Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 43

1.

Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.

Yee MC, Nichols HL, Polley D, Saifeddine M, Pal K, Lee K, Wilson EH, Daines MO, Hollenberg MD, Boitano S, DeFea KA.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L1042-L1057. doi: 10.1152/ajplung.00196.2018. Epub 2018 Oct 18.

PMID:
30335499
2.

Arresting CCR4: A New Look at an Old Approach to Combating Asthma.

DeFea K.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):673-675. doi: 10.1165/rcmb.2017-0396ED. No abstract available.

PMID:
29856260
3.

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.

Pal K, Hwang SH, Somatilaka B, Badgandi H, Jackson PK, DeFea K, Mukhopadhyay S.

J Cell Biol. 2016 Mar 28;212(7):861-75. doi: 10.1083/jcb.201506132. Epub 2016 Mar 21.

4.

Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation.

Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H.

Clin Exp Allergy. 2015 Dec;45(12):1844-55. doi: 10.1111/cea.12628.

PMID:
26312432
5.

The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo.

Boitano S, Hoffman J, Flynn AN, Asiedu MN, Tillu DV, Zhang Z, Sherwood CL, Rivas CM, DeFea KA, Vagner J, Price TJ.

Br J Pharmacol. 2015 Sep;172(18):4535-4545. doi: 10.1111/bph.13238. Epub 2015 Aug 3.

6.

Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.

Walker JK, DeFea KA.

Curr Opin Pharmacol. 2014 Jun;16:142-7. doi: 10.1016/j.coph.2014.03.007. Epub 2014 Jun 5. Review.

7.

Molecular mechanisms underlying beta-arrestin-dependent chemotaxis and actin-cytoskeletal reorganization.

McGovern KW, DeFea KA.

Handb Exp Pharmacol. 2014;219:341-59. doi: 10.1007/978-3-642-41199-1_17.

PMID:
24292838
8.

Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway.

Mittal N, Roberts K, Pal K, Bentolila LA, Fultz E, Minasyan A, Cahill C, Pradhan A, Conner D, DeFea K, Evans C, Walwyn W.

Cell Rep. 2013 Nov 27;5(4):1010-21. doi: 10.1016/j.celrep.2013.10.015. Epub 2013 Nov 14.

9.

Arrestins in actin reorganization and cell migration.

DeFea KA.

Prog Mol Biol Transl Sci. 2013;118:205-22. doi: 10.1016/B978-0-12-394440-5.00008-5. Review.

PMID:
23764055
10.

β-Arrestin-kinase scaffolds: turn them on or turn them off?

Lin A, DeFea KA.

Wiley Interdiscip Rev Syst Biol Med. 2013 Mar-Apr;5(2):231-41. doi: 10.1002/wsbm.1203. Epub 2013 Jan 14. Review.

PMID:
23319470
11.

Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.

Pal K, Mathur M, Kumar P, DeFea K.

J Biol Chem. 2013 Feb 1;288(5):3265-74. doi: 10.1074/jbc.M112.400234. Epub 2012 Dec 12.

12.

β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway.

Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T, Vliagoftis H, Hollenberg MD, Wilson EH, Walker JK, DeFea KA.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16660-5. doi: 10.1073/pnas.1208881109. Epub 2012 Sep 25.

13.

Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning.

Pontrello CG, Sun MY, Lin A, Fiacco TA, DeFea KA, Ethell IM.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E442-51. doi: 10.1073/pnas.1118803109. Epub 2012 Jan 30.

14.

Targeting proteinase-activated receptors: therapeutic potential and challenges.

Ramachandran R, Noorbakhsh F, Defea K, Hollenberg MD.

Nat Rev Drug Discov. 2012 Jan 3;11(1):69-86. doi: 10.1038/nrd3615. Review.

PMID:
22212680
15.

β-arrestin-dependent actin reorganization: bringing the right players together at the leading edge.

Min J, Defea K.

Mol Pharmacol. 2011 Nov;80(5):760-8. doi: 10.1124/mol.111.072470. Epub 2011 Aug 11. Review.

PMID:
21836019
16.

Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).

Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA, DeFea KA, Bouvier M, Hollenberg MD.

