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Items: 32

1.

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.

Allen SP, Hall B, Castelli LM, Francis L, Woof R, Siskos AP, Kouloura E, Gray E, Thompson AG, Talbot K, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Hemingway J, Bauer CS, Webster CP, De Vos KJ, Turner MR, Keun HC, Hautbergue GM, Ferraiuolo L, Shaw PJ.

Brain. 2019 Mar 1;142(3):586-605. doi: 10.1093/brain/awy353.

2.

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.

Moller A, Bauer CS, Cohen RN, Webster CP, De Vos KJ.

Hum Mol Genet. 2017 Dec 1;26(23):4668-4679. doi: 10.1093/hmg/ddx348.

3.

C9orf72 expansion disrupts ATM-mediated chromosomal break repair.

Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, Lukashchuk V, Chiang SC, Ray S, Mulcahy PJ, Jurga M, Tsagakis I, Iannitti T, Chandran J, Coldicott I, De Vos KJ, Hassan MK, Higginbottom A, Shaw PJ, Hautbergue GM, Azzouz M, El-Khamisy SF.

Nat Neurosci. 2017 Sep;20(9):1225-1235. doi: 10.1038/nn.4604. Epub 2017 Jul 17.

4.

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, Myszczynska MA, Alam SM, Garneret P, Chandran JS, Karyka E, Stopford MJ, Smith EF, Kirby J, Meyer K, Kaspar BK, Isaacs AM, El-Khamisy SF, De Vos KJ, Ning K, Azzouz M, Whitworth AJ, Shaw PJ.

Nat Commun. 2017 Jul 5;8:16063. doi: 10.1038/ncomms16063.

5.

The role of mitochondria in amyotrophic lateral sclerosis.

Smith EF, Shaw PJ, De Vos KJ.

Neurosci Lett. 2017 Jun 30. pii: S0304-3940(17)30544-X. doi: 10.1016/j.neulet.2017.06.052. [Epub ahead of print] Review.

6.

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

Webster CP, Smith EF, Shaw PJ, De Vos KJ.

Front Mol Neurosci. 2017 May 2;10:123. doi: 10.3389/fnmol.2017.00123. eCollection 2017. Review.

7.

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

De Vos KJ, Hafezparast M.

Neurobiol Dis. 2017 Sep;105:283-299. doi: 10.1016/j.nbd.2017.02.004. Epub 2017 Feb 22. Review.

8.

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.

Stopford MJ, Higginbottom A, Hautbergue GM, Cooper-Knock J, Mulcahy PJ, De Vos KJ, Renton AE, Pliner H, Calvo A, Chio A, Traynor BJ, Azzouz M, Heath PR; ITALSGEN Consortium, NeuroX Consortium, Kirby J, Shaw PJ.

Hum Mol Genet. 2017 Mar 15;26(6):1133-1145. doi: 10.1093/hmg/ddx022.

9.

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.

Webster CP, Smith EF, Grierson AJ, De Vos KJ.

Small GTPases. 2018 Sep 3;9(5):399-408. doi: 10.1080/21541248.2016.1240495. Epub 2016 Oct 21. Review.

10.

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE, Hanger DP, Noble W, Miller CC.

EMBO Rep. 2016 Sep;17(9):1326-42. doi: 10.15252/embr.201541726. Epub 2016 Jul 14.

11.

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ.

EMBO J. 2016 Aug 1;35(15):1656-76. doi: 10.15252/embj.201694401. Epub 2016 Jun 22.

12.

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.

Rodríguez-Martín T, Pooler AM, Lau DHW, Mórotz GM, De Vos KJ, Gilley J, Coleman MP, Hanger DP.

Neurobiol Dis. 2016 Jan;85:1-10. doi: 10.1016/j.nbd.2015.10.007. Epub 2015 Oct 11.

13.

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ, De Vos KJ.

Nat Commun. 2014 Oct 15;5:5245. doi: 10.1038/ncomms6245.

14.

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC.

Nat Commun. 2014 Jun 3;5:3996. doi: 10.1038/ncomms4996.

15.

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.

Chapman AL, Bennett EJ, Ramesh TM, De Vos KJ, Grierson AJ.

PLoS One. 2013 Jun 26;8(6):e67276. doi: 10.1371/journal.pone.0067276. Print 2013.

16.

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.

