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Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease: Diagnostic and Additional Therapeutic Consequences.

De Mey JGR, Bloksgaard M, Aalkjær C.

Physiology (Bethesda). 2019 Mar 1;34(2):82-83. doi: 10.1152/physiol.00053.2018. No abstract available.


Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.

Bijkerk R, Aleksinskaya MA, Duijs JMGJ, Veth J, Husen B, Reiche D, Prehn C, Adamski J, Rabelink TJ, De Mey JGR, van Zonneveld AJ.

Clin Sci (Lond). 2019 Jan 22;133(2):239-252. doi: 10.1042/CS20180882. Print 2019 Jan 31.


Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients.

Elie AGIM, Bloksgaard M, Sun WY, Yang K, Man AWC, Xu A, Irmukhamedov A, Riber LP, Wang Y, De Mey JGR.

PLoS One. 2018 Nov 5;13(11):e0206802. doi: 10.1371/journal.pone.0206802. eCollection 2018.


Deletion of endothelial arginase 1 does not improve vasomotor function in diabetic mice.

Chennupati R, Meens MJ, Janssen BJ, van Dijk P, Hakvoort TBM, Lamers WH, De Mey JGR, Koehler SE.

Physiol Rep. 2018 Jun;6(11):e13717. doi: 10.14814/phy2.13717.


Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy.

Bloksgaard M, Thorsted B, Brewer JR, De Mey JGR.

J Vis Exp. 2018 Apr 9;(134). doi: 10.3791/57451.


Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.

Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y.

ESC Heart Fail. 2017 Nov;4(4):563-575. doi: 10.1002/ehf2.12183. Epub 2017 Jun 27.


Relaxing Responses to Hydrogen Peroxide and Nitric Oxide in Human Pericardial Resistance Arteries Stimulated with Endothelin-1.

Leurgans TM, Bloksgaard M, Irmukhamedov A, Riber LP, De Mey JGR.

Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):74-81. doi: 10.1111/bcpt.12843. Epub 2017 Jul 30.


Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries.

Bloksgaard M, Leurgans TM, Spronck B, Heusinkveld MHG, Thorsted B, Rosenstand K, Nissen I, Hansen UM, Brewer JR, Bagatolli LA, Rasmussen LM, Irmukhamedov A, Reesink KD, De Mey JGR.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H164-H178. doi: 10.1152/ajpheart.00110.2017. Epub 2017 Apr 21.


Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR.

Lemkens P, Spijkers LJ, Meens MJ, Nelissen J, Janssen B, Peters SL, Schiffers PM, De Mey JG.

Hypertens Res. 2017 Aug;40(8):738-745. doi: 10.1038/hr.2017.38. Epub 2017 Mar 16.


Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.

Bai B, Man AW, Yang K, Guo Y, Xu C, Tse HF, Han W, Bloksgaard M, De Mey JG, Vanhoutte PM, Xu A, Wang Y.

Oncotarget. 2016 Jun 28;7(26):39065-39081. doi: 10.18632/oncotarget.9687.


Endothelium-dependent hyperpolarizations in health and disease.

Hansen PB, De Mey JG, Vanhoutte PM.

Acta Physiol (Oxf). 2017 Jan;219(1):97-99. doi: 10.1111/apha.12716. Epub 2016 Jun 16. No abstract available.


Adipokine Imbalance in the Pericardial Cavity of Cardiac and Vascular Disease Patients.

Elie AG, Jensen PS, Nissen KD, Geraets IM, Xu A, Song E, Hansen ML, Irmukhamedov A, Rasmussen LM, Wang Y, De Mey JG.

PLoS One. 2016 May 3;11(5):e0154693. doi: 10.1371/journal.pone.0154693. eCollection 2016.


Endothelin-1 shifts the mediator of bradykinin-induced relaxation from NO to H2 O2 in resistance arteries from patients with cardiovascular disease.

Leurgans TM, Bloksgaard M, Brewer JR, Bagatolli LA, Fredgart MH, Rosenstand K, Hansen ML, Rasmussen LM, Irmukhamedov A, De Mey JG.

Br J Pharmacol. 2016 May;173(10):1653-64. doi: 10.1111/bph.13467. Epub 2016 Apr 6.


