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Items: 34

1.

Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.

Walters JLH, De Iuliis GN, Dun MD, Aitken RJ, McLaughlin EA, Nixon B, Bromfield EG.

Biol Reprod. 2018 Jun 1;98(6):784-794. doi: 10.1093/biolre/ioy058.

PMID:
29546268
2.

Characteristics of the Epididymal Luminal Environment Responsible for Sperm Maturation and Storage.

Zhou W, De Iuliis GN, Dun MD, Nixon B.

Front Endocrinol (Lausanne). 2018 Feb 28;9:59. doi: 10.3389/fendo.2018.00059. eCollection 2018. Review.

3.

Heat exposure induces oxidative stress and DNA damage in the male germ line.

Houston BJ, Nixon B, Martin JH, De Iuliis GN, Trigg NA, Bromfield EG, McEwan KE, Aitken RJ.

Biol Reprod. 2018 Apr 1;98(4):593-606. doi: 10.1093/biolre/ioy009.

PMID:
29351587
4.

(Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway.

Gilbert J, De Iuliis GN, Tarleton M, McCluskey A, Sakoff JA.

Mol Pharmacol. 2018 Feb;93(2):168-177. doi: 10.1124/mol.117.109827. Epub 2017 Dec 21.

PMID:
29269419
5.

Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.

Zhou W, Anderson AL, Turner AP, De Iuliis GN, McCluskey A, McLaughlin EA, Nixon B.

Mol Hum Reprod. 2017 Oct 1;23(10):657-673. doi: 10.1093/molehr/gax044.

PMID:
29044420
6.

The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte.

Mihalas BP, De Iuliis GN, Redgrove KA, McLaughlin EA, Nixon B.

Sci Rep. 2017 Jul 24;7(1):6247. doi: 10.1038/s41598-017-06372-z.

7.

Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.

Zhou W, De Iuliis GN, Turner AP, Reid AT, Anderson AL, McCluskey A, McLaughlin EA, Nixon B.

Biol Reprod. 2017 Jan 1;96(1):159-173. doi: 10.1095/biolreprod.116.145433.

PMID:
28395327
8.

Heat Shock Protein A2 (HSPA2): Regulatory Roles in Germ Cell Development and Sperm Function.

Nixon B, Bromfield EG, Cui J, De Iuliis GN.

Adv Anat Embryol Cell Biol. 2017;222:67-93. doi: 10.1007/978-3-319-51409-3_4. Review.

PMID:
28389751
9.

The effects of radiofrequency electromagnetic radiation on sperm function.

Houston BJ, Nixon B, King BV, De Iuliis GN, Aitken RJ.

Reproduction. 2016 Dec;152(6):R263-R276. Epub 2016 Sep 6. Review.

10.

Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology.

Aitken RJ, Muscio L, Whiting S, Connaughton HS, Fraser BA, Nixon B, Smith ND, De Iuliis GN.

Biochem Pharmacol. 2016 Dec 1;121:78-96. doi: 10.1016/j.bcp.2016.09.015. Epub 2016 Sep 19.

PMID:
27659810
11.

Potential importance of transition metals in the induction of DNA damage by sperm preparation media.

Aitken RJ, Finnie JM, Muscio L, Whiting S, Connaughton HS, Kuczera L, Rothkirch TB, De Iuliis GN.

Hum Reprod. 2014 Oct 10;29(10):2136-47. doi: 10.1093/humrep/deu204. Epub 2014 Aug 19.

PMID:
25141857
12.

Oxidative stress and male reproductive health.

Aitken RJ, Smith TB, Jobling MS, Baker MA, De Iuliis GN.

Asian J Androl. 2014 Jan-Feb;16(1):31-8. doi: 10.4103/1008-682X.122203. Review.

13.

The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line.

Smith TB, De Iuliis GN, Lord T, Aitken RJ.

Reproduction. 2013 Jul 31;146(3):253-62. doi: 10.1530/REP-13-0186. Print 2013 Sep.

14.

The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies.

Aitken RJ, Bronson R, Smith TB, De Iuliis GN.

Mol Hum Reprod. 2013 Aug;19(8):475-85. doi: 10.1093/molehr/gat025. Epub 2013 Apr 1. Review.

PMID:
23548339
15.

On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid.

Aitken RJ, Smith TB, Lord T, Kuczera L, Koppers AJ, Naumovski N, Connaughton H, Baker MA, De Iuliis GN.

Andrology. 2013 Mar;1(2):192-205. doi: 10.1111/j.2047-2927.2012.00056.x. Epub 2013 Jan 13.

16.

Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols.

Aitken RJ, Gibb Z, Mitchell LA, Lambourne SR, Connaughton HS, De Iuliis GN.

Biol Reprod. 2012 Nov 8;87(5):110. doi: 10.1095/biolreprod.112.102020. Print 2012 Nov.

PMID:
22933515
17.

Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase.

