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Items: 1 to 50 of 133

1.

Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes.

Wigton EJ, DeFranco AL, Ansel KM.

Immunohorizons. 2019 Aug 19;3(8):389-401. doi: 10.4049/immunohorizons.1900030.

PMID:
31427364
2.

Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul.

DeFranco AL.

Front Immunol. 2018 Apr 23;9:739. doi: 10.3389/fimmu.2018.00739. eCollection 2018.

3.

B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle.

Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL, Hou B.

J Immunol. 2018 Feb 1;200(3):937-948. doi: 10.4049/jimmunol.1701067. Epub 2017 Dec 27.

4.

Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.

Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P.

J Leukoc Biol. 2017 Sep;102(3):791-803. doi: 10.1189/jlb.3MA0217-054RR. Epub 2017 Jun 22.

5.

Innate B cells cleave to the marginal zone.

DeFranco AL.

Nat Immunol. 2017 Feb 15;18(3):248-250. doi: 10.1038/ni.3685. No abstract available.

PMID:
28198824
6.

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL.

PLoS One. 2016 Dec 15;11(12):e0167693. doi: 10.1371/journal.pone.0167693. eCollection 2016.

7.

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.

Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL.

J Clin Invest. 2016 Oct 3;126(10):3758-3771. doi: 10.1172/JCI84440. Epub 2016 Aug 29.

8.

Germinal centers and autoimmune disease in humans and mice.

DeFranco AL.

Immunol Cell Biol. 2016 Nov;94(10):918-924. doi: 10.1038/icb.2016.78. Epub 2016 Aug 26. Review.

9.

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M.

PLoS Pathog. 2016 Aug 19;12(8):e1005787. doi: 10.1371/journal.ppat.1005787. eCollection 2016 Aug.

10.

The germinal center antibody response in health and disease.

DeFranco AL.

F1000Res. 2016 May 25;5. pii: F1000 Faculty Rev-999. doi: 10.12688/f1000research.7717.1. eCollection 2016. Review.

11.

Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses.

Rookhuizen DC, DeFranco AL.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3224-33. doi: 10.1073/pnas.1323985111. Epub 2014 Jul 22.

12.

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.

Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X.

J Exp Med. 2014 May 5;211(5):887-907. doi: 10.1084/jem.20131314. Epub 2014 Apr 21. Erratum in: J Exp Med. 2014 May 5;211(5):1003. Ransohoff, Richard M [added].

13.

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL.

J Immunol. 2014 Feb 1;192(3):875-85. doi: 10.4049/jimmunol.1300683. Epub 2013 Dec 30.

14.

B cell-specific loss of Lyn kinase leads to autoimmunity.

Lamagna C, Hu Y, DeFranco AL, Lowell CA.

J Immunol. 2014 Feb 1;192(3):919-28. doi: 10.4049/jimmunol.1301979. Epub 2013 Dec 27.

15.

Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.

Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL.

Sci Signal. 2013 Oct 15;6(297):ra91. doi: 10.1126/scisignal.2004189.

16.

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3311-20. doi: 10.1073/pnas.1300617110. Epub 2013 Aug 12.

17.

Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.

Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y.

Immunity. 2013 Jun 27;38(6):1211-22. doi: 10.1016/j.immuni.2013.05.012. Epub 2013 Jun 20.

18.

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells.

Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F.

Nat Immunol. 2013 Feb;14(2):136-42. doi: 10.1038/ni.2508. Epub 2012 Dec 23.

19.

Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control.

Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL.

PLoS One. 2012;7(10):e48126. doi: 10.1371/journal.pone.0048126. Epub 2012 Oct 29.

20.

Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.

Wheeler ML, Defranco AL.

J Immunol. 2012 Nov 1;189(9):4405-16. doi: 10.4049/jimmunol.1201433. Epub 2012 Sep 28.

21.

Contribution of Toll-like receptor signaling to germinal center antibody responses.

DeFranco AL, Rookhuizen DC, Hou B.

Immunol Rev. 2012 May;247(1):64-72. doi: 10.1111/j.1600-065X.2012.01115.x. Review.

22.

Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.

Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF.

J Immunol. 2012 Mar 15;188(6):2834-46. doi: 10.4049/jimmunol.1100254. Epub 2012 Feb 15.

