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Items: 1 to 50 of 200

1.

Isothiocyanates and Glucosinolates from Sisymbrium officinale (L.) Scop. ("the Singers' Plant"): Isolation and in Vitro Assays on the Somatosensory and Pain Receptor TRPA1 Channel.

Borgonovo G, Zimbaldi N, Guarise M, De Nisi P, De Petrocellis L, Schiano Moriello A, Bassoli A.

Molecules. 2019 Mar 8;24(5). pii: E949. doi: 10.3390/molecules24050949.

2.

Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart.

Gorbunov AS, Maslov LN, Jaggi AS, Singh N, De Petrocellis L, Boshchenko AA, Roohbakhsh A, Bezuglov VV, Oeltgen PR.

Curr Cardiol Rev. 2019 Mar 6. doi: 10.2174/1573403X15666190307112326. [Epub ahead of print]

PMID:
30848206
3.

Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats.

Leone S, Ferrante C, Recinella L, Chiavaroli A, Mollica A, Tömböly C, Stefanucci A, Dimmito MP, Dvorácskó S, Verratti V, De Petrocellis L, Orlando G, Brunetti L.

Neuropeptides. 2018 Dec;72:38-46. doi: 10.1016/j.npep.2018.10.002. Epub 2018 Oct 27.

PMID:
30396596
4.

Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists.

Schiano Moriello A, López Chinarro S, Novo Fernández O, Eras J, Amodeo P, Canela-Garayoa R, Vitale RM, Di Marzo V, De Petrocellis L.

J Med Chem. 2018 Sep 27;61(18):8255-8281. doi: 10.1021/acs.jmedchem.8b00734. Epub 2018 Sep 14.

PMID:
30176215
5.

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

Lopatriello A, Caprioglio D, Minassi A, Schiano Moriello A, Formisano C, De Petrocellis L, Appendino G, Taglialatela-Scafati O.

Bioorg Med Chem. 2018 Aug 15;26(15):4532-4536. doi: 10.1016/j.bmc.2018.07.044. Epub 2018 Jul 27.

PMID:
30077611
6.

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice.

Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D'Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V.

Br J Pharmacol. 2018 Aug 3. doi: 10.1111/bph.14460. [Epub ahead of print]

PMID:
30074247
7.

TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba.

Chianese G, Sirignano C, Shokoohinia Y, Mohammadi Z, Bazvandi L, Jafari F, Jalilian F, Schiano Moriello A, De Petrocellis L, Taglialatela-Scafati O, Rigano D.

Molecules. 2018 Jul 17;23(7). pii: E1750. doi: 10.3390/molecules23071750.

8.

Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2018 Apr;126:35-39. doi: 10.1016/j.fitote.2018.04.002. Epub 2018 Apr 11. No abstract available.

PMID:
29655820
9.

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

Pollastro F, Caprioglio D, Marotta P, Moriello AS, De Petrocellis L, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2018 Mar 23;81(3):630-633. doi: 10.1021/acs.jnatprod.7b00946. Epub 2017 Dec 14.

PMID:
29240420
10.

Anorexigenic effects induced by RVD-hemopressin(α) administration.

Ferrante C, Recinella L, Leone S, Chiavaroli A, Di Nisio C, Martinotti S, Mollica A, Macedonio G, Stefanucci A, Dvorácskó S, Tömböly C, De Petrocellis L, Vacca M, Brunetti L, Orlando G.

Pharmacol Rep. 2017 Dec;69(6):1402-1407. doi: 10.1016/j.pharep.2017.05.015. Epub 2017 Jun 3.

PMID:
29145068
11.

Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats.

Leone S, Recinella L, Chiavaroli A, Martinotti S, Ferrante C, Mollica A, Macedonio G, Stefanucci A, Dvorácskó S, Tömböly C, De Petrocellis L, Vacca M, Brunetti L, Orlando G.

Pharmacol Rep. 2017 Dec;69(6):1247-1253. doi: 10.1016/j.pharep.2017.06.010. Epub 2017 Jun 23.

PMID:
29128806
12.

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2017 Nov;123:13-17. doi: 10.1016/j.fitote.2017.09.010. Epub 2017 Sep 20. No abstract available. Corrected and republished in: Fitoterapia. 2018 Apr;126:35-39.

PMID:
28941742
13.

Effects of curcumin and curcumin analogues on TRP channels.

Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L.

Fitoterapia. 2017 Oct;122:126-131. doi: 10.1016/j.fitote.2017.09.007. Epub 2017 Sep 10. Review.

PMID:
28903060
14.

Actions and Regulation of Ionotropic Cannabinoid Receptors.

De Petrocellis L, Nabissi M, Santoni G, Ligresti A.

Adv Pharmacol. 2017;80:249-289. doi: 10.1016/bs.apha.2017.04.001. Epub 2017 Jun 12. Review.

PMID:
28826537
15.

Extracts and compounds active on TRP ion channels from Waldheimia glabra, a ritual medicinal plant from Himalaya.

