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Items: 1 to 20 of 131

1.

Molecular biology and evolution of cancer: from discovery to action.

Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP.

Mol Biol Evol. 2019 Oct 23. pii: msz242. doi: 10.1093/molbev/msz242. [Epub ahead of print]

PMID:
31642480
2.

Somatic maintenance impacts the evolution of mutation rate.

Rozhok A, DeGregori J.

BMC Evol Biol. 2019 Aug 23;19(1):172. doi: 10.1186/s12862-019-1496-y.

3.

Studying Cancer Evolution and Therapeutic Responses in Different Organs: The Pros and Cons of a Broad Focus.

Pham-Danis C, DeGregori J.

Cancer Res. 2019 Sep 15;79(18):4582-4584. doi: 10.1158/0008-5472.CAN-19-1303. Epub 2019 Aug 22.

PMID:
31439547
4.

FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue.

Liggett LA, Sharma A, De S, DeGregori J.

G3 (Bethesda). 2019 Sep 4;9(9):2977-2987. doi: 10.1534/g3.119.400438.

5.

Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O'Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A.

J Natl Cancer Inst. 2019 Dec 1;111(12):1245-1254. doi: 10.1093/jnci/djz136.

PMID:
31321426
6.

TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging.

Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J.

Blood. 2019 Aug 29;134(9):727-740. doi: 10.1182/blood.2019000200. Epub 2019 Jul 16.

7.

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II.

Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT.

Blood. 2019 Jul 25;134(4):389-394. doi: 10.1182/blood.2019898114. Epub 2019 May 17.

PMID:
31101624
8.

A generalized theory of age-dependent carcinogenesis.

Rozhok A, DeGregori J.

Elife. 2019 Apr 29;8. pii: e39950. doi: 10.7554/eLife.39950.

9.

Elimination of unfit cells in young and ageing skin.

Bilousova G, DeGregori J.

Nature. 2019 Apr;568(7752):318-319. doi: 10.1038/d41586-019-00825-3. No abstract available.

PMID:
30980033
10.

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.

Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J.

Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. doi: 10.1158/1078-0432.CCR-18-3223. Epub 2019 Apr 2.

PMID:
30940653
11.

Decoy fitness peaks, tumor suppression, and aging.

Higa KC, DeGregori J.

Aging Cell. 2019 Jun;18(3):e12938. doi: 10.1111/acel.12938. Epub 2019 Mar 8.

12.

Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC.

Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D, Collins C, Paola JTD, D'Alessandro A, DeGregori J.

Mol Cancer Res. 2019 Jun;17(6):1351-1364. doi: 10.1158/1541-7786.MCR-18-1068. Epub 2019 Feb 26.

PMID:
30808730
13.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2019 Feb 11;35(2):333-335. doi: 10.1016/j.ccell.2019.01.013. No abstract available.

14.

SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.

Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL.

Cancer Res. 2019 Feb 15;79(4):720-734. doi: 10.1158/0008-5472.CAN-18-1791. Epub 2019 Jan 3.

PMID:
30606720
15.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005. Erratum in: Cancer Cell. 2019 Feb 11;35(2):333-335.

16.

Adenoviral vectors transduce alveolar macrophages in lung cancer models.

Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP.

Oncoimmunology. 2018 Mar 6;7(6):e1438105. doi: 10.1080/2162402X.2018.1438105. eCollection 2018.

17.

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.

Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC.

Oncotarget. 2018 Jan 16;9(10):8823-8835. doi: 10.18632/oncotarget.24260. eCollection 2018 Feb 6.

18.

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J.

Exp Hematol. 2018 Feb;58:52-58. doi: 10.1016/j.exphem.2017.09.007. Epub 2017 Sep 22.

19.

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.

Henry CJ, Nemkov T, Casás-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J.

Haematologica. 2017 Dec;102(12):1985-1994. doi: 10.3324/haematol.2017.171074. Epub 2017 Sep 7.

20.

Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments.

DeGregori J.

Cancer Res. 2017 Nov 15;77(22):6065-6068. doi: 10.1158/0008-5472.CAN-17-1207. Epub 2017 Jul 28.

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