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The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin.

Zhang Y, Li Z, Hao Q, Tan W, Sun J, Li J, Chen CW, Li Z, Meng Y, Zhou Y, Han Z, Pei H, DePamphilis ML, Zhu W.

Cancer Res. 2019 Oct 1;79(19):4896-4910. doi: 10.1158/0008-5472.CAN-19-0020. Epub 2019 Aug 20.


A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis.

Sharma G, Guardia CM, Roy A, Vassilev A, Saric A, Griner LN, Marugan J, Ferrer M, Bonifacino JS, DePamphilis ML.

Autophagy. 2019 Oct;15(10):1694-1718. doi: 10.1080/15548627.2019.1586257. Epub 2019 Mar 8.


DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2).

Chen CW, Li Y, Hu S, Zhou W, Meng Y, Li Z, Zhang Y, Sun J, Bo Z, DePamphilis ML, Yen Y, Han Z, Zhu W.

Oncogene. 2019 Mar;38(13):2364-2379. doi: 10.1038/s41388-018-0584-6. Epub 2018 Dec 5.


CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin.

Ullah R, Dar S, Ahmad T, de Renty C, Usman M, DePamphilis ML, Faisal A, Shahzad-Ul-Hussan S, Ullah Z.

Placenta. 2018 Jun;66:57-64. doi: 10.1016/j.placenta.2018.05.003. Epub 2018 May 17.


Links between DNA Replication, Stem Cells and Cancer.

Vassilev A, DePamphilis ML.

Genes (Basel). 2017 Jan 25;8(2). pii: E45. doi: 10.3390/genes8020045. Review.


Geminin Is Essential for Pluripotent Cell Viability During Teratoma Formation, but Not for Differentiated Cell Viability During Teratoma Expansion.

Adler-Wailes DC, Kramer JA, DePamphilis ML.

Stem Cells Dev. 2017 Feb 15;26(4):285-302. doi: 10.1089/scd.2016.0260. Epub 2016 Nov 7.



DePamphilis ML.

Curr Top Dev Biol. 2016;120:xiii-xxi. doi: 10.1016/S0070-2153(16)30163-6. No abstract available.


Genome Duplication at the Beginning of Mammalian Development.

DePamphilis ML.

Curr Top Dev Biol. 2016;120:55-102. doi: 10.1016/bs.ctdb.2016.04.003. Epub 2016 May 31. Review.


Identification of genes that are essential to restrict genome duplication to once per cell division.

Vassilev A, Lee CY, Vassilev B, Zhu W, Ormanoglu P, Martin SE, DePamphilis ML.

Oncotarget. 2016 Jun 7;7(23):34956-76. doi: 10.18632/oncotarget.9008.


Genome Duplication: The Heartbeat of Developing Organisms.

DePamphilis ML.

Curr Top Dev Biol. 2016;116:201-29. doi: 10.1016/bs.ctdb.2015.10.002. Epub 2016 Jan 20. Review.


Geminin is Essential to Prevent DNA Re-Replication-Dependent Apoptosis in Pluripotent Cells, but not in Differentiated Cells.

Huang YY, Kaneko KJ, Pan H, DePamphilis ML.

Stem Cells. 2015 Nov;33(11):3239-53. doi: 10.1002/stem.2092. Epub 2015 Jul 16.


And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.

Hao J, de Renty C, Li Y, Xiao H, Kemp MG, Han Z, DePamphilis ML, Zhu W.

EMBO J. 2015 Aug 4;34(15):2096-110. doi: 10.15252/embj.201488016. Epub 2015 Jun 16.


Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.

de Renty C, DePamphilis ML, Ullah Z.

PLoS One. 2014 May 21;9(5):e97434. doi: 10.1371/journal.pone.0097434. eCollection 2014.


The dual roles of geminin during trophoblast proliferation and differentiation.

de Renty C, Kaneko KJ, DePamphilis ML.

Dev Biol. 2014 Mar 1;387(1):49-63. doi: 10.1016/j.ydbio.2013.12.034. Epub 2014 Jan 9.


TEAD4 establishes the energy homeostasis essential for blastocoel formation.

Kaneko KJ, DePamphilis ML.

Development. 2013 Sep;140(17):3680-90. doi: 10.1242/dev.093799. Epub 2013 Jul 31.



Zielke N, Edgar BA, DePamphilis ML.

Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a012948. doi: 10.1101/cshperspect.a012948. Review.


The involvement of acidic nucleoplasmic DNA-binding protein (And-1) in the regulation of prereplicative complex (pre-RC) assembly in human cells.

Li Y, Xiao H, de Renty C, Jaramillo-Lambert A, Han Z, DePamphilis ML, Brown KJ, Zhu W.

J Biol Chem. 2012 Dec 14;287(51):42469-79. doi: 10.1074/jbc.M112.404277. Epub 2012 Oct 23.


"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.

Depamphilis ML, de Renty CM, Ullah Z, Lee CY.

Front Physiol. 2012 Sep 26;3:368. doi: 10.3389/fphys.2012.00368. eCollection 2012.


Checkpoint kinase-1: one actor playing two roles in "maintaining genomic integrity".

Ullah Z, DePamphilis ML.

Cell Cycle. 2012 May 15;11(10):1873. doi: 10.4161/cc.20509. Epub 2012 May 15. No abstract available.


High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them.

Lee CY, Johnson RL, Wichterman-Kouznetsova J, Guha R, Ferrer M, Tuzmen P, Martin SE, Zhu W, DePamphilis ML.