Aitken RJ, Whiting S, De Iuliis GN, McClymont S, Mitchell LA, Baker MA.

J Biol Chem. 2012 Sep 21;287(39):33048-60. Epub 2012 Jul 31.

18.

The Simmet lecture: new horizons on an old landscape--oxidative stress, DNA damage and apoptosis in the male germ line.

Aitken RJ, De Iuliis GN, Gibb Z, Baker MA.

Reprod Domest Anim. 2012 Aug;47 Suppl 4:7-14. doi: 10.1111/j.1439-0531.2012.02049.x.

PMID:
22827344
19.

New insights into sperm physiology and pathology.

Aitken RJ, Baker MA, De Iuliis GN, Nixon B.

Handb Exp Pharmacol. 2010;(198):99-115. doi: 10.1007/978-3-642-02062-9_7. Review.

PMID:
20839089
20.

Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria.

Aitken RJ, De Iuliis GN, Finnie JM, Hedges A, McLachlan RI.

Hum Reprod. 2010 Oct;25(10):2415-26. doi: 10.1093/humrep/deq214. Epub 2010 Aug 17.

PMID:
20716559
21.

The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: development of an improved methodology.

Mitchell LA, De Iuliis GN, Aitken RJ.

Int J Androl. 2011 Feb;34(1):2-13. doi: 10.1111/j.1365-2605.2009.01042.x.

PMID:
20158539
22.

Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro.

De Iuliis GN, Newey RJ, King BV, Aitken RJ.

PLoS One. 2009 Jul 31;4(7):e6446. doi: 10.1371/journal.pone.0006446. Erratum in: PLoS One. 2013;8(3). doi:10.1371/annotation/9a8a0172-3850-4059-b852-72c330769c1b.

23.

On the possible origins of DNA damage in human spermatozoa.

Aitken RJ, De Iuliis GN.

Mol Hum Reprod. 2010 Jan;16(1):3-13. doi: 10.1093/molehr/gap059. Epub 2009 Jul 31. Review.

PMID:
19648152
24.

Acrosomal integrity, viability, and DNA damage of sperm from dasyurid marsupials after freezing or freeze drying.

Czarny NA, Harris MS, De Iuliis GN, Rodger JC.

Theriogenology. 2009 Oct 1;72(6):817-25. doi: 10.1016/j.theriogenology.2009.05.018. Epub 2009 Jul 18.

PMID:
19616836
25.

Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis.

Thomson LK, Fleming SD, Aitken RJ, De Iuliis GN, Zieschang JA, Clark AM.

Hum Reprod. 2009 Sep;24(9):2061-70. doi: 10.1093/humrep/dep214. Epub 2009 Jun 12.

PMID:
19525298
26.

DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress.

De Iuliis GN, Thomson LK, Mitchell LA, Finnie JM, Koppers AJ, Hedges A, Nixon B, Aitken RJ.

Biol Reprod. 2009 Sep;81(3):517-24. doi: 10.1095/biolreprod.109.076836. Epub 2009 Jun 3.

PMID:
19494251
27.

Biological and clinical significance of DNA damage in the male germ line.

Aitken RJ, De Iuliis GN, McLachlan RI.

Int J Androl. 2009 Feb;32(1):46-56. doi: 10.1111/j.1365-2605.2008.00943.x. Epub 2008 Dec 2. Review.

PMID:
19076252
28.

Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa.

Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ.

J Clin Endocrinol Metab. 2008 Aug;93(8):3199-207. doi: 10.1210/jc.2007-2616. Epub 2008 May 20.

PMID:
18492763
29.

Impact of estrogenic compounds on DNA integrity in human spermatozoa: evidence for cross-linking and redox cycling activities.

Bennetts LE, De Iuliis GN, Nixon B, Kime M, Zelski K, McVicar CM, Lewis SE, Aitken RJ.

Mutat Res. 2008 May 10;641(1-2):1-11. doi: 10.1016/j.mrfmmm.2008.02.002. Epub 2008 Feb 9.

PMID:
18342339
30.

Value of DNA integrity assays for fertility evaluation.

Aitken RJ, De Iuliis GN.

Soc Reprod Fertil Suppl. 2007;65:81-92. Review.

PMID:
17644956
31.

Origins and consequences of DNA damage in male germ cells.

Aitken RJ, De Iuliis GN.

Reprod Biomed Online. 2007 Jun;14(6):727-33. Review.

PMID:
17579989
32.

Analysis of lipid peroxidation in human spermatozoa using BODIPY C11.

Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA.

Mol Hum Reprod. 2007 Apr;13(4):203-11. Epub 2007 Feb 27.

PMID:
17327268
33.

Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa.

Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA.

J Clin Endocrinol Metab. 2006 Oct;91(10):4154-63. Epub 2006 Aug 8.

PMID:
16895947
34.

Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa.

De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ.

J Clin Endocrinol Metab. 2006 May;91(5):1968-75. Epub 2006 Feb 28.

PMID:
16507629

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