Nitric Oxide Resistance Reduces Arteriovenous Fistula Maturation in Chronic Kidney Disease in Rats.

Geenen IL, Kolk FF, Molin DG, Wagenaar A, Compeer MG, Tordoir JH, Schurink GW, De Mey JG, Post MJ.

PLoS One. 2016 Jan 4;11(1):e0146212. doi: 10.1371/journal.pone.0146212. eCollection 2016.


Phosphodiesterase 1 regulation is a key mechanism in vascular aging.

Bautista Niño PK, Durik M, Danser AH, de Vries R, Musterd-Bhaggoe UM, Meima ME, Kavousi M, Ghanbari M, Hoeijmakers JH, O'Donnell CJ, Franceschini N, Janssen GM, De Mey JG, Liu Y, Shanahan CM, Franco OH, Dehghan A, Roks AJ.

Clin Sci (Lond). 2015 Dec;129(12):1061-75. doi: 10.1042/CS20140753. Epub 2015 Jun 25.


Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis.

Kosanovic D, Luitel H, Dahal BK, Cornitescu T, Janssen W, Danser AH, Garrelds IM, De Mey JG, Fazzi G, Schiffers P, Iglarz M, Fischli W, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Reiss I, Schermuly RT.

Eur Respir J. 2015 Oct;46(4):1084-94. doi: 10.1183/09031936.00018215. Epub 2015 Jun 25.


Elastin organization in pig and cardiovascular disease patients' pericardial resistance arteries.

Bloksgaard M, Leurgans TM, Nissen I, Jensen PS, Hansen ML, Brewer JR, Bagatolli LA, Marcussen N, Irmukhamedov A, Rasmussen LM, De Mey JG.

J Vasc Res. 2015;52(1):1-11. doi: 10.1159/000376548. Epub 2015 Mar 31.


Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetes.

Hanssen NM, Brouwers O, Gijbels MJ, Wouters K, Wijnands E, Cleutjens JP, De Mey JG, Miyata T, Biessen EA, Stehouwer CD, Schalkwijk CG.

Cardiovasc Res. 2014 Oct 1;104(1):160-70. doi: 10.1093/cvr/cvu189. Epub 2014 Aug 18.


Imaging evidence for endothelin ETA/ETB receptor heterodimers in isolated rat mesenteric resistance arteries.

Kapsokalyvas D, Schiffers PM, Maij N, Suylen DP, Hackeng TM, van Zandvoort MA, De Mey JG.

Life Sci. 2014 Aug 28;111(1-2):36-41. doi: 10.1016/j.lfs.2014.07.007. Epub 2014 Jul 24.


Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice.

Chennupati R, Meens MJ, Marion V, Janssen BJ, Lamers WH, De Mey JG, Köhler SE.

PLoS One. 2014 Jul 17;9(7):e102264. doi: 10.1371/journal.pone.0102264. eCollection 2014.


End o' the line revisited: moving on from nitric oxide to CGRP.

De Mey JG, Vanhoutte PM.

Life Sci. 2014 Nov 24;118(2):120-8. doi: 10.1016/j.lfs.2014.04.012. Epub 2014 Apr 18. Review.


Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.

Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG.

Diabetologia. 2014 Jan;57(1):224-35. doi: 10.1007/s00125-013-3088-5. Epub 2013 Oct 26.


Long-lasting physiological antagonism of calcitonin gene-related peptide towards endothelin-1 in rat mesenteric arteries and human coronary arteries.

Labruijere S, Compeer MG, van den Bogaerdt AJ, van den Brink AM, De Mey JG, Danser AH, Batenburg WW.

Eur J Pharmacol. 2013 Nov 15;720(1-3):303-9. doi: 10.1016/j.ejphar.2013.10.012. Epub 2013 Oct 18.


Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries.

Compeer MG, Janssen GM, De Mey JG.

Br J Pharmacol. 2013 Nov;170(6):1199-209. doi: 10.1111/bph.12332.


Identification of free nitric oxide radicals in rat bone marrow: implications for progenitor cell mobilization in hypertension.

Aleksinskaya MA, van Faassen EE, Nelissen J, Janssen BJ, De Mey JG, Hanemaaijer R, Rabelink T, van Zonneveld AJ.

