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Items: 39


PAK2 links cell survival to mechanotransduction and metabolism.

Campbell HK, Salvi AM, O'Brien T, Superfine R, DeMali KA.

J Cell Biol. 2019 Jun 3;218(6):1958-1971. doi: 10.1083/jcb.201807152. Epub 2019 Apr 2.


SHP-2 is activated in response to force on E-cadherin and dephosphorylates vinculin Y822.

Campbell H, Heidema C, Pilarczyk DG, DeMali KA.

J Cell Sci. 2018 Dec 14;131(24). pii: jcs216648. doi: 10.1242/jcs.216648.


Mechanisms linking mechanotransduction and cell metabolism.

Salvi AM, DeMali KA.

Curr Opin Cell Biol. 2018 Oct;54:114-120. doi: 10.1016/ Epub 2018 Jun 11. Review.


It takes energy to resist force.

Bays JL, DeMali KA.

Cell Cycle. 2017 Oct 2;16(19):1733-1734. doi: 10.1080/15384101.2017.1360654. Epub 2017 Aug 18. No abstract available.


Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.

Bays JL, Campbell HK, Heidema C, Sebbagh M, DeMali KA.

Nat Cell Biol. 2017 Jun;19(6):724-731. doi: 10.1038/ncb3537. Epub 2017 May 29.


Vinculin in cell-cell and cell-matrix adhesions.

Bays JL, DeMali KA.

Cell Mol Life Sci. 2017 Aug;74(16):2999-3009. doi: 10.1007/s00018-017-2511-3. Epub 2017 Apr 11. Review.


Interplay between tight junctions & adherens junctions.

Campbell HK, Maiers JL, DeMali KA.

Exp Cell Res. 2017 Sep 1;358(1):39-44. doi: 10.1016/j.yexcr.2017.03.061. Epub 2017 Mar 31. Review.


Bone marrow stromal antigen 2 expressed in cancer cells promotes mammary tumor growth and metastasis.

Mahauad-Fernandez WD, DeMali KA, Olivier AK, Okeoma CM.

Breast Cancer Res. 2014 Dec 13;16(6):493. doi: 10.1186/s13058-014-0493-8.


Force transmission at cell-cell and cell-matrix adhesions.

DeMali KA, Sun X, Bui GA.

Biochemistry. 2014 Dec 16;53(49):7706-17. doi: 10.1021/bi501181p. Epub 2014 Dec 4. Review.


Vinculin-dependent actin bundling regulates cell migration and traction forces.

Jannie KM, Ellerbroek SM, Zhou DW, Chen S, Crompton DJ, García AJ, DeMali KA.

Biochem J. 2015 Feb 1;465(3):383-93. doi: 10.1042/BJ20140872.


Interferon regulatory factor 6 regulates keratinocyte migration.

Biggs LC, Naridze RL, DeMali KA, Lusche DF, Kuhl S, Soll DR, Schutte BC, Dunnwald M.

J Cell Sci. 2014 Jul 1;127(Pt 13):2840-8. doi: 10.1242/jcs.139246. Epub 2014 Apr 28.


Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions.

Bays JL, Peng X, Tolbert CE, Guilluy C, Angell AE, Pan Y, Superfine R, Burridge K, DeMali KA.

J Cell Biol. 2014 Apr 28;205(2):251-63. doi: 10.1083/jcb.201309092. Epub 2014 Apr 21.


ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions.

Maiers JL, Peng X, Fanning AS, DeMali KA.

J Cell Sci. 2013 Sep 1;126(Pt 17):3904-15. doi: 10.1242/jcs.126565. Epub 2013 Jun 26.


Functional analysis of a de novo ACTB mutation in a patient with atypical Baraitser-Winter syndrome.

Johnston JJ, Wen KK, Keppler-Noreuil K, McKane M, Maiers JL, Greiner A, Sapp JC; NIH Intramural Sequencing Center, Demali KA, Rubenstein PA, Biesecker LG.

Hum Mutat. 2013 Sep;34(9):1242-9. doi: 10.1002/humu.22350. Epub 2013 May 28.


Signals regulating adhesion dynamics.

Webb DJ, Brown CM, DeMali KA.

J Signal Transduct. 2012;2012:785196. doi: 10.1155/2012/785196. Epub 2012 Dec 31. No abstract available.


