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Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration.

Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Gibbs ST, Granville CA, Blystone CR.

Xenobiotica. 2019 Nov 7:1-11. doi: 10.1080/00498254.2019.1683776. [Epub ahead of print]


Toxicokinetics of 8:2 fluorotelomer alcohol (8:2-FTOH) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration.

Huang MC, Robinson VG, Waidyanatha S, Dzierlenga AL, DeVito MJ, Eifrid MA, Gibbs ST, Blystone CR.

Toxicol Rep. 2019 Aug 20;6:924-932. doi: 10.1016/j.toxrep.2019.08.009. eCollection 2019.


Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data.

Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV.

Toxicol Sci. 2019 Dec 1;172(2):316-329. doi: 10.1093/toxsci/kfz189.


Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration.

Huang MC, Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Granville CA, Gibbs ST, Blystone CR.

Toxicol Rep. 2019 Jun 28;6:645-655. doi: 10.1016/j.toxrep.2019.06.016. eCollection 2019.


Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS.

Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Gordon O, Pelch KE, Auerbach SS, Paules RS, DeVito MJ, Waalkes MP, Tokar EJ.

PLoS One. 2019 Apr 22;14(4):e0215504. doi: 10.1371/journal.pone.0215504. eCollection 2019.


Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.

Hubbard TD, Hsieh JH, Rider CV, Sipes NS, Sedykh A, Collins BJ, Auerbach SS, Xia M, Huang R, Walker NJ, DeVito MJ.

Appl In Vitro Toxicol. 2019 Mar 1;5(1):10-25. doi: 10.1089/aivt.2018.0020. Epub 2019 Mar 9.


The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling.

Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS.

Toxicol Sci. 2019 Jun 1;169(2):553-566. doi: 10.1093/toxsci/kfz065.


A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing.

Patlewicz G, Richard AM, Williams AJ, Grulke CM, Sams R, Lambert J, Noyes PD, DeVito MJ, Hines RN, Strynar M, Guiseppi-Elie A, Thomas RS.

Environ Health Perspect. 2019 Jan;127(1):14501. doi: 10.1289/EHP4555.


Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats.

Dunnick JK, Pandiri AR, Merrick BA, Kissling GE, Cunny H, Mutlu E, Waidyanatha S, Sills RC, Hong HL, Ton TV, Maynor T, Rescio L, Phillips SL, Devito MJ, Brix A.

Data Brief. 2018 Oct 28;21:2125-2128. doi: 10.1016/j.dib.2018.10.104. eCollection 2018 Dec.


Evaluation and Optimization of Pharmacokinetic Models for in Vitro to in Vivo Extrapolation of Estrogenic Activity for Environmental Chemicals.

Casey WM, Chang X, Allen DG, Ceger PC, Choksi NY, Hsieh JH, Wetmore BA, Ferguson SS, DeVito MJ, Sprankle CS, Kleinstreuer NC.

Environ Health Perspect. 2018 Sep;126(9):97001. doi: 10.1289/EHP1655.


NTP Research Report on Baseline Characteristics of Diversity Outbred (J:DO) Mice Relevant to Toxicology Studies: Research Report 6 [Internet].

Harrill AH, Borghoff S, Zorrilla L, Blystone C, Kissling GE, Malarkey D, Shockley K, Travlos G, DeVito MJ.

Durham (NC): National Toxicology Program; 2018 Jun.


Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice.

Dunnick JK, Pandiri AR, Merrick BA, Kissling GE, Cunny H, Mutlu E, Waidyanatha S, Sills R, Hong HL, Ton TV, Maynor T, Recio L, Phillips SL, Devito MJ, Brix A.

Toxicol Rep. 2018 May 25;5:615-624. doi: 10.1016/j.toxrep.2018.05.010. eCollection 2018.


The Influence of Obesity on the Pharmacokinetics of Dioxin in Mice: An Assessment Using Classical and PBPK Modeling.

Emond C, DeVito MJ, Diliberto JJ, Birnbaum LS.

Toxicol Sci. 2018 Jul 1;164(1):218-228. doi: 10.1093/toxsci/kfy078.


Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation.

Walker VR, Boyles AL, Pelch KE, Holmgren SD, Shapiro AJ, Blystone CR, Devito MJ, Newbold RR, Blain R, Hartman P, Thayer KA, Rooney AA.

