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Items: 1 to 50 of 117

1.

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.

Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA.

Nat Commun. 2019 Jun 24;10(1):2760. doi: 10.1038/s41467-019-10591-5.

2.

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice.

Irimia JM, Meyer CM, Segvich DM, Surendran S, DePaoli-Roach AA, Morral N, Roach PJ.

J Biol Chem. 2017 Jun 23;292(25):10455-10464. doi: 10.1074/jbc.M117.786525. Epub 2017 May 8.

3.

Novel method for detection of glycogen in cells.

Skurat AV, Segvich DM, DePaoli-Roach AA, Roach PJ.

Glycobiology. 2017 May 1;27(5):416-424. doi: 10.1093/glycob/cwx005.

4.

Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.

Mahalingan KK, Baskaran S, DePaoli-Roach AA, Roach PJ, Hurley TD.

Biochemistry. 2017 Jan 10;56(1):179-188. doi: 10.1021/acs.biochem.6b00884. Epub 2016 Dec 20.

5.

Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes.

Ruchti E, Roach PJ, DePaoli-Roach AA, Magistretti PJ, Allaman I.

IBRO Rep. 2016 Oct 4;1:46-53. doi: 10.1016/j.ibror.2016.10.002. eCollection 2016 Dec.

6.

Incorporation of phosphate into glycogen by glycogen synthase.

Contreras CJ, Segvich DM, Mahalingan K, Chikwana VM, Kirley TL, Hurley TD, DePaoli-Roach AA, Roach PJ.

Arch Biochem Biophys. 2016 May 1;597:21-9. doi: 10.1016/j.abb.2016.03.020. Epub 2016 Mar 29.

7.

Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice.

Irimia JM, Tagliabracci VS, Meyer CM, Segvich DM, DePaoli-Roach AA, Roach PJ.

J Biol Chem. 2015 Sep 11;290(37):22686-98. doi: 10.1074/jbc.M115.673897. Epub 2015 Jul 27.

8.

Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease.

DePaoli-Roach AA, Contreras CJ, Segvich DM, Heiss C, Ishihara M, Azadi P, Roach PJ.

J Biol Chem. 2015 Jan 9;290(2):841-50. doi: 10.1074/jbc.M114.607796. Epub 2014 Nov 21.

9.

Protein degradation and quality control in cells from laforin and malin knockout mice.

Garyali P, Segvich DM, DePaoli-Roach AA, Roach PJ.

J Biol Chem. 2014 Jul 25;289(30):20606-14.

10.

Glycogen and its metabolism: some new developments and old themes.

Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS.

Biochem J. 2012 Feb 1;441(3):763-87. doi: 10.1042/BJ20111416. Review.

11.

Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.

DePaoli-Roach AA, Segvich DM, Meyer CM, Rahimi Y, Worby CA, Gentry MS, Roach PJ.

Hum Mol Genet. 2012 Apr 1;21(7):1604-10. doi: 10.1093/hmg/ddr598. Epub 2011 Dec 20.

12.

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.

Baskaran S, Chikwana VM, Contreras CJ, Davis KD, Wilson WA, DePaoli-Roach AA, Roach PJ, Hurley TD.

J Biol Chem. 2011 Sep 30;286(39):33999-4006. doi: 10.1074/jbc.M111.264531. Epub 2011 Aug 11.

13.

PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease.

Turnbull J, DePaoli-Roach AA, Zhao X, Cortez MA, Pencea N, Tiberia E, Piliguian M, Roach PJ, Wang P, Ackerley CA, Minassian BA.

PLoS Genet. 2011 Apr;7(4):e1002037. doi: 10.1371/journal.pgen.1002037. Epub 2011 Apr 28.

14.

Phosphate incorporation during glycogen synthesis and Lafora disease.

Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ.

Cell Metab. 2011 Mar 2;13(3):274-82. doi: 10.1016/j.cmet.2011.01.017.

15.

Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.

Cheng G, Takahashi M, Shunmugavel A, Wallenborn JG, DePaoli-Roach AA, Gergs U, Neumann J, Kuppuswamy D, Menick DR, Cooper G 4th.

J Biol Chem. 2010 Dec 3;285(49):38125-40. doi: 10.1074/jbc.M110.148650. Epub 2010 Oct 2.

