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Items: 30

1.

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer.

Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM.

Elife. 2019 May 20;8. pii: e45572. doi: 10.7554/eLife.45572.

2.

The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival.

Combs JA, DeNicola GM.

Cancers (Basel). 2019 May 16;11(5). pii: E678. doi: 10.3390/cancers11050678. Review.

3.

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS.

Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21.

PMID:
30799286
4.

The Strategic Teamwork for Effective Practice Mentor Development Program (STEP-MDP): Expanding capacity for clinical and translational science by investing in research staff.

Denicola C, Altshuler L, Denicola G, Zabar S.

J Clin Transl Sci. 2018 Jun;2(3):173-177. doi: 10.1017/cts.2018.28. Epub 2018 Aug 30.

5.

Recent advances in cancer metabolism: a technological perspective.

Kang YP, Ward NP, DeNicola GM.

Exp Mol Med. 2018 Apr 16;50(4):31. doi: 10.1038/s12276-018-0027-z. Review.

6.

Stressing Out PanIN: NRF2 Pushes over the Edge.

Torrente L, DeNicola GM.

Cancer Cell. 2017 Dec 11;32(6):723-725. doi: 10.1016/j.ccell.2017.11.014.

7.

The Regulation of NRF2 by Nutrient-Responsive Signaling and Its Role in Anabolic Cancer Metabolism.

Lee SB, Sellers BN, DeNicola GM.

Antioxid Redox Signal. 2018 Dec 10;29(17):1774-1791. doi: 10.1089/ars.2017.7356. Epub 2017 Oct 16.

PMID:
28899208
8.

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3.

Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS.

J Biol Chem. 2017 Sep 29;292(39):16161-16173. doi: 10.1074/jbc.M117.785410. Epub 2017 Jul 24.

9.

A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating?

Permuth JB, Choi JW, Chen DT, Jiang K, DeNicola G, Li JN, Coppola D, Centeno BA, Magliocco A, Balagurunathan Y, Merchant N, Trevino JG, Jeong D.

Cancer Biol Med. 2017 Feb;14(1):66-73. doi: 10.20892/j.issn.2095-3941.2017.0006.

10.

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA.

Cell. 2016 Aug 11;166(4):963-976. doi: 10.1016/j.cell.2016.06.056. Epub 2016 Jul 28.

11.

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.

Moon JS, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabón MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM.

Nat Med. 2016 Sep;22(9):1002-12. doi: 10.1038/nm.4153. Epub 2016 Jul 25.

12.

Making sense of reAKTive oxygen species.

DeNicola GM, Harris IS.

Cell Death Differ. 2016 Aug;23(8):1269-70. doi: 10.1038/cdd.2016.57. Epub 2016 Jun 17. No abstract available.

13.

Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer.

DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC.

Nat Genet. 2016 Apr;48(4):473. doi: 10.1038/ng0329-473a. No abstract available.

PMID:
27023779
14.

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1585.

15.

Cancer's Fuel Choice: New Flavors for a Picky Eater.

DeNicola GM, Cantley LC.

Mol Cell. 2015 Nov 19;60(4):514-23. doi: 10.1016/j.molcel.2015.10.018. Review.

16.

NRF2 regulates serine biosynthesis in non-small cell lung cancer.

DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC.

Nat Genet. 2015 Dec;47(12):1475-81. doi: 10.1038/ng.3421. Epub 2015 Oct 19. Erratum in: Nat Genet. 2016 Apr;48(4):473.

17.

The utility of transposon mutagenesis for cancer studies in the era of genome editing.

DeNicola GM, Karreth FA, Adams DJ, Wong CC.

Genome Biol. 2015 Oct 19;16:229. doi: 10.1186/s13059-015-0794-y. Review.

18.

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.

Moon JS, Hisata S, Park MA, DeNicola GM, Ryter SW, Nakahira K, Choi AMK.

Cell Rep. 2015 Jul 7;12(1):102-115. doi: 10.1016/j.celrep.2015.05.046. Epub 2015 Jun 25.

19.

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC.

Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057.

20.

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1.

DeNicola GF, Martin ED, Chaikuad A, Bassi R, Clark J, Martino L, Verma S, Sicard P, Tata R, Atkinson RA, Knapp S, Conte MR, Marber MS.

Nat Struct Mol Biol. 2013 Oct;20(10):1182-90. doi: 10.1038/nsmb.2668. Epub 2013 Sep 15.

21.

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.

Gopinathan A, Denicola GM, Frese KK, Cook N, Karreth FA, Mayerle J, Lerch MM, Reinheckel T, Tuveson DA.

Gut. 2012 Jun;61(6):877-84. doi: 10.1136/gutjnl-2011-300850. Epub 2011 Dec 9.

PMID:
22157328
22.

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

Karreth FA, Frese KK, DeNicola GM, Baccarini M, Tuveson DA.

Cancer Discov. 2011 Jul;1(2):128-36. doi: 10.1158/2159-8290.CD-10-0044. Epub 2011 May 11.

23.

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.

Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP.

Cell. 2011 Oct 14;147(2):382-95. doi: 10.1016/j.cell.2011.09.032. Erratum in: Cell. 2011 Nov 11;147(4):948.

24.

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer.

Caldwell ME, DeNicola GM, Martins CP, Jacobetz MA, Maitra A, Hruban RH, Tuveson DA.

Oncogene. 2012 Mar 22;31(12):1599-608. doi: 10.1038/onc.2011.350. Epub 2011 Aug 22.

25.

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.

Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189.

26.

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.

Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG.

EMBO J. 2011 May 20;30(13):2719-33. doi: 10.1038/emboj.2011.158.

27.

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

Karreth FA, DeNicola GM, Winter SP, Tuveson DA.

Mol Cell. 2009 Nov 13;36(3):477-86. doi: 10.1016/j.molcel.2009.10.017.

28.

RAS in cellular transformation and senescence.

DeNicola GM, Tuveson DA.

Eur J Cancer. 2009 Sep;45 Suppl 1:211-6. doi: 10.1016/S0959-8049(09)70036-X. Review. No abstract available.

PMID:
19775620
29.

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA.

Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.

30.

VAV1: a new target in pancreatic cancer?

Denicola G, Tuveson DA.

Cancer Biol Ther. 2005 May;4(5):509-11. Epub 2005 May 2. Review.

PMID:
15970675

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