorhouse R, Farrah TE, MacIntyre IM, Asai T, Gallacher PJ, Kerr D, Melville V, Czopek A, Morrison EE, Ivy JR, Dear JW, Bailey MA, Goddard J, Webb DJ, Dhaun N.

Hypertension. 2017 Jul;70(1):192-200. doi: 10.1161/HYPERTENSIONAHA.116.08832. Epub 2017 May 15.


Resolution of Hypoglycemia and Cardiovascular Dysfunction After Rituximab Treatment of Insulin Autoimmune Syndrome.

Church D, Hunter RW, Lyall M, Clarke C, Vliegenthart ADB, Dear JW, Semple R, Dhaun N, Dover AR.

Diabetes Care. 2017 Jul;40(7):e80-e82. doi: 10.2337/dc17-0264. Epub 2017 May 1. No abstract available.


MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury.

Vliegenthart ADB, Berends C, Potter CMJ, Kersaudy-Kerhoas M, Dear JW.

Br J Clin Pharmacol. 2017 Sep;83(9):2027-2033. doi: 10.1111/bcp.13282. Epub 2017 Apr 5.


Should we treat very large paracetamol overdose differently?

Bateman DN, Dear JW.

Br J Clin Pharmacol. 2017 Jun;83(6):1163-1165. doi: 10.1111/bcp.13279. Epub 2017 Apr 5. No abstract available.


Transformative biomarkers for drug-induced liver injury: are we there yet?

Antoine DJ, Dear JW.

Biomark Med. 2017 Feb;11(2):103-106. doi: 10.2217/bmm-2016-0338. Epub 2017 Jan 18. No abstract available.


Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction.

Balmforth C, van Bragt JJ, Ruijs T, Cameron JR, Kimmitt R, Moorhouse R, Czopek A, Hu MK, Gallacher PJ, Dear JW, Borooah S, MacIntyre IM, Pearson TM, Willox L, Talwar D, Tafflet M, Roubeix C, Sennlaub F, Chandran S, Dhillon B, Webb DJ, Dhaun N.

JCI Insight. 2016 Dec 8;1(20):e89173. doi: 10.1172/jci.insight.89173.


Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells.

Oosthuyzen W, Scullion KM, Ivy JR, Morrison EE, Hunter RW, Starkey Lewis PJ, O'Duibhir E, Street JM, Caporali A, Gregory CD, Forbes SJ, Webb DJ, Bailey MA, Dear JW.

J Am Soc Nephrol. 2016 Nov;27(11):3345-3355. Epub 2016 Mar 28.


Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.

Vliegenthart A, Kimmitt RA, Seymour JH, Homer NZ, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW.

Clin Pharmacol Ther. 2017 Apr;101(4):531-540. doi: 10.1002/cpt.541. Epub 2016 Nov 30.


The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122.

Rivoli L, Vliegenthart AD, de Potter CM, van Bragt JJ, Tzoumas N, Gallacher P, Farrah TE, Dhaun N, Dear JW.

Br J Clin Pharmacol. 2017 Mar;83(3):584-592. doi: 10.1111/bcp.13136. Epub 2016 Oct 21.


Guidance on acetylcysteine for paracetamol ingestion needs review.

Thomas SH, Bateman DN, Dear JW.

BMJ. 2016 Jun 28;353:i3455. doi: 10.1136/bmj.i3455. No abstract available.


Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine.

Cairney DG, Beckwith HK, Al-Hourani K, Eddleston M, Bateman DN, Dear JW.

Clin Toxicol (Phila). 2016 Jun;54(5):405-10. doi: 10.3109/15563650.2016.1159309.


Renal extracellular vesicles: from physiology to clinical application.

Morrison EE, Bailey MA, Dear JW.

J Physiol. 2016 Oct 15;594(20):5735-5748. doi: 10.1113/JP272182. Epub 2016 May 27. Review.


Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter.

Ivy JR, Oosthuyzen W, Peltz TS, Howarth AR, Hunter RW, Dhaun N, Al-Dujaili EA, Webb DJ, Dear JW, Flatman PW, Bailey MA.

Hypertension. 2016 May;67(5):1029-37. doi: 10.1161/HYPERTENSIONAHA.115.06977. Epub 2016 Mar 7. Erratum in: Hypertension. 2016 Jul;68(1):e5.


Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?

Clarke JI, Dear JW, Antoine DJ.

Expert Opin Drug Saf. 2016 May;15(5):625-34. doi: 10.1517/14740338.2016.1160057. Epub 2016 Mar 17. Review.


How to treat paracetamol overdose and when to do it.

Antoine DJ, Dear JW.

Expert Rev Clin Pharmacol. 2016;9(5):633-5. doi: 10.1586/17512433.2016.1154786. Epub 2016 Mar 2. No abstract available.


New regimens for intravenous acetylcysteine, where are we now?

