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Items: 1 to 50 of 61

1.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.

2.

Understanding early TLR signaling through the Myddosome.

Balka KR, De Nardo D.

J Leukoc Biol. 2019 Feb;105(2):339-351. doi: 10.1002/JLB.MR0318-096R. Epub 2018 Sep 26. Review.

PMID:
30256449
3.

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.

De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL.

J Biol Chem. 2018 Sep 28;293(39):15195-15207. doi: 10.1074/jbc.RA118.003314. Epub 2018 Aug 3.

4.

A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy.

Saldanha RG, Balka KR, Davidson S, Wainstein BK, Wong M, Macintosh R, Loo CKC, Weber MA, Kamath V; CIRCA; AADRY, Moghaddas F, De Nardo D, Gray PE, Masters SL.

Front Immunol. 2018 Jul 6;9:1535. doi: 10.3389/fimmu.2018.01535. eCollection 2018.

5.

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar PE, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL.

J Allergy Clin Immunol. 2018 Dec;142(6):1956-1967.e6. doi: 10.1016/j.jaci.2018.04.033. Epub 2018 May 17.

6.

Immortalization of Murine Bone Marrow-Derived Macrophages.

De Nardo D, Kalvakolanu DV, Latz E.

Methods Mol Biol. 2018;1784:35-49. doi: 10.1007/978-1-4939-7837-3_4.

PMID:
29761386
7.

Generation of Innate Immune Reporter Cells Using Retroviral Transduction.

Cardona Gloria Y, Latz E, De Nardo D.

Methods Mol Biol. 2018;1714:97-117. doi: 10.1007/978-1-4939-7519-8_7.

PMID:
29177858
8.

Emerging Concepts in Innate Immunity.

Pelka K, De Nardo D.

Methods Mol Biol. 2018;1714:1-18. doi: 10.1007/978-1-4939-7519-8_1. Review.

PMID:
29177852
9.
10.

A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.

Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, Wicks IP, Pelegrin P, Arostegui JI, Masters SL.

Ann Rheum Dis. 2017 Dec;76(12):2085-2094. doi: 10.1136/annrheumdis-2017-211473. Epub 2017 Aug 23.

11.

Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition.

Baker PJ, De Nardo D, Moghaddas F, Tran LS, Bachem A, Nguyen T, Hayman T, Tye H, Vince JE, Bedoui S, Ferrero RL, Masters SL.

Physiol Rev. 2017 Jul 1;97(3):1165-1209. doi: 10.1152/physrev.00026.2016. Review.

12.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.

13.

Erratum to: Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.

Beilharz M, De Nardo D, Latz E, Franklin BS.

Methods Mol Biol. 2016;1417:E1. No abstract available.

PMID:
27699711
14.

Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.

Beilharz M, De Nardo D, Latz E, Franklin BS.

Methods Mol Biol. 2016;1417:145-58. doi: 10.1007/978-1-4939-3566-6_9. Erratum in: Methods Mol Biol. 2016;1417:E1.

PMID:
27221487
15.

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E.

Sci Transl Med. 2016 Apr 6;8(333):333ra50. doi: 10.1126/scitranslmed.aad6100.

16.

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A.

Sci Transl Med. 2016 Mar 30;8(332):332ra45. doi: 10.1126/scitranslmed.aaf1471.

17.

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID.

Sci Signal. 2016 Jan 5;9(409):ra3. doi: 10.1126/scisignal.aab2191.

18.

Angiotensin 1-7 significantly reduces diabetes-induced leukocyte recruitment both in vivo and in vitro.

Bossi F, Bernardi S, De Nardo D, Bramante A, Candido R, Carretta R, Fischetti F, Fabris B.

Atherosclerosis. 2016 Jan;244:121-30. doi: 10.1016/j.atherosclerosis.2015.11.017. Epub 2015 Nov 25.

PMID:
26630181
19.

ATF3 Is a Key Regulator of Macrophage IFN Responses.

Labzin LI, Schmidt SV, Masters SL, Beyer M, Krebs W, Klee K, Stahl R, Lütjohann D, Schultze JL, Latz E, De Nardo D.

J Immunol. 2015 Nov 1;195(9):4446-55. doi: 10.4049/jimmunol.1500204. Epub 2015 Sep 28.

20.

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL.

