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Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.

De Greve H, Virdi V, Bakshi S, Depicker A.

Curr Opin Biotechnol. 2019 Dec 3;61:96-101. doi: 10.1016/j.copbio.2019.11.006. [Epub ahead of print] Review.


Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax.

Fioravanti A, Van Hauwermeiren F, Van der Verren SE, Jonckheere W, Goncalves A, Pardon E, Steyaert J, De Greve H, Lamkanfi M, Remaut H.

Nat Microbiol. 2019 Nov;4(11):1805-1814. doi: 10.1038/s41564-019-0499-1. Epub 2019 Jul 15.


Enzymes Catalyzing the TCA- and Urea Cycle Influence the Matrix Composition of Biofilms Formed by Methicillin-Resistant Staphylococcus aureus USA300.

De Backer S, Sabirova J, De Pauw I, De Greve H, Hernalsteens JP, Goossens H, Malhotra-Kumar S.

Microorganisms. 2018 Oct 29;6(4). pii: E113. doi: 10.3390/microorganisms6040113.


In planta expression of nanobody-based designer chicken antibodies targeting Campylobacter.

Vanmarsenille C, Elseviers J, Yvanoff C, Hassanzadeh-Ghassabeh G, Garcia Rodriguez G, Martens E, Depicker A, Martel A, Haesebrouck F, Pasmans F, Hernalsteens JP, De Greve H.

PLoS One. 2018 Sep 27;13(9):e0204222. doi: 10.1371/journal.pone.0204222. eCollection 2018.


Exaptation as a Mechanism for Functional Reinforcement of an Animal Pheromone System.

Maex M, Treer D, De Greve H, Proost P, Van Bocxlaer I, Bossuyt F.

Curr Biol. 2018 Sep 24;28(18):2955-2960.e5. doi: 10.1016/j.cub.2018.06.074. Epub 2018 Sep 6.


Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.

Talavera A, Hendrix J, Versées W, Jurėnas D, Van Nerom K, Vandenberk N, Singh RK, Konijnenberg A, De Gieter S, Castro-Roa D, Barth A, De Greve H, Sobott F, Hofkens J, Zenkin N, Loris R, Garcia-Pino A.

Sci Adv. 2018 Mar 14;4(3):eaap9714. doi: 10.1126/sciadv.aap9714. eCollection 2018 Mar.


Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment.

Bernedo-Navarro RA, Romão E, Yano T, Pinto J, De Greve H, Sterckx YG, Muyldermans S.

Toxins (Basel). 2018 Mar 1;10(3). pii: E108. doi: 10.3390/toxins10030108.


Nanobodies targeting conserved epitopes on the major outer membrane protein of Campylobacter as potential tools for control of Campylobacter colonization.

Vanmarsenille C, Díaz Del Olmo I, Elseviers J, Hassanzadeh Ghassabeh G, Moonens K, Vertommen D, Martel A, Haesebrouck F, Pasmans F, Hernalsteens JP, De Greve H.

Vet Res. 2017 Dec 8;48(1):86. doi: 10.1186/s13567-017-0491-9.


Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.

Vandervelde A, Drobnak I, Hadži S, Sterckx YG, Welte T, De Greve H, Charlier D, Efremov R, Loris R, Lah J.

Nucleic Acids Res. 2017 Apr 7;45(6):2937-2950. doi: 10.1093/nar/gkx108.


Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.

Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, Hultgren SJ.

Cell Host Microbe. 2016 Oct 12;20(4):482-492. doi: 10.1016/j.chom.2016.08.013. Epub 2016 Sep 22.


Duality of β-glucan microparticles: antigen carrier and immunostimulants.

Baert K, De Geest BG, De Greve H, Cox E, Devriendt B.

Int J Nanomedicine. 2016 May 31;11:2463-9. doi: 10.2147/IJN.S101881. eCollection 2016.


An intrinsically disordered entropic switch determines allostery in Phd-Doc regulation.

Garcia-Pino A, De Gieter S, Talavera A, De Greve H, Efremov RG, Loris R.

Nat Chem Biol. 2016 Jul;12(7):490-6. doi: 10.1038/nchembio.2078. Epub 2016 May 2.


Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.

Zorzini V, Mernik A, Lah J, Sterckx YG, De Jonge N, Garcia-Pino A, De Greve H, Versées W, Loris R.

