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Items: 43

1.

Non-canonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure.

Sil P, Suwanpradid J, Muse G, Gruzdev A, Liu L, Corcoran DL, Willson CJ, Janardhan K, Grimm S, Myers P, Degraff LM, MacLeod AS, Martinez J.

J Allergy Clin Immunol. 2019 Dec 11. pii: S0091-6749(19)31637-9. doi: 10.1016/j.jaci.2019.11.041. [Epub ahead of print]

2.

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.

Edin ML, Hamedani BG, Gruzdev A, Graves JP, Lih FB, Arbes SJ 3rd, Singh R, Orjuela Leon AC, Bradbury JA, DeGraff LM, Hoopes SL, Arand M, Zeldin DC.

J Biol Chem. 2018 Mar 2;293(9):3281-3292. doi: 10.1074/jbc.RA117.000298. Epub 2018 Jan 3.

3.

Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Edin ML, Zeldin DC.

Drug Metab Dispos. 2017 Jul;45(7):807-816. doi: 10.1124/dmd.117.075697. Epub 2017 Apr 27.

4.

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

Hoopes SL, Gruzdev A, Edin ML, Graves JP, Bradbury JA, Flake GP, Lih FB, DeGraff LM, Zeldin DC.

PLoS One. 2017 Apr 6;12(4):e0175348. doi: 10.1371/journal.pone.0175348. eCollection 2017.

5.

Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.

House JS, Nichols CE, Li H, Brandenberger C, Virgincar RS, DeGraff LM, Driehuys B, Zeldin DC, London SJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L520-L530. doi: 10.1152/ajplung.00495.2016. Epub 2017 Jan 27.

6.

Multiwalled Carbon Nanotube Functionalization with High Molecular Weight Hyaluronan Significantly Reduces Pulmonary Injury.

Hussain S, Ji Z, Taylor AJ, DeGraff LM, George M, Tucker CJ, Chang CH, Li R, Bonner JC, Garantziotis S.

ACS Nano. 2016 Aug 23;10(8):7675-88. doi: 10.1021/acsnano.6b03013. Epub 2016 Aug 2.

7.

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

Wells MA, Vendrov KC, Edin ML, Ferslew BC, Zha W, Nguyen BK, Church RJ, Lih FB, DeGraff LM, Brouwer KL, Barritt AS 4th, Zeldin DC, Lee CR.

Prostaglandins Other Lipid Mediat. 2016 Sep;125:19-29. doi: 10.1016/j.prostaglandins.2016.07.002. Epub 2016 Jul 9.

8.

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.

Jia J, Davis CM, Zhang W, Edin ML, Jouihan S, Jia T, Bradbury JA, Graves JP, DeGraff LM, Lee CR, Ronnekleiv O, Wang R, Xu Y, Zeldin DC, Alkayed NJ.

Exp Neurol. 2016 May;279:75-85. doi: 10.1016/j.expneurol.2016.02.016. Epub 2016 Feb 20.

9.

Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis.

Cheng J, Dackor RT, Bradbury JA, Li H, DeGraff LM, Hong LK, King D, Lih FB, Gruzdev A, Edin ML, Travlos GS, Flake GP, Tomer KB, Zeldin DC.

FASEB J. 2016 Jan;30(1):160-73. doi: 10.1096/fj.14-268458. Epub 2015 Sep 22.

10.

Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Li H, House JS, Hoopes SL, Edin ML, Zeldin DC.

Drug Metab Dispos. 2015 Aug;43(8):1169-80. doi: 10.1124/dmd.115.064139. Epub 2015 May 20.

11.

Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.

House JS, Li H, DeGraff LM, Flake G, Zeldin DC, London SJ.

FASEB J. 2015 Jan;29(1):323-35. doi: 10.1096/fj.14-253898. Epub 2014 Oct 23.

12.

The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.

Schuck RN, Zha W, Edin ML, Gruzdev A, Vendrov KC, Miller TM, Xu Z, Lih FB, DeGraff LM, Tomer KB, Jones HM, Makowski L, Huang L, Poloyac SM, Zeldin DC, Lee CR.

PLoS One. 2014 Oct 13;9(10):e110162. doi: 10.1371/journal.pone.0110162. eCollection 2014.

13.

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.

Zha W, Edin ML, Vendrov KC, Schuck RN, Lih FB, Jat JL, Bradbury JA, DeGraff LM, Hua K, Tomer KB, Falck JR, Zeldin DC, Lee CR.

