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2020 Herbert Tabor Early Career Investigator Awards: Call for nominations.

Gierasch LM, DeMartino GN.

J Biol Chem. 2019 Sep 6;294(36):13526. doi: 10.1074/jbc.E119.010739. No abstract available.


2019 Herbert Tabor Young Investigator Awards: Call for nominations.

DeMartino GN.

J Biol Chem. 2018 Sep 14;293(37):14571. doi: 10.1074/jbc.E118.005617. No abstract available.


Introduction to the Thematic Minireview Series: Autophagy.

DeMartino GN.

J Biol Chem. 2018 Apr 13;293(15):5384-5385. doi: 10.1074/jbc.TM118.002429. Epub 2018 Feb 21. Review.


The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.

Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ.

Genes Dev. 2016 Aug 1;30(15):1698-703. doi: 10.1101/gad.282756.116. Epub 2016 Aug 4.


Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function.

Li X, Thompson D, Kumar B, DeMartino GN.

J Biol Chem. 2014 Jun 20;289(25):17392-405. doi: 10.1074/jbc.M114.561183. Epub 2014 Apr 25.


Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.

Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM.

Cell. 2012 Dec 21;151(7):1581-94. doi: 10.1016/j.cell.2012.11.040.


ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome.

Kim YC, Li X, Thompson D, DeMartino GN.

J Biol Chem. 2013 Feb 1;288(5):3334-45. doi: 10.1074/jbc.M112.424788. Epub 2012 Dec 4.


Reconstitution of PA700, the 19S regulatory particle, from purified precursor complexes.

Demartino GN.

Methods Mol Biol. 2012;832:443-52. doi: 10.1007/978-1-61779-474-2_31.


C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome.

Kim YC, DeMartino GN.

J Biol Chem. 2011 Jul 29;286(30):26652-66. doi: 10.1074/jbc.M111.246793. Epub 2011 May 31.


PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome.

Agarwal AK, Xing C, DeMartino GN, Mizrachi D, Hernandez MD, Sousa AB, Martínez de Villarreal L, dos Santos HG, Garg A.

Am J Hum Genet. 2010 Dec 10;87(6):866-72. doi: 10.1016/j.ajhg.2010.10.031.


The C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation.

Kumar B, Kim YC, DeMartino GN.

J Biol Chem. 2010 Dec 10;285(50):39523-35. doi: 10.1074/jbc.M110.153627. Epub 2010 Oct 11.


Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations.

Lewis KA, Yaeger A, DeMartino GN, Thomas PJ.

J Bioenerg Biomembr. 2010 Feb;42(1):85-95. doi: 10.1007/s10863-009-9258-y. Epub 2010 Feb 11.


Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.

Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL, Ye J.

J Biol Chem. 2009 Dec 11;284(50):34889-900. doi: 10.1074/jbc.M109.044875. Epub 2009 Oct 8.


Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II.

Djakovic SN, Schwarz LA, Barylko B, DeMartino GN, Patrick GN.

J Biol Chem. 2009 Sep 25;284(39):26655-65. doi: 10.1074/jbc.M109.021956. Epub 2009 Jul 28.


Subcomplexes of PA700, the 19 S regulator of the 26 S proteasome, reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activity.

Thompson D, Hakala K, DeMartino GN.

J Biol Chem. 2009 Sep 11;284(37):24891-903. doi: 10.1074/jbc.M109.023218. Epub 2009 Jul 9.


Variably modulated gating of the 26S proteasome by ATP and polyubiquitin.

Li X, Demartino GN.

Biochem J. 2009 Jul 15;421(3):397-404. doi: 10.1042/BJ20090528.


PUPylation: something old, something new, something borrowed, something Glu.

DeMartino GN.

Trends Biochem Sci. 2009 Apr;34(4):155-8. doi: 10.1016/j.tibs.2008.12.005. Epub 2009 Mar 11.


Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome.

Gillette TG, Kumar B, Thompson D, Slaughter CA, DeMartino GN.

J Biol Chem. 2008 Nov 14;283(46):31813-22. doi: 10.1074/jbc.M805935200. Epub 2008 Sep 16.


JAMP optimizes ERAD to protect cells from unfolded proteins.

Tcherpakov M, Broday L, Delaunay A, Kadoya T, Khurana A, Erdjument-Bromage H, Tempst P, Qiu XB, DeMartino GN, Ronai Z.

Mol Biol Cell. 2008 Nov;19(11):5019-28. doi: 10.1091/mbc.E08-08-0839. Epub 2008 Sep 10.


Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.

Koulich E, Li X, DeMartino GN.

Mol Biol Cell. 2008 Mar;19(3):1072-82. Epub 2007 Dec 27.


Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.

Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, Beachy PA, Beales PL, DeMartino GN, Fisher S, Badano JL, Katsanis N.

Nat Genet. 2007 Nov;39(11):1350-60. Epub 2007 Sep 30.


Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.

Wahlman J, DeMartino GN, Skach WR, Bulleid NJ, Brodsky JL, Johnson AE.

Cell. 2007 Jun 1;129(5):943-55.


