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CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation.

Miller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DD.

J Biol Chem. 2015 Oct 9;290(41):24858-74. doi: 10.1074/jbc.M115.665752. Epub 2015 Aug 26.


NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.

Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA.

Cancer Res. 2015 Jul 15;75(14):2788-99. doi: 10.1158/0008-5472.CAN-14-3011. Epub 2015 May 19.


Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.

Leiker AJ, DeGraff W, Choudhuri R, Sowers AL, Thetford A, Cook JA, Van Waes C, Mitchell JB.

Clin Cancer Res. 2015 Jun 15;21(12):2792-801. doi: 10.1158/1078-0432.CCR-14-3279. Epub 2015 Feb 27.


CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.

Soto-Pantoja DR, Terabe M, Ghosh A, Ridnour LA, DeGraff WG, Wink DA, Berzofsky JA, Roberts DD.

Cancer Res. 2014 Dec 1;74(23):6771-83. doi: 10.1158/0008-5472.CAN-14-0037-T. Epub 2014 Oct 8.


Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC.

PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014.


Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma.

Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM.

Oncotarget. 2012 Nov;3(11):1472-82.


CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.

Soto-Pantoja DR, Miller TW, Pendrak ML, DeGraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD.

Autophagy. 2012 Nov;8(11):1628-42. doi: 10.4161/auto.21562. Epub 2012 Aug 9.


The effects of resveratrol and selected metabolites on the radiation and antioxidant response.

Fabre KM, Saito K, DeGraff W, Sowers AL, Thetford A, Cook JA, Krishna MC, Mitchell JB.

Cancer Biol Ther. 2011 Nov 15;12(10):915-23. doi: 10.4161/cbt.12.10.17714. Epub 2011 Nov 15.


Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.

Saleh AD, Savage JE, Cao L, Soule BP, Ly D, DeGraff W, Harris CC, Mitchell JB, Simone NL.

PLoS One. 2011;6(10):e24429. doi: 10.1371/journal.pone.0024429. Epub 2011 Oct 11. Erratum in: PLoS One. 2012;7(4): doi/10.1371/annotation/5c1dd48c-38e4-41ed-b827-748f62e28365. PLoS One. 2012;7(4): doi/10.1371/annotation/9b0f3eff-0376-43ca-b357-adfd8fc9ac7a.


A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

Davis RM, Sowers AL, DeGraff W, Bernardo M, Thetford A, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2011 Aug 1;51(3):780-90. doi: 10.1016/j.freeradbiomed.2011.05.019. Epub 2011 May 25.


Guggulsterone-mediated enhancement of radiosensitivity in human tumor cell lines.

Choudhuri R, Degraff W, Gamson J, Mitchell JB, Cook JA.

Front Oncol. 2011 Jul 21;1:19. doi: 10.3389/fonc.2011.00019. eCollection 2011.


Inhibition of adipogenesis by Tempol in 3T3-L1 cells.

Samuni Y, Cook JA, Choudhuri R, Degraff W, Sowers AL, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2010 Aug 15;49(4):667-73. doi: 10.1016/j.freeradbiomed.2010.05.028. Epub 2010 Jun 16.


Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling.

Maxhimer JB, Soto-Pantoja DR, Ridnour LA, Shih HB, Degraff WG, Tsokos M, Wink DA, Isenberg JS, Roberts DD.

Sci Transl Med. 2009 Oct 21;1(3):3ra7. doi: 10.1126/scitranslmed.3000139.


Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines.

Soule BP, Simone NL, DeGraff WG, Choudhuri R, Cook JA, Mitchell JB.

Radiat Oncol. 2010 Feb 3;5:8. doi: 10.1186/1748-717X-5-8.


Enhancement of 5-Aminolevulinic acid-induced oxidative stress on two cancer cell lines by gold nanoparticles.

Ito S, Miyoshi N, Degraff WG, Nagashima K, Kirschenbaum LJ, Riesz P.

Free Radic Res. 2009 Dec;43(12):1214-24. doi: 10.3109/10715760903271249.


Halofuginone enhances the radiation sensitivity of human tumor cell lines.

Cook JA, Choudhuri R, Degraff W, Gamson J, Mitchell JB.