Environ Int. 2018 Jun;115:48-69. doi: 10.1016/j.envint.2017.12.032. Epub 2018 Mar 14. Review.


Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS.

Toxicol Sci. 2017 Nov 1;160(1):189-190. doi: 10.1093/toxsci/kfx194. No abstract available.


An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.

Environ Sci Technol. 2017 Sep 19;51(18):10786-10796. doi: 10.1021/acs.est.7b00650. Epub 2017 Sep 6.


From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS.

Toxicol Sci. 2017 Sep 1;159(1):124-136. doi: 10.1093/toxsci/kfx122. Erratum in: Toxicol Sci. 2017 Nov 1;160(1):189-190.


Dose-response assessment of the dermal toxicity of Virginia cedarwood oil in F344/N rats and B6C3F1/N mice.

Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.

Food Chem Toxicol. 2016 Dec;98(Pt B):159-168. doi: 10.1016/j.fct.2016.10.016. Epub 2016 Oct 18.


Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat.

Hughes MF, Ross DG, Starr JM, Scollon EJ, Wolansky MJ, Crofton KM, DeVito MJ.

Toxicology. 2016 Jun 1;359-360:19-28. doi: 10.1016/j.tox.2016.06.013. Epub 2016 Jun 18.


Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat.

Hughes MF, Ross DG, Edwards BC, DeVito MJ, Starr JM.

Xenobiotica. 2016;46(5):430-8. doi: 10.3109/00498254.2015.1081710. Epub 2015 Sep 14.


Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats.

Starr JM, Graham SE, Ross DG, Tornero-Velez R, Scollon EJ, Devito MJ, Crofton KM, Wolansky MJ, Hughes MF.

Toxicology. 2014 Jun 5;320:15-24. doi: 10.1016/j.tox.2014.02.016. Epub 2014 Mar 12.


In vitro metabolism of thyroxine by rat and human hepatocytes.

Richardson VM, Ferguson SS, Sey YM, Devito MJ.

Xenobiotica. 2014 May;44(5):391-403. doi: 10.3109/00498254.2013.847990. Epub 2013 Oct 31.


Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A.

Toxicol Sci. 2013 Nov;136(1):4-18. doi: 10.1093/toxsci/kft178. Epub 2013 Aug 19.


Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds.

van den Berg M, Denison MS, Birnbaum LS, Devito MJ, Fiedler H, Falandysz J, Rose M, Schrenk D, Safe S, Tohyama C, Tritscher A, Tysklind M, Peterson RE.

Toxicol Sci. 2013 Jun;133(2):197-208. doi: 10.1093/toxsci/kft070. Epub 2013 Mar 14.


Mixtures research at NIEHS: an evolving program.

Rider CV, Carlin DJ, Devito MJ, Thompson CL, Walker NJ.

Toxicology. 2013 Nov 16;313(2-3):94-102. doi: 10.1016/j.tox.2012.10.017. Epub 2012 Nov 9.


Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids.

Starr JM, Scollon EJ, Hughes MF, Ross DG, Graham SE, Crofton KM, Wolansky MJ, Devito MJ, Tornero-Velez R.

Toxicol Sci. 2012 Dec;130(2):309-18. doi: 10.1093/toxsci/kfs245. Epub 2012 Aug 7.


A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.

Tornero-Velez R, Davis J, Scollon EJ, Starr JM, Setzer RW, Goldsmith MR, Chang DT, Xue J, Zartarian V, DeVito MJ, Hughes MF.

Toxicol Sci. 2012 Nov;130(1):33-47. doi: 10.1093/toxsci/kfs236. Epub 2012 Aug 1.


Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action.

Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, DeVito MJ, Crofton KM.

Toxicology. 2012 Oct 9;300(1-2):31-45. doi: 10.1016/j.tox.2012.05.023. Epub 2012 Jun 1.


Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.

Scollon EJ, Starr JM, Crofton KM, Wolansky MJ, DeVito MJ, Hughes MF.

Toxicology. 2011 Nov 28;290(1):1-6. doi: 10.1016/j.tox.2011.08.002. Epub 2011 Aug 10.


Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats.

Paul KB, Hedge JM, Devito MJ, Crofton KM.

Environ Toxicol Chem. 2010 Dec;29(12):2840-4. doi: 10.1002/etc.339. Epub 2010 Oct 15.


Employing a Mechanistic Model for the MAPK Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response.

Luke NS, Devito MJ, Portier CJ, El-Masri HA.