Proteasomes: machines for all reasons.

Demartino GN, Gillette TG.

Cell. 2007 May 18;129(4):659-62. Review.


ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome.

Liu CW, Li X, Thompson D, Wooding K, Chang TL, Tang Z, Yu H, Thomas PJ, DeMartino GN.

Mol Cell. 2006 Oct 6;24(1):39-50.


Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells.

Wójcik C, Rowicka M, Kudlicki A, Nowis D, McConnell E, Kujawa M, DeMartino GN.

Mol Biol Cell. 2006 Nov;17(11):4606-18. Epub 2006 Aug 16.


Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.

Yao T, Song L, Xu W, DeMartino GN, Florens L, Swanson SK, Washburn MP, Conaway RC, Conaway JW, Cohen RE.

Nat Cell Biol. 2006 Sep;8(9):994-1002. Epub 2006 Aug 13.


Purification of PA700, the 19S regulatory complex of the 26S proteasome.

DeMartino GN.

Methods Enzymol. 2005;398:295-306.


Modulation of gene expression by RNAi.

Wójcik C, Fabunmi R, DeMartino GN.

Methods Mol Med. 2005;108:381-93.


Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome.

Liu CW, Strickland E, Demartino GN, Thomas PJ.

Methods Mol Biol. 2005;301:71-81.


A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.

Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ.

J Biol Chem. 2005 Jun 17;280(24):22670-8. Epub 2005 Apr 19.


Proteasome inhibition: mechanism of action.

DeMartino GN.

J Natl Compr Canc Netw. 2004 Nov;2 Suppl 4:S5-9. Review.


Lewy-body formation is an aggresome-related process: a hypothesis.

Olanow CW, Perl DP, DeMartino GN, McNaught KS.

Lancet Neurol. 2004 Aug;3(8):496-503. Review.


Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein.

Lee RJ, Liu CW, Harty C, McCracken AA, Latterich M, Römisch K, DeMartino GN, Thomas PJ, Brodsky JL.

EMBO J. 2004 Jun 2;23(11):2206-15. Epub 2004 May 20.


Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes.

Puttaparthi K, Wojcik C, Rajendran B, DeMartino GN, Elliott JL.

J Neurochem. 2003 Nov;87(4):851-60.


Intracellular localization of proteasomes.

Wójcik C, DeMartino GN.

Int J Biochem Cell Biol. 2003 May;35(5):579-89. Review.


Endoproteolytic activity of the proteasome.

Liu CW, Corboy MJ, DeMartino GN, Thomas PJ.

Science. 2003 Jan 17;299(5605):408-11. Epub 2002 Dec 12.


Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome.

Liu CW, Millen L, Roman TB, Xiong H, Gilbert HF, Noiva R, DeMartino GN, Thomas PJ.

J Biol Chem. 2002 Jul 26;277(30):26815-20. Epub 2002 May 14.


Analysis of Drosophila 26 S proteasome using RNA interference.

Wójcik C, DeMartino GN.

J Biol Chem. 2002 Feb 22;277(8):6188-97. Epub 2001 Dec 5.


Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies.

Fabunmi RP, Wigley WC, Thomas PJ, DeMartino GN.

J Cell Sci. 2001 Jan;114(Pt 1):29-36.


cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome.

McCutchen-Maloney SL, Matsuda K, Shimbara N, Binns DD, Tanaka K, Slaughter CA, DeMartino GN.

J Biol Chem. 2000 Jun 16;275(24):18557-65.


Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle.

Ordway GA, Neufer PD, Chin ER, DeMartino GN.

J Appl Physiol (1985). 2000 Mar;88(3):1134-41.


Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome.

Strickland E, Hakala K, Thomas PJ, DeMartino GN.

J Biol Chem. 2000 Feb 25;275(8):5565-72.


Activity and regulation of the centrosome-associated proteasome.

Fabunmi RP, Wigley WC, Thomas PJ, DeMartino GN.

J Biol Chem. 2000 Jan 7;275(1):409-13.


The proteasome, a novel protease regulated by multiple mechanisms.

DeMartino GN, Slaughter CA.

J Biol Chem. 1999 Aug 6;274(32):22123-6. Review. No abstract available.


26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate.

Ben-Shahar S, Komlosh A, Nadav E, Shaked I, Ziv T, Admon A, DeMartino GN, Reiss Y.

J Biol Chem. 1999 Jul 30;274(31):21963-72.


Dynamic association of proteasomal machinery with the centrosome.

Wigley WC, Fabunmi RP, Lee MG, Marino CR, Muallem S, DeMartino GN, Thomas PJ.

J Cell Biol. 1999 May 3;145(3):481-90.


Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone.

Stenoien DL, Cummings CJ, Adams HP, Mancini MG, Patel K, DeMartino GN, Marcelli M, Weigel NL, Mancini MA.

Hum Mol Genet. 1999 May;8(5):731-41.


Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity.

Adams GM, Crotchett B, Slaughter CA, DeMartino GN, Gogol EP.

Biochemistry. 1998 Sep 15;37(37):12927-32.


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