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Items: 1 to 50 of 208

1.

Hypothermia Reduces Mortality, Prevents the Calcium Plateau, and Is Neuroprotective Following Status Epilepticus in Rats.

Phillips KF, Deshpande LS, DeLorenzo RJ.

Front Neurol. 2018 Jun 11;9:438. doi: 10.3389/fneur.2018.00438. eCollection 2018.

2.

Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication.

Deshpande LS, Blair RE, Phillips KF, DeLorenzo RJ.

Ann N Y Acad Sci. 2016 Jun;1374(1):176-83. doi: 10.1111/nyas.13122. Epub 2016 Jun 21. Review.

3.

Pharmacological blockade of the calcium plateau provides neuroprotection following organophosphate paraoxon induced status epilepticus in rats.

Deshpande LS, Blair RE, Huang BA, Phillips KF, DeLorenzo RJ.

Neurotoxicol Teratol. 2016 Jul-Aug;56:81-86. doi: 10.1016/j.ntt.2016.05.002. Epub 2016 May 17.

4.

Cannabinoids: is there a potential treatment role in epilepsy?

Blair RE, Deshpande LS, DeLorenzo RJ.

Expert Opin Pharmacother. 2015;16(13):1911-4. Epub 2015 Aug 3.

5.

Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity.

Deshpande LS, Phillips K, Huang B, DeLorenzo RJ.

Neurotoxicology. 2014 Sep;44:352-7. doi: 10.1016/j.neuro.2014.08.008. Epub 2014 Aug 27.

6.

Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.

Deshpande LS, Carter DS, Phillips KF, Blair RE, DeLorenzo RJ.

Neurotoxicology. 2014 Sep;44:17-26. doi: 10.1016/j.neuro.2014.04.006. Epub 2014 Apr 29.

7.

Mechanisms of levetiracetam in the control of status epilepticus and epilepsy.

Deshpande LS, Delorenzo RJ.

Front Neurol. 2014 Jan 31;5:11. doi: 10.3389/fneur.2014.00011. eCollection 2014. Review.

8.

Hypothermia reduces calcium entry via the N-methyl-D-aspartate and ryanodine receptors in cultured hippocampal neurons.

Phillips KF, Deshpande LS, DeLorenzo RJ.

Eur J Pharmacol. 2013 Jan 5;698(1-3):186-92. doi: 10.1016/j.ejphar.2012.10.010. Epub 2012 Oct 17.

9.

Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

Sayers KW, Nguyen PT, Blair RE, Sim-Selley LJ, DeLorenzo RJ.

Epilepsia. 2012 May;53(5):897-907. doi: 10.1111/j.1528-1167.2012.03460.x. Epub 2012 Apr 17.

10.

Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons.

Deshpande LS, Blair RE, DeLorenzo RJ.

Exp Neurol. 2011 Jun;229(2):264-73. doi: 10.1016/j.expneurol.2011.02.007. Epub 2011 Feb 12.

11.

Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals.

Carter DS, Deshpande LS, Rafiq A, Sombati S, DeLorenzo RJ.

Seizure. 2011 Apr;20(3):218-24. doi: 10.1016/j.seizure.2010.11.022. Epub 2010 Dec 18.

12.

An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

Ziobro JM, Deshpande LS, Delorenzo RJ.

Brain Res. 2011 Jan 31;1371:110-20. doi: 10.1016/j.brainres.2010.11.065. Epub 2010 Nov 25.

13.

Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.

Deshpande LS, DeLorenzo RJ.

Neuroreport. 2011 Jan 5;22(1):15-8. doi: 10.1097/WNR.0b013e3283413231.

14.

Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus.

Nagarkatti N, Deshpande LS, Carter DS, DeLorenzo RJ.

Eur J Neurosci. 2010 Jul;32(1):80-8. doi: 10.1111/j.1460-9568.2010.07262.x. Epub 2010 Jun 28.

15.

Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.

Deshpande LS, Carter DS, Blair RE, DeLorenzo RJ.

Toxicol Sci. 2010 Aug;116(2):623-31. doi: 10.1093/toxsci/kfq157. Epub 2010 May 23.

16.

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.

Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ.

Neuropharmacology. 2009 Sep;57(3):208-18. doi: 10.1016/j.neuropharm.2009.06.007. Epub 2009 Jun 18.

17.

Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis.

Nagarkatti N, Deshpande LS, DeLorenzo RJ.

Expert Rev Neurother. 2009 Jun;9(6):813-24. doi: 10.1586/ern.09.21. Review.

18.

Age-dependent mortality in the pilocarpine model of status epilepticus.

Blair RE, Deshpande LS, Holbert WH 2nd, Churn SB, DeLorenzo RJ.

Neurosci Lett. 2009 Apr 10;453(3):233-7. doi: 10.1016/j.neulet.2009.02.035. Epub 2009 Feb 21.

19.

Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus.

Falenski KW, Carter DS, Harrison AJ, Martin BR, Blair RE, DeLorenzo RJ.

Brain Res. 2009 Mar 25;1262:64-72. doi: 10.1016/j.brainres.2009.01.036. Epub 2009 Jan 31.

20.

Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia.

DeLorenzo RJ, Kirmani B, Deshpande LS, Jakkampudi V, Towne AR, Waterhouse E, Garnett L, Ramakrishnan V.

Seizure. 2009 Jul;18(6):405-11. doi: 10.1016/j.seizure.2009.02.005. Epub 2009 Mar 25.

21.

Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury.

Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, DeLorenzo RJ.

Neurosci Lett. 2008 Aug 15;441(1):115-9. doi: 10.1016/j.neulet.2008.05.113. Epub 2008 Jun 7.

22.
23.

Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons.

