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Items: 10

1.

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Couto Alves A, De Silva NMG, Karhunen V, Sovio U, Das S, Taal HR, Warrington NM, Lewin AM, Kaakinen M, Cousminer DL, Thiering E, Timpson NJ, Bond TA, Lowry E, Brown CD, Estivill X, Lindi V, Bradfield JP, Geller F, Speed D, Coin LJM, Loh M, Barton SJ, Beilin LJ, Bisgaard H, Bønnelykke K, Alili R, Hatoum IJ, Schramm K, Cartwright R, Charles MA, Salerno V, Clément K, Claringbould AAJ; BIOS Consortium, van Duijn CM, Moltchanova E, Eriksson JG, Elks C, Feenstra B, Flexeder C, Franks S, Frayling TM, Freathy RM, Elliott P, Widén E, Hakonarson H, Hattersley AT, Rodriguez A, Banterle M, Heinrich J, Heude B, Holloway JW, Hofman A, Hyppönen E, Inskip H, Kaplan LM, Hedman AK, Läärä E, Prokisch H, Grallert H, Lakka TA, Lawlor DA, Melbye M, Ahluwalia TS, Marinelli M, Millwood IY, Palmer LJ, Pennell CE, Perry JR, Ring SM, Savolainen MJ, Rivadeneira F, Standl M, Sunyer J, Tiesler CMT, Uitterlinden AG, Schierding W, O'Sullivan JM, Prokopenko I, Herzig KH, Smith GD, O'Reilly P, Felix JF, Buxton JL, Blakemore AIF, Ong KK, Jaddoe VWV, Grant SFA, Sebert S, McCarthy MI, Järvelin MR; Early Growth Genetics (EGG) Consortium.

Sci Adv. 2019 Sep 4;5(9):eaaw3095. doi: 10.1126/sciadv.aaw3095. eCollection 2019 Sep.

2.

Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study.

De Silva NMG, Borges MC, Hingorani AD, Engmann J, Shah T, Zhang X, Luan J, Langenberg C, Wong A, Kuh D, Chambers JC, Zhang W, Jarvelin MR, Sebert S, Auvinen J; UCLEB consortium, Gaunt TR, Lawlor DA.

Diabetes. 2019 Aug;68(8):1681-1691. doi: 10.2337/db18-1048. Epub 2019 May 14.

PMID:
31088856
3.

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NM, Wood AR, Horikoshi M, Geller F, Myhre R, Bradfield JP, Kreiner-Møller E, Huikari V, Painter JN, Hottenga JJ, Allard C, Berry DJ, Bouchard L, Das S, Evans DM, Hakonarson H, Hayes MG, Heikkinen J, Hofman A, Knight B, Lind PA, McCarthy MI, McMahon G, Medland SE, Melbye M, Morris AP, Nodzenski M, Reichetzeder C, Ring SM, Sebert S, Sengpiel V, Sørensen TI, Willemsen G, de Geus EJ, Martin NG, Spector TD, Power C, Järvelin MR, Bisgaard H, Grant SF, Nohr EA, Jaddoe VW, Jacobsson B, Murray JC, Hocher B, Hattersley AT, Scholtens DM, Davey Smith G, Hivert MF, Felix JF, Hyppönen E, Lowe WL Jr, Frayling TM, Lawlor DA, Freathy RM; Early Growth Genetics (EGG) Consortium.

JAMA. 2016 Mar 15;315(11):1129-40. doi: 10.1001/jama.2016.1975. Erratum in: JAMA. 2016 Apr 19;315(15):1661.

4.

ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes.

Lawlor DA, Benn M, Zuccolo L, De Silva NM, Tybjaerg-Hansen A, Smith GD, Nordestgaard BG.

PLoS One. 2014 Dec 15;9(12):e114294. doi: 10.1371/journal.pone.0114294. eCollection 2014.

5.

Evaluation of common type 2 diabetes risk variants in a South Asian population of Sri Lankan descent.

Hassanali N, De Silva NM, Robertson N, Rayner NW, Barrett A, Bennett AJ, Groves CJ, Matthews DR, Katulanda P, Frayling TM, McCarthy MI.

PLoS One. 2014 Jun 13;9(6):e98608. doi: 10.1371/journal.pone.0098608. eCollection 2014.

6.

Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis.

Islam M, Jafar TH, Wood AR, De Silva NM, Caulfield M, Chaturvedi N, Frayling TM.

Diabetologia. 2012 Aug;55(8):2193-204. doi: 10.1007/s00125-012-2560-y. Epub 2012 Apr 28.

PMID:
22538361
7.

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.

De Silva NM, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN, Shields B, Knight BA, Ward KJ, Sandhu MS, Harbord RM, McCarthy MI, Smith GD, Ebrahim S, Hattersley AT, Wareham N, Lawlor DA, Morris AD, Palmer CN, Frayling TM.

Diabetes. 2011 Mar;60(3):1008-18. doi: 10.2337/db10-1317. Epub 2011 Jan 31.

8.

Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits.

De Silva NM, Frayling TM.

Curr Opin Lipidol. 2010 Feb;21(1):44-50. doi: 10.1097/MOL.0b013e328334fdb6. Review.

PMID:
19956073
9.

The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.

De Silva NM, Steele A, Shields B, Knight B, Parnell K, Weedon MN, Hattersley AT, Frayling TM.

Diabet Med. 2007 Oct;24(10):1067-72. Epub 2007 Aug 24.

PMID:
17725629
10.

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