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Operative vaginal delivery and pelvic floor complications.

Deane RP.

Best Pract Res Clin Obstet Gynaecol. 2019 Apr;56:81-92. doi: 10.1016/j.bpobgyn.2019.01.013. Epub 2019 Feb 10. Review.


Port insertion for minimally invasive surgery: a report of practices in the Irish Republic.

Harrington CM, Kavanagh DO, Tierney S, Deane R, Hehir D.

Ir J Med Sci. 2018 Nov;187(4):1021-1027. doi: 10.1007/s11845-017-1732-7. Epub 2018 Feb 6.


Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.

Mol Neurodegener. 2017 Jan 12;12(1):3. doi: 10.1186/s13024-016-0147-7. No abstract available.


Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.

Mol Neurodegener. 2016 Dec 8;11(1):74. Erratum in: Mol Neurodegener. 2017 Jan 12;12 (1):3.


Proposed learning strategies of medical students in a clinical rotation in obstetrics and gynecology: a descriptive study.

Deane RP, Murphy DJ.

Adv Med Educ Pract. 2016 Aug 10;7:489-96. doi: 10.2147/AMEP.S108008. eCollection 2016.


Glymphatic clearance controls state-dependent changes in brain lactate concentration.

Lundgaard I, Lu ML, Yang E, Peng W, Mestre H, Hitomi E, Deane R, Nedergaard M.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2112-2124. doi: 10.1177/0271678X16661202. Epub 2016 Jan 1.


Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.

Peng W, Achariyar TM, Li B, Liao Y, Mestre H, Hitomi E, Regan S, Kasper T, Peng S, Ding F, Benveniste H, Nedergaard M, Deane R.

Neurobiol Dis. 2016 Sep;93:215-25. doi: 10.1016/j.nbd.2016.05.015. Epub 2016 May 24.


Student and staff experiences of attendance monitoring in undergraduate obstetrics and gynecology: a cross-sectional survey.

Deane RP, Murphy DJ.

Adv Med Educ Pract. 2016 Apr 4;7:233-40. doi: 10.2147/AMEP.S99447. eCollection 2016.


The Effect of Body Posture on Brain Glymphatic Transport.

Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, Benveniste H.

J Neurosci. 2015 Aug 5;35(31):11034-44. doi: 10.1523/JNEUROSCI.1625-15.2015.


Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell JD, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M.

Nat Commun. 2015 Apr 23;6:6807. doi: 10.1038/ncomms7807.


The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, Chen M, Hyrien O, Iliff JJ, Deane R, Huang JH, Nedergaard M.

Surg Neurol Int. 2014 Dec 23;5:184. doi: 10.4103/2152-7806.147566. eCollection 2014.


Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M.

J Neurosci. 2015 Jan 14;35(2):518-26. doi: 10.1523/JNEUROSCI.3742-14.2015.


Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.

Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M.

J Neurosci. 2014 Dec 3;34(49):16180-93. doi: 10.1523/JNEUROSCI.3020-14.2014.


Impairment of paravascular clearance pathways in the aging brain.

Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, Xie L, Kang H, Xu Q, Liew JA, Plog BA, Ding F, Deane R, Nedergaard M.

Ann Neurol. 2014 Dec;76(6):845-61. doi: 10.1002/ana.24271. Epub 2014 Sep 26.


A close-pair binary in a distant triple supermassive black hole system.

Deane RP, Paragi Z, Jarvis MJ, Coriat M, Bernardi G, Fender RP, Frey S, Heywood I, Klöckner HR, Grainge K, Rumsey C.

Nature. 2014 Jul 3;511(7507):57-60. doi: 10.1038/nature13454. Epub 2014 Jun 25.


The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH.

J Neurotrauma. 2014 Jul 1;31(13):1211-24. doi: 10.1089/neu.2013.3255. Epub 2014 Jun 12.


Student attendance and academic performance in undergraduate obstetrics/gynecology clinical rotations.

Deane RP, Murphy DJ.

JAMA. 2013 Dec 4;310(21):2282-8. doi: 10.1001/jama.2013.282228.


Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.

Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M.

J Neurosci. 2013 Nov 13;33(46):18190-9. doi: 10.1523/JNEUROSCI.1592-13.2013.


Sleep drives metabolite clearance from the adult brain.

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M.

Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224.


Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.

Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M.

Sci Rep. 2013;3:2582. doi: 10.1038/srep02582.


Population-based study of smoking behaviour throughout pregnancy and adverse perinatal outcomes.

