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Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.

Sosa EA, Moriyama Y, Ding Y, Tejeda-Muñoz N, Colozza G, De Robertis EM.

Int J Dev Biol. 2019;63(6-7):301-309. doi: 10.1387/ijdb.190006ed.


Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins.

Tejeda-Muñoz N, Albrecht LV, Bui MH, De Robertis EM.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10402-10411. doi: 10.1073/pnas.1903506116. Epub 2019 May 6.


Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.

Albrecht LV, Bui MH, De Robertis EM.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2987-2995. doi: 10.1073/pnas.1820161116. Epub 2019 Jan 24.


Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis.

Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9135-E9144. doi: 10.1073/pnas.1812117115. Epub 2018 Sep 12.


Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking.

Albrecht LV, Ploper D, Tejeda-Muñoz N, De Robertis EM.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5317-E5325. doi: 10.1073/pnas.1804091115. Epub 2018 May 17.


Embryonic regeneration by relocalization of the Spemann organizer during twinning in Xenopus.

Moriyama Y, De Robertis EM.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4815-E4822. doi: 10.1073/pnas.1802749115. Epub 2018 Apr 23.


Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover.

Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C.

Dev Cell. 2017 Oct 9;43(1):71-82.e6. doi: 10.1016/j.devcel.2017.09.011.


Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson.

De Robertis EM, Moriyama Y, Colozza G.

Dev Growth Differ. 2017 Sep;59(7):580-592. doi: 10.1111/dgd.12388. Epub 2017 Aug 16.


Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis.

Ding Y, Ploper D, Sosa EA, Colozza G, Moriyama Y, Benitez MD, Zhang K, Merkurjev D, De Robertis EM.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3081-E3090. doi: 10.1073/pnas.1700766114. Epub 2017 Mar 27.


Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling.

Demagny H, De Robertis EM.

Mol Cell Oncol. 2015 Jan 30;3(2):e989133. doi: 10.4161/23723556.2014.989133. eCollection 2016 Mar.


Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling.

Demagny H, De Robertis EM.

Mol Cell Oncol. 2015 Apr 14;3(1):e1025181. doi: 10.1080/23723556.2015.1025181. eCollection 2016 Jan.


Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula.

Ding Y, Colozza G, Zhang K, Moriyama Y, Ploper D, Sosa EA, Benitez MDJ, De Robertis EM.

Dev Biol. 2017 Jun 15;426(2):176-187. doi: 10.1016/j.ydbio.2016.02.032. Epub 2016 Mar 23.


The Chordin Morphogenetic Pathway.

De Robertis EM, Moriyama Y.

Curr Top Dev Biol. 2016;116:231-45. doi: 10.1016/bs.ctdb.2015.10.003. Epub 2016 Jan 7. Review.


Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins.

De Robertis EM, Ploper D.

Dev Cell. 2015 Nov 23;35(4):401-2. doi: 10.1016/j.devcel.2015.11.009.


Morpholinos: Antisense and Sensibility.

Blum M, De Robertis EM, Wallingford JB, Niehrs C.

Dev Cell. 2015 Oct 26;35(2):145-9. doi: 10.1016/j.devcel.2015.09.017. Review.


EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning.

Bier E, De Robertis EM.

Science. 2015 Jun 26;348(6242):aaa5838. doi: 10.1126/science.aaa5838. Review.


Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway.

Kim H, Vick P, Hedtke J, Ploper D, De Robertis EM.

Cell Rep. 2015 May 26;11(8):1151-9.


The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.

Ploper D, De Robertis EM.

Pharmacol Res. 2015 Sep;99:36-43. doi: 10.1016/j.phrs.2015.04.006. Epub 2015 May 21. Review.


MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.

Ploper D, Taelman VF, Robert L, Perez BS, Titz B, Chen HW, Graeber TG, von Euw E, Ribas A, De Robertis EM.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E420-9. doi: 10.1073/pnas.1424576112. Epub 2015 Jan 20.


Lessons from a great developmental biologist.

De Robertis EM.

Differentiation. 2014 Jul;88(1):3-8. doi: 10.1016/j.diff.2013.12.004. Epub 2014 Nov 20.


The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling.

Demagny H, Araki T, De Robertis EM.

Cell Rep. 2014 Oct 23;9(2):688-700. doi: 10.1016/j.celrep.2014.09.020. Epub 2014 Oct 16.


Herbert Steinbeisser: a life with the Xenopus embryo.

De Robertis EM, Niehrs C.

Int J Dev Biol. 2014;58(5):299-302. doi: 10.1387/ijdb.140117ed. No abstract available.


Yoshiki Sasai 1962-2014.

De Robertis EM.

Cell. 2014 Sep 11;158(6):1233-5. No abstract available.


Yoshiki Sasai 1962–2014.

De Robertis EM.

Dev Cell. 2014 Sep 8;30(5):509-11. No abstract available.


Maternal syntabulin is required for dorsal axis formation and is a germ plasm component in Xenopus.

Colozza G, De Robertis EM.

Differentiation. 2014 Jul;88(1):17-26. doi: 10.1016/j.diff.2014.03.002. Epub 2014 May 3.


Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo.

Plouhinec JL, Zakin L, Moriyama Y, De Robertis EM.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20372-9. doi: 10.1073/pnas.1319745110. Epub 2013 Nov 27.


