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Mitochondrial Arginase-2 is a cell autonomous regulator of CD8+ T cell function and anti-tumor efficacy.

Martí I Líndez AA, Dunand-Sauthier I, Conti M, Gobet F, Núñez N, Hannich JT, Riezman H, Geiger R, Piersigilli A, Hahn K, Lemeille S, Becher B, De Smedt T, Hugues S, Reith W.

JCI Insight. 2019 Nov 21. pii: 132975. doi: 10.1172/jci.insight.132975. [Epub ahead of print]


ADVANCE: Towards near real-time monitoring of vaccination coverage, benefits and risks using European electronic health record databases.

Bollaerts K, de Smedt T, McGee C, Emborg HD, Villa M, Alexandridou M, Duarte-Salles T, Gini R, Bartolini C, de Lusignan S, Tin Tin Htar M, Titievsky L, Sturkenboom M, Bauchau V.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)31051-5. doi: 10.1016/j.vaccine.2019.08.012. [Epub ahead of print]


ADVANCE system testing: Benefit-risk analysis of a marketed vaccine using multi-criteria decision analysis and individual-level state transition modelling.

Bollaerts K, Ledent E, de Smedt T, Weibel D, Emborg HD, Danieli G, Duarte-Salles T, Huerta C, Martín-Merino E, Picelli G, Tramontan L, Sturkenboom M, Bauchau V.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)31243-5. doi: 10.1016/j.vaccine.2019.09.034. [Epub ahead of print]


ADVANCE system testing: Can safety studies be conducted using electronic healthcare data? An example using pertussis vaccination.

Weibel D, Dodd C, Mahaux O, Haguinet F, De Smedt T, Duarte-Salles T, Picelli G, Tramontan L, Danieli G, Correa A, McGee C, Martín-Merino E, Huerta C, Berencsi K, Emborg HD, Bollaerts K, Bauchau V, Titievsky L, Sturkenboom M.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)30802-3. doi: 10.1016/j.vaccine.2019.06.040. [Epub ahead of print]


Bias due to differential and non-differential disease- and exposure misclassification in studies of vaccine effectiveness.

De Smedt T, Merrall E, Macina D, Perez-Vilar S, Andrews N, Bollaerts K.

PLoS One. 2018 Jun 15;13(6):e0199180. doi: 10.1371/journal.pone.0199180. eCollection 2018.


Benefit-Risk Monitoring of Vaccines Using an Interactive Dashboard: A Methodological Proposal from the ADVANCE Project.

Bollaerts K, De Smedt T, Donegan K, Titievsky L, Bauchau V.

Drug Saf. 2018 Aug;41(8):775-786. doi: 10.1007/s40264-018-0658-y.


Methodology for computing the burden of disease of adverse events following immunization.

McDonald SA, Nijsten D, Bollaerts K, Bauwens J, Praet N, van der Sande M, Bauchau V, de Smedt T, Sturkenboom M, Hahné S.

Pharmacoepidemiol Drug Saf. 2018 Jul;27(7):724-730. doi: 10.1002/pds.4419. Epub 2018 Mar 24.


Comparative long-term trend analysis of daily weather conditions with daily pollen concentrations in Brussels, Belgium.

Bruffaerts N, De Smedt T, Delcloo A, Simons K, Hoebeke L, Verstraeten C, Van Nieuwenhuyse A, Packeu A, Hendrickx M.

Int J Biometeorol. 2018 Mar;62(3):483-491. doi: 10.1007/s00484-017-1457-3. Epub 2017 Oct 24.


Thyroid Cancer Incidence around the Belgian Nuclear Sites, 2000-2014.

Demoury C, De Smedt T, De Schutter H, Sonck M, Van Damme N, Bollaerts K, Molenberghs G, Van Bladel L, Van Nieuwenhuyse A.

Int J Environ Res Public Health. 2017 Aug 31;14(9). pii: E988. doi: 10.3390/ijerph14090988.


