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Items: 1 to 50 of 162

1.

Functional Analysis of Somatic Mutations Affecting Receptor Tyrosine Kinase Family in Metastatic Colorectal Cancer.

Duplaquet L, Figeac M, Leprêtre F, Frandemiche C, Villenet C, Sebda S, Sarafan-Vasseur N, Bénozène M, Vinchent A, Goormachtigh G, Wicquart L, Rousseau N, Beaussire L, Truant S, Michel P, Sabourin JC, Galateau-Sallé F, Copin MC, Zalcman G, De Launoit Y, Fafeur V, Tulasne D.

Mol Cancer Ther. 2019 Jun;18(6):1137-1148. doi: 10.1158/1535-7163.MCT-18-0582. Epub 2019 Mar 29.

PMID:
30926633
2.

Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy.

Benkhelifa S, Rafa H, Belhadef S, Ait-Kaci H, Medjeber O, Belkhelfa M, Hetit S, Ait-Younes S, De Launoit Y, Moralès O, Mahfouf H, Delhem N, Touil-Boukoffa C.

Inflammopharmacology. 2019 Aug;27(4):685-700. doi: 10.1007/s10787-019-00566-9. Epub 2019 Jan 24.

PMID:
30680650
3.

TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases.

Delliaux C, Tian TV, Bouchet M, Fradet A, Vanpouille N, Flourens A, Deplus R, Villers A, Leroy X, Clézardin P, de Launoit Y, Bonnelye E, Duterque-Coquillaud M.

Cancer Lett. 2018 Dec 1;438:32-43. doi: 10.1016/j.canlet.2018.08.027. Epub 2018 Sep 7.

PMID:
30201302
4.

ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.

Dumortier M, Ladam F, Damour I, Vacher S, Bièche I, Marchand N, de Launoit Y, Tulasne D, Chotteau-Lelièvre A.

Breast Cancer Res. 2018 Jul 11;20(1):73. doi: 10.1186/s13058-018-0992-0.

5.

All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.

Rafa H, Benkhelifa S, AitYounes S, Saoula H, Belhadef S, Belkhelfa M, Boukercha A, Toumi R, Soufli I, Moralès O, de Launoit Y, Mahfouf H, Nakmouche M, Delhem N, Touil-Boukoffa C.

Mediators Inflamm. 2017;2017:7353252. doi: 10.1155/2017/7353252. Epub 2017 Mar 20.

6.

TMPRSS2-ERG fusion promotes prostate cancer metastases in bone.

Deplus R, Delliaux C, Marchand N, Flourens A, Vanpouille N, Leroy X, de Launoit Y, Duterque-Coquillaud M.

Oncotarget. 2017 Feb 14;8(7):11827-11840. doi: 10.18632/oncotarget.14399.

7.

PEA3 transcription factors are downstream effectors of Met signaling involved in migration and invasiveness of Met-addicted tumor cells.

Kherrouche Z, Monte D, Werkmeister E, Stoven L, De Launoit Y, Cortot AB, Tulasne D, Chotteau-Lelievre A.

Mol Oncol. 2015 Nov;9(9):1852-67. doi: 10.1016/j.molonc.2015.07.001. Epub 2015 Jul 15.

8.

The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids.

Gutierrez-Aguilar R, Thompson A, Marchand N, Dumont P, Woods SC, de Launoit Y, Seeley RJ, Ulrich-Lai YM.

Physiol Behav. 2015 Oct 15;150:38-42. doi: 10.1016/j.physbeh.2015.03.027. Epub 2015 Mar 24.

9.

TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.

Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, Bokhobza A, Bidaux G, Degerny C, Verreman K, Guarmit B, Benahmed M, de Launoit Y, Bindels RJ, Fiorio Pla A, Prevarskaya N.

J Cell Biol. 2015 Jan 5;208(1):89-107. doi: 10.1083/jcb.201402076.

10.

Effect of nasopharyngeal carcinoma-derived exosomes on human regulatory T cells.

Mrizak D, Martin N, Barjon C, Jimenez-Pailhes AS, Mustapha R, Niki T, Guigay J, Pancré V, de Launoit Y, Busson P, Moralès O, Delhem N.

J Natl Cancer Inst. 2014 Dec 12;107(1):363. doi: 10.1093/jnci/dju363. Print 2015 Jan.

PMID:
25505237
11.

Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.

Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F.

Cell Rep. 2014 Aug 7;8(3):743-53. doi: 10.1016/j.celrep.2014.06.048. Epub 2014 Jul 24.

12.

Epstein-Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients.

Morales O, Mrizak D, François V, Mustapha R, Miroux C, Depil S, Decouvelaere AV, Lionne-Huyghe P, Auriault C, de Launoit Y, Pancré V, Delhem N.