Cancer Lett. 2010 Mar 1;289(1):119-26. doi: 10.1016/j.canlet.2009.08.009. Epub 2009 Aug 26.


Ionizing radiation-induced oxidative stress alters miRNA expression.

Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB.

PLoS One. 2009 Jul 27;4(7):e6377. doi: 10.1371/journal.pone.0006377.


Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation.

Matsumoto K, Okajo A, Nagata K, Degraff WG, Nyui M, Ueno M, Nakanishi I, Ozawa T, Mitchell JB, Krishna MC, Yamamoto H, Endo K, Anzai K.

Biol Pharm Bull. 2009 Apr;32(4):542-7.


Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury.

Isenberg JS, Maxhimer JB, Hyodo F, Pendrak ML, Ridnour LA, DeGraff WG, Tsokos M, Wink DA, Roberts DD.

Am J Pathol. 2008 Oct;173(4):1100-12. doi: 10.2353/ajpath.2008.080237. Epub 2008 Sep 11.


PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.

Palayoor ST, Mitchell JB, Cerna D, Degraff W, John-Aryankalayil M, Coleman CN.

Int J Cancer. 2008 Nov 15;123(10):2430-7. doi: 10.1002/ijc.23807.


Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts.

Arany PR, Flanders KC, DeGraff W, Cook J, Mitchell JB, Roberts AB.

J Dermatol Sci. 2007 Oct;48(1):35-42. Epub 2007 Jul 12.


Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation.

Tsai MH, Cook JA, Chandramouli GV, DeGraff W, Yan H, Zhao S, Coleman CN, Mitchell JB, Chuang EY.

Cancer Res. 2007 Apr 15;67(8):3845-52.


Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo.

Cook JA, Chuang EY, Tsai MH, Coffin D, Degraff W, Sowers AL, Mitchell JB.

Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1263-72.


Superoxide fluxes limit nitric oxide-induced signaling.

Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, DeGraff W, Roberts DD, Mitchell JB, Wink DA.

J Biol Chem. 2006 Sep 8;281(36):25984-93. Epub 2006 Jul 7.


n-Alkyl glucopyranosides completely inhibit ultrasound-induced cytolysis.

Sostaric JZ, Miyoshi N, Riesz P, DeGraff WG, Mitchell JB.

Free Radic Biol Med. 2005 Dec 15;39(12):1539-48. Epub 2005 Aug 30. Erratum in: Free Radic Biol Med. 2006 Apr 1;40(7):1279.


Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells.

Samuni AM, Kasid U, Chuang EY, Suy S, Degraff W, Krishna MC, Russo A, Mitchell JB.

Cancer Res. 2005 Jan 15;65(2):579-86.


The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells.

Samuni AM, DeGraff W, Cook JA, Krishna MC, Russo A, Mitchell JB.

Free Radic Biol Med. 2004 Nov 15;37(10):1648-55.


Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: chemoprevention strategies with antioxidants.

Samuni AM, Chuang EY, Krishna MC, Stein W, DeGraff W, Russo A, Mitchell JB.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5390-5. Epub 2003 Apr 17.


Low-energy X-radiation for prevention of restenosis results in localized inhibition of V79 fibroblast cell proliferation.

Vodovotz Y, Chan RC, DeGraff W, Chornenky VI, Mitchell JB, Waksman R.

Int J Cardiovasc Intervent. 1998;1(1):41-44.


Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.

Chuang YY, Chen Y, Gadisetti, Chandramouli VR, Cook JA, Coffin D, Tsai MH, DeGraff W, Yan H, Zhao S, Russo A, Liu ET, Mitchell JB.

Cancer Res. 2002 Nov 1;62(21):6246-54.


Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.

Xavier S, Yamada K, Samuni AM, Samuni A, DeGraff W, Krishna MC, Mitchell JB.

Biochim Biophys Acta. 2002 Nov 14;1573(2):109-20.


Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity.

Samuni AM, DeGraff W, Krishna MC, Mitchell JB.

Mol Cell Biochem. 2002 May-Jun;234-235(1-2):327-33.


Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.

Samuni AM, Krishna MC, DeGraff W, Russo A, Planalp RP, Brechbiel MW, Mitchell JB.