J Biol Chem. 2016 May 20;291(21):10950-60. doi: 10.1074/jbc.M116.715912. Epub 2016 Mar 29.


A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex.

Sterckx YG, Jové T, Shkumatov AV, Garcia-Pino A, Geerts L, De Kerpel M, Lah J, De Greve H, Van Melderen L, Loris R.

J Mol Biol. 2016 Apr 24;428(8):1589-603. doi: 10.1016/j.jmb.2016.03.007. Epub 2016 Mar 18.


Fatty acid kinase A is an important determinant of biofilm formation in Staphylococcus aureus USA300.

Sabirova JS, Hernalsteens JP, De Backer S, Xavier BB, Moons P, Turlej-Rogacka A, De Greve H, Goossens H, Malhotra-Kumar S.

BMC Genomics. 2015 Oct 26;16:861. doi: 10.1186/s12864-015-1956-8.


β-glucan microparticles targeted to epithelial APN as oral antigen delivery system.

Baert K, de Geest BG, de Rycke R, da Fonseca Antunes AB, de Greve H, Cox E, Devriendt B.

J Control Release. 2015 Dec 28;220(Pt A):149-159. doi: 10.1016/j.jconrel.2015.10.025. Epub 2015 Oct 17.


Structural and adhesive properties of the long polar fimbriae protein LpfD from adherent-invasive Escherichia coli.

Coppens F, Iyyathurai J, Ruer S, Fioravanti A, Taganna J, Vereecke L, De Greve H, Remaut H.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1615-26. doi: 10.1107/S1399004715009803. Epub 2015 Jul 28.


Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.

Moonens K, Van den Broeck I, Okello E, Pardon E, De Kerpel M, Remaut H, De Greve H.

Vet Res. 2015 Feb 24;46:14. doi: 10.1186/s13567-015-0151-x.


Side-by-side secretion of Late Palaeozoic diverged courtship pheromones in an aquatic salamander.

Van Bocxlaer I, Treer D, Maex M, Vandebergh W, Janssenswillen S, Stegen G, Kok P, Willaert B, Matthijs S, Martens E, Mortier A, de Greve H, Proost P, Bossuyt F.

Proc Biol Sci. 2015 Mar 22;282(1803):20142960. doi: 10.1098/rspb.2014.2960.


Structural and functional insight into the carbohydrate receptor binding of F4 fimbriae-producing enterotoxigenic Escherichia coli.

Moonens K, Van den Broeck I, De Kerpel M, Deboeck F, Raymaekers H, Remaut H, De Greve H.

J Biol Chem. 2015 Mar 27;290(13):8409-19. doi: 10.1074/jbc.M114.618595. Epub 2015 Jan 28.


Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli.

Moonens K, De Kerpel M, Coddens A, Cox E, Pardon E, Remaut H, De Greve H.

PLoS One. 2014 Dec 11;9(12):e114691. doi: 10.1371/journal.pone.0114691. eCollection 2014.


The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.

De Gieter S, Konijnenberg A, Talavera A, Butterer A, Haesaerts S, De Greve H, Sobott F, Loris R, Garcia-Pino A.

J Biol Chem. 2014 Dec 5;289(49):34013-23. doi: 10.1074/jbc.M114.572396. Epub 2014 Oct 16.


Enterotoxigenic Escherichia coli strains are highly prevalent in Ugandan piggeries but disease outbreaks are masked by antibiotic prophylaxis.

Okello E, Moonens K, Erume J, De Greve H.

Trop Anim Health Prod. 2015 Jan;47(1):117-22. doi: 10.1007/s11250-014-0694-2. Epub 2014 Oct 14.


Comparison of biofilm formation between major clonal lineages of methicillin resistant Staphylococcus aureus.

Vanhommerig E, Moons P, Pirici D, Lammens C, Hernalsteens JP, De Greve H, Kumar-Singh S, Goossens H, Malhotra-Kumar S.

PLoS One. 2014 Aug 8;9(8):e104561. doi: 10.1371/journal.pone.0104561. eCollection 2014.


Employing whole genome mapping for optimal de novo assembly of bacterial genomes.

Xavier BB, Sabirova J, Pieter M, Hernalsteens JP, de Greve H, Goossens H, Malhotra-Kumar S.

