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Items: 22

1.

Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors.

Bijvelds MJC, Tresadern G, Hellemans A, Smans K, Nieuwenhuijze NDA, Meijsen KF, Bongartz JP, Ver Donck L, de Jonge HR, Schuurkes JAJ, De Maeyer JH.

J Biol Chem. 2018 May 25;293(21):8173-8181. doi: 10.1074/jbc.RA118.002835. Epub 2018 Apr 13.

2.

Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist.

Conlon K, De Maeyer JH, Bruce C, Schuurkes JAJ, Christie L, McRedmond J, Derakhchan K, Wade PR.

J Pharmacol Exp Ther. 2018 Feb;364(2):156-169. doi: 10.1124/jpet.117.244079. Epub 2017 Nov 27.

PMID:
29180358
3.

Synergistic effect between 5-HT4 receptor agonist and phosphodiesterase 4-inhibitor in releasing acetylcholine in pig gastric circular muscle in vitro.

Lefebvre RA, Van Colen I, Pauwelyn V, De Maeyer JH.

Eur J Pharmacol. 2016 Jun 15;781:76-82. doi: 10.1016/j.ejphar.2016.04.003. Epub 2016 Apr 6.

PMID:
27060014
4.

Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors.

Bijvelds MJ, Loos M, Bronsveld I, Hellemans A, Bongartz JP, Ver Donck L, Cox E, de Jonge HR, Schuurkes JA, De Maeyer JH.

J Infect Dis. 2015 Dec 1;212(11):1806-15. doi: 10.1093/infdis/jiv300. Epub 2015 May 21.

PMID:
25999056
5.

SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice.

Lo AC, De Maeyer JH, Vermaercke B, Callaerts-Vegh Z, Schuurkes JA, D'Hooge R.

Neuropharmacology. 2014 Oct;85:178-89. doi: 10.1016/j.neuropharm.2014.05.013. Epub 2014 May 23.

PMID:
24863046
6.

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice.

Dupont LL, Bracke KR, De Maeyer JH, Compan V, Joos GF, Lefebvre RA, Brusselle GG.

Pulm Pharmacol Ther. 2014 Jun;28(1):60-7. doi: 10.1016/j.pupt.2013.10.003. Epub 2013 Oct 31.

PMID:
24183679
7.

Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility.

Broad J, Kung VW, Boundouki G, Aziz Q, De Maeyer JH, Knowles CH, Sanger GJ.

Br J Pharmacol. 2013 Nov;170(6):1253-61. doi: 10.1111/bph.12397.

8.

Predominant mucosal expression of 5-HT₄(+h) receptor splice variants in pig stomach and colon.

Priem EK, De Maeyer JH, Vandewoestyne M, Deforce D, Lefebvre RA.

World J Gastroenterol. 2013 Jun 28;19(24):3747-60. doi: 10.3748/wjg.v19.i24.3747.

9.

Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor.

Buiter HJ, Windhorst AD, Huisman MC, De Maeyer JH, Schuurkes JA, Lammertsma AA, Leysen JE.

EJNMMI Res. 2013 Apr 4;3(1):24. doi: 10.1186/2191-219X-3-24.

10.

Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium.

Weninger S, De Maeyer JH, Lefebvre RA.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Aug;386(8):671-84. doi: 10.1007/s00210-013-0855-2. Epub 2013 Apr 3.

PMID:
23549671
11.

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.

Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B.

Neurobiol Aging. 2013 Jul;34(7):1779-89. doi: 10.1016/j.neurobiolaging.2013.01.020. Epub 2013 Mar 6.

PMID:
23474291
12.

Influence of phosphodiesterases on basal and 5-HT₄ receptor facilitated cholinergic contractility in pig descending colon.

Priem EK, De Maeyer JH, Lefebvre RA.

Eur J Pharmacol. 2013 Apr 5;705(1-3):156-63. doi: 10.1016/j.ejphar.2013.02.011. Epub 2013 Feb 20.

PMID:
23454061
13.

Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atrium.

Weninger S, De Maeyer JH, Lefebvre RA.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Jun;385(6):565-77. doi: 10.1007/s00210-012-0746-y. Epub 2012 Mar 17.

PMID:
22426996
14.

Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.

Tack J, Camilleri M, Chang L, Chey WD, Galligan JJ, Lacy BE, Müller-Lissner S, Quigley EM, Schuurkes J, De Maeyer JH, Stanghellini V.

Aliment Pharmacol Ther. 2012 Apr;35(7):745-67. doi: 10.1111/j.1365-2036.2012.05011.x. Epub 2012 Feb 22. Review.

15.

Inotropic effects of prokinetic agents with 5-HT(4) receptor agonist actions on human isolated myocardial trabeculae.

Chai W, Chan KY, de Vries R, van den Bogeardt AJ, de Maeyer JH, Schuurkes JA, Villalón CM, Saxena PR, Danser AH, MaassenVanDenBrink A.

Life Sci. 2012 Apr 9;90(13-14):538-44. doi: 10.1016/j.lfs.2012.01.009. Epub 2012 Feb 1.

PMID:
22326501
16.

The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4.

Priem E, Van Colen I, De Maeyer JH, Lefebvre RA.

Neuropharmacology. 2012 Apr;62(5-6):2126-35. doi: 10.1016/j.neuropharm.2011.12.020. Epub 2011 Dec 28.

PMID:
22266217
17.

In-vitro acetylcholine release is not a straightforward model to study hippocampal 5-HT₄ receptors.

de Vin F, De Maeyer JH, Lefebvre RA.

Neuroreport. 2011 Dec 7;22(17):892-6. doi: 10.1097/WNR.0b013e32834c7fd4.

PMID:
21946331
18.

Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach.

De Maeyer JH, Schuurkes JA, Lefebvre RA.

Br J Pharmacol. 2009 Jan;156(2):362-76. doi: 10.1111/j.1476-5381.2008.00007.x. Epub 2009 Jan 13.

19.

Alternative splicing and exon duplication generates 10 unique porcine 5-HT 4 receptor splice variants including a functional homofusion variant.

De Maeyer JH, Aerssens J, Verhasselt P, Lefebvre RA.

Physiol Genomics. 2008 Jun 12;34(1):22-33. doi: 10.1152/physiolgenomics.00038.2008. Epub 2008 Apr 22.

PMID:
18430808
20.

5-HT4 receptor agonists: similar but not the same.

De Maeyer JH, Lefebvre RA, Schuurkes JA.

Neurogastroenterol Motil. 2008 Feb;20(2):99-112. doi: 10.1111/j.1365-2982.2007.01059.x. Review.

PMID:
18199093
21.
22.

Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development.

De Maeyer JH, Straetemans R, Schuurkes JA, Lefebvre RA.

Br J Pharmacol. 2006 Jan;147(2):140-57.

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