16.

Structural basis for glucose-6-phosphate activation of glycogen synthase.

Baskaran S, Roach PJ, DePaoli-Roach AA, Hurley TD.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17563-8. doi: 10.1073/pnas.1006340107. Epub 2010 Sep 27.

17.

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism.

Jiang S, Heller B, Tagliabracci VS, Zhai L, Irimia JM, DePaoli-Roach AA, Wells CD, Skurat AV, Roach PJ.

J Biol Chem. 2010 Nov 5;285(45):34960-71. doi: 10.1074/jbc.M110.150839. Epub 2010 Sep 1. Erratum in: J Biol Chem. 2011 Nov 11;286(45):39673.

18.

Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.

DePaoli-Roach AA, Tagliabracci VS, Segvich DM, Meyer CM, Irimia JM, Roach PJ.

J Biol Chem. 2010 Aug 13;285(33):25372-81. doi: 10.1074/jbc.M110.148668. Epub 2010 Jun 10.

19.

Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A.

Eckerdt F, Pascreau G, Phistry M, Lewellyn AL, DePaoli-Roach AA, Maller JL.

Cell Cycle. 2009 Aug;8(15):2413-9. Epub 2009 Aug 22.

PMID:
19556869
20.

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.

Tagliabracci VS, Girard JM, Segvich D, Meyer C, Turnbull J, Zhao X, Minassian BA, Depaoli-Roach AA, Roach PJ.

J Biol Chem. 2008 Dec 5;283(49):33816-25. doi: 10.1074/jbc.M807428200. Epub 2008 Oct 13.

21.

Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.

Brüchert N, Mavila N, Boknik P, Baba HA, Fabritz L, Gergs U, Kirchhefer U, Kirchhof P, Matus M, Schmitz W, DePaoli-Roach AA, Neumann J.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1539-46. doi: 10.1152/ajpheart.00515.2008. Epub 2008 Aug 8.

22.

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.

Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA.

PLoS Med. 2008 Jan 29;5(1):e27. doi: 10.1371/journal.pmed.0050027. Erratum in: PLoS Med. 2008 Dec;5(12):e246.. Solanky, Bhavana [added]; Deelchand, Dinesh [added].

23.

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.

Tagliabracci VS, Turnbull J, Wang W, Girard JM, Zhao X, Skurat AV, Delgado-Escueta AV, Minassian BA, Depaoli-Roach AA, Roach PJ.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19262-6. Epub 2007 Nov 26.

24.

Structural basis for regulation of protein phosphatase 1 by inhibitor-2.

Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA.

J Biol Chem. 2007 Sep 28;282(39):28874-83. Epub 2007 Jul 18.

25.

Glycogen metabolism in tissues from a mouse model of Lafora disease.

Wang W, Lohi H, Skurat AV, DePaoli-Roach AA, Minassian BA, Roach PJ.

Arch Biochem Biophys. 2007 Jan 15;457(2):264-9. Epub 2006 Nov 3.

26.

Relationship between glycogen accumulation and the laforin dual specificity phosphatase.

Wang W, Parker GE, Skurat AV, Raben N, DePaoli-Roach AA, Roach PJ.

Biochem Biophys Res Commun. 2006 Nov 24;350(3):588-92. Epub 2006 Sep 26.

27.

Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation.

Jeoung NH, Wu P, Joshi MA, Jaskiewicz J, Bock CB, Depaoli-Roach AA, Harris RA.

Biochem J. 2006 Aug 1;397(3):417-25.

28.

Glucose metabolism in mice lacking muscle glycogen synthase.

Pederson BA, Schroeder JM, Parker GE, Smith MW, DePaoli-Roach AA, Roach PJ.

Diabetes. 2005 Dec;54(12):3466-73.

29.

Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.

Kirchhefer U, Baba HA, Bokník P, Breeden KM, Mavila N, Brüchert N, Justus I, Matus M, Schmitz W, Depaoli-Roach AA, Neumann J.

Cardiovasc Res. 2005 Oct 1;68(1):98-108.

PMID:
15975567
30.

Mice with elevated muscle glycogen stores do not have improved exercise performance.

Pederson BA, Cope CR, Irimia JM, Schroeder JM, Thurberg BL, Depaoli-Roach AA, Roach PJ.

