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Items: 1 to 50 of 160

1.

Combined Genetic Deletion of IL (Interleukin)-4, IL-5, IL-9, and IL-13 Does Not Affect Ischemic Brain Injury in Mice.

Perego C, Fumagalli S, Miteva K, Kallikourdis M, De Simoni MG.

Stroke. 2019 Aug;50(8):2207-2215. doi: 10.1161/STROKEAHA.119.025196. Epub 2019 Jul 5.

PMID:
31272316
2.

Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury.

Neglia L, Oggioni M, Mercurio D, De Simoni MG, Fumagalli S.

Cell Mol Immunol. 2019 Apr 9. doi: 10.1038/s41423-019-0225-1. [Epub ahead of print]

PMID:
30967639
3.

SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance.

Varone E, Pozzer D, Di Modica S, Chernorudskiy A, Nogara L, Baraldo M, Cinquanta M, Fumagalli S, Villar-Quiles RN, De Simoni MG, Blaauw B, Ferreiro A, Zito E.

Redox Biol. 2019 Jun;24:101176. doi: 10.1016/j.redox.2019.101176. Epub 2019 Mar 23.

4.

Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model.

Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M.

ACS Nano. 2019 Apr 23;13(4):4410-4423. doi: 10.1021/acsnano.8b09655. Epub 2019 Mar 18.

PMID:
30883091
5.

The phagocytic state of brain myeloid cells after ischemia revealed by superresolution structured illumination microscopy.

Fumagalli S, Fiordaliso F, Perego C, Corbelli A, Mariani A, De Paola M, De Simoni MG.

J Neuroinflammation. 2019 Jan 16;16(1):9. doi: 10.1186/s12974-019-1401-z.

6.

Radioguided surgery with β radiation: a novel application with Ga68.

Collamati F, Bocci V, Castellucci P, De Simoni M, Fanti S, Faccini R, Giordano A, Maccora D, Mancini-Terracciano C, Marafini M, Mirabelli R, Morganti S, Schiavina R, Scotognella T, Traini G, Solfaroli Camillocci E.

Sci Rep. 2018 Nov 1;8(1):16171. doi: 10.1038/s41598-018-34626-x.

7.

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α.

Orsini F, Fumagalli S, Császár E, Tóth K, De Blasio D, Zangari R, Lénárt N, Dénes Á, De Simoni MG.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2678-2690. doi: 10.1161/ATVBAHA.118.311058.

8.

Induction of a transmissible tau pathology by traumatic brain injury.

Zanier ER, Bertani I, Sammali E, Pischiutta F, Chiaravalloti MA, Vegliante G, Masone A, Corbelli A, Smith DH, Menon DK, Stocchetti N, Fiordaliso F, De Simoni MG, Stewart W, Chiesa R.

Brain. 2018 Sep 1;141(9):2685-2699. doi: 10.1093/brain/awy193.

PMID:
30084913
9.

Human brain trauma severity is associated with lectin complement pathway activation.

De Blasio D, Fumagalli S, Orsini F, Neglia L, Perego C, Ortolano F, Zanier ER, Picetti E, Locatelli M, Stocchetti N, Longhi L, Garred P, De Simoni MG.

J Cereb Blood Flow Metab. 2019 May;39(5):794-807. doi: 10.1177/0271678X18758881. Epub 2018 Feb 9.

10.

Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury.

Pischiutta F, Micotti E, Hay JR, Marongiu I, Sammali E, Tolomeo D, Vegliante G, Stocchetti N, Forloni G, De Simoni MG, Stewart W, Zanier ER.

Exp Neurol. 2018 Feb;300:167-178. doi: 10.1016/j.expneurol.2017.11.003. Epub 2017 Nov 7.

11.

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques.

Pilely K, Fumagalli S, Rosbjerg A, Genster N, Skjoedt MO, Perego C, Ferrante AMR, De Simoni MG, Garred P.

Front Immunol. 2017 Aug 29;8:1040. doi: 10.3389/fimmu.2017.01040. eCollection 2017.

12.

Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice.

Sammali E, Alia C, Vegliante G, Colombo V, Giordano N, Pischiutta F, Boncoraglio GB, Barilani M, Lazzari L, Caleo M, De Simoni MG, Gaipa G, Citerio G, Zanier ER.

Sci Rep. 2017 Jul 31;7(1):6962. doi: 10.1038/s41598-017-07274-w.

13.

Lectin Pathway of Complement Activation Is Associated with Vulnerability of Atherosclerotic Plaques.