J Exp Med. 2015 Jun 1;212(6):927-38. doi: 10.1084/jem.20142384. Epub 2015 May 25.

21.

Toll-like receptors: Activation, signalling and transcriptional modulation.

De Nardo D.

Cytokine. 2015 Aug;74(2):181-9. doi: 10.1016/j.cyto.2015.02.025. Epub 2015 Apr 3. Review.

PMID:
25846205
22.

The inflammasomes and autoinflammatory syndromes.

Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E.

Annu Rev Pathol. 2015;10:395-424. doi: 10.1146/annurev-pathol-012414-040431. Epub 2014 Nov 19. Review.

PMID:
25423351
23.

Optimization of transcription factor binding map accuracy utilizing knockout-mouse models.

Krebs W, Schmidt SV, Goren A, De Nardo D, Labzin L, Bovier A, Ulas T, Theis H, Kraut M, Latz E, Beyer M, Schultze JL.

Nucleic Acids Res. 2014 Dec 1;42(21):13051-60. doi: 10.1093/nar/gku1078. Epub 2014 Nov 5.

24.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

25.

Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells.

Kwa MQ, Nguyen T, Huynh J, Ramnath D, De Nardo D, Lam PY, Reynolds EC, Hamilton JA, Sweet MJ, Scholz GM.

J Biol Chem. 2014 Jul 11;289(28):19758-68. doi: 10.1074/jbc.M114.584540. Epub 2014 May 28.

26.

Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.

Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro A, Mallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL.

Immunity. 2014 Feb 20;40(2):274-88. doi: 10.1016/j.immuni.2014.01.006. Epub 2014 Feb 13.

27.

Innate immunity.

Masters SL, De Nardo D.

Curr Opin Immunol. 2014 Feb;26:v-vi. doi: 10.1016/j.coi.2013.12.006. Epub 2014 Feb 1. No abstract available.

PMID:
24495628
28.

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E.

Nat Immunol. 2014 Feb;15(2):152-60. doi: 10.1038/ni.2784. Epub 2013 Dec 8.

29.

New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease.

De Nardo D, De Nardo CM, Latz E.

Am J Pathol. 2014 Jan;184(1):42-54. doi: 10.1016/j.ajpath.2013.09.007. Epub 2013 Oct 30. Review.

30.

NLRP3 inflammasomes link inflammation and metabolic disease.

De Nardo D, Latz E.

Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4. Review.

31.

Long-term anti-TNF-alpha treatments reverse the endothelial dysfunction in rheumatoid arthritis: the biological coherence between synovial and endothelial inflammation.

Capria A, De Nardo D, Baffetti FR, Barbini U, Violo A, Tondo T, Fontana L.

Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):255-62.

PMID:
20378011
32.

Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.

De Nardo D, De Nardo CM, Nguyen T, Hamilton JA, Scholz GM.

J Immunol. 2009 Dec 15;183(12):8110-8. doi: 10.4049/jimmunol.0901031.

33.

Regulation of IRAK-1 activation by its C-terminal domain.

Nguyen T, De Nardo D, Masendycz P, Hamilton JA, Scholz GM.

Cell Signal. 2009 May;21(5):719-26. doi: 10.1016/j.cellsig.2009.01.010. Epub 2009 Jan 7.

PMID:
19166926
34.

Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages.

De Nardo D, Nguyen T, Hamilton JA, Scholz GM.

Cell Signal. 2009 Feb;21(2):246-52. doi: 10.1016/j.cellsig.2008.10.009. Epub 2008 Oct 25.

PMID:
18992325
35.

The critical role of the colony-stimulating factor-1 receptor in the differentiation of myeloblastic leukemia cells.

Hamilton JA, Whitty G, Masendycz P, Wilson NJ, Jackson J, De Nardo D, Scholz GM.

Mol Cancer Res. 2008 Mar;6(3):458-67. doi: 10.1158/1541-7786.MCR-07-0361.

36.

High levels of peripheral blood NK cells in women suffering from recurrent spontaneous abortion are reverted from high-dose intravenous immunoglobulins.

Perricone R, Di Muzio G, Perricone C, Giacomelli R, De Nardo D, Fontana L, De Carolis C.

Am J Reprod Immunol. 2006 Mar;55(3):232-9.

PMID:
16451358
37.

A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.

De Nardo D, Masendycz P, Ho S, Cross M, Fleetwood AJ, Reynolds EC, Hamilton JA, Scholz GM.