BMC Res Notes. 2014 Jul 30;7:484. doi: 10.1186/1756-0500-7-484.


The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.

Lo AW, Moonens K, De Kerpel M, Brys L, Pardon E, Remaut H, De Greve H.

J Biol Chem. 2014 Sep 5;289(36):25374-81. doi: 10.1074/jbc.M114.566257. Epub 2014 Jul 22.


Complete Genome Sequences of Two Prolific Biofilm-Forming Staphylococcus aureus Isolates Belonging to USA300 and EMRSA-15 Clonal Lineages.

Sabirova JS, Xavier BB, Hernalsteens JP, De Greve H, Ieven M, Goossens H, Malhotra-Kumar S.

Genome Announc. 2014 Jun 26;2(3). pii: e00610-14. doi: 10.1128/genomeA.00610-14.


Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.

Zorzini V, Buts L, Sleutel M, Garcia-Pino A, Talavera A, Haesaerts S, De Greve H, Cheung A, van Nuland NA, Loris R.

Nucleic Acids Res. 2014 Jun;42(10):6709-25. doi: 10.1093/nar/gku266. Epub 2014 Apr 19.


Secretion and functional display of fusion proteins through the curli biogenesis pathway.

Van Gerven N, Goyal P, Vandenbussche G, De Kerpel M, Jonckheere W, De Greve H, Remaut H.

Mol Microbiol. 2014 Mar;91(5):1022-35. doi: 10.1111/mmi.12515. Epub 2014 Feb 12.


Hurdles in bacteriophage therapy: deconstructing the parameters.

Tsonos J, Vandenheuvel D, Briers Y, De Greve H, Hernalsteens JP, Lavigne R.

Vet Microbiol. 2014 Jul 16;171(3-4):460-9. doi: 10.1016/j.vetmic.2013.11.001. Epub 2013 Nov 15. Review.


A cocktail of in vitro efficient phages is not a guarantee for in vivo therapeutic results against avian colibacillosis.

Tsonos J, Oosterik LH, Tuntufye HN, Klumpp J, Butaye P, De Greve H, Hernalsteens JP, Lavigne R, Goddeeris BM.

Vet Microbiol. 2014 Jul 16;171(3-4):470-9. doi: 10.1016/j.vetmic.2013.10.021. Epub 2013 Nov 4.


Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection.

Virdi V, Coddens A, De Buck S, Millet S, Goddeeris BM, Cox E, De Greve H, Depicker A.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11809-14. doi: 10.1073/pnas.1301975110. Epub 2013 Jun 25.


The quiescin sulfhydryl oxidase (hQSOX1b) tunes the expression of resistin-like molecule alpha (RELM-α or mFIZZ1) in a wheat germ cell-free extract.

Gad W, Nair MG, Van Belle K, Wahni K, De Greve H, Van Ginderachter JA, Vandenbussche G, Endo Y, Artis D, Messens J.

PLoS One. 2013;8(1):e55621. doi: 10.1371/journal.pone.0055621. Epub 2013 Jan 31.


Cloning, expression, and purification of the N-terminal domain of the Flo1 flocculation protein from Saccharomyces cerevisiae in Pichia pastoris.

Goossens KV, De Greve H, Willaert RG.

Protein Expr Purif. 2013 Mar;88(1):114-9. doi: 10.1016/j.pep.2012.12.001. Epub 2012 Dec 14.


Complete genome sequence of the novel Escherichia coli phage phAPEC8.

Tsonos J, Adriaenssens EM, Klumpp J, Hernalsteens JP, Lavigne R, De Greve H.

J Virol. 2012 Dec;86(23):13117-8. doi: 10.1128/JVI.02374-12.


Structural insight in histo-blood group binding by the F18 fimbrial adhesin FedF.

Moonens K, Bouckaert J, Coddens A, Tran T, Panjikar S, De Kerpel M, Cox E, Remaut H, De Greve H.

Mol Microbiol. 2012 Oct;86(1):82-95. doi: 10.1111/j.1365-2958.2012.08174.x. Epub 2012 Aug 13.


Alternative interactions define gyrase specificity in the CcdB family.

