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Items: 1 to 50 of 990

1.

Vitamin D is not required for adaptive immunity to listeria.

Baisa GA, Plum L, Marling S, Seeman J, DeLuca HF.

Physiol Rep. 2019 Aug;7(16):e14209. doi: 10.14814/phy2.14209.

2.

A New 1,25 Dihydroxy Vitamin D Analog with Strong Bone Anabolic Activity in OVX Rats with Little or no Bone Resorptive Activity.

Plum LA, Zella J, Clagett-Dame M, DeLuca HF.

J Bone Miner Res. 2019 Aug 1. doi: 10.1002/jbmr.3838. [Epub ahead of print]

PMID:
31369169
3.

Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D.

Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N.

Br J Clin Pharmacol. 2018 Oct;84(10):2194-2207. doi: 10.1111/bcp.13652. Epub 2018 Jul 17. Review.

PMID:
29851137
4.

Vitamin D deficiency in the ApcPirc/+ rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective.

Irving AA, Duchow EG, Plum LA, DeLuca HF.

Dis Model Mech. 2018 Mar 7;11(3). pii: dmm032300. doi: 10.1242/dmm.032300.

5.

Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid.

Ahrens JM, Jones JD, Nieves NJ, Mitzey AM, DeLuca HF, Clagett-Dame M.

PLoS One. 2017 Nov 28;12(11):e0188887. doi: 10.1371/journal.pone.0188887. eCollection 2017.

6.

Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis.

Pandey R, Zella JB, Zhu JG, Plum LA, Clagett-Dame M, Blaser WJ, Bedale W, DeLuca HF, Coyne DW.

Drugs R D. 2017 Dec;17(4):597-605. doi: 10.1007/s40268-017-0210-z.

8.

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice.

Wang Y, Marling SJ, Plum LA, DeLuca HF.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8528-8531. doi: 10.1073/pnas.1703995114. Epub 2017 Jul 24.

9.

Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.

Taban IM, Zhu J, DeLuca HF, Simons C.

Bioorg Med Chem. 2017 Aug 1;25(15):4076-4087. doi: 10.1016/j.bmc.2017.05.055. Epub 2017 May 29.

PMID:
28601511
10.

Design, synthesis and biological properties of seco-d-ring modified 1α,25-dihydroxyvitamin D3 analogues.

Szybinski M, Sektas K, Sicinski RR, Plum LA, Frelek J, DeLuca HF.

J Steroid Biochem Mol Biol. 2017 Jul;171:144-154. doi: 10.1016/j.jsbmb.2017.03.006. Epub 2017 Mar 8.

PMID:
28285018
11.

Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid.

Irving AA, Marling SJ, Plum LA, DeLuca HF.

BMC Neurosci. 2017 Jan 5;18(1):8. doi: 10.1186/s12868-016-0323-2.

12.

UVB radiation, vitamin D and multiple sclerosis.

DeLuca HF, Plum L.

Photochem Photobiol Sci. 2017 Mar 16;16(3):411-415. doi: 10.1039/c6pp00308g. Review.

PMID:
27910985
13.

2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial.

Thadhani R, Zella JB, Knutson DC, Blaser WJ, Plum LA, Clagett-Dame M, Buck RD, DeLuca HF.

Am J Nephrol. 2017;45(1):40-48. doi: 10.1159/000452680. Epub 2016 Nov 24.

PMID:
27880946
14.

D-seco-Vitamin D analogs having reversed configurations at C-13 and C-14: Synthesis, docking studies and biological evaluation.

Szybinski M, Sokolowska K, Sicinski RR, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2017 Oct;173:57-63. doi: 10.1016/j.jsbmb.2016.08.009. Epub 2016 Aug 26.

PMID:
27576086
15.

The association of mineral metabolism with vascular access patency.

Rosenberg JE, Astor BC, Deluca HF, Yevzlin AS.