Br J Haematol. 2014 Sep;166(6):875-90. doi: 10.1111/bjh.12980. Epub 2014 Jul 9.

PMID:
25041527
13.

PLA2R1 mediates tumor suppression by activating JAK2.

Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D.

Cancer Res. 2013 Oct 15;73(20):6334-45. doi: 10.1158/0008-5472.CAN-13-0318. Epub 2013 Sep 5.

14.

PLA2R1 kills cancer cells by inducing mitochondrial stress.

Augert A, Vindrieux D, Girard CA, Le Calvé B, Gras B, Ferrand M, Bouchet BP, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D.

Free Radic Biol Med. 2013 Dec;65:969-977. doi: 10.1016/j.freeradbiomed.2013.08.177. Epub 2013 Aug 29.

PMID:
23994771
15.

Loss of a negative feedback loop involving pea3 and cyclin d2 is required for pea3-induced migration in transformed mammary epithelial cells.

Ladam F, Damour I, Dumont P, Kherrouche Z, de Launoit Y, Tulasne D, Chotteau-Lelievre A.

Mol Cancer Res. 2013 Nov;11(11):1412-24. doi: 10.1158/1541-7786.MCR-13-0229. Epub 2013 Aug 29.

16.

Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2.

Tian TV, Tomavo N, Huot L, Flourens A, Bonnelye E, Flajollet S, Hot D, Leroy X, de Launoit Y, Duterque-Coquillaud M.

Oncogene. 2014 Apr 24;33(17):2204-14. doi: 10.1038/onc.2013.176. Epub 2013 May 27.

PMID:
23708657
17.

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members.

Verger A, Baert JL, Verreman K, Dewitte F, Ferreira E, Lens Z, de Launoit Y, Villeret V, Monté D.

Nucleic Acids Res. 2013 May;41(9):4847-59. doi: 10.1093/nar/gkt199. Epub 2013 Mar 26.

18.

IL-23/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: immunomodulatory effect of retinoic acid.

Rafa H, Saoula H, Belkhelfa M, Medjeber O, Soufli I, Toumi R, de Launoit Y, Moralès O, Nakmouche M, Delhem N, Touil-Boukoffa C.

J Interferon Cytokine Res. 2013 Jul;33(7):355-68. doi: 10.1089/jir.2012.0063. Epub 2013 Mar 8.

PMID:
23472658
19.

Overexpression of Regulatory T Cells Type 1 (Tr1) Specific Markers in a Patient with HCV-Induced Hepatocellular Carcinoma.

Ouaguia L, Morales O, Mrizak D, Ghazal K, Boleslawski E, Auriault C, Pancré V, de Launoit Y, Conti F, Delhem N.

ISRN Hepatol. 2013 Oct 23;2013:928485. doi: 10.1155/2013/928485. eCollection 2013.

20.

Corticosteroids do not reverse the inhibitory effect of cyclosporine on regulatory T-cell activity in contrast to mycophenolate mofetil.

Miroux C, Morales O, Ouaguia L, Aoudjehane L, Boleslawski E, Pancré V, de Launoit Y, Calmus Y, Conti F, Delhem N.

Transplant Proc. 2012 Nov;44(9):2834-9. doi: 10.1016/j.transproceed.2012.09.091.

PMID:
23146536
21.

Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.

Le Goff A, Ji Z, Leclercq B, Bourette RP, Mougel A, Guerardel C, de Launoit Y, Vicogne J, Goormachtigh G, Fafeur V.

J Biol Chem. 2012 Oct 12;287(42):35382-96. doi: 10.1074/jbc.M112.409797. Epub 2012 Aug 22.

22.

Altered expression of the poly(ADP-ribosyl)ation enzymes in uveal melanoma and regulation of PARG gene expression by the transcription factor ERM.

Molloy-Simard V, St-Laurent JF, Vigneault F, Gaudreault M, Dargis N, Guérin MC, Leclerc S, Morcos M, Black D, Molgat Y, Bergeron D, de Launoit Y, Boudreau F, Desnoyers S, Guérin S.

Invest Ophthalmol Vis Sci. 2012 Sep 14;53(10):6219-31. doi: 10.1167/iovs.11-8853.

PMID:
22915039
23.

In vitro effects of cyclosporine A and tacrolimus on regulatory T-cell proliferation and function.

Miroux C, Morales O, Ghazal K, Othman SB, de Launoit Y, Pancré V, Conti F, Delhem N.

Transplantation. 2012 Jul 27;94(2):123-31. doi: 10.1097/TP.0b013e3182590d8f.

PMID:
22743548
24.

EBV Latency II-derived peptides induce a specific CD4+ cytotoxic T-cell activity and not a CD4+ regulatory T-cell response.