Deshpande LS, Nagarkatti N, Ziobro JM, Sombati S, DeLorenzo RJ.

Epilepsia. 2008 Oct;49(10):1795-802. doi: 10.1111/j.1528-1167.2008.01667.x. Epub 2008 May 20.

24.

Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture.

Nagarkatti N, Deshpande LS, DeLorenzo RJ.

Neurosci Lett. 2008 May 16;436(3):289-93. doi: 10.1016/j.neulet.2008.02.076. Epub 2008 Mar 21.

25.

Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus.

Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ.

Epilepsy Res. 2008 May;79(2-3):213-23. doi: 10.1016/j.eplepsyres.2008.02.006. Epub 2008 Apr 3.

26.

Traumatic brain injury causes a long-lasting calcium (Ca2+)-plateau of elevated intracellular Ca levels and altered Ca2+ homeostatic mechanisms in hippocampal neurons surviving brain injury.

Sun DA, Deshpande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, DeLorenzo RJ.

Eur J Neurosci. 2008 Apr;27(7):1659-72. doi: 10.1111/j.1460-9568.2008.06156.x. Epub 2008 Mar 25.

27.

The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.

Deshpande LS, Nagarkatti N, Sombati S, DeLorenzo RJ.

Epilepsy Res. 2008 May;79(2-3):158-65. doi: 10.1016/j.eplepsyres.2008.01.002. Epub 2008 Mar 18.

28.

Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry.

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, DeLorenzo RJ.

Eur J Pharmacol. 2008 Mar 31;583(1):73-83. doi: 10.1016/j.ejphar.2008.01.025. Epub 2008 Feb 5.

29.

In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons.

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, DeLorenzo RJ.

Epilepsy Res. 2007 Jul;75(2-3):171-9.

30.
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32.

Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy.

Falenski KW, Blair RE, Sim-Selley LJ, Martin BR, DeLorenzo RJ.

Neuroscience. 2007 May 25;146(3):1232-44. Epub 2007 Apr 12.

33.

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons.

Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, DeLorenzo RJ.

Neurosci Lett. 2007 May 11;418(1):77-81. Epub 2007 Mar 12.

34.

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.

Deshpande LS, Blair RE, Nagarkatti N, Sombati S, Martin BR, DeLorenzo RJ.

Exp Neurol. 2007 Apr;204(2):705-13. Epub 2007 Jan 9.

35.

Endocannabinoids block status epilepticus in cultured hippocampal neurons.

Deshpande LS, Blair RE, Ziobro JM, Sombati S, Martin BR, DeLorenzo RJ.

Eur J Pharmacol. 2007 Mar 8;558(1-3):52-9. Epub 2006 Nov 22.

36.

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.

Deshpande LS, Sombati S, Blair RE, Carter DS, Martin BR, DeLorenzo RJ.

Neurosci Lett. 2007 Jan 3;411(1):11-6. Epub 2006 Nov 15.

37.

Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture.

Carter DS, Haider SN, Blair RE, Deshpande LS, Sombati S, DeLorenzo RJ.

J Pharmacol Exp Ther. 2006 Dec;319(3):1021-31. Epub 2006 Sep 13.

39.

Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus.

Blair RE, Deshpande LS, Sombati S, Falenski KW, Martin BR, DeLorenzo RJ.

J Pharmacol Exp Ther. 2006 Jun;317(3):1072-8. Epub 2006 Feb 9.

40.

Basic research in epilepsy and aging.

Leppik IE, Kelly KM, deToledo-Morrell L, Patrylo PR, DeLorenzo RJ, Mathern GW, White HS.

Epilepsy Res. 2006 Jan;68 Suppl 1:S21-37. Epub 2005 Dec 27. Review.

PMID:
16384687
41.

Epidemiology and clinical presentation of status epilepticus.

DeLorenzo RJ.

Adv Neurol. 2006;97:199-215. No abstract available.

PMID:
16383129
42.

Basic mechanisms in status epilepticus: role of calcium in neuronal injury and the induction of epileptogenesis.

DeLorenzo RJ, Sun DA.

Adv Neurol. 2006;97:187-97. Review. No abstract available.

PMID:
16383128
43.

Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintainance of epilepsy.

Delorenzo RJ, Sun DA, Deshpande LS.

Pharmacol Ther. 2005 Mar;105(3):229-66. Epub 2004 Dec 9. Review. Corrected and republished in: Pharmacol Ther. 2006 Jul;111(1):288-325. Erratum in: Pharmacol Ther. 2006 Jul;111(1):287.

44.

Estimating the economic burden of status epilepticus to the health care system.

Penberthy LT, Towne A, Garnett LK, Perlin JB, DeLorenzo RJ.

Seizure. 2005 Jan;14(1):46-51.

45.

Evidence that injury-induced changes in hippocampal neuronal calcium dynamics during epileptogenesis cause acquired epilepsy.

Raza M, Blair RE, Sombati S, Carter DS, Deshpande LS, DeLorenzo RJ.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17522-7. Epub 2004 Dec 6.

46.
47.
48.

Inhibition of sustained repetitive firing in cultured hippocampal neurons by an aqueous fraction isolated from Delphinium denudatum.

Raza M, Shaheen F, Choudhary MI, Sombati S, Rahman AU, DeLorenzo RJ.

J Ethnopharmacol. 2004 Feb;90(2-3):367-74.

PMID:
15013203
49.

Status epilepticus in a population-based Virginia twin sample.

Corey LA, Pellock JM, DeLorenzo RJ.

Epilepsia. 2004 Feb;45(2):159-65.

50.

Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy.

Sun DA, Sombati S, Blair RE, DeLorenzo RJ.

Cell Calcium. 2004 Feb;35(2):155-63.

PMID:
14706289

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