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Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine.

Kapadia CH, Tian S, Perry JL, Luft JC, DeSimone JM.

ACS Omega. 2019 Mar 31;4(3):5547-5555. doi: 10.1021/acsomega.8b03391. Epub 2019 Mar 19.


3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body.

Oh HJ, Aboian MS, Yi MYJ, Maslyn JA, Loo WS, Jiang X, Parkinson DY, Wilson MW, Moore T, Yee CR, Robbins GR, Barth FM, DeSimone JM, Hetts SW, Balsara NP.

ACS Cent Sci. 2019 Mar 27;5(3):419-427. doi: 10.1021/acscentsci.8b00700. Epub 2019 Jan 9.


Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes.

Shah DB, Nguyen HQ, Grundy LS, Olson KR, Mecham SJ, DeSimone JM, Balsara NP.

Phys Chem Chem Phys. 2019 Apr 21;21(15):7857-7866. doi: 10.1039/c9cp00216b. Epub 2019 Mar 27.


Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype.

Metz SW, Thomas A, Brackbill A, Xianwen Y, Stone M, Horvath K, Miley MJ, Luft C, DeSimone JM, Tian S, de Silva AM.

PLoS Negl Trop Dis. 2018 Sep 24;12(9):e0006793. doi: 10.1371/journal.pntd.0006793. eCollection 2018 Sep.


Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery.

Wilson EM, Luft JC, DeSimone JM.

Pharm Res. 2018 Aug 23;35(10):195. doi: 10.1007/s11095-018-2452-z.


Use of iontophoresis for the treatment of cancer.

Byrne JD, Yeh JJ, DeSimone JM.

J Control Release. 2018 Aug 28;284:144-151. doi: 10.1016/j.jconrel.2018.06.020. Epub 2018 Jun 15. Review.


Spatially controlled coating of continuous liquid interface production microneedles for transdermal protein delivery.

Caudill CL, Perry JL, Tian S, Luft JC, DeSimone JM.

J Control Release. 2018 Aug 28;284:122-132. doi: 10.1016/j.jconrel.2018.05.042. Epub 2018 Jun 9.


Impact of formulation on the iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer.

Byrne JD, Jajja MRN, O'Neill AT, Schorzman AN, Keeler AW, Luft JC, Zamboni WC, DeSimone JM, Yeh JJ.

Cancer Chemother Pharmacol. 2018 Jun;81(6):991-998. doi: 10.1007/s00280-018-3570-3. Epub 2018 Mar 30.


Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins.

Bloomquist CJ, Mecham MB, Paradzinsky MD, Janusziewicz R, Warner SB, Luft JC, Mecham SJ, Wang AZ, DeSimone JM.

J Control Release. 2018 May 28;278:9-23. doi: 10.1016/j.jconrel.2018.03.026. Epub 2018 Mar 27.


Extending antigen release from particulate vaccines results in enhanced antitumor immune response.

Kapadia CH, Tian S, Perry JL, Sailer D, Christopher Luft J, DeSimone JM.

J Control Release. 2018 Jan 10;269:393-404. doi: 10.1016/j.jconrel.2017.11.020. Epub 2017 Nov 13.


Mechanism of ion transport in perfluoropolyether electrolytes with a lithium salt.

Timachova K, Chintapalli M, Olson KR, Mecham SJ, DeSimone JM, Balsara NP.

Soft Matter. 2017 Aug 16;13(32):5389-5396. doi: 10.1039/c7sm00794a.


Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.

Min Y, Roche KC, Tian S, Eblan MJ, McKinnon KP, Caster JM, Chai S, Herring LE, Zhang L, Zhang T, DeSimone JM, Tepper JE, Vincent BG, Serody JS, Wang AZ.

Nat Nanotechnol. 2017 Sep;12(9):877-882. doi: 10.1038/nnano.2017.113. Epub 2017 Jun 26.


Incipient microphase separation in short chain perfluoropolyether-block-poly(ethylene oxide) copolymers.

Chintapalli M, Timachova K, Olson KR, Banaszak M, Thelen JL, Mecham SJ, DeSimone JM, Balsara NP.