Development: scaling to size by protease inhibition.

De Robertis EM, Colozza G.

Curr Biol. 2013 Aug 5;23(15):R652-4. doi: 10.1016/j.cub.2013.06.055.


Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.

Dobrowolski R, Vick P, Ploper D, Gumper I, Snitkin H, Sabatini DD, De Robertis EM.

Cell Rep. 2012 Nov 29;2(5):1316-28. doi: 10.1016/j.celrep.2012.09.026. Epub 2012 Nov 1.


Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles.

Dobrowolski R, De Robertis EM.

Nat Rev Mol Cell Biol. 2011 Nov 23;13(1):53-60. doi: 10.1038/nrm3244. Review.


Phosphorylation of Mad controls competition between wingless and BMP signaling.

Eivers E, Demagny H, Choi RH, De Robertis EM.

Sci Signal. 2011 Oct 11;4(194):ra68. doi: 10.1126/scisignal.2002034.


Systems control of BMP morphogen flow in vertebrate embryos.

Plouhinec JL, Zakin L, De Robertis EM.

Curr Opin Genet Dev. 2011 Dec;21(6):696-703. doi: 10.1016/j.gde.2011.09.001. Epub 2011 Sep 19. Review.


Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm.

Vorwald-Denholtz PP, De Robertis EM.

Gene Expr Patterns. 2011 Oct;11(7):456-63. doi: 10.1016/j.gep.2011.07.004. Epub 2011 Jul 28.


Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.

Ploper D, Lee HX, De Robertis EM.

Dev Biol. 2011 Apr 15;352(2):317-28. doi: 10.1016/j.ydbio.2011.01.029. Epub 2011 Feb 3.


Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.

Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD, De Robertis EM.

Cell. 2010 Dec 23;143(7):1136-48. doi: 10.1016/j.cell.2010.11.034.


Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.

Zakin L, Chang EY, Plouhinec JL, De Robertis EM.

Dev Biol. 2010 Nov 1;347(1):204-15. doi: 10.1016/j.ydbio.2010.08.025. Epub 2010 Aug 31.


Wnt signaling in axial patterning and regeneration: lessons from planaria.

De Robertis EM.

Sci Signal. 2010 Jun 22;3(127):pe21. doi: 10.1126/scisignal.3127pe21.


Drosophila Smad2 opposes Mad signaling during wing vein development.

Sander V, Eivers E, Choi RH, De Robertis EM.

PLoS One. 2010 Apr 28;5(4):e10383. doi: 10.1371/journal.pone.0010383.


The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.

Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O.

Development. 2010 Apr;137(7):1107-16. doi: 10.1242/dev.046045.


Extracellular regulation of BMP signaling.

Zakin L, De Robertis EM.

Curr Biol. 2010 Feb 9;20(3):R89-92. doi: 10.1016/j.cub.2009.11.021. Review.


Systems biology of the self-regulating morphogenetic gradient of the Xenopus gastrula.

Plouhinec JL, De Robertis EM.

Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a001701. doi: 10.1101/cshperspect.a001701.


Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad.

Eivers E, Demagny H, De Robertis EM.

Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):357-65. doi: 10.1016/j.cytogfr.2009.10.017. Epub 2009 Nov 5. Review.


Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity.

Lee HX, Mendes FA, Plouhinec JL, De Robertis EM.

Genes Dev. 2009 Nov 1;23(21):2551-62. doi: 10.1101/gad.1839309.


Spemann's organizer and the self-regulation of embryonic fields.

De Robertis EM.

Mech Dev. 2009 Dec;126(11-12):925-41. doi: 10.1016/j.mod.2009.08.004. Epub 2009 Sep 4. Review.


Mad is required for wingless signaling in wing development and segment patterning in Drosophila.

Eivers E, Fuentealba LC, Sander V, Clemens JC, Hartnett L, De Robertis EM.

PLoS One. 2009 Aug 6;4(8):e6543. doi: 10.1371/journal.pone.0006543.


The molecular ancestry of segmentation mechanisms.

De Robertis EM.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16411-2. doi: 10.1073/pnas.0808774105. Epub 2008 Oct 23. Review. No abstract available.


Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.

Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM.

Dev Biol. 2008 Nov 1;323(1):6-18. doi: 10.1016/j.ydbio.2008.08.019. Epub 2008 Aug 29.


Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.

Ambrosio AL, Taelman VF, Lee HX, Metzinger CA, Coffinier C, De Robertis EM.

Dev Cell. 2008 Aug;15(2):248-60. doi: 10.1016/j.devcel.2008.06.013.


Integrating positional information at the level of Smad1/5/8.

Eivers E, Fuentealba LC, De Robertis EM.

Curr Opin Genet Dev. 2008 Aug;18(4):304-10. doi: 10.1016/j.gde.2008.06.001. Epub 2008 Jul 14. Review.


Eddy M. De Robertis.

De Robertis EM.

Curr Biol. 2008 Apr 22;18(8):R318-20. No abstract available.


Asymmetric mitosis: Unequal segregation of proteins destined for degradation.

Fuentealba LC, Eivers E, Geissert D, Taelman V, De Robertis EM.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7732-7. doi: 10.1073/pnas.0803027105. Epub 2008 May 29.

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