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Items: 30


Chikungunya Virus Vaccines: Platforms, Progress, and Challenges.

DeFilippis VR.

Curr Top Microbiol Immunol. 2019 Jul 24. doi: 10.1007/82_2019_175. [Epub ahead of print]


Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist.

Zhang X, Liu B, Tang L, Su Q, Hwang N, Sehgal M, Cheng J, Ma J, Zhang X, Tan Y, Zhou Y, Duan Z, DeFilippis VR, Viswanathan U, Kulp J, Du Y, Guo JT, Chang J.

ACS Infect Dis. 2019 Jul 12;5(7):1139-1149. doi: 10.1021/acsinfecdis.9b00010. Epub 2019 May 14.


Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.

Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02325-18. doi: 10.1128/AAC.02325-18. Print 2019 Apr.


Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.

Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR.

MBio. 2019 Feb 12;10(1). pii: e02510-18. doi: 10.1128/mBio.02510-18.


High-Throughput Screening for Identification of Novel Innate Immune Activators.

Gall BJ, DeFilippis VR.

Methods Mol Biol. 2017;1656:183-193. doi: 10.1007/978-1-4939-7237-1_12.


A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.

Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR.

MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17.


Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN.

PLoS Pathog. 2017 Apr 5;13(4):e1006317. doi: 10.1371/journal.ppat.1006317. eCollection 2017 Apr.


Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN.

PLoS Pathog. 2017 Mar 9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. eCollection 2017 Mar. Erratum in: PLoS Pathog. 2017 Apr 5;13(4):e1006317.


A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression.

Greene TT, Tokuyama M, Knudsen GM, Kunz M, Lin J, Greninger AL, DeFilippis VR, DeRisi JL, Raulet DH, Coscoy L.

Elife. 2016 Nov 22;5. pii: e14749. doi: 10.7554/eLife.14749.


Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.

Uhrlaub JL, Pulko V, DeFilippis VR, Broeckel R, Streblow DN, Coleman GD, Park BS, Lindo JF, Vickers I, Anzinger JJ, Nikolich-Žugich J.

PLoS Pathog. 2016 Oct 13;12(10):e1005891. doi: 10.1371/journal.ppat.1005891. eCollection 2016 Oct.


Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.

Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR.

PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec.


The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.

Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Früh K, Verweij MC.

J Virol. 2015 Sep;89(17):8687-700. doi: 10.1128/JVI.01149-15. Epub 2015 Jun 17.


Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.

Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C, Goulet ML, DeFilippis VR, Streblow DN, Haddad EK, Trautmann L, Ross T, Lin R, Hiscott J.

J Virol. 2015 Aug;89(15):8011-25. doi: 10.1128/JVI.00845-15. Epub 2015 May 27.


Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.

Verweij MC, Wellish M, Whitmer T, Malouli D, Lapel M, Jonjić S, Haas JG, DeFilippis VR, Mahalingam R, Früh K.

PLoS Pathog. 2015 May 14;11(5):e1004901. doi: 10.1371/journal.ppat.1004901. eCollection 2015 May.


Cytomegalovirus pp65 limits dissemination but is dispensable for persistence.

Malouli D, Hansen SG, Nakayasu ES, Marshall EE, Hughes CM, Ventura AB, Gilbride RM, Lewis MS, Xu G, Kreklywich C, Whizin N, Fischer M, Legasse AW, Viswanathan K, Siess D, Camp DG 2nd, Axthelm MK, Kahl C, DeFilippis VR, Smith RD, Streblow DN, Picker LJ, Früh K.

J Clin Invest. 2014 May;124(5):1928-44. Epub 2014 Apr 1.


The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.

Amsler L, Verweij M, DeFilippis VR.

J Mol Biol. 2013 Dec 13;425(24):4857-71. doi: 10.1016/j.jmb.2013.08.023. Epub 2013 Sep 5. Review.


Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity.

Messaoudi I, Vomaske J, Totonchy T, Kreklywich CN, Haberthur K, Springgay L, Brien JD, Diamond MS, Defilippis VR, Streblow DN.

PLoS Negl Trop Dis. 2013 Jul 25;7(7):e2343. doi: 10.1371/journal.pntd.0002343. Print 2013.


Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially.

Pissani F, Malherbe DC, Robins H, DeFilippis VR, Park B, Sellhorn G, Stamatatos L, Overbaugh J, Haigwood NL.

Vaccine. 2012 Aug 10;30(37):5519-26. doi: 10.1016/j.vaccine.2012.06.042. Epub 2012 Jun 27.


Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff.

White LK, Sali T, Alvarado D, Gatti E, Pierre P, Streblow D, Defilippis VR.

J Virol. 2011 Jan;85(1):606-20. doi: 10.1128/JVI.00767-10. Epub 2010 Oct 20.


Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B.

DeFilippis VR, Sali T, Alvarado D, White L, Bresnahan W, Früh KJ.

J Virol. 2010 Sep;84(17):8913-25. doi: 10.1128/JVI.00169-10. Epub 2010 Jun 23.


Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

DeFilippis VR, Alvarado D, Sali T, Rothenburg S, Früh K.

J Virol. 2010 Jan;84(1):585-98. doi: 10.1128/JVI.01748-09.


Induction and evasion of the type I interferon response by cytomegaloviruses.

DeFilippis VR.

Adv Exp Med Biol. 2007;598:309-24. Review.


The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma.

Rose PP, Carroll JM, Carroll PA, DeFilippis VR, Lagunoff M, Moses AV, Roberts CT Jr, Früh K.

Oncogene. 2007 Mar 29;26(14):1995-2005. Epub 2006 Sep 25.


Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection.

DeFilippis VR, Robinson B, Keck TM, Hansen SG, Nelson JA, Früh KJ.

J Virol. 2006 Jan;80(2):1032-7.


A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism.

Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG, Wong SW, Barry PA, Nelson JA.

J Virol. 2004 Nov;78(22):12529-36.


Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells.

McAllister SC, Hansen SG, Ruhl RA, Raggo CM, DeFilippis VR, Greenspan D, Früh K, Moses AV.

Blood. 2004 May 1;103(9):3465-73. Epub 2004 Jan 15.


Evidence of diversifying selection in human papillomavirus type 16 E6 but not E7 oncogenes.

DeFilippis VR, Ayala FJ, Villarreal LP.

J Mol Evol. 2002 Oct;55(4):491-9.


A hypothesis for DNA viruses as the origin of eukaryotic replication proteins.

Villarreal LP, DeFilippis VR.

J Virol. 2000 Aug;74(15):7079-84.


Acute and persistent viral life strategies and their relationship to emerging diseases.

Villarreal LP, Defilippis VR, Gottlieb KA.

Virology. 2000 Jun 20;272(1):1-6. Review. No abstract available.

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