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Critical view of the effect site modelling of propofol.

Sepúlveda V PO, Demaría MC.

Rev Esp Anestesiol Reanim. 2019 Aug 30. pii: S0034-9356(19)30070-2. doi: 10.1016/j.redar.2019.03.001. [Epub ahead of print] Review. English, Spanish.


Learning Curve for Endoscopic Submucosal Dissection With an Untutored, Prevalence-Based Approach in the United States.

Zhang X, Ly EK, Nithyanand S, Modayil RJ, Khodorskiy DO, Neppala S, Bhumi S, DeMaria M, Widmer JL, Friedel DM, Grendell JH, Stavropoulos SN.

Clin Gastroenterol Hepatol. 2019 Jun 18. pii: S1542-3565(19)30646-9. doi: 10.1016/j.cgh.2019.06.008. [Epub ahead of print]


Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions.

Soto-Gamez A, Quax WJ, Demaria M.

J Mol Biol. 2019 Jul 12;431(15):2629-2643. doi: 10.1016/j.jmb.2019.05.036. Epub 2019 May 31. Review.


Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.

Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR, Decaluwe H, Beauséjour C.

Aging Cell. 2019 Aug;18(4):e12971. doi: 10.1111/acel.12971. Epub 2019 May 31.


Targeting senescent cells alleviates obesity-induced metabolic dysfunction.

Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL.

Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25.


Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration.

Patil P, Dong Q, Wang D, Chang J, Wiley C, Demaria M, Lee J, Kang J, Niedernhofer LJ, Robbins PD, Sowa G, Campisi J, Zhou D, Vo N.

Aging Cell. 2019 Jun;18(3):e12927. doi: 10.1111/acel.12927. Epub 2019 Mar 21.


An overview of the TROPICS NASA Earth Venture Mission.

Blackwell WJ, Braun S, Bennartz R, Velden C, DeMaria M, Atlas R, Dunion J, Marks F, Rogers R, Annane B, Leslie RV.

Q J R Meteorol Soc. 2018 Nov;144(Suppl Suppl 1):16-26. doi: 10.1002/qj.3290. Epub 2018 Sep 17.


Identification of stable senescence-associated reference genes.

Hernandez-Segura A, Rubingh R, Demaria M.

Aging Cell. 2019 Apr;18(2):e12911. doi: 10.1111/acel.12911. Epub 2019 Feb 1.


Cellular Senescence: Aging, Cancer, and Injury.

Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A.

Physiol Rev. 2019 Apr 1;99(2):1047-1078. doi: 10.1152/physrev.00020.2018. Review.


LIFE Med Hiss: An innovative cohort design for public health.

Gandini M, Scarinzi C, Bande S, Berti G, Ciancarella L, Costa G, Demaria M, Ghigo S, Marinacci C, Piersanti A, Sebastiani G, Cadum E.

MethodsX. 2018 Dec 18;6:82-91. doi: 10.1016/j.mex.2018.12.007. eCollection 2019.


Caloric restriction and cellular senescence.

Fontana L, Nehme J, Demaria M.

Mech Ageing Dev. 2018 Dec;176:19-23. doi: 10.1016/j.mad.2018.10.005. Epub 2018 Nov 3. Review.


Long term effect of air pollution on incident hospital admissions: Results from the Italian Longitudinal Study within LIFE MED HISS project.

Gandini M, Scarinzi C, Bande S, Berti G, Carnà P, Ciancarella L, Costa G, Demaria M, Ghigo S, Piersanti A, Rowinski M, Spadea T, Stroscia M, Cadum E; LIFE MEDHISS collaborative Group.

Environ Int. 2018 Dec;121(Pt 2):1087-1097. doi: 10.1016/j.envint.2018.10.020. Epub 2018 Oct 23.


Induction and Validation of Cellular Senescence in Primary Human Cells.

Hernandez-Segura A, Brandenburg S, Demaria M.

J Vis Exp. 2018 Jun 20;(136). doi: 10.3791/57782.


Gene therapy for p16-overexpressing cells.

Demaria M.

Aging (Albany NY). 2018 Apr 19;10(4):518-519. doi: 10.18632/aging.101422. No abstract available.


The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.

Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M.

Aging Cell. 2018 Jun;17(3):e12746. doi: 10.1111/acel.12746. Epub 2018 Mar 25.


A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors.

Kohli J, Campisi J, Demaria M.

Oncotarget. 2017 Dec 28;9(7):7274-7281. doi: 10.18632/oncotarget.23752. eCollection 2018 Jan 26.


Hallmarks of Cellular Senescence.

