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Items: 50

1.

A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza.

DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ.

J Immunol. 2019 Aug 9. pii: ji1900819. doi: 10.4049/jimmunol.1900819. [Epub ahead of print]

PMID:
31399519
2.

A Novel Fluorescent and Bioluminescent Bireporter Influenza A Virus To Evaluate Viral Infections.

Nogales A, Ávila-Pérez G, Rangel-Moreno J, Chiem K, DeDiego ML, Martínez-Sobrido L.

J Virol. 2019 May 1;93(10). pii: e00032-19. doi: 10.1128/JVI.00032-19. Print 2019 May 15.

PMID:
30867298
3.

Broad Hemagglutinin-Specific Memory B Cell Expansion by Seasonal Influenza Virus Infection Reflects Early-Life Imprinting and Adaptation to the Infecting Virus.

Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY.

J Virol. 2019 Apr 3;93(8). pii: e00169-19. doi: 10.1128/JVI.00169-19. Print 2019 Apr 15.

PMID:
30728266
4.

Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.

Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML.

Viruses. 2018 Dec 12;10(12). pii: E708. doi: 10.3390/v10120708. Review.

5.

Directed selection of amino acid changes in the influenza hemagglutinin and neuraminidase affecting protein antigenicity.

DeDiego ML, Chiem K, Topham DJ.

Vaccine. 2018 Oct 15;36(43):6383-6392. doi: 10.1016/j.vaccine.2018.09.005. Epub 2018 Sep 14.

PMID:
30224200
6.

Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans.

Nogales A, Martinez-Sobrido L, Chiem K, Topham DJ, DeDiego ML.

J Virol. 2018 Sep 12;92(19). pii: e01206-18. doi: 10.1128/JVI.01206-18. Print 2018 Oct 1.

7.

Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza.

Zhang H, Henry C, Anderson CS, Nogales A, DeDiego ML, Bucukovski J, Martinez-Sobrido L, Wilson PC, Topham DJ, Miller BL.

Anal Chem. 2018 Aug 7;90(15):9583-9590. doi: 10.1021/acs.analchem.8b02479. Epub 2018 Jul 20.

8.

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis.

Castaño-Rodriguez C, Honrubia JM, Gutiérrez-Álvarez J, DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Verdia-Báguena C, Queralt-Martín M, Kochan G, Perlman S, Aguilella VM, Sola I, Enjuanes L.

MBio. 2018 May 22;9(3). pii: e02325-17. doi: 10.1128/mBio.02325-17.

9.

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML.

Sci Rep. 2018 Mar 6;8(1):4265. doi: 10.1038/s41598-018-22372-z.

10.

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML.

Sci Rep. 2018 Jan 5;8(1):276. doi: 10.1038/s41598-017-17926-6.

11.

Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins.

Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ.

PLoS One. 2017 Nov 16;12(11):e0188267. doi: 10.1371/journal.pone.0188267. eCollection 2017.

12.

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML.

Sci Rep. 2017 Nov 6;7(1):14614. doi: 10.1038/s41598-017-14931-7. Erratum in: Sci Rep. 2018 Jan 5;8(1):276. Sci Rep. 2018 Mar 6;8(1):4265.

13.

The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression.

Nogales A, Chauché C, DeDiego ML, Topham DJ, Parrish CR, Murcia PR, Martínez-Sobrido L.

J Virol. 2017 Oct 27;91(22). pii: e00877-17. doi: 10.1128/JVI.00877-17. Print 2017 Nov 15.

14.

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.

Clark AM, Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML.

J Virol. 2017 Aug 10;91(17). pii: e00721-17. doi: 10.1128/JVI.00721-17. Print 2017 Sep 1.

15.

Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus.

Nogales A, Rodriguez L, DeDiego ML, Topham DJ, Martínez-Sobrido L.

J Virol. 2017 Aug 10;91(17). pii: e00720-17. doi: 10.1128/JVI.00720-17. Print 2017 Sep 1.

16.

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses.

Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML.

J Virol. 2017 Feb 14;91(5). pii: e01930-16. doi: 10.1128/JVI.01930-16. Print 2017 Mar 1.

17.

Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines.

Nogales A, Huang K, Chauché C, DeDiego ML, Murcia PR, Parrish CR, Martínez-Sobrido L.

Virology. 2017 Jan;500:1-10. doi: 10.1016/j.virol.2016.10.008. Epub 2016 Oct 15.

18.

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

DeDiego ML, Nogales A, Lambert-Emo K, Martinez-Sobrido L, Topham DJ.

J Virol. 2016 Oct 14;90(21):9693-9711. doi: 10.1128/JVI.01039-16. Print 2016 Nov 1.