De Jonge N, Simic M, Buts L, Haesaerts S, Roelants K, Garcia-Pino A, Sterckx Y, De Greve H, Lah J, Loris R.

Mol Microbiol. 2012 Jun;84(5):965-78. doi: 10.1111/j.1365-2958.2012.08069.x. Epub 2012 May 14.


O157:H7 and O104:H4 Vero/Shiga toxin-producing Escherichia coli outbreaks: respective role of cattle and humans.

Piérard D, De Greve H, Haesebrouck F, Mainil J.

Vet Res. 2012 Feb 13;43:13. doi: 10.1186/1297-9716-43-13. Review.


Nicotinamide dependence of uropathogenic Escherichia coli UTI89 and application of nadB as a neutral insertion site.

Li Z, Bouckaert J, Deboeck F, De Greve H, Hernalsteens JP.

Microbiology. 2012 Mar;158(Pt 3):736-745. doi: 10.1099/mic.0.052043-0. Epub 2011 Dec 15.


Protection of piglets against Edema disease by maternal immunization with Stx2e toxoid.

Oanh TK, Nguyen VK, De Greve H, Goddeeris BM.

Infect Immun. 2012 Jan;80(1):469-73. doi: 10.1128/IAI.05539-11. Epub 2011 Nov 14.


Calcific myonecrosis.

Tai JL, van de Kreeke WT, de Greve HK.

JBR-BTR. 2011 May-Jun;94(3):136-7. No abstract available.


Reproducible gene targeting in recalcitrant Escherichia coli isolates.

Derous V, Deboeck F, Hernalsteens JP, De Greve H.

BMC Res Notes. 2011 Jun 22;4:213. doi: 10.1186/1756-0500-4-213.


The N-terminal domain of the Flo1 flocculation protein from Saccharomyces cerevisiae binds specifically to mannose carbohydrates.

Goossens KV, Stassen C, Stals I, Donohue DS, Devreese B, De Greve H, Willaert RG.

Eukaryot Cell. 2011 Jan;10(1):110-7. doi: 10.1128/EC.00185-10. Epub 2010 Nov 12.


Escherichia coli strains causing edema disease in northern Vietnam share an identical verotoxin 2e.

Oanh TK, Nguyen VK, Do TN, Goddeeris BM, De Greve H.

Trop Anim Health Prod. 2010 Dec;42(8):1797-804. doi: 10.1007/s11250-010-9639-6. Epub 2010 Jul 27.


Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.

Garcia-Pino A, Balasubramanian S, Wyns L, Gazit E, De Greve H, Magnuson RD, Charlier D, van Nuland NA, Loris R.

Cell. 2010 Jul 9;142(1):101-11. doi: 10.1016/j.cell.2010.05.039.


Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG.

Van Molle I, Moonens K, Garcia-Pino A, Buts L, De Kerpel M, Wyns L, Bouckaert J, De Greve H.

J Mol Biol. 2009 Dec 18;394(5):957-67. doi: 10.1016/j.jmb.2009.09.059. Epub 2009 Sep 30.


Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain.

De Jonge N, Garcia-Pino A, Buts L, Haesaerts S, Charlier D, Zangger K, Wyns L, De Greve H, Loris R.

Mol Cell. 2009 Jul 31;35(2):154-63. doi: 10.1016/j.molcel.2009.05.025.


Towards a new reference test for surra in camels.

Tran T, Claes F, Verloo D, De Greve H, Büscher P.

Clin Vaccine Immunol. 2009 Jul;16(7):999-1002. doi: 10.1128/CVI.00096-09. Epub 2009 Apr 29.


The F4 fimbrial chaperone FaeE is stable as a monomer that does not require self-capping of its pilin-interactive surfaces.

Van Molle I, Moonens K, Buts L, Garcia-Pino A, Panjikar S, Wyns L, De Greve H, Bouckaert J.

Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):411-20. doi: 10.1107/S0907444909005174. Epub 2009 Apr 18.


Prevalence of enterotoxigenic Escherichia coli virulence genes from scouring piglets in Zimbabwe.

Madoroba E, Van Driessche E, De Greve H, Mast J, Ncube I, Read J, Beeckmans S.

Trop Anim Health Prod. 2009 Oct;41(7):1539-47. doi: 10.1007/s11250-009-9345-4. Epub 2009 Apr 4.


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