J Biol Chem. 2005 Mar 18;280(11):9813-22. Epub 2005 Jan 12.

38.

Non-invasive diagnostic and functional evaluation of cardiac and pulmonary involvement in systemic sclerosis.

Sergiacomi G, De Nardo D, Capria A, Manenti G, Fabiano S, Borzi M, De Sanctis G, Konda D, Sperandio M, Schillaci O, Masala S, Simonetti G, Fontana L.

In Vivo. 2004 Mar-Apr;18(2):229-35.

39.

[Hyperammonemia during hypothyroidism: an unusual biohumoral finding normalized by hormonal replacement treatment].

De Nardo D, Franconi G, Sabino D.

Ann Ital Med Int. 1999 Jul-Sep;14(3):196-201. Review. Italian.

PMID:
10566186
40.

[The effects of a left bundle-branch block on ventricular repolarization dispersion].

Calò L, Levato M, Sciarra L, Nazzaro MS, Benvissuto F, Borzi M, De Nardo D, Cannata D.

Cardiologia. 1996 Nov;41(11):1073-7. Italian.

PMID:
9064204
41.

QT interval and QT dispersion in multiple system atrophy (Shy-Drager syndrome).

Frongillo D, Stocchi F, Delfino FA, Calò L, Bramante L, Antonucci F, De Nardo D, Ruggleri S, Cannata D.

Clin Auton Res. 1996 Apr;6(2):67-70.

PMID:
8726089
42.

Signal-averaged electrocardiography in myotonic dystrophy.

Fragola PV, Calò L, Antonini G, Morino S, Luzi M, De Nardo D, Cannata D.

Int J Cardiol. 1995 Jun 2;50(1):61-8.

PMID:
7558465
43.

[The role of diuretics in antihypertensive therapy].

De Nardo D, Frongillo D, Anselmo T, Delfino FA, Cannata D.

Clin Ter. 1995 Apr;146(4):261-8. Review. Italian.

PMID:
7796557
44.

Cardiac amyloidosis detected by Tc-99m (V) DMSA myocardial uptake.

Manni C, Sangiorgi G, Boemi S, De Nardo D, Cipriani C, Cannata D.

Clin Nucl Med. 1994 Dec;19(12):1109-11. No abstract available.

PMID:
7874817
45.

Use of the signal-averaged QRS duration for diagnosing left ventricular hypertrophy in hypertensive patients.

Fragola PV, De Nardo D, Calò L, Cannata D.

Int J Cardiol. 1994 May;44(3):261-70.

PMID:
8077072
46.

Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis. A case report.

Sangiorgi G, Orlandi A, De Nardo D, Sangiorgi M, Spagnoli LG.

Ann Ital Med Int. 1993 Jan-Mar;8(1):21-4.

PMID:
8485005
47.

Ventricular conduction defects and atrial fibrillation after coronary artery bypass grafting. Multivariate analysis of preoperative, intraoperative and postoperative variables.

Caretta Q, Mercanti CA, De Nardo D, Chiarotti F, Scibilia G, Reale A, Marino B.

Eur Heart J. 1991 Oct;12(10):1107-11.

PMID:
1782937
48.

The role of indium-111 antimyosin (Fab) imaging as a noninvasive surveillance method of human heart transplant rejection.

De Nardo D, Scibilia G, Macchiarelli AG, Cassisi A, Tonelli E, Papalia U, Gallo P, Antolini M, Pitucco G, Reale A, et al.

J Heart Transplant. 1989 Sep-Oct;8(5):407-12.

PMID:
2795283
49.

Effects of uncomplicated coronary artery bypass graft surgery on global and regional left ventricular function at rest. Study by equilibrium radionuclide angiocardiography.

De Nardo D, Caretta Q, Mercanti C, Alessandri N, Scibilia G, Chiavarelli R, Antolini M, Pitucco G, Caputo V, Marino B.

Cardiology. 1989;76(4):285-92.

PMID:
2805015
50.

Myocardial necrosis imaging by 111In monoclonal antimyosin Fab.

Caputo V, De Nardo D, Antolini M, Pitucco G, Gallo P, Scibilia G, Macchiarelli AG, Cassisi A, Caretta Q, Bianco G, et al.

Int J Rad Appl Instrum B. 1989;16(6):641-3. No abstract available.

PMID:
2606720

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