J Biol Chem. 2011 Jul 15;286(28):24638-48. doi: 10.1074/jbc.M110.201988. Epub 2011 May 16.

17.

Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium.

Lau C, Lytle C, Straus DS, DeFea KA.

Am J Physiol Cell Physiol. 2011 Jan;300(1):C113-23. doi: 10.1152/ajpcell.00162.2010. Epub 2010 Nov 10.

18.

Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold?

DeFea KA.

Cell Signal. 2011 Apr;23(4):621-9. doi: 10.1016/j.cellsig.2010.10.004. Epub 2010 Oct 12. Review.

PMID:
20946952
19.

Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2.

Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA.

BMC Biochem. 2010 Sep 21;11:36. doi: 10.1186/1471-2091-11-36.

20.

beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2.

Zoudilova M, Min J, Richards HL, Carter D, Huang T, DeFea KA.

J Biol Chem. 2010 May 7;285(19):14318-29. doi: 10.1074/jbc.M109.055806. Epub 2010 Mar 5.

21.

Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MD.

Mol Pharmacol. 2009 Oct;76(4):791-801. doi: 10.1124/mol.109.055509. Epub 2009 Jul 15.

22.

Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity.

Shi Y, Pontrello CG, DeFea KA, Reichardt LF, Ethell IM.

J Neurosci. 2009 Jun 24;29(25):8129-42. doi: 10.1523/JNEUROSCI.4681-08.2009.

23.

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.

Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy JY.

Circ Res. 2009 Feb 27;104(4):496-505. doi: 10.1161/CIRCRESAHA.108.187567. Epub 2009 Jan 8.

24.

Differential regulation of chemokines by IL-17 in colonic epithelial cells.

Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS.

J Immunol. 2008 Nov 1;181(9):6536-45.

25.

Beta-arrestin multimers: does a crowd help or hinder function?

DeFea KA.

Biochem J. 2008 Jul 1;413(1):e1-3. doi: 10.1042/BJ20081009.

PMID:
18537791
26.

Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction.

Defea K.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S298-309. Epub 2007 Nov 26. Review.

27.

Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability.

Petreaca ML, Yao M, Liu Y, Defea K, Martins-Green M.

Mol Biol Cell. 2007 Dec;18(12):5014-23. Epub 2007 Oct 10.

29.

Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.

Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA.

J Biol Chem. 2007 Jul 13;282(28):20634-46. Epub 2007 May 11.

30.

Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.

Kumar P, Lau CS, Mathur M, Wang P, DeFea KA.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C346-57. Epub 2007 Apr 18.

31.
33.

Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.

Ge L, Shenoy SK, Lefkowitz RJ, DeFea K.

J Biol Chem. 2004 Dec 31;279(53):55419-24. Epub 2004 Oct 14.

34.
35.

Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins.

Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY.

Circ Res. 2003 Jun 27;92(12):1296-304. Epub 2003 May 29.

PMID:
12775580
36.

Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor.

Schmidlin F, Dery O, DeFea KO, Slice L, Patierno S, Sternini C, Grady EF, Bunnett NW.

J Biol Chem. 2001 Jul 6;276(27):25427-37. Epub 2001 Apr 16.

37.

Protein kinase C-mediated desensitization of the neurokinin 1 receptor.

Déry O, Defea KA, Bunnett NW.

Am J Physiol Cell Physiol. 2001 May;280(5):C1097-106.

38.

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.

DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Déry O, Bunnett NW.

Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11086-91.

39.

Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors.

Defea K, Schmidlin F, Déry O, Grady EF, Bunnett NW.

Biochem Soc Trans. 2000;28(4):419-26.

PMID:
10961932
40.

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW.

J Cell Biol. 2000 Mar 20;148(6):1267-81.

41.
42.

A transmembrane form of the prion protein in neurodegenerative disease.

Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, DeArmond SJ, Prusiner SB, Lingappa VR.

Science. 1998 Feb 6;279(5352):827-34.

43.

The orientation of DNA fragments in the agarose gels.

Borejdo J, DeFea K.

Anal Biochem. 1988 Nov 1;174(2):393-8.

PMID:
3239744

Supplemental Content

Support Center