Fumagalli S, Perego C, Zangari R, De Blasio D, Oggioni M, De Nigris F, Snider F, Garred P, Ferrante AM, De Simoni MG.

Front Immunol. 2017 Mar 16;8:288. doi: 10.3389/fimmu.2017.00288. eCollection 2017.

14.

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.

Pasetto L, Pozzi S, Castelnovo M, Basso M, Estevez AG, Fumagalli S, De Simoni MG, Castellaneta V, Bigini P, Restelli E, Chiesa R, Trojsi F, Monsurrò MR, Callea L, Malešević M, Fischer G, Freschi M, Tortarolo M, Bendotti C, Bonetto V.

J Neurosci. 2017 Feb 8;37(6):1413-1427. doi: 10.1523/JNEUROSCI.2462-16.2016. Epub 2016 Dec 23.

15.

Lectin Complement Pathway and Its Bloody Interactions in Brain Ischemia.

Fumagalli S, De Simoni MG.

Stroke. 2016 Dec;47(12):3067-3073. Epub 2016 Nov 3. Review. No abstract available.

PMID:
27811336
16.

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury.

Perego C, Fumagalli S, Zanier ER, Carlino E, Panini N, Erba E, De Simoni MG.

Neurobiol Dis. 2016 Dec;96:284-293. doi: 10.1016/j.nbd.2016.09.017. Epub 2016 Sep 30.

PMID:
27697537
17.

Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites.

Pischiutta F, Brunelli L, Romele P, Silini A, Sammali E, Paracchini L, Marchini S, Talamini L, Bigini P, Boncoraglio GB, Pastorelli R, De Simoni MG, Parolini O, Zanier ER.

Crit Care Med. 2016 Nov;44(11):e1118-e1131.

PMID:
27441900
18.

Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1.

Orsini F, Chrysanthou E, Dudler T, Cummings WJ, Takahashi M, Fujita T, Demopulos G, De Simoni MG, Schwaeble W.

J Neuroinflammation. 2016 Aug 30;13(1):213. doi: 10.1186/s12974-016-0684-6.

19.

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.

Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH.

Aging Cell. 2016 Oct;15(5):953-63. doi: 10.1111/acel.12508. Epub 2016 Jul 29.

20.

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury.

De Blasio D, Fumagalli S, Longhi L, Orsini F, Palmioli A, Stravalaci M, Vegliante G, Zanier ER, Bernardi A, Gobbi M, De Simoni MG.

J Cereb Blood Flow Metab. 2017 Mar;37(3):938-950. doi: 10.1177/0271678X16647397. Epub 2016 Jul 20.

21.

Internalization of nanopolymeric tracers does not alter characteristics of placental cells.

Bigini P, Zanier ER, Saragozza S, Maciotta S, Romele P, Bonassi Signoroni P, Silini A, Pischiutta F, Sammali E, Balducci C, Violatto MB, Talamini L, Garry D, Moscatelli D, Ferrari R, Salmona M, De Simoni MG, Maggi F, Simoni G, Grati FR, Parolini O.

J Cell Mol Med. 2016 Jun;20(6):1036-48. doi: 10.1111/jcmm.12820. Epub 2016 Mar 14.

22.

A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors.

Stravalaci M, De Blasio D, Orsini F, Perego C, Palmioli A, Goti G, Bernardi A, De Simoni MG, Gobbi M.

J Biomol Screen. 2016 Aug;21(7):749-57. doi: 10.1177/1087057116637563. Epub 2016 Mar 11.

23.

Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke.

Zangari R, Zanier ER, Torgano G, Bersano A, Beretta S, Beghi E, Casolla B, Checcarelli N, Lanfranconi S, Maino A, Mandelli C, Micieli G, Orzi F, Picetti E, Silvestrini M, Stocchetti N, Zecca B, Garred P, De Simoni MG; LEPAS group.

J Neuroinflammation. 2016 Jan 20;13:16. doi: 10.1186/s12974-016-0481-2.

24.

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin.

Goti G, Palmioli A, Stravalaci M, Sattin S, De Simoni MG, Gobbi M, Bernardi A.

Chemistry. 2016 Mar 7;22(11):3686-91. doi: 10.1002/chem.201504388. Epub 2016 Jan 15.

25.

Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating.

Petitbarat M, Durigutto P, Macor P, Bulla R, Palmioli A, Bernardi A, De Simoni MG, Ledee N, Chaouat G, Tedesco F.