Giorgi A, Bassoli A, Borgonovo G, Panseri S, Manzo A, Pentimalli D, Schiano Moriello A, De Petrocellis L.

Phytomedicine. 2017 Aug 15;32:80-87. doi: 10.1016/j.phymed.2017.04.012. Epub 2017 May 1.

PMID:
28732812
16.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

17.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

18.

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology.

Ligresti A, De Petrocellis L, Di Marzo V.

Physiol Rev. 2016 Oct;96(4):1593-659. doi: 10.1152/physrev.00002.2016. Review.

19.

Correction to Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

De Petrocellis L, Arroyo FJ, Orlando P, Schiano Moriello A, Vitale RM, Amodeo P, Sánchez A, Roncero C, Bianchini G, Martín MA, López-Alvarado P, Menéndez JC.

J Med Chem. 2016 Aug 25;59(16):7697. doi: 10.1021/acs.jmedchem.6b01091. Epub 2016 Aug 3. No abstract available.

PMID:
27487560
20.

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.

Pollastro F, Golin S, Chianese G, Putra MY, Schiano Moriello A, De Petrocellis L, García V, Munoz E, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2016 Jul 22;79(7):1762-8. doi: 10.1021/acs.jnatprod.6b00141. Epub 2016 Jun 28.

PMID:
27352042
21.

Assay of TRPV1 Receptor Signaling.

Moriello AS, De Petrocellis L.

Methods Mol Biol. 2016;1412:65-76. doi: 10.1007/978-1-4939-3539-0_7.

PMID:
27245892
22.

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

De Petrocellis L, Arroyo FJ, Orlando P, Schiano Moriello A, Vitale RM, Amodeo P, Sánchez A, Roncero C, Bianchini G, Martín MA, López-Alvarado P, Menéndez JC.

J Med Chem. 2016 Jun 23;59(12):5661-83. doi: 10.1021/acs.jmedchem.5b01448. Epub 2016 Jun 14. Erratum in: J Med Chem. 2016 Aug 25;59(16):7697.

PMID:
27232526
23.

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

Monti L, Stefanucci A, Pieretti S, Marzoli F, Fidanza L, Mollica A, Mirzaie S, Carradori S, De Petrocellis L, Schiano Moriello A, Benyhe S, Zádor F, Szűcs E, Ötvös F, Erdei AI, Samavati R, Dvorácskó S, Tömböly C, Novellino E.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):1638-47. doi: 10.3109/14756366.2016.1160902. Epub 2016 Apr 11.

PMID:
27063555
24.

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress.

Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A.

ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333. Epub 2016 Mar 22.

PMID:
26942555
25.

Arylboronic acids as dual-action FAAH and TRPV1 ligands.

Morera E, Di Marzo V, Monti L, Allarà M, Schiano Moriello A, Nalli M, Ortar G, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1401-5. doi: 10.1016/j.bmcl.2016.01.071. Epub 2016 Jan 25.

PMID:
26850005
26.

TRPA1 channels as targets for resveratrol and related stilbenoids.

Nalli M, Ortar G, Moriello AS, Morera E, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):899-902. doi: 10.1016/j.bmcl.2015.12.065. Epub 2015 Dec 19.

PMID:
26750258
27.

Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists.

Maslov LN, Khaliulin I, Zhang Y, Krylatov AV, Naryzhnaya NV, Mechoulam R, De Petrocellis L, Downey JM.

J Cardiovasc Pharmacol Ther. 2016 May;21(3):262-72. doi: 10.1177/1074248415612593. Epub 2015 Oct 19. Review.

PMID:
26487546
28.

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

De Petrocellis L, Schiano Moriello A, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Di Marzo V.

Pharmacol Res. 2015 Sep;99:362-9. doi: 10.1016/j.phrs.2015.07.009. Epub 2015 Jul 17.

PMID:
26192347
29.

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives.

Congiu C, Onnis V, Balboni G, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Eur J Med Chem. 2015 Jul 15;100:129-38. doi: 10.1016/j.ejmech.2015.05.041. Epub 2015 Jun 6.

PMID:
26079089
30.

Structure-activity relationships of the prototypical TRPM8 agonist icilin.

De Petrocellis L, Ortar G, Schiano Moriello A, Serum EM, Rusterholz DB.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2285-90. doi: 10.1016/j.bmcl.2015.04.032. Epub 2015 Apr 16.

PMID:
25935641
31.

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

Del Prete D, Caprioglio D, Appendino G, Minassi A, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1009-11. doi: 10.1016/j.bmcl.2015.01.039. Epub 2015 Jan 28.

PMID:
25666822
32.

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels.

Petrosino S, Schiano Moriello A, Cerrato S, Fusco M, Puigdemont A, De Petrocellis L, Di Marzo V.

Br J Pharmacol. 2016 Apr;173(7):1154-62. doi: 10.1111/bph.13084. Epub 2015 Mar 26.