Biochim Biophys Acta. 2002 Jul 3;1571(3):211-8.


Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.

Miranda KM, Yamada K, Espey MG, Thomas DD, DeGraff W, Mitchell JB, Krishna MC, Colton CA, Wink DA.

Arch Biochem Biophys. 2002 May 15;401(2):134-44.


Cellular sites of H2O2-induced damage and their protection by nitroxides.

Samuni AM, DeGraff W, Krishna MC, Mitchell JB.

Biochim Biophys Acta. 2001 Feb 16;1525(1-2):70-6.


Multifunctional antioxidant activity of HBED iron chelator.

Samuni AM, Afeworki M, Stein W, Yordanov AT, DeGraff W, Krishna MC, Mitchell JB, Brechbiel MW.

Free Radic Biol Med. 2001 Jan 15;30(2):170-7.


Radiation and the Apo2L/TRAIL apoptotic pathway preferentially inhibit the colonization of premalignant human breast cells overexpressing cyclin D1.

Zhou Q, Fukushima P, DeGraff W, Mitchell JB, Stetler Stevenson M, Ashkenazi A, Steeg PS.

Cancer Res. 2000 May 15;60(10):2611-5.


Regulation of transforming growth factor beta1 by nitric oxide.

Vodovotz Y, Chesler L, Chong H, Kim SJ, Simpson JT, DeGraff W, Cox GW, Roberts AB, Wink DA, Barcellos-Hoff MH.

Cancer Res. 1999 May 1;59(9):2142-9.


The use of Zn-desferrioxamine for radioprotection in mice, tissue culture, and isolated DNA.

Samuni Y, Coffin D, DeLuca AM, DeGraff WG, Venson DJ, Ambudkar I, Chevion M, Mitchell JB.

Cancer Res. 1999 Jan 15;59(2):405-9.


Antioxidant effects of nitric oxide.

Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB.

Methods Enzymol. 1999;301:413-24. Review. No abstract available.


Redox generation of nitric oxide to radiosensitize hypoxic cells.

Mitchell JB, DeGraff W, Kim S, Cook JA, Gamson J, Christodoulou D, Feelisch M, Wink DA.

Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):795-8.


The role of nitric oxide chemistry in cancer treatment.

Wink DA, Vodovotz Y, Cook JA, Krishna MC, Kim S, Coffin D, DeGraff W, Deluca AM, Liebmann J, Mitchell JB.

Biochemistry (Mosc). 1998 Jul;63(7):802-9. Review.


Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage.

Krishna MC, DeGraff W, Hankovszky OH, Sár CP, Kálai T, Jeko J, Russo A, Mitchell JB, Hideg K.

J Med Chem. 1998 Aug 27;41(18):3477-92.


The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO.

Wink DA, Feelisch M, Fukuto J, Chistodoulou D, Jourd'heuil D, Grisham MB, Vodovotz Y, Cook JA, Krishna M, DeGraff WG, Kim S, Gamson J, Mitchell JB.

Arch Biochem Biophys. 1998 Mar 1;351(1):66-74.


Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin.

Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB.

Nitric Oxide. 1997 Feb;1(1):88-94.


Nitric oxide enhancement of melphalan-induced cytotoxicity.

Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA.

Br J Cancer. 1997;76(3):325-34.


Direct evidence for in vivo nitroxide free radical production from a new antiarrhythmic drug by EPR spectroscopy.

Twomey P, Taira J, DeGraff W, Mitchell JB, Russo A, Krishna MC, Hankovszky OH, Frank L, Hideg K.

Free Radic Biol Med. 1997;22(5):909-16.


Overproduction of three genes leads to camphor resistance and chromosome condensation in Escherichia coli.

Hu KH, Liu E, Dean K, Gingras M, DeGraff W, Trun NJ.

Genetics. 1996 Aug;143(4):1521-32.


The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection.

Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB.

Arch Biochem Biophys. 1996 Jul 15;331(2):241-8.


Radiation sensitisation by nitric oxide releasing agents.

Mitchell JB, Cook JA, Krishna MC, DeGraff W, Gamson J, Fisher J, Christodoulou D, Wink DA.

Br J Cancer Suppl. 1996 Jul;27:S181-4.

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