J Vasc Access. 2016 Sep 21;17(5):392-396. doi: 10.5301/jva.5000584. Epub 2016 Jul 23.

PMID:
27470251
16.

The absence of 25-hydroxyvitamin D3-1α-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light.

Wang Y, Marling SJ, Martino VM, Prahl JM, Deluca HF.

J Steroid Biochem Mol Biol. 2016 Oct;163:98-102. doi: 10.1016/j.jsbmb.2016.04.010. Epub 2016 Apr 21.

PMID:
27108944
17.

Use of 2MD, a Novel Oral Calcitriol Analog, in Hemodialysis Patients with Secondary Hyperparathyroidism.

Pandey R, Zella J, Clagett-Dame M, Plum LA, DeLuca HF, Coyne DW.

Am J Nephrol. 2016;43(3):213-20. doi: 10.1159/000445756. Epub 2016 Apr 21.

PMID:
27096733
18.

Analogs of 1α,25-Dihydroxyvitamin D₃ in Clinical Use.

DeLuca HF, Plum LA.

Vitam Horm. 2016;100:151-64. doi: 10.1016/bs.vh.2015.11.002. Epub 2016 Jan 2. Review.

PMID:
26827952
19.

Vitamin D: Historical Overview.

DeLuca HF.

Vitam Horm. 2016;100:1-20. doi: 10.1016/bs.vh.2015.11.001. Epub 2015 Dec 19. Review.

PMID:
26827946
20.

A new suprasterol by photochemical reaction of 1α,25-dihydroxy-9-methylene-19-norvitamin D3.

Kulesza U, Plum LA, DeLuca HF, Mouriño A, Sicinski RR.

Org Biomol Chem. 2016 Feb 7;14(5):1646-52. doi: 10.1039/c5ob01896j.

PMID:
26693597
21.

A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.

Flores A, Massarelli I, Thoden JB, Plum LA, DeLuca HF.

J Med Chem. 2015 Dec 24;58(24):9731-41. doi: 10.1021/acs.jmedchem.5b01564. Epub 2015 Dec 9.

22.

Synthesis and Biological Activity of 2-Methylene Analogues of Calcitriol and Related Compounds.

Sibilska IK, Szybinski M, Sicinski RR, Plum LA, DeLuca HF.

J Med Chem. 2015 Dec 24;58(24):9653-62. doi: 10.1021/acs.jmedchem.5b01295. Epub 2015 Dec 2.

PMID:
26574921
23.

A novel, fully-automated, chemiluminescent assay for the detection of 1,25-dihydroxyvitamin D in biological samples.

Valcour A, Zierold C, Podgorski AL, Olson GT, Wall JV, DeLuca HF, Bonelli F.

J Steroid Biochem Mol Biol. 2016 Nov;164:120-126. doi: 10.1016/j.jsbmb.2015.08.005. Epub 2015 Aug 21.

24.

Novel 9-Alkyl- and 9-Alkylidene-Substituted 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological Examinations.

Kulesza U, Plum LA, DeLuca HF, Mouriño A, Sicinski RR.

J Med Chem. 2015 Aug 13;58(15):6237-47. doi: 10.1021/acs.jmedchem.5b00795. Epub 2015 Aug 5.

PMID:
26206427
25.

1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components.

Lee SM, Riley EM, Meyer MB, Benkusky NA, Plum LA, DeLuca HF, Pike JW.

J Biol Chem. 2015 Jul 17;290(29):18199-215. doi: 10.1074/jbc.M115.665794. Epub 2015 Jun 3.

26.

Vitamin D deficiency independent of hypocalcemia elevates blood pressure in rats.

Sundersingh F, Plum LA, DeLuca HF.

Biochem Biophys Res Commun. 2015 Jun 12;461(4):589-91. doi: 10.1016/j.bbrc.2015.04.069. Epub 2015 Apr 21.

PMID:
25911319
27.

Cholecalciferol or 25-hydroxycholecalciferol neither prevents nor treats adenomas in a rat model of familial colon cancer.