19.

Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates.

Anderson CS, DeDiego ML, Thakar J, Topham DJ.

PLoS One. 2016 Aug 5;11(8):e0160510. doi: 10.1371/journal.pone.0160510. eCollection 2016.

20.

Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines.

Nogales A, DeDiego ML, Topham DJ, Martínez-Sobrido L.

J Virol. 2016 Jun 24;90(14):6291-6302. doi: 10.1128/JVI.00410-16. Print 2016 Jul 15.

21.

Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection.

Anderson CS, DeDiego ML, Topham DJ, Thakar J.

Comput Math Methods Med. 2016;2016:7686081. doi: 10.1155/2016/7686081. Epub 2016 Feb 14.

22.

Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection.

DeDiego ML, Anderson CS, Yang H, Holden-Wiltse J, Fitzgerald T, Treanor JJ, Topham DJ.

Immunology. 2016 Jun;148(2):160-73. doi: 10.1111/imm.12594. Epub 2016 Mar 30.

23.

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine.

Jimenez-Guardeño JM, Regla-Nava JA, Nieto-Torres JL, DeDiego ML, Castaño-Rodriguez C, Fernandez-Delgado R, Perlman S, Enjuanes L.

PLoS Pathog. 2015 Oct 29;11(10):e1005215. doi: 10.1371/journal.ppat.1005215. eCollection 2015 Oct.

24.

Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A.

Misra RS, Johnston CJ, Groves AM, DeDiego ML, St Martin J, Reed C, Hernady E, Miller JN, Love T, Finkelstein JN, Williams JP.

Radiat Res. 2015 Jul;184(1):3-13. Epub 2015 Jun 26.

25.

Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates.

Regla-Nava JA, Nieto-Torres JL, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodríguez C, Perlman S, Enjuanes L, DeDiego ML.

J Virol. 2015 Apr;89(7):3870-87. doi: 10.1128/JVI.03566-14. Epub 2015 Jan 21.

26.

The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis.

Jimenez-Guardeño JM, Nieto-Torres JL, DeDiego ML, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Enjuanes L.

PLoS Pathog. 2014 Aug 14;10(8):e1004320. doi: 10.1371/journal.ppat.1004320. eCollection 2014 Aug.

27.

Coronavirus virulence genes with main focus on SARS-CoV envelope gene.

DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Usera F, Enjuanes L.

Virus Res. 2014 Dec 19;194:124-37. doi: 10.1016/j.virusres.2014.07.024. Epub 2014 Aug 2. Review.

28.

Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.

Nieto-Torres JL, DeDiego ML, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Alcaraz A, Torres J, Aguilella VM, Enjuanes L.

PLoS Pathog. 2014 May 1;10(5):e1004077. doi: 10.1371/journal.ppat.1004077. eCollection 2014 May.

29.

Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival.

DeDiego ML, Nieto-Torres JL, Regla-Nava JA, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodriguez C, Perlman S, Enjuanes L.

J Virol. 2014 Jan;88(2):913-24. doi: 10.1128/JVI.02576-13. Epub 2013 Nov 6.

30.

Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate.

Almazán F, DeDiego ML, Sola I, Zuñiga S, Nieto-Torres JL, Marquez-Jurado S, Andrés G, Enjuanes L.

MBio. 2013 Sep 10;4(5):e00650-13. doi: 10.1128/mBio.00650-13.

31.

The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines.

Regla-Nava JA, Jimenez-Guardeño JM, Nieto-Torres JL, Gallagher TM, Enjuanes L, DeDiego ML.

J Virol Methods. 2013 Nov;193(2):639-46. doi: 10.1016/j.jviromet.2013.07.039. Epub 2013 Aug 1.

32.

Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge.

Verdiá-Báguena C, Nieto-Torres JL, Alcaraz A, Dediego ML, Enjuanes L, Aguilella VM.

Biochim Biophys Acta. 2013 Sep;1828(9):2026-31. doi: 10.1016/j.bbamem.2013.05.008. Epub 2013 May 18.

33.

Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein.

Fett C, DeDiego ML, Regla-Nava JA, Enjuanes L, Perlman S.

J Virol. 2013 Jun;87(12):6551-9. doi: 10.1128/JVI.00087-13. Epub 2013 Apr 10.

34.

Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread.

Mahlakõiv T, Ritz D, Mordstein M, DeDiego ML, Enjuanes L, Müller MA, Drosten C, Staeheli P.

J Gen Virol. 2012 Dec;93(Pt 12):2601-5. doi: 10.1099/vir.0.046284-0. Epub 2012 Sep 5.

PMID:
22956738
35.

Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA.

Tanaka T, Kamitani W, DeDiego ML, Enjuanes L, Matsuura Y.

J Virol. 2012 Oct;86(20):11128-37. Epub 2012 Aug 1.

36.

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids.

Verdiá-Báguena C, Nieto-Torres JL, Alcaraz A, DeDiego ML, Torres J, Aguilella VM, Enjuanes L.

Virology. 2012 Oct 25;432(2):485-94. doi: 10.1016/j.virol.2012.07.005. Epub 2012 Jul 24.

37.

Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo.

Calvo E, DeDiego ML, García P, López JA, Pérez-Breña P, Falcón A.

Virus Res. 2012 Oct;169(1):282-8. doi: 10.1016/j.virusres.2012.07.012. Epub 2012 Jul 20.

PMID:
22820404
38.

Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase.

Adedeji AO, Singh K, Calcaterra NE, DeDiego ML, Enjuanes L, Weiss S, Sarafianos SG.

Antimicrob Agents Chemother. 2012 Sep;56(9):4718-28. doi: 10.1128/AAC.00957-12. Epub 2012 Jun 25.

39.

Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.

DeDiego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Regla-Nava JA, Alvarez E, Oliveros JC, Zhao J, Fett C, Perlman S, Enjuanes L.

PLoS Pathog. 2011 Oct;7(10):e1002315. doi: 10.1371/journal.ppat.1002315. Epub 2011 Oct 20.

40.

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein.

Nieto-Torres JL, Dediego ML, Alvarez E, Jiménez-Guardeño JM, Regla-Nava JA, Llorente M, Kremer L, Shuo S, Enjuanes L.

Virology. 2011 Jul 5;415(2):69-82. doi: 10.1016/j.virol.2011.03.029. Epub 2011 Apr 27.

41.

The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated.

Alvarez E, DeDiego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Marcos-Villar L, Enjuanes L.

Virology. 2010 Jul 5;402(2):281-91. doi: 10.1016/j.virol.2010.03.015. Epub 2010 Apr 20.

42.

Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease.

Netland J, DeDiego ML, Zhao J, Fett C, Álvarez E, Nieto-Torres JL, Enjuanes L, Perlman S.

Virology. 2010 Mar 30;399(1):120-128. doi: 10.1016/j.virol.2010.01.004. Epub 2010 Jan 27.

43.

Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication.

Pan J, Peng X, Gao Y, Li Z, Lu X, Chen Y, Ishaq M, Liu D, Dediego ML, Enjuanes L, Guo D.

PLoS One. 2008 Oct 1;3(10):e3299. doi: 10.1371/journal.pone.0003299.

44.

A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters.

Lamirande EW, DeDiego ML, Roberts A, Jackson JP, Alvarez E, Sheahan T, Shieh WJ, Zaki SR, Baric R, Enjuanes L, Subbarao K.

J Virol. 2008 Aug;82(15):7721-4. doi: 10.1128/JVI.00304-08. Epub 2008 May 7.

45.

Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice.

Dediego ML, Pewe L, Alvarez E, Rejas MT, Perlman S, Enjuanes L.

Virology. 2008 Jul 5;376(2):379-89. doi: 10.1016/j.virol.2008.03.005. Epub 2008 May 2.

46.

Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease.

Enjuanes L, Dediego ML, Alvarez E, Deming D, Sheahan T, Baric R.

Virus Res. 2008 Apr;133(1):45-62. Epub 2007 Apr 9.

47.

A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo.

DeDiego ML, Alvarez E, Almazán F, Rejas MT, Lamirande E, Roberts A, Shieh WJ, Zaki SR, Subbarao K, Enjuanes L.

J Virol. 2007 Feb;81(4):1701-13. Epub 2006 Nov 15.

48.

Identification of essential genes as a strategy to select a SARS candidate vaccine using a SARS-CoV infectious cDNA.

Almazán F, DeDiego ML, Galán C, Alvarez E, Enjuanes L.

Adv Exp Med Biol. 2006;581:579-83. No abstract available.

PMID:
17037601
49.

Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.

Almazán F, Dediego ML, Galán C, Escors D, Alvarez E, Ortego J, Sola I, Zuñiga S, Alonso S, Moreno JL, Nogales A, Capiscol C, Enjuanes L.

J Virol. 2006 Nov;80(21):10900-6. Epub 2006 Aug 23.

50.

Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein.

You J, Dove BK, Enjuanes L, DeDiego ML, Alvarez E, Howell G, Heinen P, Zambon M, Hiscox JA.

J Gen Virol. 2005 Dec;86(Pt 12):3303-10.

PMID:
16298975

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