J Lipid Res. 2014 Oct;55(10):2124-36. doi: 10.1194/jlr.M053199. Epub 2014 Aug 11.

14.

Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity.

Takeda Y, Kang HS, Freudenberg J, DeGraff LM, Jothi R, Jetten AM.

PLoS Genet. 2014 May 15;10(5):e1004331. doi: 10.1371/journal.pgen.1004331. eCollection 2014.

15.

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

Cheng J, Edin ML, Hoopes SL, Li H, Bradbury JA, Graves JP, DeGraff LM, Lih FB, Garcia V, Shaik JS, Tomer KB, Flake GP, Falck JR, Lee CR, Poloyac SM, Schwartzman ML, Zeldin DC.

FASEB J. 2014 Jul;28(7):2915-31. doi: 10.1096/fj.13-241927. Epub 2014 Mar 25.

16.

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.

Westphal C, Spallek B, Konkel A, Marko L, Qadri F, DeGraff LM, Schubert C, Bradbury JA, Regitz-Zagrosek V, Falck JR, Zeldin DC, Müller DN, Schunck WH, Fischer R.

PLoS One. 2013 Aug 30;8(8):e73490. doi: 10.1371/journal.pone.0073490. eCollection 2013.

17.

β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice.

Trivedi DB, Loftin CD, Clark J, Myers P, DeGraff LM, Cheng J, Zeldin DC, Langenbach R.

Circ Res. 2013 Apr 26;112(9):1219-29. doi: 10.1161/CIRCRESAHA.112.280399. Epub 2013 Mar 22.

18.

CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistance.

Kang HS, Liao G, DeGraff LM, Gerrish K, Bortner CD, Garantziotis S, Jetten AM.

PLoS One. 2013;8(3):e58417. doi: 10.1371/journal.pone.0058417. Epub 2013 Mar 7.

19.

Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB.

Li H, Edin ML, Bradbury JA, Graves JP, DeGraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, Garantziotis S, Jetten AM, Zeldin DC.

Am J Respir Crit Care Med. 2013 Apr 15;187(8):812-22. doi: 10.1164/rccm.201211-2073OC.

20.

Regulation of T helper cell subsets by cyclooxygenases and their metabolites.

Li H, Edin ML, Gruzdev A, Cheng J, Bradbury JA, Graves JP, DeGraff LM, Zeldin DC.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:74-83. doi: 10.1016/j.prostaglandins.2012.11.002. Epub 2012 Nov 28. Review.

21.

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.

Li R, Xu X, Chen C, Yu X, Edin ML, Degraff LM, Lee CR, Zeldin DC, Wang DW.

Prostaglandins Other Lipid Mediat. 2012 Dec;99(3-4):68-78. doi: 10.1016/j.prostaglandins.2012.09.004. Epub 2012 Oct 2.

22.

Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction.

Dackor RT, Cheng J, Voltz JW, Card JW, Ferguson CD, Garrett RC, Bradbury JA, DeGraff LM, Lih FB, Tomer KB, Flake GP, Travlos GS, Ramsey RW Jr, Edin ML, Morgan DL, Zeldin DC.

Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L645-55. doi: 10.1152/ajplung.00176.2011. Epub 2011 Aug 19.

23.

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.

Edin ML, Wang Z, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Foley JF, Torphy R, Ronnekleiv OK, Tomer KB, Lee CR, Zeldin DC.

FASEB J. 2011 Oct;25(10):3436-47. doi: 10.1096/fj.11-188300. Epub 2011 Jun 22.

24.

Identification of candidate genes downstream of TLR4 signaling after ozone exposure in mice: a role for heat-shock protein 70.

Bauer AK, Rondini EA, Hummel KA, Degraff LM, Walker C, Jedlicka AE, Kleeberger SR.

Environ Health Perspect. 2011 Aug;119(8):1091-7. doi: 10.1289/ehp.1003326. Epub 2011 May 4.

25.

Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis.

Kang HS, Okamoto K, Takeda Y, Beak JY, Gerrish K, Bortner CD, DeGraff LM, Wada T, Xie W, Jetten AM.

Physiol Genomics. 2011 Jul 14;43(13):818-28. doi: 10.1152/physiolgenomics.00206.2010. Epub 2011 May 3.

26.

Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation.

Li H, Bradbury JA, Dackor RT, Edin ML, Graves JP, DeGraff LM, Wang PM, Bortner CD, Maruoka S, Lih FB, Cook DN, Tomer KB, Jetten AM, Zeldin DC.

