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Items: 6


Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy.

Lek A, Zhang Y, Woodman KG, Huang S, DeSimone AM, Cohen J, Ho V, Conner J, Mead L, Kodani A, Pakula A, Sanjana N, King OD, Jones PL, Wagner KR, Lek M, Kunkel LM.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaay0271. doi: 10.1126/scitranslmed.aay0271.


Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy.

DeSimone AM, Leszyk J, Wagner K, Emerson CP Jr.

Sci Adv. 2019 Dec 11;5(12):eaaw7099. doi: 10.1126/sciadv.aaw7099. eCollection 2019 Dec.


Facioscapulohumeral Muscular Dystrophy.

DeSimone AM, Pakula A, Lek A, Emerson CP Jr.

Compr Physiol. 2017 Sep 12;7(4):1229-1279. doi: 10.1002/cphy.c160039. Review.


Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo.

Taggart AJ, DeSimone AM, Shih JS, Filloux ME, Fairbrother WG.

Nat Struct Mol Biol. 2012 Jun 17;19(7):719-21. doi: 10.1038/nsmb.2327.


Combinatorial binding of transcription factors in the pluripotency control regions of the genome.

Ferraris L, Stewart AP, Kang J, DeSimone AM, Gemberling M, Tantin D, Fairbrother WG.

Genome Res. 2011 Jul;21(7):1055-64. doi: 10.1101/gr.115824.110. Epub 2011 Apr 28.


Corepressor-directed preacetylation of histone H3 in promoter chromatin primes rapid transcriptional switching of cell-type-specific genes in yeast.

Desimone AM, Laney JD.

Mol Cell Biol. 2010 Jul;30(13):3342-56. doi: 10.1128/MCB.01450-09. Epub 2010 May 3.

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