J Immunol. 2015 Dec 15;195(12):5602-7. doi: 10.4049/jimmunol.1501361. Epub 2015 Nov 11.

26.

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A.

Sci Transl Med. 2015 Aug 5;7(299):299ra121. doi: 10.1126/scitranslmed.aaa9853.

PMID:
26246166
27.

Corrigendum: Versatility of the complement system in neuroinflammation, neurodegeneration, and brain homeostasis.

Orsini F, De Blasio D, Zangari R, Zanier ER, De Simoni MG.

Front Cell Neurosci. 2015 Jul 7;9:263. doi: 10.3389/fncel.2015.00263. eCollection 2015.

28.

Shape descriptors of the "never resting" microglia in three different acute brain injury models in mice.

Zanier ER, Fumagalli S, Perego C, Pischiutta F, De Simoni MG.

Intensive Care Med Exp. 2015 Dec;3(1):39. doi: 10.1186/s40635-015-0039-0. Epub 2015 Feb 24.

29.

Fractalkine Receptor Deficiency Is Associated with Early Protection but Late Worsening of Outcome following Brain Trauma in Mice.

Zanier ER, Marchesi F, Ortolano F, Perego C, Arabian M, Zoerle T, Sammali E, Pischiutta F, De Simoni MG.

J Neurotrauma. 2016 Jun 1;33(11):1060-72. doi: 10.1089/neu.2015.4041. Epub 2015 Sep 8.

30.

The ischemic environment drives microglia and macrophage function.

Fumagalli S, Perego C, Pischiutta F, Zanier ER, De Simoni MG.

Front Neurol. 2015 Apr 8;6:81. doi: 10.3389/fneur.2015.00081. eCollection 2015. Review.

31.

Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis.

Orsini F, De Blasio D, Zangari R, Zanier ER, De Simoni MG.

Front Cell Neurosci. 2014 Nov 7;8:380. doi: 10.3389/fncel.2014.00380. eCollection 2014. Review. Erratum in: Front Cell Neurosci. 2015;9:263.

32.

A close look at brain dynamics: cells and vessels seen by in vivo two-photon microscopy.

Fumagalli S, Ortolano F, De Simoni MG.

Prog Neurobiol. 2014 Oct;121:36-54. doi: 10.1016/j.pneurobio.2014.06.005. Epub 2014 Jul 8. Review.

PMID:
25014527
33.

Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma.

Zanier ER, Pischiutta F, Riganti L, Marchesi F, Turola E, Fumagalli S, Perego C, Parotto E, Vinci P, Veglianese P, D'Amico G, Verderio C, De Simoni MG.

Neurotherapeutics. 2014 Jul;11(3):679-95. doi: 10.1007/s13311-014-0277-y.

34.

Mannose-binding lectin is expressed after clinical and experimental traumatic brain injury and its deletion is protective.

Longhi L, Orsini F, De Blasio D, Fumagalli S, Ortolano F, Locatelli M, Stocchetti N, De Simoni MG.

Crit Care Med. 2014 Aug;42(8):1910-8. doi: 10.1097/CCM.0000000000000399.

PMID:
24810526
35.

Ficolin-3-mediated lectin complement pathway activation in patients with subarachnoid hemorrhage.

Zanier ER, Zangari R, Munthe-Fog L, Hein E, Zoerle T, Conte V, Orsini F, Tettamanti M, Stocchetti N, Garred P, De Simoni MG.

Neurology. 2014 Jan 14;82(2):126-34. doi: 10.1212/WNL.0000000000000020. Epub 2013 Dec 11.

PMID:
24336142
36.

Immunosuppression does not affect human bone marrow mesenchymal stromal cell efficacy after transplantation in traumatized mice brain.

Pischiutta F, D'Amico G, Dander E, Biondi A, Biagi E, Citerio G, De Simoni MG, Zanier ER.

Neuropharmacology. 2014 Apr;79:119-26. doi: 10.1016/j.neuropharm.2013.11.001. Epub 2013 Nov 15.

PMID:
24246661
37.

Three-dimensional confocal analysis of microglia/macrophage markers of polarization in experimental brain injury.

Perego C, Fumagalli S, De Simoni MG.

J Vis Exp. 2013 Sep 4;(79). doi: 10.3791/50605.

38.

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury.

Franke H, Parravicini C, Lecca D, Zanier ER, Heine C, Bremicker K, Fumagalli M, Rosa P, Longhi L, Stocchetti N, De Simoni MG, Weber M, Abbracchio MP.