Irving AA, Plum LA, Blaser WJ, Ford MR, Weng C, Clipson L, DeLuca HF, Dove WF.

J Nutr. 2015 Feb;145(2):291-8. doi: 10.3945/jn.114.204396. Epub 2014 Dec 24.

28.

UV light selectively inhibits spinal cord inflammation and demyelination in experimental autoimmune encephalomyelitis.

Wang Y, Marling SJ, Beaver EF, Severson KS, Deluca HF.

Arch Biochem Biophys. 2015 Feb 1;567:75-82. doi: 10.1016/j.abb.2014.12.017. Epub 2014 Dec 23.

PMID:
25541149
29.

The vitamin D receptor in the proximal renal tubule is a key regulator of serum 1α,25-dihydroxyvitamin D₃.

Wang Y, Zhu J, DeLuca HF.

Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E201-5. doi: 10.1152/ajpendo.00422.2014. Epub 2014 Nov 25.

30.

Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation.

Ferla S, Gomaa MS, Brancale A, Zhu J, Ochalek JT, DeLuca HF, Simons C.

Eur J Med Chem. 2014 Nov 24;87:39-51. doi: 10.1016/j.ejmech.2014.09.035. Epub 2014 Sep 16.

PMID:
25240094
31.

Synthesis and Biological Activity of 25-Hydroxy-2-methylene-vitamin D3 analogues monohydroxylated in the A-ring.

Sibilska IK, Sicinski RR, Ochalek JT, Plum LA, DeLuca HF.

J Med Chem. 2014 Oct 23;57(20):8319-31. doi: 10.1021/jm500750b. Epub 2014 Oct 2.

PMID:
25221942
32.

Is there more to learn about functional vitamin D metabolism?

DeLuca HF.

J Steroid Biochem Mol Biol. 2015 Apr;148:3-6. doi: 10.1016/j.jsbmb.2014.08.020. Epub 2014 Sep 4.

PMID:
25194637
33.

Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation.

Ferla S, Aboraia AS, Brancale A, Pepper CJ, Zhu J, Ochalek JT, DeLuca HF, Simons C.

J Med Chem. 2014 Sep 25;57(18):7702-15. doi: 10.1021/jm5009314. Epub 2014 Sep 8.

PMID:
25148392
34.

Novel, selective vitamin D analog suppresses parathyroid hormone in uremic animals and postmenopausal women.

Zella JB, Plum LA, Plowchalk DR, Potochoiba M, Clagett-Dame M, DeLuca HF.

Am J Nephrol. 2014;39(6):476-83. doi: 10.1159/000362846. Epub 2014 May 17.

35.

The development of a bone- and parathyroid-specific analog of vitamin D: 2-methylene-19-Nor-(20S)-1α,25-dihydroxyvitamin D3.

Deluca HF.

Bonekey Rep. 2014 Mar 5;3:514. doi: 10.1038/bonekey.2014.9. eCollection 2014. Review.

36.

Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD.

Kaufmann M, Gallagher JC, Peacock M, Schlingmann KP, Konrad M, DeLuca HF, Sigueiro R, Lopez B, Mourino A, Maestro M, St-Arnaud R, Finkelstein JS, Cooper DP, Jones G.

J Clin Endocrinol Metab. 2014 Jul;99(7):2567-74. doi: 10.1210/jc.2013-4388. Epub 2014 Mar 26.

37.

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine.

Chiellini G, Grzywacz P, Plum LA, Clagett-Dame M, DeLuca HF.

Steroids. 2014 May;83:27-38. doi: 10.1016/j.steroids.2014.01.012. Epub 2014 Feb 7.

38.

History of the discovery of vitamin D and its active metabolites.

Deluca HF.

Bonekey Rep. 2014 Jan 8;3:479. doi: 10.1038/bonekey.2013.213. eCollection 2014 Jan 8. Review.

39.

Triennial Growth Symposium--Vitamin D: bones and beyond.