Am J Respir Crit Care Med. 2011 Jul 1;184(1):37-49. doi: 10.1164/rccm.201010-1637OC. Epub 2011 Apr 7.

27.

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.

Deng Y, Edin ML, Theken KN, Schuck RN, Flake GP, Kannon MA, DeGraff LM, Lih FB, Foley J, Bradbury JA, Graves JP, Tomer KB, Falck JR, Zeldin DC, Lee CR.

FASEB J. 2011 Feb;25(2):703-13. doi: 10.1096/fj.10-171488. Epub 2010 Nov 8.

28.

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC.

FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.

29.

Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis.

Bauer AK, Fostel J, Degraff LM, Rondini EA, Walker C, Grissom SF, Foley J, Kleeberger SR.

Mol Cancer. 2009 Nov 19;8:107. doi: 10.1186/1476-4598-8-107.

30.

Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity.

Zhang Y, El-Sikhry H, Chaudhary KR, Batchu SN, Shayeganpour A, Jukar TO, Bradbury JA, Graves JP, DeGraff LM, Myers P, Rouse DC, Foley J, Nyska A, Zeldin DC, Seubert JM.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H37-46. doi: 10.1152/ajpheart.00983.2008. Epub 2009 May 8.

31.

Increased blood pressure in mice lacking cytochrome P450 2J5.

Athirakul K, Bradbury JA, Graves JP, DeGraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Coffman TM, Zeldin DC.

FASEB J. 2008 Dec;22(12):4096-108. doi: 10.1096/fj.08-114413. Epub 2008 Aug 20.

32.

Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis.

Voltz JW, Card JW, Carey MA, Degraff LM, Ferguson CD, Flake GP, Bonner JC, Korach KS, Zeldin DC.

Am J Respir Cell Mol Biol. 2008 Jul;39(1):45-52. doi: 10.1165/rcmb.2007-0340OC. Epub 2008 Feb 14.

33.

Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice.

Ke Q, Xiao YF, Bradbury JA, Graves JP, Degraff LM, Seubert JM, Zeldin DC.

Mol Pharmacol. 2007 Oct;72(4):1063-73. Epub 2007 Jul 24.

34.

Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis.

Card JW, Voltz JW, Carey MA, Bradbury JA, Degraff LM, Lih FB, Bonner JC, Morgan DL, Flake GP, Zeldin DC.

Am J Respir Cell Mol Biol. 2007 Sep;37(3):300-8. Epub 2007 May 11.

35.

Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation.

Card JW, Voltz JW, Ferguson CD, Carey MA, DeGraff LM, Peddada SD, Morgan DL, Zeldin DC.

Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L908-14. Epub 2006 Dec 8.

36.

The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.

Whitehead GS, Wang T, DeGraff LM, Card JW, Lira SA, Graham GJ, Cook DN.

Am J Respir Crit Care Med. 2007 Feb 1;175(3):243-9. Epub 2006 Nov 9.

37.

Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammation.

Card JW, Carey MA, Bradbury JA, Graves JP, Lih FB, Moorman MP, Morgan DL, DeGraff LM, Zhao Y, Foley JF, Zeldin DC.

J Immunol. 2006 Oct 1;177(7):4785-93.

38.

Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.

Zhang D, Stumpo DJ, Graves JP, DeGraff LM, Grissom SF, Collins JB, Li L, Zeldin DC, Blackshear PJ.

J Neurochem. 2006 Aug;98(3):860-75.

39.

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC.

Circ Res. 2006 Aug 18;99(4):442-50. Epub 2006 Jul 20.

40.

Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation.

Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, Flake GP, Zeldin DC.

J Immunol. 2006 Jul 1;177(1):621-30.

41.

Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis.

Bauer AK, Dixon D, DeGraff LM, Cho HY, Walker CR, Malkinson AM, Kleeberger SR.

J Natl Cancer Inst. 2005 Dec 7;97(23):1778-81.

PMID:
16333033
42.

Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2.

Xiao YF, Ke Q, Seubert JM, Bradbury JA, Graves J, Degraff LM, Falck JR, Krausz K, Gelboin HV, Morgan JP, Zeldin DC.

Mol Pharmacol. 2004 Dec;66(6):1607-16. Epub 2004 Sep 10.

PMID:
15361551
43.

Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.

Seubert J, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman J, Mao L, Rockman HA, Hammock BD, Murphy E, Zeldin DC.

Circ Res. 2004 Sep 3;95(5):506-14. Epub 2004 Jul 15.

PMID:
15256482

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