Purinergic Signal. 2013 Sep;9(3):451-62. doi: 10.1007/s11302-013-9366-3. Epub 2013 Jun 26.

39.

Six-month ischemic mice show sensorimotor and cognitive deficits associated with brain atrophy and axonal disorganization.

Zanier ER, Pischiutta F, Villa P, Paladini A, Montinaro M, Micotti E, Orrù A, Cervo L, De Simoni MG.

CNS Neurosci Ther. 2013 Sep;19(9):695-704. doi: 10.1111/cns.12128. Epub 2013 Jun 7.

40.

Heart-fatty acid-binding and tau proteins relate to brain injury severity and long-term outcome in subarachnoid haemorrhage patients.

Zanier ER, Zoerle T, Fiorini M, Longhi L, Cracco L, Bersano A, Branca V, Benedetti MD, De Simoni MG, Monaco S, Stocchetti N.

Br J Anaesth. 2013 Sep;111(3):424-32. doi: 10.1093/bja/aet149. Epub 2013 May 5.

41.

Tumor necrosis factor in traumatic brain injury: effects of genetic deletion of p55 or p75 receptor.

Longhi L, Perego C, Ortolano F, Aresi S, Fumagalli S, Zanier ER, Stocchetti N, De Simoni MG.

J Cereb Blood Flow Metab. 2013 Aug;33(8):1182-9. doi: 10.1038/jcbfm.2013.65. Epub 2013 Apr 24.

42.

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice.

Fumagalli S, Perego C, Ortolano F, De Simoni MG.

Glia. 2013 Jun;61(6):827-42. doi: 10.1002/glia.22474. Epub 2013 Feb 26.

PMID:
23440897
43.

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.

Orsini F, Villa P, Parrella S, Zangari R, Zanier ER, Gesuete R, Stravalaci M, Fumagalli S, Ottria R, Reina JJ, Paladini A, Micotti E, Ribeiro-Viana R, Rojo J, Pavlov VI, Stahl GL, Bernardi A, Gobbi M, De Simoni MG.

Circulation. 2012 Sep 18;126(12):1484-94. doi: 10.1161/CIRCULATIONAHA.112.103051. Epub 2012 Aug 9.

44.

Proteomic analysis of mouse brain cortex identifies metabolic down-regulation as a general feature of ischemic pre-conditioning.

Scornavacca G, Gesuete R, Orsini F, Pastorelli R, Fanelli R, de Simoni MG, Airoldi L.

J Neurochem. 2012 Sep;122(6):1219-29. doi: 10.1111/j.1471-4159.2012.07874.x. Epub 2012 Aug 3.

45.

The genetics of small-vessel disease.

Bersano A, Debette S, Zanier ER, Lanfranconi S, De Simoni MG, Zuffardi O, Micieli G.

Curr Med Chem. 2012;19(24):4124-41. Review.

PMID:
22680632
46.

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice.

Perego C, Fumagalli S, De Simoni MG.

J Neuroinflammation. 2011 Dec 10;8:174. doi: 10.1186/1742-2094-8-174.

47.

CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents.

Cipriani R, Villa P, Chece G, Lauro C, Paladini A, Micotti E, Perego C, De Simoni MG, Fredholm BB, Eusebi F, Limatola C.

J Neurosci. 2011 Nov 9;31(45):16327-35. doi: 10.1523/JNEUROSCI.3611-11.2011.

48.

Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.

Helmy A, De Simoni MG, Guilfoyle MR, Carpenter KL, Hutchinson PJ.

Prog Neurobiol. 2011 Nov;95(3):352-72. doi: 10.1016/j.pneurobio.2011.09.003. Epub 2011 Sep 16. Review.

PMID:
21939729
49.

Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma.

Zanier ER, Montinaro M, Vigano M, Villa P, Fumagalli S, Pischiutta F, Longhi L, Leoni ML, Rebulla P, Stocchetti N, Lazzari L, De Simoni MG.

Crit Care Med. 2011 Nov;39(11):2501-10. doi: 10.1097/CCM.0b013e31822629ba.

PMID:
21725237
50.

Glial cells drive preconditioning-induced blood-brain barrier protection.

Gesuete R, Orsini F, Zanier ER, Albani D, Deli MA, Bazzoni G, De Simoni MG.

Stroke. 2011 May;42(5):1445-53. doi: 10.1161/STROKEAHA.110.603266. Epub 2011 Apr 7.

PMID:
21474800

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