DeLuca HF.

J Anim Sci. 2014 Mar;92(3):917-29. doi: 10.2527/jas.2013-7237. Epub 2013 Dec 20. Review.

PMID:
24363329
40.

Identification of the vitamin D receptor in osteoblasts and chondrocytes but not osteoclasts in mouse bone.

Wang Y, Zhu J, DeLuca HF.

J Bone Miner Res. 2014 Mar;29(3):685-92. doi: 10.1002/jbmr.2081.

41.

CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo.

Zhu JG, Ochalek JT, Kaufmann M, Jones G, Deluca HF.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15650-5. doi: 10.1073/pnas.1315006110. Epub 2013 Sep 9.

42.

Suppression of experimental autoimmune encephalomyelitis by 300-315nm ultraviolet light.

Wang Y, Marling SJ, McKnight SM, Danielson AL, Severson KS, Deluca HF.

Arch Biochem Biophys. 2013 Aug 1;536(1):81-6. doi: 10.1016/j.abb.2013.05.010. Epub 2013 Jun 5.

PMID:
23747577
43.

Safety assessment of the post-harvest treatment of button mushrooms (Agaricus bisporus) using ultraviolet light.

Simon RR, Borzelleca JF, DeLuca HF, Weaver CM.

Food Chem Toxicol. 2013 Jun;56:278-89. doi: 10.1016/j.fct.2013.02.009. Epub 2013 Feb 26. Review.

PMID:
23485617
44.

26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo.

Grzywacz P, Plum LA, Clagett-Dame M, DeLuca HF.

Bioorg Chem. 2013 Apr;47:9-16. doi: 10.1016/j.bioorg.2013.01.001. Epub 2013 Feb 9.

45.

Highly potent 2-methylene analogs of 1α,25-dihydroxyvitamin D3: synthesis and biological evaluation.

Sibilska IK, Szybinski M, Sicinski RR, Plum LA, Deluca HF.

J Steroid Biochem Mol Biol. 2013 Jul;136:9-13. doi: 10.1016/j.jsbmb.2013.02.001. Epub 2013 Feb 11. Review.

PMID:
23410597
46.

Synthesis and biological activity of 25-hydroxy-2-methylene-vitamin D3 compounds.

Sibilska I, Sicinski RR, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2013 Jul;136:17-22. doi: 10.1016/j.jsbmb.2012.12.012. Epub 2012 Dec 27. Review.

PMID:
23274116
47.

Synthesis of novel 19-norvitamin D3 analogs with unnatural triene system.

Kulesza U, Mouriño A, Plum LA, Deluca HF, Sicinski RR.

J Steroid Biochem Mol Biol. 2013 Jul;136:23-6. doi: 10.1016/j.jsbmb.2012.12.008. Epub 2012 Dec 25. Review.

PMID:
23270753
48.

Synthesis and biological evaluation of novel 6-substituted analogs of 1α,25-dihydroxy-19-norvitamin D3.

Sokolowska K, Sicinski RR, Mouriño A, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2013 Jul;136:30-3. doi: 10.1016/j.jsbmb.2012.10.016. Epub 2012 Oct 30. Review.

PMID:
23116698
49.

Ring-A-seco analogs of 1α,25-dihydroxy-19-norvitamin D3.

Glebocka A, Sicinski RR, Plum LA, Deluca HF.

J Steroid Biochem Mol Biol. 2013 Jul;136:39-43. doi: 10.1016/j.jsbmb.2012.09.030. Epub 2012 Oct 9. Review.

50.

Efficient stable isotope labeling and purification of vitamin D receptor from inclusion bodies.

Zhu J, Rao H, Tonelli M, Westler WM, Singarapu KK, Markley JL, DeLuca HF, Assadi-Porter FM.

Protein Expr Purif. 2012 Sep;85(1):25-31. doi: 10.1016/j.pep.2012.06.012. Epub 2012 Jun 29.

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