Biochem Biophys Res Commun. 2005 Jun 3;331(2):491-6.

PMID:
15850786
31.

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.

Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG.

Circ Res. 2005 Apr 15;96(7):756-66. Epub 2005 Mar 3.

PMID:
15746443
32.

Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise.

Pederson BA, Cope CR, Schroeder JM, Smith MW, Irimia JM, Thurberg BL, DePaoli-Roach AA, Roach PJ.

J Biol Chem. 2005 Apr 29;280(17):17260-5. Epub 2005 Feb 11.

33.

Abnormal cardiac development in the absence of heart glycogen.

Pederson BA, Chen H, Schroeder JM, Shou W, DePaoli-Roach AA, Roach PJ.

Mol Cell Biol. 2004 Aug;24(16):7179-87.

34.

A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.

Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA, Colbran RJ.

J Biol Chem. 2004 May 21;279(21):21714-23. Epub 2004 Mar 11.

35.

PKC-alpha regulates cardiac contractility and propensity toward heart failure.

Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD.

Nat Med. 2004 Mar;10(3):248-54. Epub 2004 Feb 15.

36.

Determination of mammalian glycogen synthase phosphatase activity.

DePaoli-Roach AA, Vilardo PG, Kim JH, Mavila N, Vemuri B, Roach PJ.

Methods Enzymol. 2003;366:17-34. No abstract available.

PMID:
14674236
37.

Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase.

Hurley JH, Zhang S, Bye LS, Marshall MS, DePaoli-Roach AA, Guan K, Fox AP, Yu L.

BMC Neurosci. 2003 Jun 9;4:10.

38.

Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).

Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, Servillo G, Della Fazia MA, Kranias EG, Depaoli-Roach AA, Sassone-Corsi P, Kass DA.

FASEB J. 2003 Feb;17(2):144-51.

PMID:
12554693
39.
40.

Type 1 phosphatase, a negative regulator of cardiac function.

Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, Kranias EG.

Mol Cell Biol. 2002 Jun;22(12):4124-35.

41.

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.

Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC.

J Biol Chem. 2002 Jul 26;277(30):27449-67. Epub 2002 Apr 15.

42.

Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.

Gasa R, Clark C, Yang R, DePaoli-Roach AA, Newgard CB.

J Biol Chem. 2002 Jan 11;277(2):1524-30. Epub 2001 Nov 13.

43.

The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise.

Aschenbach WG, Suzuki Y, Breeden K, Prats C, Hirshman MF, Dufresne SD, Sakamoto K, Vilardo PG, Steele M, Kim JH, Jing SL, Goodyear LJ, DePaoli-Roach AA.

J Biol Chem. 2001 Oct 26;276(43):39959-67. Epub 2001 Aug 24.

44.

Gene structure and expression of the targeting subunit, RGL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G.

Lannér C, Suzuki Y, Bi C, Zhang H, Cooper LD, Bowker-Kinley MM, DePaoli-Roach AA.

Arch Biochem Biophys. 2001 Apr 1;388(1):135-45.

PMID:
11361130
45.

Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.

Suzuki Y, Lanner C, Kim JH, Vilardo PG, Zhang H, Yang J, Cooper LD, Steele M, Kennedy A, Bock CB, Scrimgeour A, Lawrence JC Jr, DePaoli-Roach AA.

Mol Cell Biol. 2001 Apr;21(8):2683-94.

46.

Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes.

Gasa R, Jensen PB, Berman HK, Brady MJ, DePaoli-Roach AA, Newgard CB.

J Biol Chem. 2000 Aug 25;275(34):26396-403.

48.

Structure and chromosomal localization of the human glycogenin-2 gene GYG2.

Zhai L, Mu J, Zong H, DePaoli-Roach AA, Roach PJ.

Gene. 2000 Jan 25;242(1-2):229-35.

PMID:
10721716
49.

Decreased protein phosphatase 2A activity in hippocampal long-term potentiation.

Fukunaga K, Muller D, Ohmitsu M, Bakó E, DePaoli-Roach AA, Miyamoto E.

J Neurochem. 2000 Feb;74(2):807-17.

50.

Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase.

Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD.

J Biol Chem. 1999 Feb 5;274(6):3485-95.

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