33.

Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice.

Maione S, Radanova L, De Gregorio D, Luongo L, De Petrocellis L, Di Marzo V, Imming P.

Eur J Pharmacol. 2015 Feb 5;748:115-22. doi: 10.1016/j.ejphar.2014.12.022. Epub 2014 Dec 31.

PMID:
25557763
34.

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5507-11. doi: 10.1016/j.bmcl.2014.10.012. Epub 2014 Oct 12.

PMID:
25455494
35.

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

Borrelli F, Pagano E, Romano B, Panzera S, Maiello F, Coppola D, De Petrocellis L, Buono L, Orlando P, Izzo AA.

Carcinogenesis. 2014 Dec;35(12):2787-97. doi: 10.1093/carcin/bgu205. Epub 2014 Sep 30.

PMID:
25269802
36.

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.

Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A, Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V.

Bioorg Med Chem. 2014 Sep 1;22(17):4770-83. doi: 10.1016/j.bmc.2014.07.006. Epub 2014 Jul 12.

PMID:
25065940
37.

Modulation of the TRPV1 channel: current clinical trials and recent patents with focus on neurological conditions.

De Petrocellis L, Moriello AS.

Recent Pat CNS Drug Discov. 2013 Dec;8(3):180-204. Review.

PMID:
24330123
38.

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5614-8. doi: 10.1016/j.bmcl.2013.08.039. Epub 2013 Aug 14.

PMID:
23993334
39.

Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida.

Shokoohinia Y, Chianese G, Appendino G, Di Marzo V, De Petrocellis L, Ghannadi A, Taghvayi R, Fattahian K, Soltani R, Taglialatela-Scafati O.

Fitoterapia. 2013 Oct;90:247-51. doi: 10.1016/j.fitote.2013.08.001. Epub 2013 Aug 13.

PMID:
23954176
40.

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.

De Petrocellis L, Schiano Moriello A, Fontana G, Sacchetti A, Passarella D, Appendino G, Di Marzo V.

Br J Pharmacol. 2014 May;171(10):2608-20. doi: 10.1111/bph.12320.

41.

Analogues of perillaketone as highly potent agonists of TRPA1 channel.

Bassoli A, Borgonovo G, Morini G, De Petrocellis L, Schiano Moriello A, Di Marzo V.

Food Chem. 2013 Dec 1;141(3):2044-51. doi: 10.1016/j.foodchem.2013.05.063. Epub 2013 May 24.

PMID:
23870926
42.

Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.

Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, Petrosino S, De Petrocellis L, Cristino L, Przewlocka B, Di Marzo V.

PLoS One. 2013;8(4):e60040. doi: 10.1371/journal.pone.0060040. Epub 2013 Apr 3.

43.

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Ortar G, Morera E, De Petrocellis L, Ligresti A, Schiano Moriello A, Morera L, Nalli M, Ragno R, Pirolli A, Di Marzo V.

Eur J Med Chem. 2013 May;63:118-32. doi: 10.1016/j.ejmech.2013.02.005. Epub 2013 Feb 15.

PMID:
23474898
44.

Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

Ortar G, De Petrocellis L, Moriello AS, Allarà M, Morera E, Nalli M, Di Marzo V.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):138-42. doi: 10.1016/j.bmcl.2012.10.137. Epub 2012 Nov 12.

PMID:
23206861
45.

Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels.

Chianese G, Fattorusso E, Putra MY, Calcinai B, Bavestrello G, Moriello AS, De Petrocellis L, Di Marzo V, Taglialatela-Scafati O.

Mar Drugs. 2012 Nov 2;10(11):2435-47. doi: 10.3390/md10112435.

46.

2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.

De Petrocellis L, Schiano Moriello A.

Expert Opin Ther Pat. 2013 Jan;23(1):119-47. doi: 10.1517/13543776.2013.736496. Epub 2012 Nov 6.

PMID:
23126422
47.

Why do cannabinoid receptors have more than one endogenous ligand?

Di Marzo V, De Petrocellis L.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3216-28. doi: 10.1098/rstb.2011.0382. Review.

48.

A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons.

De Petrocellis L, Schiano Moriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V.

Br J Pharmacol. 2012 Dec;167(8):1643-51. doi: 10.1111/j.1476-5381.2012.02122.x.

49.

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, Momma S, Lewin GR, Ligresti A, De Petrocellis L, Cristino L, Di Marzo V, Kettenmann H, Glass R.

Nat Med. 2012 Aug;18(8):1232-8. doi: 10.1038/nm.2827. Epub 2012 Jul 22.

50.

Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.

Luongo L, Costa B, D'Agostino B, Guida F, Comelli F, Gatta L, Matteis M, Sullo N, De Petrocellis L, de Novellis V, Maione S, Di Marzo V.

Pharmacol Res. 2012 Sep;66(3):243-50. doi: 10.1016/j.phrs.2012.05.005. Epub 2012 May 24.

PMID:
22634607

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