Biomarkers in patients admitted to the emergency department after exposure to acrylonitrile in a major railway incident involving bulk chemical material.

Colenbie S, Buylaert W, Stove C, Deschepper E, Vandewoude K, De Smedt T, Bader M, Göen T, Van Nieuwenhuyse A, De Paepe P.

Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):261-270. doi: 10.1016/j.ijheh.2016.12.012. Epub 2017 Jan 3.


Childhood leukaemia near nuclear sites in Belgium, 2002-2008.

Bollaerts K, Simons K, Van Bladel L, De Smedt T, Sonck M, Fierens S, Poffijn A, Geraets D, Gosselin P, Van Oyen H, Francart J, Van Nieuwenhuyse A.

Eur J Cancer Prev. 2018 Mar;27(2):184-191. doi: 10.1097/CEJ.0000000000000272.


Nanobodies® as inhaled biotherapeutics for lung diseases.

Van Heeke G, Allosery K, De Brabandere V, De Smedt T, Detalle L, de Fougerolles A.

Pharmacol Ther. 2017 Jan;169:47-56. doi: 10.1016/j.pharmthera.2016.06.012. Epub 2016 Jun 29. Review.


Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium.

Simons K, De Smedt T, Stove C, De Paepe P, Bader M, Nemery B, Vleminckx C, De Cremer K, Van Overmeire I, Fierens S, Mertens B, Göen T, Schettgen T, Van Oyen H, Van Loco J, Van Nieuwenhuyse A.

Environ Res. 2016 Jul;148:256-263. doi: 10.1016/j.envres.2016.03.031. Epub 2016 Apr 15.


Nicotine Dependence and Urinary Nicotine, Cotinine and Hydroxycotinine Levels in Daily Smokers.

Van Overmeire IP, De Smedt T, Dendale P, Nackaerts K, Vanacker H, Vanoeteren JF, Van Laethem DM, Van Loco J, De Cremer KA.

Nicotine Tob Res. 2016 Sep;18(9):1813-9. doi: 10.1093/ntr/ntw099. Epub 2016 Apr 15.


Acrylonitrile exposure in the general population following a major train accident in Belgium: a human biomonitoring study.

De Smedt T, De Cremer K, Vleminckx C, Fierens S, Mertens B, Van Overmeire I, Bader M, De Paepe P, Göen T, Nemery B, Schettgen T, Stove C, Van Oyen H, Van Loco J, Van Nieuwenhuyse A.

Toxicol Lett. 2014 Dec 15;231(3):344-51. doi: 10.1016/j.toxlet.2014.09.009. Epub 2014 Sep 16.


Acrylonitrile exposure assessment in the emergency responders of a major train accident in Belgium: a human biomonitoring study.

Van Nieuwenhuyse A, Fierens S, De Smedt T, De Cremer K, Vleminckx C, Mertens B, Van Overmeire I, Bader M, De Paepe P, Göen T, Nemery B, Schettgen T, Stove C, Van Oyen H, Van Loco J.

Toxicol Lett. 2014 Dec 15;231(3):352-9. doi: 10.1016/j.toxlet.2014.08.013. Epub 2014 Aug 13.


Accuracy of placement of the glenoid component in reversed shoulder arthroplasty with and without navigation.

Verborgt O, De Smedt T, Vanhees M, Clockaerts S, Parizel PM, Van Glabbeek F.

J Shoulder Elbow Surg. 2011 Jan;20(1):21-6. doi: 10.1016/j.jse.2010.07.014.


Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis.

Rottiers P, De Smedt T, Steidler L.

Int Rev Immunol. 2009;28(6):465-86. doi: 10.3109/08830180903197498. Review.


Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat.

Raedt R, Van Dycke A, Van Melkebeke D, De Smedt T, Claeys P, Wyckhuys T, Vonck K, Wadman W, Boon P.