PLoS One. 2013;8(3):e57761. doi: 10.1371/journal.pone.0057761. Epub 2013 Mar 12.


Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes.

Chennupati R, Lamers WH, Koehler SE, De Mey JG.

Br J Pharmacol. 2013 Aug;169(7):1486-99. doi: 10.1111/bph.12175.


Cardiac remodeling during and after renin-angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats.

Heijnen BF, Pelkmans LP, Danser AH, Garrelds IM, Mullins JJ, De Mey JG, Struijker-Boudier HA, Janssen BJ.

J Renin Angiotensin Aldosterone Syst. 2014 Mar;15(1):69-81. doi: 10.1177/1470320313480537. Epub 2013 Mar 5.


Dual neural endopeptidase/endothelin-converting [corrected] enzyme inhibition improves endothelial function in mesenteric resistance arteries of young spontaneously hypertensive rats.

Lemkens P, Nelissen J, Meens MJ, Janssen BJ, Schiffers PM, De Mey JG.

J Hypertens. 2012 Sep;30(9):1799-808. doi: 10.1097/HJH.0b013e3283569c7a. Erratum in: J Hypertens. 2012 Dec;30(12):2445.


Impaired flow-induced arterial remodeling in DOCA-salt hypertensive rats.

Lemkens P, Nelissen J, Meens MJ, Fazzi GE, Janssen GJ, Debets JJ, Janssen BJ, Schiffers PM, De Mey JG.

Hypertens Res. 2012 Nov;35(11):1093-101. doi: 10.1038/hr.2012.94. Epub 2012 Jul 12.


Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods.

Büther K, Compeer MG, De Mey JG, Schober O, Schäfers M, Bremer C, Riemann B, Höltke C.

Endocrinology. 2012 Jun;153(6):2907-18. doi: 10.1210/en.2011-2017. Epub 2012 Apr 17.


Endothelin-1 and -2: two amino acids matter.

Compeer MG, Suylen DP, Hackeng TM, De Mey JG.

Life Sci. 2012 Oct 15;91(13-14):607-12. doi: 10.1016/j.lfs.2012.02.011. Epub 2012 Mar 3.


Pharmacokinetic and pharmacodynamic properties of SOL1: a novel dual inhibitor of neutral endopeptidase and endothelin converting enzyme.

Nelissen J, Lemkens P, Sann H, Bindl M, Bassissi F, Jasserand D, De Mey JG, Janssen BJ.

Life Sci. 2012 Oct 15;91(13-14):587-92. doi: 10.1016/j.lfs.2012.01.015. Epub 2012 Feb 17.


Agonist-dependent modulation of arterial endothelinA receptor function.

Compeer MG, Meens MJ, Hackeng TM, Neugebauer WA, Höltke C, De Mey JG.

Br J Pharmacol. 2012 Jul;166(6):1833-45. doi: 10.1111/j.1476-5381.2012.01896.x.


Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.

Spijkers LJ, Janssen BJ, Nelissen J, Meens MJ, Wijesinghe D, Chalfant CE, De Mey JG, Alewijnse AE, Peters SL.

PLoS One. 2011;6(12):e29222. doi: 10.1371/journal.pone.0029222. Epub 2011 Dec 15.


G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide.

Meens MJ, Mattheij NJ, van Loenen PB, Spijkers LJ, Lemkens P, Nelissen J, Compeer MG, Alewijnse AE, De Mey JG.

Br J Pharmacol. 2012 May;166(1):297-308. doi: 10.1111/j.1476-5381.2011.01774.x.


Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y₁₂ antagonist ticagrelor.

Kuijpers MJ, Megens RT, Nikookhesal E, Feijge MA, De Mey JG, oude Egbrink MG, van Giezen JJ, Heemskerk JW.

Thromb Haemost. 2011 Dec;106(6):1179-88. doi: 10.1160/TH11-04-0252. Epub 2011 Nov 10.


The redox state of transglutaminase 2 controls arterial remodeling.

van den Akker J, VanBavel E, van Geel R, Matlung HL, Guvenc Tuna B, Janssen GM, van Veelen PA, Boelens WC, De Mey JG, Bakker EN.