Moralès O, Depil S, Mrizak D, Martin N, Ndour PA, Dufosse F, Miroux C, Coll J, de Launoit Y, Auriault C, Pancre V, Delhem N.

J Immunother. 2012 Apr;35(3):254-66. doi: 10.1097/CJI.0b013e31824d72c5.

PMID:
22421943
25.

Activation of a helper and not regulatory human CD4+ T cell response by oncolytic H-1 parvovirus.

Moralès O, Richard A, Martin N, Mrizak D, Sénéchal M, Miroux C, Pancré V, Rommelaere J, Caillet-Fauquet P, de Launoit Y, Delhem N.

PLoS One. 2012;7(2):e32197. doi: 10.1371/journal.pone.0032197. Epub 2012 Feb 16.

26.

The coactivator activator CoAA regulates PEA3 group member transcriptional activity.

Verreman K, Baert JL, Verger A, Drobecq H, Ferreira E, de Launoit Y, Monte D.

Biochem J. 2011 Nov 1;439(3):469-77. doi: 10.1042/BJ20110728.

PMID:
21736557
27.

Purification of SUMO-1 modified IκBα and complex formation with NF-κB.

Lens Z, Dewitte F, Van Lint C, de Launoit Y, Villeret V, Verger A.

Protein Expr Purif. 2011 Dec;80(2):211-6. doi: 10.1016/j.pep.2011.06.009. Epub 2011 Jun 25.

PMID:
21708266
28.

NMR structure of the human Mediator MED25 ACID domain.

Bontems F, Verger A, Dewitte F, Lens Z, Baert JL, Ferreira E, de Launoit Y, Sizun C, Guittet E, Villeret V, Monté D.

J Struct Biol. 2011 Apr;174(1):245-51. doi: 10.1016/j.jsb.2010.10.011. Epub 2010 Oct 23.

PMID:
20974256
29.

Solution structure of the N-terminal transactivation domain of ERM modified by SUMO-1.

Lens Z, Dewitte F, Monté D, Baert JL, Bompard C, Sénéchal M, Van Lint C, de Launoit Y, Villeret V, Verger A.

Biochem Biophys Res Commun. 2010 Aug 13;399(1):104-10. doi: 10.1016/j.bbrc.2010.07.049. Epub 2010 Jul 18.

PMID:
20647002
30.

Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

Dessein AF, Stechly L, Jonckheere N, Dumont P, Monté D, Leteurtre E, Truant S, Pruvot FR, Figeac M, Hebbar M, Lecellier CH, Lesuffleur T, Dessein R, Grard G, Dejonghe MJ, de Launoit Y, Furuichi Y, Prévost G, Porchet N, Gespach C, Huet G.

Cancer Res. 2010 Jun 1;70(11):4644-54. doi: 10.1158/0008-5472.CAN-09-3828. Epub 2010 May 11.

31.

The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity.

Baert JL, Monte D, Verreman K, Degerny C, Coutte L, de Launoit Y.

Oncogene. 2010 Mar 25;29(12):1810-20. doi: 10.1038/onc.2009.471. Epub 2010 Jan 11.

PMID:
20062082
32.

Functional cooperation between Stat-1 and ets-1 to optimize icam-1 gene transcription.

Yockell-Lelièvre J, Spriet C, Cantin P, Malenfant P, Heliot L, de Launoit Y, Audette M.

Biochem Cell Biol. 2009 Dec;87(6):905-18. doi: 10.1139/o09-055.

PMID:
19935876
33.

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D.

EMBO J. 2010 Jan 20;29(2):376-86. doi: 10.1038/emboj.2009.342. Epub 2009 Nov 19.

34.

Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells.

Gosselin K, Martien S, Pourtier A, Vercamer C, Ostoich P, Morat L, Sabatier L, Duprez L, T'kint de Roodenbeke C, Gilson E, Malaquin N, Wernert N, Slijepcevic P, Ashtari M, Chelli F, Deruy E, Vandenbunder B, De Launoit Y, Abbadie C.

Cancer Res. 2009 Oct 15;69(20):7917-25. doi: 10.1158/0008-5472.CAN-08-2510. Epub 2009 Oct 13.

35.

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Reuse S, Calao M, Kabeya K, Guiguen A, Gatot JS, Quivy V, Vanhulle C, Lamine A, Vaira D, Demonte D, Martinelli V, Veithen E, Cherrier T, Avettand V, Poutrel S, Piette J, de Launoit Y, Moutschen M, Burny A, Rouzioux C, De Wit S, Herbein G, Rohr O, Collette Y, Lambotte O, Clumeck N, Van Lint C.

PLoS One. 2009 Jun 30;4(6):e6093. doi: 10.1371/journal.pone.0006093.

36.

A genetic screen identifies topoisomerase 1 as a regulator of senescence.