Divergence of Rho residue 43 impacts GEF activity.

Sloan CM, Quinn CV, Peters JP, Farley J, Goetzinger C, Wernli M, DeMali KA, Ellerbroek SM.

Small GTPases. 2012 Jan-Mar;3(1):15-22. doi: 10.4161/sgtp.19557. Epub 2012 Jan 1.


α-Catenin uses a novel mechanism to activate vinculin.

Peng X, Maiers JL, Choudhury D, Craig SW, DeMali KA.

J Biol Chem. 2012 Mar 2;287(10):7728-37. doi: 10.1074/jbc.M111.297481. Epub 2012 Jan 10.


Vinculin activators target integrins from within the cell to increase melanoma sensitivity to chemotherapy.

Nelson ES, Folkmann AW, Henry MD, DeMali KA.

Mol Cancer Res. 2011 Jun;9(6):712-23. doi: 10.1158/1541-7786.MCR-10-0599. Epub 2011 Apr 1.


New insights into vinculin function and regulation.

Peng X, Nelson ES, Maiers JL, DeMali KA.

Int Rev Cell Mol Biol. 2011;287:191-231. doi: 10.1016/B978-0-12-386043-9.00005-0. Review.


The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ.

J Mol Biol. 2010 May 21;398(5):730-46. doi: 10.1016/j.jmb.2010.03.047. Epub 2010 Mar 31.


Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin.

Peng X, Cuff LE, Lawton CD, DeMali KA.

J Cell Sci. 2010 Feb 15;123(Pt 4):567-77. doi: 10.1242/jcs.056432. Epub 2010 Jan 19.


Vinculin nucleates actin polymerization and modifies actin filament structure.

Wen KK, Rubenstein PA, DeMali KA.

J Biol Chem. 2009 Oct 30;284(44):30463-73. doi: 10.1074/jbc.M109.021295. Epub 2009 Sep 7.


Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts.

Johnson JL, Winterwood N, DeMali KA, Stipp CS.

J Cell Sci. 2009 Jul 1;122(Pt 13):2263-73. doi: 10.1242/jcs.045997. Epub 2009 Jun 9.


IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry.

Demali KA, Jue AL, Burridge K.

J Biol Chem. 2006 Dec 22;281(51):39534-41. Epub 2006 Oct 22.


Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration.

Sandquist JC, Swenson KI, Demali KA, Burridge K, Means AR.

J Biol Chem. 2006 Nov 24;281(47):35873-83. Epub 2006 Oct 3.


Vinculin--a dynamic regulator of cell adhesion.

Demali KA.

Trends Biochem Sci. 2004 Nov;29(11):565-7.


SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.

Ellerbroek SM, Wennerberg K, Arthur WT, Dunty JM, Bowman DR, DeMali KA, Der C, Burridge K.

Mol Biol Cell. 2004 Jul;15(7):3309-19. Epub 2004 May 7.


Integrin signaling to the actin cytoskeleton.

DeMali KA, Wennerberg K, Burridge K.

Curr Opin Cell Biol. 2003 Oct;15(5):572-82. Review.


Coupling membrane protrusion and cell adhesion.

DeMali KA, Burridge K.

J Cell Sci. 2003 Jun 15;116(Pt 12):2389-97. Review.


Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion.

DeMali KA, Barlow CA, Burridge K.

J Cell Biol. 2002 Dec 9;159(5):881-91. Epub 2002 Dec 9.


Multiple roles for Src in a PDGF-stimulated cell.

DeMali KA, Godwin SL, Soltoff SP, Kazlauskas A.

Exp Cell Res. 1999 Nov 25;253(1):271-9. Review.


Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.

Schlesinger TK, Demali KA, Johnson GL, Kazlauskas A.

Biochem J. 1999 Dec 1;344 Pt 2:519-26.


c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.

Plattner R, Kadlec L, DeMali KA, Kazlauskas A, Pendergast AM.

Genes Dev. 1999 Sep 15;13(18):2400-11.


Platelet-derived growth factor receptor is a novel modulator of type A gamma-aminobutyric acid-gated ion channels.

Valenzuela CF, Kazlauskas A, Brozowski SJ, Weiner JL, Demali KA, McDonald BJ, Moss SJ, Dunwiddie TV, Harris RA.

Mol Pharmacol. 1995 Dec;48(6):1099-107.


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