Murphy DJ, Dunney C, Mullally A, Adnan N, Deane R.

Int J Environ Res Public Health. 2013 Aug 27;10(9):3855-67. doi: 10.3390/ijerph10093855.


Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.

Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, Kasper RT, Deane R.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14771-6. doi: 10.1073/pnas.1302212110. Epub 2013 Aug 19.


Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer.

Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M.

J Transl Med. 2013 May 1;11:107. doi: 10.1186/1479-5876-11-107.


The developmental and social history of repetitively aggressive mental health patients.

Grenyer BF, Lewis KL, Ilkiw-Lavalle O, Deane R, Milicevic D, Pai N.

Aust N Z J Psychiatry. 2013 May;47(5):463-9. doi: 10.1177/0004867412474106. Epub 2013 Jan 22.


Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15502-7. Epub 2012 Aug 27.


The future of neurodegenerative diseases: emerging targets, treatments and technologies.

Voss J, Ebert A, Wolfe M, Lindsley C, Cookson M, Deane R.

Future Med Chem. 2012 Sep;4(13):1661-9. doi: 10.4155/fmc.12.118. No abstract available.


A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M.

Sci Transl Med. 2012 Aug 15;4(147):147ra111. doi: 10.1126/scitranslmed.3003748.


Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities.

Sagare AP, Deane R, Zlokovic BV.

Pharmacol Ther. 2012 Oct;136(1):94-105. doi: 10.1016/j.pharmthera.2012.07.008. Epub 2012 Jul 20. Review.


Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV.

Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087.


Is RAGE still a therapeutic target for Alzheimer's disease?

Deane RJ.

Future Med Chem. 2012 May;4(7):915-25. doi: 10.4155/fmc.12.51. Review.


A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.

Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV.

J Clin Invest. 2012 Apr;122(4):1377-92. doi: 10.1172/JCI58642. Epub 2012 Mar 12.


From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels.

Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV.

J Neurosci Res. 2011 Jul;89(7):967-8. doi: 10.1002/jnr.22670. Epub 2011 Apr 19. No abstract available.


Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.

Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV.

J Alzheimers Dis. 2011;24(1):25-34. doi: 10.3233/JAD-2010-101248.


Methamphetamine causes sustained depression in cerebral blood flow.

Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S.

Brain Res. 2011 Feb 10;1373:91-100. doi: 10.1016/j.brainres.2010.12.017. Epub 2010 Dec 13.


Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.

Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV.

Neuron. 2010 Nov 4;68(3):409-27. doi: 10.1016/j.neuron.2010.09.043.


Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain.

Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA.

J Neurochem. 2010 Dec;115(5):1077-89. doi: 10.1111/j.1471-4159.2010.07002.x. Epub 2010 Oct 5. Review.


Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV.

Blood. 2010 Jun 10;115(23):4963-72. doi: 10.1182/blood-2010-01-262386. Epub 2010 Mar 26.


Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.

Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC.

Brain Res. 2010 Mar 4;1317:218-26. doi: 10.1016/j.brainres.2009.11.084. Epub 2010 Jan 4.


Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV.

J Clin Invest. 2009 Nov;119(11):3437-49. doi: 10.1172/JCI38476. Epub 2009 Oct 19.


Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.

Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV.

Eur J Neurosci. 2009 Mar;29(6):1119-30. doi: 10.1111/j.1460-9568.2009.06664.x.


Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.

Deane R, Bell RD, Sagare A, Zlokovic BV.

CNS Neurol Disord Drug Targets. 2009 Mar;8(1):16-30. Review.


Severe maternal morbidity for 2004-2005 in the three Dublin maternity hospitals.

Murphy CM, Murad K, Deane R, Byrne B, Geary MP, McAuliffe FM.

Eur J Obstet Gynecol Reprod Biol. 2009 Mar;143(1):34-7. doi: 10.1016/j.ejogrb.2008.11.008. Epub 2009 Jan 12.


SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.

Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV.

Nat Cell Biol. 2009 Feb;11(2):143-53. doi: 10.1038/ncb1819. Epub 2008 Dec 21.


apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV.

J Clin Invest. 2008 Dec;118(12):4002-13. doi: 10.1172/JCI36663. Epub 2008 Nov 13.


Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.

Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV.

J Cereb Blood Flow Metab. 2009 Jan;29(1):25-33. doi: 10.1038/jcbfm.2008.117. Epub 2008 Oct 8.


ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV.

Nat Neurosci. 2008 Apr;11(4):420-2. doi: 10.1038/nn2073. Epub 2008 Mar 16.


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