Methods. 2012 Jun;57(2):234-48. doi: 10.1016/j.ymeth.2012.03.031. Epub 2012 Apr 5. Review.


Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation.

Ullah Z, de Renty C, DePamphilis ML.

Mol Cell Biol. 2011 Oct;31(19):4129-43. doi: 10.1128/MCB.05723-11. Epub 2011 Jul 26.


Spotlight on geminin.

DePamphilis ML.

Breast Cancer Res. 2011 Jun 1;13(3):109. doi: 10.1186/bcr2881.


Assembly of the human origin recognition complex occurs through independent nuclear localization of its components.

Ghosh S, Vassilev AP, Zhang J, Zhao Y, DePamphilis ML.

J Biol Chem. 2011 Jul 8;286(27):23831-41. doi: 10.1074/jbc.M110.215988. Epub 2011 May 9.


An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells.

Zhu W, Lee CY, Johnson RL, Wichterman J, Huang R, DePamphilis ML.

Mol Cancer Res. 2011 Mar;9(3):294-310. doi: 10.1158/1541-7786.MCR-10-0570. Epub 2011 Jan 21. Erratum in: Mol Cancer Res. 2011 Jul;9(7):976.


Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.

Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V.

Nat Commun. 2010 Apr 12;1:9. doi: 10.1038/ncomms1008.


The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida.

Kohn MJ, Sztein J, Yagi R, DePamphilis ML, Kaneko KJ.

Fertil Steril. 2010 Mar 15;93(5):1533-7. doi: 10.1016/j.fertnstert.2009.06.010. Epub 2009 Jul 10.


The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.

Kaneko KJ, Kohn MJ, Liu C, DePamphilis ML.

Fertil Steril. 2010 Mar 15;93(5):1526-32. doi: 10.1016/j.fertnstert.2009.06.011. Epub 2009 Jul 10.


Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy.

Ullah Z, Lee CY, Depamphilis ML.

Cell Div. 2009 Jun 2;4:10. doi: 10.1186/1747-1028-4-10.


Selective killing of cancer cells by suppression of geminin activity.

Zhu W, Depamphilis ML.

Cancer Res. 2009 Jun 1;69(11):4870-7. doi: 10.1158/0008-5472.CAN-08-4559.


Developmentally programmed endoreduplication in animals.

Ullah Z, Lee CY, Lilly MA, DePamphilis ML.

Cell Cycle. 2009 May 15;8(10):1501-9. Epub 2009 May 2.


Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex.

Chon H, Vassilev A, DePamphilis ML, Zhao Y, Zhang J, Burgers PM, Crouch RJ, Cerritelli SM.

Nucleic Acids Res. 2009 Jan;37(1):96-110. doi: 10.1093/nar/gkn913. Epub 2008 Nov 16.


Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.

Ullah Z, Kohn MJ, Yagi R, Vassilev LT, DePamphilis ML.

Genes Dev. 2008 Nov 1;22(21):3024-36. doi: 10.1101/gad.1718108.


Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.

Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, DePamphilis ML, Buonanno A.

Development. 2007 Nov;134(21):3827-36. Epub 2007 Oct 3.


Transcription factor TEAD2 is involved in neural tube closure.

Kaneko KJ, Kohn MJ, Liu C, DePamphilis ML.

Genesis. 2007 Sep;45(9):577-87.


The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo.

Noguchi K, Vassilev A, Ghosh S, Yates JL, DePamphilis ML.

EMBO J. 2006 Nov 15;25(22):5372-82. Epub 2006 Oct 26.


Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex.

Radichev I, Kwon SW, Zhao Y, DePamphilis ML, Vassilev A.

J Biol Chem. 2006 Aug 11;281(32):23264-73. Epub 2006 Jun 7.


Regulating the licensing of DNA replication origins in metazoa.

DePamphilis ML, Blow JJ, Ghosh S, Saha T, Noguchi K, Vassilev A.

Curr Opin Cell Biol. 2006 Jun;18(3):231-9. Epub 2006 May 2. Review.


Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis.

Saha T, Ghosh S, Vassilev A, DePamphilis ML.

J Cell Sci. 2006 Apr 1;119(Pt 7):1371-82. Epub 2006 Mar 14.


The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.

Park JM, Kohn MJ, Bruinsma MW, Vech C, Intine RV, Fuhrmann S, Grinberg A, Mukherjee I, Love PE, Ko MS, DePamphilis ML, Maraia RJ.

Mol Cell Biol. 2006 Feb;26(4):1445-51.


DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis.

Kohn MJ, Kaneko KJ, DePamphilis ML.

Mol Reprod Dev. 2005 Aug;71(4):516-22.


Cell cycle dependent regulation of the origin recognition complex.

DePamphilis ML.

Cell Cycle. 2005 Jan;4(1):70-9. Epub 2005 Jan 29. Review.


Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.

Intine RV, Dundr M, Vassilev A, Schwartz E, Zhao Y, Zhao Y, Depamphilis ML, Maraia RJ.

Mol Cell Biol. 2004 Dec;24(24):10894-904.


Methods for detecting cells in S phase.

Sun WH, DePamphilis ML.

Methods Mol Biol. 2004;241:37-53. No abstract available.


Eukaryotic DNA replication origins: reconciling disparate data.

DePamphilis ML.

Cell. 2003 Aug 8;114(3):274-5. No abstract available.


The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication.

DePamphilis ML.

Gene. 2003 May 22;310:1-15. Review.


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