Hernandez-Segura A, Nehme J, Demaria M.

Trends Cell Biol. 2018 Jun;28(6):436-453. doi: 10.1016/j.tcb.2018.02.001. Epub 2018 Feb 21. Review.


Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

Chinta SJ, Woods G, Demaria M, Rane A, Zou Y, McQuade A, Rajagopalan S, Limbad C, Madden DT, Campisi J, Andersen JK.

Cell Rep. 2018 Jan 23;22(4):930-940. doi: 10.1016/j.celrep.2017.12.092. Epub 2018 Jan 28.


The contribution of behavioural and metabolic risk factors to socioeconomic inequalities in mortality: the Italian Longitudinal Study.

Piccinelli C, Carnà P, Stringhini S, Sebastiani G, Demaria M, Marra M, Costa G, d'Errico A.

Int J Public Health. 2018 Apr;63(3):325-335. doi: 10.1007/s00038-018-1076-8. Epub 2018 Jan 30.


The Role of Contextual Socioeconomic Circumstances and Neighborhood Poverty Segregation on Mortality in 4 European Cities.

Marinacci C, Demaria M, Melis G, Borrell C, Corman D, Dell'Olmo MM, Rodriguez M, Costa G.

Int J Health Serv. 2017 Oct;47(4):636-654. doi: 10.1177/0020731417732959. Epub 2017 Oct 2.


Unmasking Transcriptional Heterogeneity in Senescent Cells.

Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M.

Curr Biol. 2017 Sep 11;27(17):2652-2660.e4. doi: 10.1016/j.cub.2017.07.033. Epub 2017 Aug 30.


Senescent cells: New target for an old treatment?

Demaria M.

Mol Cell Oncol. 2017 Apr 3;4(3):e1299666. doi: 10.1080/23723556.2017.1299666. eCollection 2017.


Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.


Therapeutic interventions for aging: the case of cellular senescence.

Soto-Gamez A, Demaria M.

Drug Discov Today. 2017 May;22(5):786-795. doi: 10.1016/j.drudis.2017.01.004. Epub 2017 Jan 19. Review.


Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J.

Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15.


Mortality study of employees at a chemical manufacturing plant using administrative databases.

Bena A, Farina E, Demaria M, Cadum E.

Am J Ind Med. 2016 Oct;59(10):866-76. doi: 10.1002/ajim.22617. Epub 2016 Jun 6.


Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review.

Velarde MC, Demaria M.

Gerontology. 2016;62(5):513-8. doi: 10.1159/000444877. Epub 2016 Apr 1. Review.


Cellular senescence and tumor promotion: Is aging the key?

Loaiza N, Demaria M.

Biochim Biophys Acta. 2016 Apr;1865(2):155-67. doi: 10.1016/j.bbcan.2016.01.007. Epub 2016 Feb 2. Review.


Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37.

Jones EL, Wee JL, Demaria MC, Blakeley J, Ho PK, Vega-Ramos J, Villadangos JA, van Spriel AB, Hickey MJ, Hämmerling GJ, Wright MD.

J Immunol. 2016 Feb 1;196(3):978-87. doi: 10.4049/jimmunol.1500357. Epub 2016 Jan 4.


Simvastatin suppresses breast cancer cell proliferation induced by senescent cells.

Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P.

Sci Rep. 2015 Dec 14;5:17895. doi: 10.1038/srep17895.


Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D.

Nat Med. 2016 Jan;22(1):78-83. doi: 10.1038/nm.4010. Epub 2015 Dec 14.


Chemical and Sensory Quality Preservation in Coated Almonds with the Addition of Antioxidants.

Larrauri M, Demaría MG, Ryan LC, Asensio CM, Grosso NR, Nepote V.

J Food Sci. 2016 Jan;81(1):S208-15. doi: 10.1111/1750-3841.13164. Epub 2015 Nov 23.


The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ.

Science. 2015 Sep 25;349(6255):aaa5612. doi: 10.1126/science.aaa5612.


Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.

Velarde MC, Demaria M, Melov S, Campisi J.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10407-12. doi: 10.1073/pnas.1505675112. Epub 2015 Aug 3.


Desert Dust Outbreaks in Southern Europe: Contribution to Daily PM₁₀ Concentrations and Short-Term Associations with Mortality and Hospital Admissions.

Stafoggia M, Zauli-Sajani S, Pey J, Samoli E, Alessandrini E, Basagaña X, Cernigliaro A, Chiusolo M, Demaria M, Díaz J, Faustini A, Katsouyanni K, Kelessis AG, Linares C, Marchesi S, Medina S, Pandolfi P, Pérez N, Querol X, Randi G, Ranzi A, Tobias A, Forastiere F; MED-PARTICLES Study Group.