Humbert N, Martien S, Augert A, Da Costa M, Mauen S, Abbadie C, de Launoit Y, Gil J, Bernard D.

Cancer Res. 2009 May 15;69(10):4101-6. doi: 10.1158/0008-5472.CAN-08-2864. Epub 2009 May 12.

37.

The M-type receptor PLA2R regulates senescence through the p53 pathway.

Augert A, Payré C, de Launoit Y, Gil J, Lambeau G, Bernard D.

EMBO Rep. 2009 Mar;10(3):271-7. doi: 10.1038/embor.2008.255. Epub 2009 Feb 6.

38.

Senescent keratinocytes die by autophagic programmed cell death.

Gosselin K, Deruy E, Martien S, Vercamer C, Bouali F, Dujardin T, Slomianny C, Houel-Renault L, Chelli F, De Launoit Y, Abbadie C.

Am J Pathol. 2009 Feb;174(2):423-35. doi: 10.2353/ajpath.2009.080332. Epub 2009 Jan 15.

39.

Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription.

Firlej V, Ladam F, Brysbaert G, Dumont P, Fuks F, de Launoit Y, Benecke A, Chotteau-Lelievre A.

J Cell Sci. 2008 Oct 15;121(Pt 20):3393-402. doi: 10.1242/jcs.027201. Epub 2008 Sep 30.

40.

[Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of Ets factors].

de Launoit Y, Degerny C, Wohlkonig A, Baert JL.

Bull Mem Acad R Med Belg. 2007;162(5-6):299-305; discussion 306. French.

PMID:
18404999
41.

Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.

Gouyer V, Fontaine D, Dumont P, de Wever O, Fontayne-Devaud H, Leteurtre E, Truant S, Delacour D, Drobecq H, Kerckaert JP, de Launoit Y, Bracke M, Gespach C, Desseyn JL, Huet G.

Oncogene. 2008 Jul 3;27(29):4024-33. doi: 10.1038/onc.2008.42. Epub 2008 Mar 3. Review.

PMID:
18317448
42.

ERM transcription factor contains an inhibitory domain which functions in sumoylation-dependent manner.

Degerny C, de Launoit Y, Baert JL.

Biochim Biophys Acta. 2008 Mar;1779(3):183-94. doi: 10.1016/j.bbagrm.2008.01.002. Epub 2008 Jan 17.

PMID:
18243147
43.

Transcriptional regulation of the bovine leukemia virus promoter by the cyclic AMP-response element modulator tau isoform.

Nguyên TL, de Walque S, Veithen E, Dekoninck A, Martinelli V, de Launoit Y, Burny A, Harrod R, Van Lint C.

J Biol Chem. 2007 Jul 20;282(29):20854-67. Epub 2007 May 25.

44.

[PEA3 family of transcription factors and the regulation of oncogenesis].

de Launoit Y, Baert JL, Chotteau-Lelievre A, Monte D, Coutte L, Mauen S, Firlej V, Degerny C, Verreman K.

Bull Cancer. 2006 Oct;93(10):985-9. Review. French.

45.

Viral oncoproteins target the DNA methyltransferases.

Burgers WA, Blanchon L, Pradhan S, de Launoit Y, Kouzarides T, Fuks F.

Oncogene. 2007 Mar 8;26(11):1650-5. Epub 2006 Sep 18.

46.

The 26S proteasome system degrades the ERM transcription factor and regulates its transcription-enhancing activity.

Baert JL, Beaudoin C, Monte D, Degerny C, Mauen S, de Launoit Y.

Oncogene. 2007 Jan 18;26(3):415-24. Epub 2006 Jul 10.

PMID:
16832340
47.

Does quantification of virus transcription provide a real measure of parvovirus B19 infectivity?

Caillet-Fauquet P, Di Giambattista M, de Launoit Y, Laub R.

J Clin Virol. 2006 Sep;37(1):77-8. Epub 2006 Jun 21. No abstract available.

PMID:
16797228
48.

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".

Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K.

Mol Cell Biol. 2006 Jul;26(13):5070-85.

49.

Expression, purification, and structural prediction of the Ets transcription factor ERM.

Mauen S, Huvent I, Raussens V, Demonte D, Baert JL, Tricot C, Ruysschaert JM, Van Lint C, Moguilevsky N, de Launoit Y.

Biochim Biophys Acta. 2006 Aug;1760(8):1192-201. Epub 2006 Mar 31.

PMID:
16730909
50.

Hypoxic-response elements in the oncolytic parvovirus Minute virus of mice do not allow for increased vector production at low oxygen concentration.

Servais C, Caillet-Fauquet P, Draps ML, Velu T, de Launoit Y, Brandenburger A.

J Gen Virol. 2006 May;87(Pt 5):1197-201.

PMID:
16603521

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