PLoS One. 2011;6(8):e23067. doi: 10.1371/journal.pone.0023067. Epub 2011 Aug 25.


Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide.

Spijkers LJ, van den Akker RF, Janssen BJ, Debets JJ, De Mey JG, Stroes ES, van den Born BJ, Wijesinghe DS, Chalfant CE, MacAleese L, Eijkel GB, Heeren RM, Alewijnse AE, Peters SL.

PLoS One. 2011;6(7):e21817. doi: 10.1371/journal.pone.0021817. Epub 2011 Jul 19.


Calcitonin gene-related peptide terminates long-lasting vasopressor responses to endothelin 1 in vivo.

Meens MJ, Mattheij NJ, Nelissen J, Lemkens P, Compeer MG, Janssen BJ, De Mey JG.

Hypertension. 2011 Jul;58(1):99-106. doi: 10.1161/HYPERTENSIONAHA.110.169128. Epub 2011 May 23.


ETA-receptor antagonists or allosteric modulators?

De Mey JG, Compeer MG, Lemkens P, Meens MJ.

Trends Pharmacol Sci. 2011 Jun;32(6):345-51. doi: 10.1016/ Epub 2011 Apr 12.


Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8–10 October 2010.

Steckelings UM, De Mey JG, Pinto-Sietsma SJ, Henrion D, Unger T.

Expert Rev Cardiovasc Ther. 2011 Jan;9(1):21-5. doi: 10.1586/erc.10.178.


Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.

Storkebaum E, Ruiz de Almodovar C, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Miskiewicz K, Poesen K, Lambrechts D, Janssen GM, Fazzi GE, Verstreken P, Haigh J, Schiffers PM, Rohrer H, Van der Linden A, De Mey JG, Carmeliet P.

Circulation. 2010 Jul 20;122(3):273-81. doi: 10.1161/CIRCULATIONAHA.109.929364. Epub 2010 Jul 6.


Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ET(A)-receptor complexes.

Meens MJ, Compeer MG, Hackeng TM, van Zandvoort MA, Janssen BJ, De Mey JG.

PLoS One. 2010 Jun 1;5(6):e10917. doi: 10.1371/journal.pone.0010917.


Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.

Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, De Mey JG, Schalkwijk CG.

Diabetologia. 2010 May;53(5):989-1000. doi: 10.1007/s00125-010-1677-0. Epub 2010 Feb 26.


Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain.

Zoer B, Cogolludo AL, Perez-Vizcaino F, De Mey JG, Blanco CE, Villamor E.

Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1026-34. doi: 10.1152/ajpregu.00500.2009. Epub 2010 Jan 20.


Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries.

Hilgers RH, Janssen GM, Fazzi GE, De Mey JG.

J Pharmacol Exp Ther. 2010 Apr;333(1):210-7. doi: 10.1124/jpet.109.161448. Epub 2009 Dec 29.


Calcitonin gene-related peptide selectively relaxes contractile responses to endothelin-1 in rat mesenteric resistance arteries.

Meens MJ, Fazzi GE, van Zandvoort MA, De Mey JG.

J Pharmacol Exp Ther. 2009 Oct;331(1):87-95. doi: 10.1124/jpet.109.155143. Epub 2009 Jul 23.


Effects of prenatal hypoxia on pulmonary vascular reactivity in chickens prone to pulmonary hypertension.

Zoer B, Kessels L, Vereijken A, De Mey JG, Bruggeman V, Decuypere E, Blanco CE, Villamor E.

J Physiol Pharmacol. 2009 Mar;60(1):119-30.


Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1.

Hilgers RH, De Mey JG.

Br J Pharmacol. 2009 Apr;156(8):1239-47. doi: 10.1111/j.1476-5381.2009.00128.x. Epub 2009 Mar 19.


Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.

Rensen SS, Niessen PM, van Deursen JM, Janssen BJ, Heijman E, Hermeling E, Meens M, Lie N, Gijbels MJ, Strijkers GJ, Doevendans PA, Hofker MH, De Mey JG, van Eys GJ.

Circulation. 2008 Aug 19;118(8):828-36. doi: 10.1161/CIRCULATIONAHA.107.743690. Epub 2008 Aug 4.


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