Environ Health Perspect. 2016 Apr;124(4):413-9. doi: 10.1289/ehp.1409164. Epub 2015 Jul 24.


Decreasing educational differences in mortality over 40 years: evidence from the Turin Longitudinal Study (Italy).

Stringhini S, Spadea T, Stroscia M, Onorati R, Demaria M, Zengarini N, Costa G.

J Epidemiol Community Health. 2015 Dec;69(12):1208-16. doi: 10.1136/jech-2015-205673. Epub 2015 Jul 16.


p53 and rapamycin are additive.

Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P.

Oncotarget. 2015 Jun 30;6(18):15802-13.


MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J.

Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6.


Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.

Demaria M, Desprez PY, Campisi J, Velarde MC.

J Invest Dermatol. 2015 Jul;135(7):1722-1726. doi: 10.1038/jid.2015.108. Epub 2015 Apr 9. Review.


Socioeconomic inequalities in cause-specific mortality in 15 European cities.

Marí-Dell'Olmo M, Gotsens M, Palència L, Burström B, Corman D, Costa G, Deboosere P, Díez È, Domínguez-Berjón F, Dzúrová D, Gandarillas A, Hoffmann R, Kovács K, Martikainen P, Demaria M, Pikhart H, Rodríguez-Sanz M, Saez M, Santana P, Schwierz C, Tarkiainen L, Borrell C.

J Epidemiol Community Health. 2015 May;69(5):432-41. doi: 10.1136/jech-2014-204312. Epub 2015 Jan 28.


Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.

Neves J, Demaria M, Campisi J, Jasper H.

Dev Cell. 2015 Jan 12;32(1):9-18. doi: 10.1016/j.devcel.2014.11.028. Review.


An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J.

Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11.


The influence of text messaging on oral hygiene effectiveness.

Bowen TB, Rinchuse DJ, Zullo T, DeMaria ME.

Angle Orthod. 2015 Jul;85(4):543-8. doi: 10.2319/071514-495.1. Epub 2014 Oct 24.


Cellular senescence and the aging brain.

Chinta SJ, Woods G, Rane A, Demaria M, Campisi J, Andersen JK.

Exp Gerontol. 2015 Aug;68:3-7. doi: 10.1016/j.exger.2014.09.018. Epub 2014 Oct 1.


STAT3 Activities and Energy Metabolism: Dangerous Liaisons.

Camporeale A, Demaria M, Monteleone E, Giorgi C, Wieckowski MR, Pinton P, Poli V.

Cancers (Basel). 2014 Jul 31;6(3):1579-96. doi: 10.3390/cancers6031579.


STAT3 and metabolism: how many ways to use a single molecule?

Demaria M, Camporeale A, Poli V.

Int J Cancer. 2014 Nov 1;135(9):1997-2003. doi: 10.1002/ijc.28767. Epub 2014 Feb 19. Review.


[Air pollution and mortality in twenty-five Italian cities: results of the EpiAir2 Project].

Alessandrini ER, Faustini A, Chiusolo M, Stafoggia M, Gandini M, Demaria M, Antonelli A, Arena P, Biggeri A, Canova C, Casale G, Cernigliaro A, Garrone E, Gherardi B, Gianicolo EA, Giannini S, Iuzzolino C, Lauriola P, Mariottini M, Pasetto P, Randi G, Ranzi A, Santoro M, Selle V, Serinelli M, Stivanello E, Tominz R, Vigotti MA, Zauli-Sajani S, Forastiere F, Cadum E; Gruppo collaborativo EpiAir2.

Epidemiol Prev. 2013 Jul-Oct;37(4-5):220-9. Italian.


Mitochondrial DNA damage induces apoptosis in senescent cells.

Laberge RM, Adler D, DeMaria M, Mechtouf N, Teachenor R, Cardin GB, Desprez PY, Campisi J, Rodier F.

Cell Death Dis. 2013 Jul 18;4:e727. doi: 10.1038/cddis.2013.199.


Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

Chinta SJ, Lieu CA, Demaria M, Laberge RM, Campisi J, Andersen JK.

J Intern Med. 2013 May;273(5):429-36. doi: 10.1111/joim.12029. Review.


Senescent cells and their secretory phenotype as targets for cancer therapy.

Velarde MC, Demaria M, Campisi J.

Interdiscip Top Gerontol. 2013;38:17-27. doi: 10.1159/000343572. Epub 2013 Jan 17. Review.

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