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Items: 1 to 50 of 163

1.

A natural killer T-cell subset that protects against airway hyperreactivity.

Chuang YT, Leung K, Chang YJ, DeKruyff RH, Savage PB, Cruse R, Benoit C, Elewaut D, Baumgarth N, Umetsu DT.

J Allergy Clin Immunol. 2018 May 29. pii: S0091-6749(18)30769-3. doi: 10.1016/j.jaci.2018.03.022. [Epub ahead of print]

PMID:
29852257
2.

Combining anti-IgE with oral immunotherapy.

Lin C, Lee IT, Sampath V, Dinakar C, DeKruyff RH, Schneider LC, Nadeau KC.

Pediatr Allergy Immunol. 2017 Nov;28(7):619-627. doi: 10.1111/pai.12767. Epub 2017 Sep 7. Review.

PMID:
28782296
3.

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry.

Morales-Kastresana A, Telford B, Musich TA, McKinnon K, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, Freeman GJ, DeKruyff RH, Pavlakis GN, Terabe M, Robert-Guroff M, Berzofsky JA, Jones JC.

Sci Rep. 2017 May 12;7(1):1878. doi: 10.1038/s41598-017-01731-2.

4.

Epigenetic Changes During Food-Specific Immunotherapy.

Bunning BJ, DeKruyff RH, Nadeau KC.

Curr Allergy Asthma Rep. 2016 Nov;16(12):87. Review.

PMID:
27943047
5.

Innate lymphoid cells in asthma: Will they take your breath away?

Kim HY, Umetsu DT, Dekruyff RH.

Eur J Immunol. 2016 Apr;46(4):795-806. doi: 10.1002/eji.201444557. Epub 2016 Mar 16. Review.

6.

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.

Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum JL, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):456-65. doi: 10.1161/ATVBAHA.115.306860. Epub 2016 Jan 28.

7.

Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse.

Echbarthi M, Zonca M, Mellwig R, Schwab Y, Kaplan G, DeKruyff RH, Roda-Navarro P, Casasnovas JM.

Traffic. 2015 Nov;16(11):1193-207. doi: 10.1111/tra.12329. Epub 2015 Sep 25.

8.

Innate immunity in the lung regulates the development of asthma.

DeKruyff RH, Yu S, Kim HY, Umetsu DT.

Immunol Rev. 2014 Jul;260(1):235-48. doi: 10.1111/imr.12187. Review.

PMID:
24942693
9.

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.

Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, DeKruyff RH, Freeman GJ.

J Exp Med. 2014 May 5;211(5):943-59. doi: 10.1084/jem.20130790. Epub 2014 Apr 21.

10.

Innate lymphoid cells and asthma.

Yu S, Kim HY, Chang YJ, DeKruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2014 Apr;133(4):943-50; quiz 51. doi: 10.1016/j.jaci.2014.02.015. Review.

PMID:
24679467
11.

Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.

Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT.

Nat Med. 2014 Jan;20(1):54-61. doi: 10.1038/nm.3423. Epub 2013 Dec 15.

12.

Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity.

Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT.

Nat Med. 2013 Oct;19(10):1297-304. doi: 10.1038/nm.3321. Epub 2013 Sep 1.

13.

The role of type 2 innate lymphoid cells in asthma.

Chang YJ, DeKruyff RH, Umetsu DT.

J Leukoc Biol. 2013 Nov;94(5):933-40. doi: 10.1189/jlb.0313127. Epub 2013 Jun 25. Review.

PMID:
23801654
14.

T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death.

Kim HY, Chang YJ, Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2013 Aug;132(2):414-25.e6. doi: 10.1016/j.jaci.2013.03.025. Epub 2013 May 11.

15.

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, Dekruyff RH, Choe H.

PLoS Pathog. 2013 Mar;9(3):e1003232. doi: 10.1371/journal.ppat.1003232. Epub 2013 Mar 28.

16.

TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells.

Albacker LA, Yu S, Bedoret D, Lee WL, Umetsu SE, Monahan S, Freeman GJ, Umetsu DT, DeKruyff RH.

