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Items: 7

1.

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists.

Deora GS, Qin CX, Vecchio EA, Debono AJ, Priebbenow DL, Brady RM, Beveridge J, Teguh SC, Deo M, May LT, Krippner G, Ritchie RH, Baell JB.

J Med Chem. 2019 May 23;62(10):5242-5248. doi: 10.1021/acs.jmedchem.8b01912. Epub 2019 May 13.

PMID:
31038950
2.

Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives.

Muthiah D, Henshaw GK, DeBono AJ, Capuano B, Scammells PJ, Callaghan R.

Drug Metab Dispos. 2019 Feb;47(2):164-172. doi: 10.1124/dmd.118.083188. Epub 2018 Nov 26.

PMID:
30478158
3.

Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'.

Qin CX, May LT, Sexton PM, DeBono AJ, Baell JB, Christopoulos A, Ritchie RH.

Nat Commun. 2018 Feb 7;9(1):530. doi: 10.1038/s41467-017-02656-0. No abstract available.

4.

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

Dennis ML, Lee MD, Harjani JR, Ahmed M, DeBono AJ, Pitcher NP, Wang ZC, Chhabra S, Barlow N, Rahmani R, Cleary B, Dolezal O, Hattarki M, Aurelio L, Shonberg J, Graham B, Peat TS, Baell JB, Swarbrick JD.

Chemistry. 2018 Feb 6;24(8):1922-1930. doi: 10.1002/chem.201704730. Epub 2018 Jan 9.

PMID:
29171692
5.

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.

Dennis ML, Pitcher NP, Lee MD, DeBono AJ, Wang ZC, Harjani JR, Rahmani R, Cleary B, Peat TS, Baell JB, Swarbrick JD.

J Med Chem. 2016 Jun 9;59(11):5248-63. doi: 10.1021/acs.jmedchem.6b00002. Epub 2016 Apr 26.

PMID:
27094768
6.

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents.

Debono AJ, Mistry SJ, Xie J, Muthiah D, Phillips J, Ventura S, Callaghan R, Pouton CW, Capuano B, Scammells PJ.

ChemMedChem. 2014 Feb;9(2):399-410. doi: 10.1002/cmdc.201300395. Epub 2013 Dec 11.

PMID:
24339417
7.

Synthesis and biological evaluation of N-substituted noscapine analogues.

DeBono AJ, Xie JH, Ventura S, Pouton CW, Capuano B, Scammells PJ.

ChemMedChem. 2012 Dec;7(12):2122-33. doi: 10.1002/cmdc.201200365. Epub 2012 Oct 10.

PMID:
23055449

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