Soft Matter. 2017 Jun 7;13(22):4047-4056. doi: 10.1039/c7sm00738h.


Mediating Passive Tumor Accumulation through Particle Size, Tumor Type, and Location.

Perry JL, Reuter KG, Luft JC, Pecot CV, Zamboni W, DeSimone JM.

Nano Lett. 2017 May 10;17(5):2879-2886. doi: 10.1021/acs.nanolett.7b00021. Epub 2017 Apr 11.


Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer.

Bowerman CJ, Byrne JD, Chu KS, Schorzman AN, Keeler AW, Sherwood CA, Perry JL, Luft JC, Darr DB, Deal AM, Napier ME, Zamboni WC, Sharpless NE, Perou CM, DeSimone JM.

Nano Lett. 2017 Jan 11;17(1):242-248. doi: 10.1021/acs.nanolett.6b03971. Epub 2016 Dec 22.


Novel materials.

Rogers JA, DeSimone JM.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11667-11669. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7346.


Layerless fabrication with continuous liquid interface production.

Janusziewicz R, Tumbleston JR, Quintanilla AL, Mecham SJ, DeSimone JM.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11703-11708. Epub 2016 Sep 26.


Organic Polymer Chemistry in the Context of Novel Processes.

DeSimone JM, Mecham SJ, Farrell CL.

ACS Cent Sci. 2016 Sep 28;2(9):588-597. Epub 2016 Sep 13. Review.


Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production.

Johnson AR, Caudill CL, Tumbleston JR, Bloomquist CJ, Moga KA, Ermoshkin A, Shirvanyants D, Mecham SJ, Luft JC, DeSimone JM.

PLoS One. 2016 Sep 8;11(9):e0162518. doi: 10.1371/journal.pone.0162518. eCollection 2016.


Reduction Sensitive PEG Hydrogels for Codelivery of Antigen and Adjuvant To Induce Potent CTLs.

Kapadia CH, Tian S, Perry JL, Luft JC, DeSimone JM.

Mol Pharm. 2016 Oct 3;13(10):3381-3394. Epub 2016 Sep 22.


Co-opting Moore's law: Therapeutics, vaccines and interfacially active particles manufactured via PRINT®.

DeSimone JM.

J Control Release. 2016 Oct 28;240:541-543. doi: 10.1016/j.jconrel.2016.07.019. Epub 2016 Jul 14. Review.


Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung.

Rahhal TB, Fromen CA, Wilson EM, Kai MP, Shen TW, Luft JC, DeSimone JM.

Mol Pharm. 2016 May 2;13(5):1626-35. doi: 10.1021/acs.molpharmaceut.6b00066. Epub 2016 Apr 5.


Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma.

Byrne JD, Jajja MR, Schorzman AN, Keeler AW, Luft JC, Zamboni WC, DeSimone JM, Yeh JJ.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2200-5. doi: 10.1073/pnas.1600421113. Epub 2016 Feb 8.


Particles for Local Delivery of Proteins Using Intra-Articular Route.

Khodabandehlou K, Tian S, Luft JC, Khan SA, DeSimone JM.

Adv Healthc Mater. 2016 Mar;5(6):653-8, 626. doi: 10.1002/adhm.201500797. Epub 2016 Feb 2.


Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties.

Roode LE, Brighton H, Bo T, Perry JL, Parrott MC, Kersey F, Luft JC, Bear JE, DeSimone JM, Davis IJ.

Nanomedicine. 2016 May;12(4):1053-1062. doi: 10.1016/j.nano.2015.12.382. Epub 2016 Jan 7.


Compliant glass-polymer hybrid single ion-conducting electrolytes for lithium batteries.

Villaluenga I, Wujcik KH, Tong W, Devaux D, Wong DH, DeSimone JM, Balsara NP.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):52-7. doi: 10.1073/pnas.1520394112. Epub 2015 Dec 22.


Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells.

Fromen CA, Rahhal TB, Robbins GR, Kai MP, Shen TW, Luft JC, DeSimone JM.