Mórotz GM, De Vos KJ, Vagnoni A, Ackerley S, Shaw CE, Miller CC.

Hum Mol Genet. 2012 May 1;21(9):1979-88. doi: 10.1093/hmg/dds011. Epub 2012 Jan 17.

17.

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.

De Vos KJ, Mórotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CC.

Hum Mol Genet. 2012 Mar 15;21(6):1299-311. doi: 10.1093/hmg/ddr559. Epub 2011 Nov 30.

18.

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.

Manser C, Guillot F, Vagnoni A, Davies J, Lau KF, McLoughlin DM, De Vos KJ, Miller CC.

Oncogene. 2012 May 31;31(22):2773-82. doi: 10.1038/onc.2011.437. Epub 2011 Sep 26.

19.

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function.

Sargsyan SA, Blackburn DJ, Barber SC, Grosskreutz J, De Vos KJ, Monk PN, Shaw PJ.

BMC Neurosci. 2011 Sep 23;12:91. doi: 10.1186/1471-2202-12-91.

20.

Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.

Vagnoni A, Rodriguez L, Manser C, De Vos KJ, Miller CC.

J Cell Sci. 2011 Apr 1;124(Pt 7):1032-42. doi: 10.1242/jcs.075168. Epub 2011 Mar 8.

21.

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.

Gray EH, De Vos KJ, Dingwall C, Perkinton MS, Miller CC.

J Alzheimers Dis. 2010;21(4):1101-5. doi: 10.3233/JAD-2010-100717.

22.

Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

Tudor EL, Galtrey CM, Perkinton MS, Lau KF, De Vos KJ, Mitchell JC, Ackerley S, Hortobágyi T, Vámos E, Leigh PN, Klasen C, McLoughlin DM, Shaw CE, Miller CC.

Neuroscience. 2010 May 19;167(3):774-85. doi: 10.1016/j.neuroscience.2010.02.035. Epub 2010 Feb 24.

PMID:
20188146
23.

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.

Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CC, Shaw PJ, Grierson AJ.

J Neurochem. 2009 Jul;110(1):34-44. doi: 10.1111/j.1471-4159.2009.06104.x. Epub 2009 Apr 22.

24.

Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.

Stevenson A, Yates DM, Manser C, De Vos KJ, Vagnoni A, Leigh PN, McLoughlin DM, Miller CC.

Neurosci Lett. 2009 Apr 24;454(2):161-4. doi: 10.1016/j.neulet.2009.02.061. Epub 2009 Mar 3.

PMID:
19429076
25.

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.

Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE.

Science. 2009 Feb 27;323(5918):1208-1211. doi: 10.1126/science.1165942.

26.

Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.

Yates DM, Manser C, De Vos KJ, Shaw CE, McLoughlin DM, Miller CC.

Eur J Cell Biol. 2009 Apr;88(4):193-202. doi: 10.1016/j.ejcb.2008.11.004. Epub 2009 Jan 14.

PMID:
19147253
27.

Role of axonal transport in neurodegenerative diseases.

De Vos KJ, Grierson AJ, Ackerley S, Miller CC.

Annu Rev Neurosci. 2008;31:151-73. doi: 10.1146/annurev.neuro.31.061307.090711. Review.

PMID:
18558852
28.

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

De Vos KJ, Chapman AL, Tennant ME, Manser C, Tudor EL, Lau KF, Brownlees J, Ackerley S, Shaw PJ, McLoughlin DM, Shaw CE, Leigh PN, Miller CCJ, Grierson AJ.

Hum Mol Genet. 2007 Nov 15;16(22):2720-2728. doi: 10.1093/hmg/ddm226. Epub 2007 Aug 28.

29.

Cell-free assays for mitochondria-cytoskeleton interactions.

Boldogh IR, Pon LA, Sheetz MP, De Vos KJ.

Methods Cell Biol. 2007;80:683-706. Review. No abstract available.

PMID:
17445717
30.

Visualization and quantification of mitochondrial dynamics in living animal cells.

De Vos KJ, Sheetz MP.

Methods Cell Biol. 2007;80:627-82. Review. No abstract available.

PMID:
17445716
31.

Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission.

De Vos KJ, Allan VJ, Grierson AJ, Sheetz MP.

Curr Biol. 2005 Apr 12;15(7):678-83.

32.

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