Bateman DN, Dear JW, Thomas SH.

Clin Toxicol (Phila). 2016;54(2):75-8. doi: 10.3109/15563650.2015.1121545. Epub 2015 Dec 14.


Ethanol consumption produces a small increase in circulating miR-122 in healthy individuals.

McCrae JC, Sharkey N, Webb DJ, Vliegenthart AD, Dear JW.

Clin Toxicol (Phila). 2016;54(1):53-5. doi: 10.3109/15563650.2015.1112015. Epub 2015 Nov 17.


Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.

Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, Thompson AI, Henderson NC, Webb DJ, Sharkey J, Antoine DJ, Park BK, Bailey MA, Lader E, Simpson KJ, Dear JW.

Sci Rep. 2015 Oct 22;5:15501. doi: 10.1038/srep15501.


Paracetamol (acetaminophen) poisoning.

Park BK, Dear JW, Antoine DJ.

BMJ Clin Evid. 2015 Oct 19;2015. pii: 2101. Review.


CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.

Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ.

Gastroenterology. 2015 Dec;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053. Epub 2015 Sep 5.


Where are we now with paracetamol?

Dear JW, Antoine DJ, Park BK.

BMJ. 2015 Jul 10;351:h3705. doi: 10.1136/bmj.h3705. No abstract available.


Target biomarker profile for the clinical management of paracetamol overdose.

Vliegenthart AD, Antoine DJ, Dear JW.

Br J Clin Pharmacol. 2015 Sep;80(3):351-62. doi: 10.1111/bcp.12699. Epub 2015 Jul 29. Review.


Exosome isolation: a microfluidic road-map.

Liga A, Vliegenthart AD, Oosthuyzen W, Dear JW, Kersaudy-Kerhoas M.

Lab Chip. 2015 Jun 7;15(11):2388-94. doi: 10.1039/c5lc00240k. Review.


Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury.

Antoine DJ, Sabbisetti VS, Francis B, Jorgensen AL, Craig DG, Simpson KJ, Bonventre JV, Park BK, Dear JW.

Hepatology. 2015 Aug;62(2):591-9. doi: 10.1002/hep.27857. Epub 2015 May 29.


Limitations of AST/ALT ratio in paracetamol poisoning.

Bateman DN, Dear JW.

Clin Toxicol (Phila). 2015 Jul;53(6):580. doi: 10.3109/15563650.2015.1027904. Epub 2015 Mar 26. No abstract available.


A qualitative study of the relationship between the Scottish Medicines Consortium and their clinical experts.

Newham R, Corcoran ED, Dear JW, Hems S, McTaggart S, Bennie M.

J Eval Clin Pract. 2016 Jun;22(3):311-8. doi: 10.1111/jep.12325. Epub 2015 Mar 23.


Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: the recent United Kingdom experience.

Bateman DN, Dear JW, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Gray A, Dargan PI, Wood DM, Eddleston M, Thomas SH.

Clin Toxicol (Phila). 2014 Sep-Oct;52(8):868-72. doi: 10.3109/15563650.2014.954125.


Understanding the pathophysiological regulatory role of microRNAs in acute liver failure.

Antoine DJ, Dear JW, Goldring CE, Park BK.

Hepatology. 2015 Apr;61(4):1439-40. doi: 10.1002/hep.27349. Epub 2015 Mar 9. No abstract available.


Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes.

Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, Ito K, Sharma S, Ramadesikan S, Lee M, Briskin R, De Jager PL, Ngo TT, Radlinski M, Dear JW, Park KB, Betensky R, Krolewski AS, Bonventre JV.

J Am Soc Nephrol. 2014 Oct;25(10):2177-86. doi: 10.1681/ASN.2013070758. Epub 2014 Jun 5.


Zebrafish as model organisms for studying drug-induced liver injury.

Vliegenthart AD, Tucker CS, Del Pozo J, Dear JW.

Br J Clin Pharmacol. 2014 Dec;78(6):1217-27. doi: 10.1111/bcp.12408. Review.


Treatment of paracetamol overdose--authors' reply.

Bateman DN, Dear JW, Thanacoody HK, Thomas SH, Eddleston M.

Lancet. 2014 Apr 19;383(9926):1383. doi: 10.1016/S0140-6736(14)60680-2. No abstract available.


Urinary exosomes join the fight against infection.

Dear JW.

J Am Soc Nephrol. 2014 Sep;25(9):1889-91. doi: 10.1681/ASN.2014020204. Epub 2014 Apr 3. No abstract available.


Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment.

Bateman DN, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Cranfield KR, Hook C, Sandilands EA, Veiraiah A, Webb D, Gray A, Dargan PI, Wood DM, Thomas SH, Dear JW, Eddleston M.

Br J Clin Pharmacol. 2014 Sep;78(3):610-8. doi: 10.1111/bcp.12362.

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