Nanomedicine. 2016 Apr;12(3):677-687. doi: 10.1016/j.nano.2015.11.002. Epub 2015 Dec 1.


Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance.

Kai MP, Brighton HE, Fromen CA, Shen TW, Luft JC, Luft YE, Keeler AW, Robbins GR, Ting JP, Zamboni WC, Bear JE, DeSimone JM.

ACS Nano. 2016 Jan 26;10(1):861-70. doi: 10.1021/acsnano.5b05999. Epub 2015 Dec 2.


Nanoparticulate immunotherapy for cancer.

Kapadia CH, Perry JL, Tian S, Luft JC, DeSimone JM.

J Control Release. 2015 Dec 10;219:167-180. doi: 10.1016/j.jconrel.2015.09.062. Epub 2015 Oct 10. Review.


Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation.

Reuter KG, Perry JL, Kim D, Luft JC, Liu R, DeSimone JM.

Nano Lett. 2015 Oct 14;15(10):6371-8. doi: 10.1021/acs.nanolett.5b01362. Epub 2015 Sep 30.


Towards programming immune tolerance through geometric manipulation of phosphatidylserine.

Roberts RA, Eitas TK, Byrne JD, Johnson BM, Short PJ, McKinnon KP, Reisdorf S, Luft JC, DeSimone JM, Ting JP.

Biomaterials. 2015 Dec;72:1-10. doi: 10.1016/j.biomaterials.2015.08.040. Epub 2015 Aug 20.


Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo.

Ma D, Tian S, Baryza J, Luft JC, DeSimone JM.

Mol Pharm. 2015 Oct 5;12(10):3518-3526. doi: 10.1021/acs.molpharmaceut.5b00054. Epub 2015 Sep 4.


Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery.

Shen TW, Fromen CA, Kai MP, Luft JC, Rahhal TB, Robbins GR, DeSimone JM.

Pharm Res. 2015 Oct;32(10):3248-60. doi: 10.1007/s11095-015-1701-7. Epub 2015 May 23.


Biodistribution and trafficking of hydrogel nanoparticles in adult mosquitoes.

Paquette CC, Phanse Y, Perry JL, Sanchez-Vargas I, Airs PM, Dunphy BM, Xu J, Carlson JO, Luft JC, DeSimone JM, Bartholomay LC, Beaty BJ.

PLoS Negl Trop Dis. 2015 May 21;9(5):e0003745. doi: 10.1371/journal.pntd.0003745. eCollection 2015 May.


Biodistribution and Toxicity Studies of PRINT Hydrogel Nanoparticles in Mosquito Larvae and Cells.

Phanse Y, Dunphy BM, Perry JL, Airs PM, Paquette CC, Carlson JO, Xu J, Luft JC, DeSimone JM, Beaty BJ, Bartholomay LC.

PLoS Negl Trop Dis. 2015 May 21;9(5):e0003735. doi: 10.1371/journal.pntd.0003735. eCollection 2015 May.


Calibration-quality cancer nanotherapeutics.

Perry JL, Kai MP, Reuter KG, Bowerman C, Christopher Luft J, DeSimone JM.

Cancer Treat Res. 2015;166:275-91. doi: 10.1007/978-3-319-16555-4_12. Review.


Rapid and Persistent Delivery of Antigen by Lymph Node Targeting PRINT Nanoparticle Vaccine Carrier To Promote Humoral Immunity.

Mueller SN, Tian S, DeSimone JM.

Mol Pharm. 2015 May 4;12(5):1356-65. doi: 10.1021/mp500589c. Epub 2015 Apr 8.


Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.

Sharpe RJ, Malinowski JT, Sorana F, Luft JC, Bowerman CJ, DeSimone JM, Johnson JS.

Bioorg Med Chem. 2015 Apr 15;23(8):1849-57. doi: 10.1016/j.bmc.2015.02.022. Epub 2015 Feb 21.


Additive manufacturing. Continuous liquid interface production of 3D objects.

Tumbleston JR, Shirvanyants D, Ermoshkin N, Janusziewicz R, Johnson AR, Kelly D, Chen K, Pinschmidt R, Rolland JP, Ermoshkin A, Samulski ET, DeSimone JM.