Acta Neurol Scand. 2009 May;119(5):293-303.


Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O.

Nat Med. 2009 Feb;15(2):206-10. doi: 10.1038/nm.1906. Epub 2009 Jan 18.


Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.

Kool M, Pétrilli V, De Smedt T, Rolaz A, Hammad H, van Nimwegen M, Bergen IM, Castillo R, Lambrecht BN, Tschopp J.

J Immunol. 2008 Sep 15;181(6):3755-9.


Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD.

Busso N, Karababa M, Nobile M, Rolaz A, Van Gool F, Galli M, Leo O, So A, De Smedt T.

PLoS One. 2008 May 21;3(5):e2267. doi: 10.1371/journal.pone.0002267.


Deep brain stimulation in patients with refractory temporal lobe epilepsy.

Boon P, Vonck K, De Herdt V, Van Dycke A, Goethals M, Goossens L, Van Zandijcke M, De Smedt T, Dewaele I, Achten R, Wadman W, Dewaele F, Caemaert J, Van Roost D.

Epilepsia. 2007 Aug;48(8):1551-60.


Lateral epicondylitis in tennis: update on aetiology, biomechanics and treatment.

De Smedt T, de Jong A, Van Leemput W, Lieven D, Van Glabbeek F.

Br J Sports Med. 2007 Nov;41(11):816-9. Epub 2007 Jul 6. Review.


Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate.

De Smedt T, De Rouck S, Raedt R, Wyckhuys T, Waterschoot L, De Herdt V, Van Dycke A, Tahry RE, Vonck K, Boon P.

Seizure. 2007 Oct;16(7):620-6. Epub 2007 Jun 7.


Radiation of the rat brain suppresses seizure-induced neurogenesis and transiently enhances excitability during kindling acquisition.

Raedt R, Boon P, Persson A, Alborn AM, Boterberg T, Van Dycke A, Linder B, De Smedt T, Wadman WJ, Ben-Menachem E, Eriksson PS.

Epilepsia. 2007 Oct;48(10):1952-63. Epub 2007 Jun 6.


Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug.

De Smedt T, Raedt R, Vonck K, Boon P.

CNS Drug Rev. 2007 Spring;13(1):57-78. Review.


Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data.

De Smedt T, Raedt R, Vonck K, Boon P.

CNS Drug Rev. 2007 Spring;13(1):43-56. Review.


A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.

Mayor A, Martinon F, De Smedt T, Pétrilli V, Tschopp J.

Nat Immunol. 2007 May;8(5):497-503. Epub 2007 Apr 15.


High frequency deep brain stimulation in the hippocampus modifies seizure characteristics in kindled rats.

Wyckhuys T, De Smedt T, Claeys P, Raedt R, Waterschoot L, Vonck K, Van den Broecke C, Mabilde C, Leybaert L, Wadman W, Boon P.

Epilepsia. 2007 Aug;48(8):1543-50. Epub 2007 Mar 22.


A pilot study of IL-1 inhibition by anakinra in acute gout.

So A, De Smedt T, Revaz S, Tschopp J.

Arthritis Res Ther. 2007;9(2):R28.


Neuromodulation with levetiracetam and vagus nerve stimulation in experimental animal models of epilepsy.

Dedeurwaerdere S, Vonck K, De Herdt V, Waterschoot L, De Smedt T, Raedt R, Wyckhuys T, Legros B, Van Hese P, Van Laere K, Delbeke J, Wadman W, Boon P.

Acta Neurol Belg. 2006 Jun;106(2):91-7. Review.


Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam.

De Smedt T, Vonck K, Raedt R, Dedeurwaerdere S, Claeys P, Legros B, Wyckhuys T, Wadman W, Boon P.

Epilepsy Res. 2005 Dec;67(3):109-16. Epub 2005 Nov 9.


Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.

Zhou B, Comeau MR, De Smedt T, Liggitt HD, Dahl ME, Lewis DB, Gyarmati D, Aye T, Campbell DJ, Ziegler SF.