23.

B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.

Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F.

Immunity. 2012 Feb 24;36(2):228-38. doi: 10.1016/j.immuni.2011.11.019. Epub 2012 Feb 1.

24.

Lyn deficiency affects B-cell maturation as well as survival.

Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R.

Eur J Immunol. 2012 Feb;42(2):511-21. doi: 10.1002/eji.201141940. Epub 2011 Dec 14.

25.

Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.

Gross AJ, Proekt I, DeFranco AL.

Eur J Immunol. 2011 Dec;41(12):3645-55. doi: 10.1002/eji.201141708. Epub 2011 Nov 10.

26.

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.

Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):E823-32. doi: 10.1073/pnas.1107913108. Epub 2011 Sep 12.

27.

Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.

Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8743-8. doi: 10.1073/pnas.1019574108. Epub 2011 May 9.

28.

Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.

Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL.

Immunity. 2011 Mar 25;34(3):375-84. doi: 10.1016/j.immuni.2011.01.011. Epub 2011 Feb 25.

29.

Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88.

Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA.

Blood. 2011 Mar 17;117(11):3123-30. doi: 10.1182/blood-2010-11-318485. Epub 2011 Jan 13.

30.

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.

Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):278-83. doi: 10.1073/pnas.1011549108. Epub 2010 Dec 20.

31.

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA.

J Exp Med. 2010 Aug 2;207(8):1757-73. doi: 10.1084/jem.20100086. Epub 2010 Jul 12.

32.

Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.

Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL.

Eur J Immunol. 2010 Feb;40(2):539-47. doi: 10.1002/eji.200939645.

33.

Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.

Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL.

J Immunol. 2009 May 1;182(9):5382-92. doi: 10.4049/jimmunol.0803941.

34.

"Dangerous crystals".

DeFranco AL.

Immunity. 2008 Nov 14;29(5):670-1. doi: 10.1016/j.immuni.2008.10.005.

35.

Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.

Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL.

J Immunol. 2008 Oct 15;181(8):5374-85.

36.

Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.

Hou B, Reizis B, DeFranco AL.

Immunity. 2008 Aug 15;29(2):272-82. doi: 10.1016/j.immuni.2008.05.016. Epub 2008 Jul 24.

37.

Lipid rafts and B cell signaling.

Gupta N, DeFranco AL.

Semin Cell Dev Biol. 2007 Oct;18(5):616-26. Epub 2007 Jul 24. Review.

38.

Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics.

Gupta N, Wollscheid B, Watts JD, Scheer B, Aebersold R, DeFranco AL.

Nat Immunol. 2006 Jun;7(6):625-33. Epub 2006 Apr 30.

PMID:
16648854
39.

TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.

Nishiya T, Kajita E, Miwa S, Defranco AL.

J Biol Chem. 2005 Nov 4;280(44):37107-17. Epub 2005 Aug 16.

40.

Bcl10 can promote survival of antigen-stimulated B lymphocytes.

Tian MT, Gonzalez G, Scheer B, DeFranco AL.

Blood. 2005 Sep 15;106(6):2105-12. Epub 2005 May 5.

41.
43.

Making and breaking tolerance.

Ohashi PS, DeFranco AL.

Curr Opin Immunol. 2002 Dec;14(6):744-59. Review.

PMID:
12413525
44.

Signaling mutations and autoimmunity.

Yu CC, Mamchak AA, DeFranco AL.

Curr Dir Autoimmun. 2003;6:61-88. Review.

PMID:
12408047
45.

Vav and the B cell signalosome.

DeFranco AL.

Nat Immunol. 2001 Jun;2(6):482-4. No abstract available.

PMID:
11376331
46.
47.

Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen.

Richards JD, Davé SH, Chou CH, Mamchak AA, DeFranco AL.

J Immunol. 2001 Mar 15;166(6):3855-64.

48.

Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.

Yu CC, Yen TS, Lowell CA, DeFranco AL.

Curr Biol. 2001 Jan 9;11(1):34-8.

49.

B-cell activation 2000.

DeFranco AL.

Immunol Rev. 2000 Aug;176:5-9. Review. No abstract available.

PMID:
11043763
50.

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF.

Immunity. 2000 Jul;13(1):47-57.

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