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Items: 19

1.

Unexpected Potency Differences between B-Cell-Activating Factor (BAFF) Antagonist Antibodies against Various Forms of BAFF: Trimer, 60-Mer, and Membrane-Bound.

Nicoletti AM, Kenny CH, Khalil AM, Pan Q, Ralph KL, Ritchie J, Venkataramani S, Presky DH, DeWire SM, Brodeur SR.

J Pharmacol Exp Ther. 2016 Oct;359(1):37-44. doi: 10.1124/jpet.116.236075. Epub 2016 Jul 20.

PMID:
27440419
2.

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS.

J Med Chem. 2013 Oct 24;56(20):8019-31. doi: 10.1021/jm4010829. Epub 2013 Oct 14.

PMID:
24063433
3.

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.

DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD.

J Pharmacol Exp Ther. 2013 Mar;344(3):708-17. doi: 10.1124/jpet.112.201616. Epub 2013 Jan 8.

PMID:
23300227
4.

Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.

DeWire SM, Violin JD.

Circ Res. 2011 Jul 8;109(2):205-16. doi: 10.1161/CIRCRESAHA.110.231308. Review.

PMID:
21737816
5.

Quantifying ligand bias at seven-transmembrane receptors.

Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ.

Mol Pharmacol. 2011 Sep;80(3):367-77. doi: 10.1124/mol.111.072801. Epub 2011 May 24.

6.

Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW.

J Pharmacol Exp Ther. 2010 Dec;335(3):572-9. doi: 10.1124/jpet.110.173005. Epub 2010 Aug 26.

PMID:
20801892
7.

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ.

J Clin Invest. 2009 May;119(5):1312-21. doi: 10.1172/JCI36806. Epub 2009 Apr 6.

8.

Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.

Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ.

Circ Res. 2008 Jul 3;103(1):70-9. doi: 10.1161/CIRCRESAHA.108.172338. Epub 2008 Jun 2.

9.

Beta-arrestin-mediated signaling regulates protein synthesis.

DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ.

J Biol Chem. 2008 Apr 18;283(16):10611-20. doi: 10.1074/jbc.M710515200. Epub 2008 Feb 14.

10.

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. Epub 2007 Oct 9.

11.

Beta-arrestins and cell signaling.

DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK.

Annu Rev Physiol. 2007;69:483-510. Review.

PMID:
17305471
12.
13.

Whole-genome transcription profiling of rhesus monkey rhadinovirus.

Dittmer DP, Gonzalez CM, Vahrson W, DeWire SM, Hines-Boykin R, Damania B.

J Virol. 2005 Jul;79(13):8637-50.

15.

Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses.

Damania B, Jeong JH, Bowser BS, DeWire SM, Staudt MR, Dittmer DP.

J Virol. 2004 May;78(10):5491-9.

16.

The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors.

Wang L, Wakisaka N, Tomlinson CC, DeWire SM, Krall S, Pagano JS, Damania B.

Cancer Res. 2004 Apr 15;64(8):2774-81.

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