Nat Immunol. 2005 Oct;6(10):1047-53. Epub 2005 Sep 4.


Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood.

Dedeurwaerdere S, Boon P, De Smedt T, Claeys P, Raedt R, Bosman T, Van Hese P, Van Maele G, Vonck K.

Seizure. 2005 Sep;14(6):403-11.


Dendritic cell function in mice lacking Plexin C1.

Walzer T, Galibert L, De Smedt T.

Int Immunol. 2005 Jul;17(7):943-50. Epub 2005 Jun 20.


Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils.

Walzer T, Galibert L, De Smedt T.

Eur J Immunol. 2005 Feb;35(2):391-8.


Neurostimulation for refractory epilepsy.

Vonck K, Boon P, Goossens L, Dedeurwaerdere S, Claeys P, Gossiaux F, Van Hese P, De Smedt T, Raedt R, Achten E, Deblaere K, Thieleman A, Vandemaele P, Thiery E, Vingerhoets G, Miatton M, Caemaert J, Van Roost D, Baert E, Michielsen G, Dewaele F, Van Laere K, Thadani V, Robertson D, Williamson P.

Acta Neurol Belg. 2003 Dec;103(4):213-7. Review.


Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs.

Brawand P, Fitzpatrick DR, Greenfield BW, Brasel K, Maliszewski CR, De Smedt T.

J Immunol. 2002 Dec 15;169(12):6711-9.


Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo.

De Smedt T, Smith J, Baum P, Fanslow W, Butz E, Maliszewski C.

J Immunol. 2002 Jan 15;168(2):661-70.


CD8alpha(-) and CD8alpha(+) subclasses of dendritic cells undergo phenotypic and functional maturation in vitro and in vivo.

De Smedt T, Butz E, Smith J, Maldonado-López R, Pajak B, Moser M, Maliszewski C.

J Leukoc Biol. 2001 Jun;69(6):951-8.


Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures.

Brasel K, De Smedt T, Smith JL, Maliszewski CR.

Blood. 2000 Nov 1;96(9):3029-39.


Immunohistowax processing, a new fixation and embedding method for light microscopy, which preserves antigen immunoreactivity and morphological structures: visualisation of dendritic cells in peripheral organs.

Pajak B, De Smedt T, Moulin V, De Trez C, Maldonado-López R, Vansanten G, Briend E, Urbain J, Leo O, Moser M.

J Clin Pathol. 2000 Jul;53(7):518-24.


Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.

McKenna HJ, Stocking KL, Miller RE, Brasel K, De Smedt T, Maraskovsky E, Maliszewski CR, Lynch DH, Smith J, Pulendran B, Roux ER, Teepe M, Lyman SD, Peschon JJ.

Blood. 2000 Jun 1;95(11):3489-97.


Downregulation of antigen-presenting cell functions after administration of mitogenic anti-CD3 monoclonal antibodies in mice.

Muraille E, Andris F, Pajak B, Wissing KM, De Smedt T, Desalle F, Goldman M, Alegre ML, Urbain J, Moser M, Leo O.

Blood. 1999 Dec 15;94(12):4347-57.


RANK is essential for osteoclast and lymph node development.

Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J.

Genes Dev. 1999 Sep 15;13(18):2412-24.


Role of CD8alpha+ and CD8alpha- dendritic cells in the induction of primary immune responses in vivo.

Maldonado-López R, De Smedt T, Pajak B, Heirman C, Thielemans K, Leo O, Urbain J, Maliszewski CR, Moser M.

J Leukoc Biol. 1999 Aug;66(2):242-6.


CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo.

Maldonado-López R, De Smedt T, Michel P, Godfroid J, Pajak B, Heirman C, Thielemans K, Leo O, Urbain J, Moser M.

J Exp Med. 1999 Feb 1;189(3):587-92.

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