Dose Response. 2010 Jan 29;8(3):347-67. doi: 10.2203/dose-response.09-017.Luke.


Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model.

Godin SJ, DeVito MJ, Hughes MF, Ross DG, Scollon EJ, Starr JM, Setzer RW, Conolly RB, Tornero-Velez R.

Toxicol Sci. 2010 Jun;115(2):330-43. doi: 10.1093/toxsci/kfq051. Epub 2010 Mar 3.


Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction.

Luke NS, DeVito MJ, Shah I, El-Masri HA.

Bull Math Biol. 2010 Oct;72(7):1799-819. doi: 10.1007/s11538-010-9508-5. Epub 2010 Feb 12.


Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence.

Luke NS, Sams R 2nd, DeVito MJ, Conolly RB, El-Masri HA.

Toxicol Sci. 2010 May;115(1):253-66. doi: 10.1093/toxsci/kfq021. Epub 2010 Jan 27.


Evidence for dose-additive effects of pyrethroids on motor activity in rats.

Wolansky MJ, Gennings C, DeVito MJ, Crofton KM.

Environ Health Perspect. 2009 Oct;117(10):1563-70. doi: 10.1289/ehp.0900667. Epub 2009 Jun 8.


Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats.

Paul KB, Hedge JM, DeVito MJ, Crofton KM.

Toxicol Sci. 2010 Feb;113(2):367-79. doi: 10.1093/toxsci/kfp271. Epub 2009 Nov 12.


In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats.

Hedge JM, DeVito MJ, Crofton KM.

Int J Toxicol. 2009 Sep-Oct;28(5):382-91. doi: 10.1177/1091581809344631.


Predictive modeling of a mixture of thyroid hormone disrupting chemicals that affect production and clearance of thyroxine.

Flippin JL, Hedge JM, DeVito MJ, Leblanc GA, Crofton KM.

Int J Toxicol. 2009 Sep-Oct;28(5):368-81. doi: 10.1177/1091581809341883. Erratum in: Int J Toxicol. 2010 Jan-Feb;29(1):135.


In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms.

Scollon EJ, Starr JM, Godin SJ, DeVito MJ, Hughes MF.

Drug Metab Dispos. 2009 Jan;37(1):221-8. doi: 10.1124/dmd.108.022343. Epub 2008 Oct 23.


Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.

Lee JS, Ward WO, Wolf DC, Allen JW, Mills C, DeVito MJ, Corton JC.

Toxicol Sci. 2008 Nov;106(1):263-83. doi: 10.1093/toxsci/kfn144. Epub 2008 Jul 24.


Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS.

Smialowicz RJ, DeVito MJ, Williams WC, Birnbaum LS.

Toxicol Appl Pharmacol. 2008 Mar 15;227(3):477-84. doi: 10.1016/j.taap.2007.11.018. Epub 2007 Dec 3.


Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener.

Richardson VM, Staskal DF, Ross DG, Diliberto JJ, DeVito MJ, Birnbaum LS.

Toxicol Appl Pharmacol. 2008 Feb 1;226(3):244-50. Epub 2007 Sep 22.


Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine.

Crofton KM, Paul KB, Devito MJ, Hedge JM.

Environ Toxicol Pharmacol. 2007 Sep;24(2):194-7. doi: 10.1016/j.etap.2007.04.008. Epub 2007 Apr 27.


Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate.

Godin SJ, Crow JA, Scollon EJ, Hughes MF, DeVito MJ, Ross MK.

Drug Metab Dispos. 2007 Sep;35(9):1664-71. Epub 2007 Jun 18.


Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats.

Godin SJ, Scollon EJ, Hughes MF, Potter PM, DeVito MJ, Ross MK.

Drug Metab Dispos. 2006 Oct;34(10):1764-71. Epub 2006 Jul 19.


Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism.

Crofton KM, Craft ES, Hedge JM, Gennings C, Simmons JE, Carchman RA, Carter WH Jr, DeVito MJ.

Environ Health Perspect. 2005 Nov;113(11):1549-54.


Development of a refined database of mammalian relative potency estimates for dioxin-like compounds.

Haws LC, Su SH, Harris M, Devito MJ, Walker NJ, Farland WH, Finley B, Birnbaum LS.

Toxicol Sci. 2006 Jan;89(1):4-30. Epub 2005 Aug 24. Review.


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