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Items: 22


Burden of itch in ichthyosis: a multicentre study in 94 patients.

De Palma AM, Mazereeuw-Hautier J, Giehl K, Hernández-Martin A, Merlos M, Moons P, Morren MA.

J Eur Acad Dermatol Venereol. 2019 May 6. doi: 10.1111/jdv.15613. [Epub ahead of print]


Toward antiviral therapy/prophylaxis for rhinovirus-induced exacerbations of chronic obstructive pulmonary disease: challenges, opportunities, and strategies.

Thibaut HJ, Lacroix C, De Palma AM, Franco D, Decramer M, Neyts J.

Rev Med Virol. 2016 Jan;26(1):21-33. doi: 10.1002/rmv.1856. Epub 2015 Sep 21. Review.


The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.


Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, De Palma AM, Canard B, Neyts J, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2013 Apr;57(4):1952-6. doi: 10.1128/AAC.02084-12. Epub 2013 Jan 18.


Novel substituted 9-norbornylpurines and their activities against RNA viruses.

Sála M, Hřebabecký H, Leyssen P, Dejmek M, Dračínský M, De Palma AM, Neyts J, Nencka R.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1963-8. doi: 10.1016/j.bmcl.2012.01.040. Epub 2012 Jan 25.


Combating enterovirus replication: state-of-the-art on antiviral research.

Thibaut HJ, De Palma AM, Neyts J.

Biochem Pharmacol. 2012 Jan 15;83(2):185-92. doi: 10.1016/j.bcp.2011.08.016. Epub 2011 Aug 26. Review.


SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.

Sála M, De Palma AM, Hřebabecký H, Dejmek M, Dračínský M, Leyssen P, Neyts J, Mertlíková-Kaiserová H, Nencka R.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4271-5. doi: 10.1016/j.bmcl.2011.05.070. Epub 2011 May 27.


Towards the design of combination therapy for the treatment of enterovirus infections.

Thibaut HJ, Leyssen P, Puerstinger G, Muigg A, Neyts J, De Palma AM.

Antiviral Res. 2011 Jun;90(3):213-7. doi: 10.1016/j.antiviral.2011.03.187. Epub 2011 Apr 3.


Picornavirus non-structural proteins as targets for new anti-virals with broad activity.

Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Solà M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE, Hilgenfeld R.

Antiviral Res. 2011 Mar;89(3):204-18. doi: 10.1016/j.antiviral.2010.12.007. Epub 2011 Jan 12. Review.


Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.

Sála M, De Palma AM, Hrebabecký H, Nencka R, Dracínský M, Leyssen P, Neyts J, Holý A.

Bioorg Med Chem. 2010 Jun 15;18(12):4374-84. doi: 10.1016/j.bmc.2010.04.081. Epub 2010 Apr 29.


Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.

De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J.

Antimicrob Agents Chemother. 2009 May;53(5):1850-7. doi: 10.1128/AAC.00934-08. Epub 2009 Feb 23.


Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis.

De Palma AM, Thibaut HJ, Li S, Van Aelst I, Dillen C, Swinnen M, Verbeken E, Neyts J, Opdenakker G.

J Pathol. 2009 Apr;217(5):633-41. doi: 10.1002/path.2501.


Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.

De Palma AM, Verbeken E, Van Aelst I, Van den Steen PE, Opdenakker G, Neyts J.

Virology. 2008 Dec 5;382(1):20-7. doi: 10.1016/j.virol.2008.08.046. Epub 2008 Oct 16.


Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles.

Pürstinger G, De Palma AM, Zimmerhofer G, Huber S, Ladurner S, Neyts J.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5123-5. doi: 10.1016/j.bmcl.2008.07.099. Epub 2008 Jul 30.


The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases.

Gruez A, Selisko B, Roberts M, Bricogne G, Bussetta C, Jabafi I, Coutard B, De Palma AM, Neyts J, Canard B.

J Virol. 2008 Oct;82(19):9577-90. doi: 10.1128/JVI.00631-08. Epub 2008 Jul 16.


Potential use of antiviral agents in polio eradication.

De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J.

Emerg Infect Dis. 2008 Apr;14(4):545-51. doi: 10.3201/eid1404.070439.


Selective inhibitors of picornavirus replication.

De Palma AM, Vliegen I, De Clercq E, Neyts J.

Med Res Rev. 2008 Nov;28(6):823-84. doi: 10.1002/med.20125. Review.


The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J.

J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12.


R75761, a lead compound for the development of antiviral drugs in late stage poliomyelitis eradication strategies and beyond.

Thys B, De Palma AM, Neyts J, Andries K, Vrijsen R, Rombaut B.

Antiviral Res. 2008 Jun;78(3):278-81. doi: 10.1016/j.antiviral.2008.01.002. Epub 2008 Feb 4.


Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase.

Jabafi I, Selisko B, Coutard B, De Palma AM, Neyts J, Egloff MP, Grisel S, Dalle K, Campanacci V, Spinelli S, Cambillau C, Canard B, Gruez A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):495-8. Epub 2007 May 12.


Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.

De Palma AM, Heggermont W, Leyssen P, Pürstinger G, Wimmer E, De Clercq E, Rao A, Monforte AM, Chimirri A, Neyts J.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):628-32. Epub 2006 Dec 19.


The effect of synthetic malaria pigment (beta-haematin) on adhesion molecule expression and interleukin-6 production by human endothelial cells.

Taramelli D, Basilico N, De Palma AM, Saresella M, Ferrante P, Mussoni L, Olliaro P.

Trans R Soc Trop Med Hyg. 1998 Jan-Feb;92(1):57-62.


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