Mucosal Immunol. 2013 May;6(3):580-90. doi: 10.1038/mi.2012.100. Epub 2012 Nov 14.

17.

Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans.

Manangeeswaran M, Jacques J, Tami C, Konduru K, Amharref N, Perrella O, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ, Perrella A, Kaplan GG.

Gastroenterology. 2012 Jun;142(7):1516-25.e3. doi: 10.1053/j.gastro.2012.02.039. Epub 2012 Mar 16.

18.

Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab.

Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, Schneider LC, Nadeau KC, Umetsu DT.

Mucosal Immunol. 2012 May;5(3):267-76. doi: 10.1038/mi.2012.5. Epub 2012 Feb 8.

19.

Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy.

Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT.

Immunol Allergy Clin North Am. 2012 Feb;32(1):111-33. doi: 10.1016/j.iac.2011.11.004. Review.

PMID:
22244236
20.

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2012 Jan;129(1):216-27.e1-6. doi: 10.1016/j.jaci.2011.10.036. Epub 2011 Nov 25.

21.

Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.

Elpek KG, Bellemare-Pelletier A, Malhotra D, Reynoso ED, Lukacs-Kornek V, DeKruyff RH, Turley SJ.

PLoS One. 2011;6(8):e23921. doi: 10.1371/journal.pone.0023921. Epub 2011 Aug 19.

22.

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, Dekruyff RH, Umetsu DT.

Nat Immunol. 2011 May 29;12(7):631-8. doi: 10.1038/ni.2045.

23.

Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.

Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, DeKruyff RH, Kuchroo VK.

Eur J Immunol. 2011 Jun;41(6):1539-49. doi: 10.1002/eji.201040993. Epub 2011 May 25.

24.

A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.

Kim HY, Eyheramonho MB, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, Kuperman S, Moreiro R, Konduru K, Manangeeswaran M, Freeman GJ, Kaplan GG, DeKruyff RH, Umetsu DT, Rosenzweig SD.

J Clin Invest. 2011 Mar;121(3):1111-8. doi: 10.1172/JCI44182. Epub 2011 Feb 21.

25.

Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.

Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, Appelmelk B, Franck RW, Chen G, DeKruyff RH, Shimamura M, Illarionov P, Umetsu DT.

J Clin Invest. 2011 Jan;121(1):57-69. doi: 10.1172/JCI44845. Epub 2010 Dec 13.

26.

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.

Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH.

J Immunol. 2010 Dec 1;185(11):6839-49. doi: 10.4049/jimmunol.1001360. Epub 2010 Oct 29.

27.

Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.

Lee HH, Meyer EH, Goya S, Pichavant M, Kim HY, Bu X, Umetsu SE, Jones JC, Savage PB, Iwakura Y, Casasnovas JM, Kaplan G, Freeman GJ, DeKruyff RH, Umetsu DT.

J Immunol. 2010 Nov 1;185(9):5225-35. doi: 10.4049/jimmunol.1001116. Epub 2010 Oct 1.

28.

The many paths to asthma: phenotype shaped by innate and adaptive immunity.

Kim HY, DeKruyff RH, Umetsu DT.

Nat Immunol. 2010 Jul;11(7):577-84. doi: 10.1038/ni.1892. Epub 2010 Jun 18. Review.

29.

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.

Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH.

Immunol Rev. 2010 May;235(1):172-89. doi: 10.1111/j.0105-2896.2010.00903.x. Review.

30.

Natural killer T cells regulate the development of asthma.

Pichavant M, Matangkasombut P, Dekruyff RH, Umetsu DT.

Expert Rev Clin Immunol. 2009 May;5(3):251-60. doi: 10.1586/eci.09.7.

PMID:
20477003
31.

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: microbes, apoptosis and TIM-1 in the development of asthma.

Umetsu DT, Dekruyff RH.

Clin Exp Immunol. 2010 Apr;160(1):125-9. doi: 10.1111/j.1365-2249.2010.04136.x.

32.

Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma.

Umetsu DT, Dekruyff RH.

J Allergy Clin Immunol. 2010 May;125(5):975-9. doi: 10.1016/j.jaci.2010.02.006. Epub 2010 Mar 24. Review.

33.

T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.

DeKruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, Karisola P, Pichavant M, Kaplan GG, Umetsu DT, Freeman GJ, Casasnovas JM.

J Immunol. 2010 Feb 15;184(4):1918-30. doi: 10.4049/jimmunol.0903059. Epub 2010 Jan 18.

34.

The regulatory role of natural killer T cells in the airways.

Umetsu DT, Dekruyff RH.

Int J Biochem Cell Biol. 2010 Apr;42(4):529-34. doi: 10.1016/j.biocel.2009.10.022. Epub 2009 Nov 6. Review.

PMID:
19897049
35.

PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions.

Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, Dekruyff RH.

Mucosal Immunol. 2010 Jan;3(1):81-91. doi: 10.1038/mi.2009.112. Epub 2009 Sep 9.

36.

Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice.

Iweala OI, Smith DW, Matharu KS, Sada-Ovalle I, Nguyen DD, Dekruyff RH, Umetsu DT, Behar SM, Nagler CR.

J Immunol. 2009 Aug 15;183(4):2252-60. doi: 10.4049/jimmunol.0804011. Epub 2009 Jul 20.

37.

Natural killer T cells and the regulation of asthma.

Matangkasombut P, Pichavant M, Dekruyff RH, Umetsu DT.

Mucosal Immunol. 2009 Sep;2(5):383-92. doi: 10.1038/mi.2009.96. Epub 2009 Jul 8. Review.

PMID:
19587638
38.

Natural killer T cells in the lungs of patients with asthma.

Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, Yasumi T, Wilson SB, DeKruyff RH, Faul JL, Israel E, Akbari O, Umetsu DT.

J Allergy Clin Immunol. 2009 May;123(5):1181-5. doi: 10.1016/j.jaci.2009.02.013. Epub 2009 Apr 8. No abstract available.

39.

The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells.

Kim HY, Pichavant M, Matangkasombut P, Koh YI, Savage PB, DeKruyff RH, Umetsu DT.

J Immunol. 2009 Mar 1;182(5):3252-61. doi: 10.4049/jimmunol.0803339.

40.

Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.

Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB.

J Immunol. 2009 Feb 1;182(3):1379-85.

41.

Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice.

Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, DeKruyff RH, Umetsu DT.

J Immunol. 2008 Oct 1;181(7):4560-4569.

42.

TIM gene family and their role in atopic diseases.

Umetsu DT, Umetsu SE, Freeman GJ, DeKruyff RH.

Curr Top Microbiol Immunol. 2008;321:201-15. Review.

PMID:
18727494
43.

T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.

de Souza AJ, Oak JS, Jordanhazy R, DeKruyff RH, Fruman DA, Kane LP.

J Immunol. 2008 May 15;180(10):6518-26.

44.

ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.

Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH.

J Immunol. 2008 Apr 15;180(8):5448-56.

45.

Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates.

Matangkasombut P, Pichavant M, Yasumi T, Hendricks C, Savage PB, Dekruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2008 May;121(5):1287-9. doi: 10.1016/j.jaci.2008.02.006. Epub 2008 Mar 19. No abstract available.

46.

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.

Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, DeKruyff RH, Shore SA, Umetsu DT.

J Exp Med. 2008 Feb 18;205(2):385-93. doi: 10.1084/jem.20071507. Epub 2008 Feb 4.

47.

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.

Immunity. 2007 Dec;27(6):927-40.

48.

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB.

J Clin Invest. 2008 Feb;118(2):735-41.

49.

T cells and NKT cells in the pathogenesis of asthma.

Meyer EH, DeKruyff RH, Umetsu DT.

Annu Rev Med. 2008;59:281-92. Review.

PMID:
17937589
50.

iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.

Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT.

J Immunol. 2007 Oct 1;179(7):4661-71.

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