Science. 2015 Mar 20;347(6228):1349-52. doi: 10.1126/science.aaa2397. Epub 2015 Mar 16.


Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle.

Kai MP, Keeler AW, Perry JL, Reuter KG, Luft JC, O'Neal SK, Zamboni WC, DeSimone JM.

J Control Release. 2015 Apr 28;204:70-7. doi: 10.1016/j.jconrel.2015.03.001. Epub 2015 Mar 3.


Silylated precision particles for controlled release of proteins.

Khodabandehlou K, Kumbhar AS, Habibi S, Pandya AA, Luft JC, Khan SA, DeSimone JM.

ACS Appl Mater Interfaces. 2015 Mar 18;7(10):5756-67. doi: 10.1021/am508520z. Epub 2015 Mar 5.


Local iontophoretic administration of cytotoxic therapies to solid tumors.

Byrne JD, Jajja MR, O'Neill AT, Bickford LR, Keeler AW, Hyder N, Wagner K, Deal A, Little RE, Moffitt RA, Stack C, Nelson M, Brooks CR, Lee W, Luft JC, Napier ME, Darr D, Anders CK, Stack R, Tepper JE, Wang AZ, Zamboni WC, Yeh JJ, DeSimone JM.

Sci Transl Med. 2015 Feb 4;7(273):273ra14. doi: 10.1126/scitranslmed.3009951.


Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model.

Robbins GR, Roberts RA, Guo H, Reuter K, Shen T, Sempowski GD, McKinnon KP, Su L, DeSimone JM, Ting JP.

Nanomedicine. 2015 Apr;11(3):589-99. doi: 10.1016/j.nano.2014.11.010. Epub 2015 Jan 14.


Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization.

Fromen CA, Robbins GR, Shen TW, Kai MP, Ting JP, DeSimone JM.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):488-93. doi: 10.1073/pnas.1422923112. Epub 2014 Dec 29.


Design of asymmetric particles containing a charged interior and a neutral surface charge: comparative study on in vivo circulation of polyelectrolyte microgels.

Chen K, Xu J, Luft JC, Tian S, Raval JS, DeSimone JM.

J Am Chem Soc. 2014 Jul 16;136(28):9947-52. doi: 10.1021/ja503939n. Epub 2014 Jun 30.


Driving convergence with human diversity.

DeSimone JM, Farrell CL.

Sci Transl Med. 2014 May 28;6(238):238ed11. doi: 10.1126/scitranslmed.3004486.


Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer.

Gharpure KM, Chu KS, Bowerman CJ, Miyake T, Pradeep S, Mangala SL, Han HD, Rupaimoole R, Armaiz-Pena GN, Rahhal TB, Wu SY, Luft JC, Napier ME, Lopez-Berestein G, DeSimone JM, Sood AK.

Mol Cancer Ther. 2014 Jul;13(7):1750-7. doi: 10.1158/1535-7163.MCT-13-0930. Epub 2014 Apr 22.


Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.

Chu KS, Finniss MC, Schorzman AN, Kuijer JL, Luft JC, Bowerman CJ, Napier ME, Haroon ZA, Zamboni WC, DeSimone JM.

Nano Lett. 2014 Mar 12;14(3):1472-6. doi: 10.1021/nl4046558. Epub 2014 Feb 24.


Nonflammable perfluoropolyether-based electrolytes for lithium batteries.

Wong DH, Thelen JL, Fu Y, Devaux D, Pandya AA, Battaglia VS, Balsara NP, DeSimone JM.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3327-31. doi: 10.1073/pnas.1314615111. Epub 2014 Feb 10.


RNA replicon delivery via lipid-complexed PRINT protein particles.

Xu J, Luft JC, Yi X, Tian S, Owens G, Wang J, Johnson A, Berglund P, Smith J, Napier ME, DeSimone JM.

Mol Pharm. 2013 Sep 3;10(9):3366-74. doi: 10.1021/mp400190z. Epub 2013 Aug 21.

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